CN87103403A - Medical pulsed laser device - Google Patents
Medical pulsed laser device Download PDFInfo
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- CN87103403A CN87103403A CN87103403.4A CN87103403A CN87103403A CN 87103403 A CN87103403 A CN 87103403A CN 87103403 A CN87103403 A CN 87103403A CN 87103403 A CN87103403 A CN 87103403A
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Abstract
一种医用脉冲激光装置，涉及医用激光诊断和治疗装置。肿瘤的诊断用511nm波长的铜蒸汽激光经光纤散焦耦合装置，辐照到具有HPD的人体组织。观察其荧光即可诊断人体组织是否存在肿瘤，治疗用铜蒸气激光泵浦染料激光器产生波长为630±10nm的红色激光。本发明所提供脉冲激光装置具有已有技术的性能，还可对人体深部肿瘤进行诊治。具有诊断符合率高，治疗效果好、结构简单、操作方便、价格便宜的优点。能广泛用于肿瘤，特别是早期肿瘤的临床诊治。
A medical pulse laser device relates to a medical laser diagnosis and treatment device. Tumor diagnosis uses copper vapor laser with a wavelength of 511nm to irradiate the human tissue with HPD through the optical fiber defocus coupling device. Whether there is a tumor in human tissue can be diagnosed by observing its fluorescence. The copper vapor laser pumped dye laser for treatment produces red laser light with a wavelength of 630±10nm. The pulse laser device provided by the invention has the performance of the prior art, and can also diagnose and treat deep tumors in the human body. The invention has the advantages of high diagnostic coincidence rate, good therapeutic effect, simple structure, convenient operation and low price. It can be widely used in clinical diagnosis and treatment of tumors, especially early tumors.
Description
The present invention relates to medical laser diagnosis and therapy equipment.
In prior art, EP-01610616 proposes to inject in the human body with tumoraffin photoactive substance hematoporphyrin derivative (HPD), after a period of time, with fluorescent lamp or argon laser pumping dye laser, or whether krypton ion laser exist tumor as exciting light source diagnosis, or tumor is treated.But these light sources all are continuous lights, and power is less, can not shine darker tissue.
The clear 59-40869 of TOHKEMY shows with excimer laser pumping dye laser diagnoses and treatment tumor.This laser is the low pulse repetition frequency laser of 60 hertz or 1 hertz, and pulse width is 30ns.Diagnosis is the laser of 405nm with wavelength, and treatment is the laser of 630nm with wavelength, and single pulse energy is between number millijoule to 100 millijoule.This laser is to (tumor of about 25mm～50mm) has destruction, but because single laser pulse power is bigger, easily causes the tumor tissues vaporization, causes not the transfer of " splashing " of the tumor cell of inactivation than the depths.On the other hand, because this laser instrument repetition rate is low, mean power is little, in fact encourages the HPD energy little, and photochemical reaction is slow, brings very big inconvenience to treatment.
The objective of the invention is to overcome the existing shortcoming of prior art, a kind of medical impulse laser unit that can carry out diagnosis and treatment to deep tumor in the body of novelty is provided.
To achieve these goals, medical impulse laser unit provided by the present invention, adopt have high-average power, copper-vapor laser that high-peak power, high pulse repetition rate, wavelength are 511nm and 578nm is as light-source system.It can be the halide vapor laser instrument of fine copper vapor laser or copper.On the structure dismountable or flow-type or dismounting, flow-type.The copper-vapor laser that is provided is a diagnosis light source, also is the pump light source of dye laser.When being used to diagnose, the laser that sent enters first fiber coupling device through filter set, and first fiber coupling device that is provided can be an optic fibre defocusing coupling device, and it is made up of lens and optical fiber and holding frame.Laser focusing behind the scioptics is on the position before or after the optic fibre input end face, and like this, the laser spot diameter that arrives the optic fibre input end face is bigger than the actual diameter of optical fiber, has only part laser to enter in the optical fiber, thereby meets the requirement of diagnosis institute light requirement.Laser shines tissue after fiber-optic transfer, the body tumor tissue that has absorbed (HPD) is excited and afterwards produces peak wavelength is the red fluorescence of 630nm and 690nm, and human normal tissue does not produce red fluorescence after being excited.The fluorescence of reflection enters into light signal processing device and handles, the light signal processing device that is provided comprises filter set, optical filter filtering wavelength is the light beam of 450nm～600nm, and seeing through wavelength is the light beam of 600nm～690nm, thereby has significantly reduced the veiling glare of background.Shown that by the fluorescence after the light signal processing device processing whether recording equipment shows record, exist thereby can make a definite diagnosis tumor.Also can make a definite diagnosis tumor and whether exist with ocular estimate the be stimulated color and luster of the back fluorescence that sends of tissue that promptly directly detects by an unaided eye.When being used for the treatment of, the laser pump (ing) dye laser that the copper-vapor laser that is provided sends, the dye laser that is provided is that dye solution circulates and through supercooling, its laser that sends has the characteristic of high-average power, high-peak power and high pulse repetition frequency.The wavelength that this laser instrument can send treatment tumor effect the best is the laser of 630nm ± 10nm.The laser that dye laser sent enters second fiber coupling device, and through fiber-optic transfer, irradiation is treated to the tissue of suffering from tumor.The mean power and the peak power of this laser are moderate, neither can make the human normal tissue scorch, can make photochemical reaction rapid again, the kill tumor cell can also be penetrated into the tissue depths and treats effectively, and can not cause not the transfer of " splashing " of the tumor cell of inactivation.
In order to solve purpose of the present invention, the invention provides another kind of medical impulse laser unit, adopt have high-average power, copper-vapor laser that high-peak power, high pulse repetition frequency, wavelength are 511nm and 578nm is as light-source system.It can be the halide vapor laser instrument of fine copper vapor laser or copper, also can be dismountable or flow-type or the copper-vapor laser that haves both at the same time.The laser that the copper-vapor laser that is provided sends is used for the pumping dye laser.The dye laser that is provided is that dye solution circulates, and through supercooling, can send the dye laser of the laser with high-average power, high-peak power and high pulse repetition frequency.The wavelength that it sends treatment tumor effect the best is the laser of 630nm ± 10nm.The laser that dye laser sent enters into fiber coupling device, and through fiber-optic transfer, irradiation is treated to the tissue of suffering from tumor.
In order to realize purpose of the present invention, the invention provides another medical impulse laser unit, adopt have high-average power, copper-vapor laser that high-peak power, high pulse repetition frequency, wavelength are 511nm and 578nm is as light-source system.It can be the halide vapor laser instrument of fine copper vapor laser or copper, also can be dismountable or flow-type or dismounting, flow-type copper-vapor laser.This light-source system is as diagnosis light source, and the laser that it sends enters fiber coupling device through filter set.The fiber coupling device that is provided is a kind of optic fibre defocusing coupling device, and it is made up of lens, optical fiber and holding frame thereof.Laser focusing behind the scioptics is bigger than optical fiber actual diameter in the laser spot diameter of optic fibre input end face, has only part laser to enter in the optical fiber, thereby meets the requirement of diagnosis institute light requirement.Laser shines tissue and inspires fluorescence after fiber-optic transfer, and the body tumor tissue that has absorbed HPD is excited and afterwards produces the characteristic peak wavelength is the red fluorescence of 630nm and 690nm.The fluorescence of reflection enters into light signal processing device and handles.The light signal processing device that is provided has comprised filter set, and optical filter filtering wavelength is the light beam of 450nm～600nm, is the light beam of 600nm～690nm and see through wavelength.Thereby significantly reduced background stray light.Shown that by the fluorescence after the light signal processing device processing recording equipment shows record, can make a definite diagnosis tumor and whether exist.Whether also available ocular estimate promptly directly detects by an unaided eye existence that the color and luster that sends fluorescence after tissue is excited makes a definite diagnosis tumor.Because it is big and fluorescence is handled by the light signal processing device that has filter set that diagnosis laser has the power of high-peak power, exciting light, reduced bias light, thereby improved the coincidence rate of diagnosing tumour greatly.
Medical impulse laser unit provided by the present invention not only has the performance of prior art, also can carry out diagnosis and treatment to the tumor in human body deep.Have diagnostic accordance rate height, good, simple in structure, easy to operate, the advantages of cheap price of therapeutic effect.Can be widely used in the clinical diagnosis of tumor, particularly infantile tumour, treatment.
Fig. 1 is the sketch map of an embodiment of the said medical impulse laser unit of the present invention
Fig. 2 is the sketch map of said another enforcement of medical impulse laser unit of the present invention
Fig. 3 is the sketch map of the another embodiment of the said medical impulse laser unit of the present invention
Fig. 4 is the sketch map of blood circulation of the dye laser of the said medical impulse laser unit of the present invention
Be one embodiment of the present of invention below.
As shown in Figure 1 be medical impulse laser unit provided by the invention, light-source system be the dismounting, mobile cuprous bromide vapor laser (1).When being used to diagnose, the laser that by the wavelength of its outgoing is 511nm and 578nm is by reflecting mirror (2) and (3), be transferred to filter set (14), have only the green glow of 511nm to see through, be to have the part green laser to be coupled in the optical fiber (5) behind the lens (15) of optic fibre defocusing coupling device (4) by first fiber coupling device, ordinary optic fibre (5) transmission green laser comprises normal structure and the tumor tissues that has absorbed HPD to tested tissue (6), makes it inspire fluorescence.The fluorescence of reflection is transferred to fluorescent optical filter group (16) in the light signal processing device (8) by the optical fiber (7) of simple glass, having only wavelength is that the red fluorescence of 600nm～690nm sees through, after optical signal is handled, showing the upward record tested person fluorescence spectrum figure of soma of recording equipment (10).Whether analytical curve exists the wavelength of the tumor that has absorbed HPD is that the red characteristic peak of 630nm and 690nm can be made a definite diagnosis tissue and whether has tumor.When being used for the treatment of, the laser that bromizates wavelength that cuprous vapor laser (1) sends and be 511nm and 578nm shines directly into the pumping mirror (17) of dye laser (11), focus on the mobile dyestuff liquid level (18), dye solution is activated, three mirror resonator cavitys of the astigmatism compensation that is made of total reflective mirror (19) and (20) and flat output mirror (21) make dye laser produce vibration, by outgoing mirror (21) output wavelength is 630nm ± 10nm, and pulse recurrence rate is the dye laser of 10KHZ～30KHZ.The lens (23) of laser through second fiber coupling device (12) are coupled in the optical fiber (13), and softish optical fiber (13) can be treated Laser Transmission easily in body surface and body.
The resonator cavity of the said dismounting of present embodiment, flow-type cuprous bromide vapor laser (1) is by total reflective mirror (23), discharge tube (24), ground cover (25) and (26), and outgoing mirror (27) constitutes.The two ends ground of discharge tube (24) connects with the ground cover (25) and (26) that have the cloth window, and the place of connecting seals with vacuum grease.Can take off ground cover (25) and (26) discharge cleaning pipe (24) at any time or add the cuprous bromide operation material.When bromize copper phosphorons laser (1) is worked, gas exchange system (28) bleeds to discharge tube (24) by air vent (29), by air intake (30) discharge tube (24) is charged into the buffer gas neon, the cushion gas physical ability flows in discharge tube (24).High-repetition-rate pulse power supply (9) bromizates cuprous vapor laser and produces laser generation the discharge tube discharge.Outgoing mirror (27) is a not planoconvex lens of plated film, is the outgoing mirror of resonator cavity, is used for making the laser beam of output to focus on again.The average laser power of bromize copper phosphorons laser (1) output is that 2W～4W, peak power are that 10KW～20KW, pulse recurrence rate are that 10KHZ～30KHZ, wavelength are 511nm and 578nm.
First fiber coupling device of said impulse laser unit adopts optic fibre defocusing coupling device (4) in the present embodiment.It is made up of optical fiber (5), removable lens (15) and fixed clamp frame (32).Cuprous bromide laser enters filter set (14) through reflecting mirror (2) and (3), with the yellow laser filtering of the 578nm wavelength in the laser, and sees through the green laser of wavelength 511nm.Through lens (15) green laser is focused on optical fiber (5) the input end face position before, so have only the part green laser to be coupled in the optical fiber (5).Lens are fixed on the support (31) that can move along Z-direction, regulate support (31) and move around in Z-direction, and the green laser intensity that is coupled in the optical fiber is continuously changed.Generally be adjusted within the required best light intensity 50mw～400mw scope of diagnosis.The front end of optical fiber (5) is fixing by fixed support (32).
Increased fluorescent optical filter group (16) in the optical signal processing system of the said medical impulse laser unit of this example (8), each optical filter is the light filtering of 450nm～600nm to wavelength, transmitance is less than 1%, and to filtering long for the HONGGUANG transmitance of 600nm～690nm be 40%～80%.
As shown in Figure 4, the dye solution of the dye laser (11) in the said medical impulse laser unit of present embodiment forms liquid level (33) after shower nozzle (36) ejection, be recovered in the pump (35) through pipe (34), during pump (35) is led its ascending pipe again, enter shower nozzle (36) through chiller (37) cooling.Cold water enters from the inlet tube (38) of chiller (37), behind the dye solution heat-shift.Discharge by outlet (39).The resonator cavity of dye laser (11) is made up of three mirror cavity (19), (20) and (21) of astigmatism compensation.The radius of curvature of total reflective mirror (20), (19) and pumping mirror (17) is done shortlyer.This laser instrument (11) is 630nm ± 10nm from the wavelength of outgoing mirror (21) output, and mean power 0.2W～1.5W, peak power are 2KW～8KW, and pulse recurrence rate is that 10KHZ～30KHZ, pulse width are the dye laser of 10ns～20ns.
Be an alternative embodiment of the invention below.
Shown in Figure 2 is medical impulse laser unit provided by the invention.Light-source system is dismounting, mobile cuprous bromide vapor laser (40).The wavelength that is sent by it is the pumping mirror (43) that the laser of 511nm and 578nm shines directly into dye laser (41), focuses on the mobile dyestuff liquid level (44), makes activated by dye.Making dye laser produce vibration by completely reflecting mirror (45) and (46) with the three mirror resonator cavitys that flat output mirror (47) constitutes astigmatism compensation, is 630nm ± 10nm by outgoing mirror (47) output wavelength, and pulse recurrence rate is the dye laser of 10KHZ～30KHZ.The lens (48) of laser through fiber coupling device (42) are coupled in the optical fiber (49), and softish ordinary optic fibre (49) can be treated Laser Transmission easily in body surface and body.
The resonator cavity of the dismounting of the said medical impulse laser unit of present embodiment, flow-type cuprous bromide vapor laser (40) is made of total reflective mirror (50), discharge tube (51), ground cover (52) and (53), outgoing mirror (54).The two ends ground of discharge tube (51) connects with the ground cover (52) that has the cloth window and (53), and the place of connecting seals with vacuum grease.Can take off ground cover (52) and (53), discharge cleaning pipe (51) at any time or add the cuprous bromide operation material.When bromize copper phosphorons laser (40) is worked, gas exchange system (55) bleeds to discharge tube (51) by air vent (56), by air intake (57) discharge tube (51) is charged into the buffer gas neon, the cushion gas physical ability flows in discharge tube (51).High repeat pulse power (58) bromizates cuprous vapor laser and produces laser generation discharge tube (51) discharge.Outgoing mirror (54) is a not planoconvex lens of plated film.Be the outgoing mirror of resonator cavity, be used for making the laser beam of output to focus on again.The average laser power of bromize copper phosphorons laser (40) output is 2W～4W, and peak power is that 10KW～20KW, pulse recurrence rate are that 10KHZ～30KHZ, wavelength are 511nm and 578nm.
As shown in Figure 4, the dye solution of the dye laser (41) in the said medical impulse laser unit of present embodiment is to be sprayed by shower nozzle (36), form dyestuff liquid level (33), be recovered in the pump (35) through pipe (34), during pump (35) is led its ascending pipe again, enter shower nozzle (36) through chiller (37) cooling.Cooling water enters from the inlet tube (38) of chiller (37), behind the dye solution heat-shift, is discharged by outlet (39).The resonator cavity of dye laser (41) is that three mirror refrative cavities (45), (46) and (47) with astigmatism compensation are formed.The radius of curvature of total reflective mirror (45), (46) and pumping mirror (43) is done shortlyer, this dye laser (41) is from outgoing mirror (47) output, and wavelength is that 630nm ± 10nm, mean power 0.2W～1.5W, peak power are that 2KW～8KW, pulse recurrence rate are that 10KHZ～30KHZ pulse width is the dye laser of 10ns～20ns.
Be another embodiment of the present invention below.
Shown in Figure 3 is medical impulse laser unit provided by the invention, and light-source system is dismounting, flow-type cuprous bromide vapor laser (59).By the wavelength of its outgoing is that the laser irradiation of 511nm and 578nm is after filter set (61), have only the green glow of 511nm to see through, by having only the part green laser to be coupled in the optical fiber (63) behind the lens (62) in the optic fibre defocusing coupling device (60), ordinary optic fibre (63) transmission green laser is to tested tissue (64).Comprise normal structure and the tumor tissues that has absorbed (HPD), make it inspire fluorescence that fluorescence is inspired and be transferred to fluorescent optical filter group (67) in the optical signal processing system (66) by the optical fiber (65) of simple glass, have only the red fluorescence of wavelength 600nm～690nm to see through, after Photoelectric Signal Processing, go up the record tested person fluorescence spectrum figure of soma at display record system (68).Whether the analysis of fluorescence curve of spectrum exists the wavelength of the tumor that has absorbed (HPD) is that the red characteristic peak of 630nm and 690nm can confirm whether tissue exists tumor.
The resonator cavity of said dismounting in the present embodiment, flow-type cuprous bromide vapor laser (59) is made up of completely reflecting mirror (69), discharge tube (70), ground cover (71) and (72), outgoing mirror (73).The two ends ground of discharge tube (70) connects with the ground cover (71) and (72) that have the cloth window, and the place of connecting seals with vacuum grease.Can take off ground cover (72) and (71) at any time, discharge cleaning pipe (70) or adding cuprous bromide operation material.When laser instrument (59) was worked, gas exchange system (74) bled to discharge tube (70) by air vent (75), by air intake (76) discharge tube (70) is charged into for example neon of buffer gas, and the cushion gas physical ability flows in discharge tube (70).High-repetition-rate pulse power supply (77) bromizates cuprous vapor laser and produces laser generation discharge tube (70) discharge.Outgoing mirror (73) is a not planoconvex lens of plated film, is the outgoing mirror of resonator cavity, is used for making the laser focusing of output again.The average laser power of cuprous bromide vapor laser (59) output is 2W～4W, and peak power is that 10KW～20KW, pulse recurrence rate are that 10KHZ～30KHZ wavelength is 511nm and 578nm.
First fiber coupling device of the transmission diagnostic light of the said medical impulse laser unit of present embodiment adopts optic fibre defocusing coupling device (60).After the emitted laser of cuprous bromide vapor laser (59) enters filter set (61), with the yellow laser filtering of the 578nm wavelength in the laser.Only seeing through wavelength is the green laser of 511nm.Through the lens (62) in the optic fibre defocusing coupling device (60), green laser is focused on optical fiber (63) the input end face position before.Therefore have only the part green laser to be coupled in the optical fiber (63).Lens are fixed on the support (78) that can move along Z-direction, regulate support (78) and move around in Z-direction, and the green laser intensity that is coupled in the optical fiber (63) is continuously changed.Generally be adjusted within the required best light intensity 50mW～400mW scope of diagnosis.The front end of optical fiber (63) is fixing by fixed support (79).
Increased fluorescent optical filter group (67) in the said optical signal processing system of present embodiment (66), each optical filter is the light filtering of 450nm～600nm to wavelength, transmitance is less than 1%, and is that the HONGGUANG transmitance of 600nm～690nm is 40%～80% to wavelength.
As the conversion of above-mentioned three embodiment, the light-source system of medical impulse laser unit can be used the halide vapor laser instrument of the outer copper of the bromide of the bromide vapor laser of detachable or flow-type copper or fine copper vapor laser or copper removal instead.
As another conversion of above-mentioned three embodiment, can dismantle, the bromide vapor laser of flow-type copper and with the halide vapor laser instrument of copper or fine copper vapor laser as light-source system. Average laser power and the peak power of fine copper vapor laser are bigger, and be comparatively favourable as light source, but price is more expensive.
As another conversion of above-described embodiment, can be without the three mirror cavity of astigmatism compensation as the resonator of dye laser and use two mirror chambeies commonly used instead as the resonator of dye laser. Two mirror cavity configurations are simple but beam quality is relatively poor.
As another conversion of above-described embodiment, light-source system need not be dismantled, the flow-type bromize copper phosphorons laser, as the pump light source of dye laser, is that the fine copper laser instrument of 4KHZ～10KHZ is as pump light source and use pulse recurrence frequency instead. The laser that dye laser produces is that wavelength is 630nm ± 10nm, and pulse recurrence frequency is the laser of 4KHZ～10KHZ.
As a conversion of above-described embodiment, the light-source system of described medical impulse laser unit can be used halide laser or the fine copper laser instrument of the bromide copper outward of dismounting, mobile copper removal instead. As long as operation material is changed into halide or the fine copper of the bromide copper outward of copper removal.
A conversion as the foregoing description, the said fiber coupling device that is used for diagnostic light can be used the general optical fiber coupling device without optic fibre defocusing coupling device instead, in this device, regulate the power that enters the laser intensity in the optical fiber, can finish by before lens, inserting attenuator.
As another conversion of the foregoing description, the optic fibre defocusing coupling device that need not be configured to by optical fiber, mobile lens and fixed optical fiber clamping and using instead by optical fiber, fixed lens, moving fiber holding frame constitutes or by optical fiber, movably lens and the optic fibre defocusing coupling device that is configured to of optical fiber clamping movably.
As another conversion of present embodiment, the spectrographic method of the fluorescence spectrum of the demonstration recorder soma that diagnosing tumour can be above-mentioned, and the ocular estimate of using naked eyes direct observation tissue stimulated emission fluorescence color and luster instead.Normal structure does not absorb the HONGGUANG that (HPD) do not send 600nm～690nm, and the fluorescence spectrum of tumor tissues is that red fluorescence can conclude in the tissue of launching this fluorescence that tumor is arranged in the red wavelength band of 600nm～690nm when estimating fluorescence.
Claims (21)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 87103403 CN1012465B (en) | 1987-05-07 | 1987-05-07 | Medical pulse laser device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 87103403 CN1012465B (en) | 1987-05-07 | 1987-05-07 | Medical pulse laser device |
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| Publication Number | Publication Date |
|---|---|
| CN87103403A true CN87103403A (en) | 1988-11-23 |
| CN1012465B CN1012465B (en) | 1991-05-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 87103403 Expired CN1012465B (en) | 1987-05-07 | 1987-05-07 | Medical pulse laser device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1787778B (en) * | 2003-05-14 | 2011-01-12 | 光谱治疗股份公司 | System and method for therapy and diagnosis comprising optical components for distribution of radiation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1068247C (en) * | 1996-05-09 | 2001-07-11 | 冶金工业部包头稀土研究院 | Synthetic technology for rare-earth mineral collector |
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- 1987-05-07 CN CN 87103403 patent/CN1012465B/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1787778B (en) * | 2003-05-14 | 2011-01-12 | 光谱治疗股份公司 | System and method for therapy and diagnosis comprising optical components for distribution of radiation |
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| CN1012465B (en) | 1991-05-01 |
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