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CN86107991A - 抗高血压复合物 - Google Patents

抗高血压复合物 Download PDF

Info

Publication number
CN86107991A
CN86107991A CN198686107991A CN86107991A CN86107991A CN 86107991 A CN86107991 A CN 86107991A CN 198686107991 A CN198686107991 A CN 198686107991A CN 86107991 A CN86107991 A CN 86107991A CN 86107991 A CN86107991 A CN 86107991A
Authority
CN
China
Prior art keywords
represent
prescription
carbon atom
alkyl
pyridazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN198686107991A
Other languages
English (en)
Chinese (zh)
Inventor
伯恩沃德·加特霍夫
斯坦尼斯拉夫·卡兹达
安德烈亚斯·诺尔
马塞尔·杰罗尔德
弗里多林·赫夫蒂
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Bayer AG
Original Assignee
F Hoffmann La Roche AG
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Bayer AG filed Critical F Hoffmann La Roche AG
Publication of CN86107991A publication Critical patent/CN86107991A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN198686107991A 1985-12-04 1986-12-01 抗高血压复合物 Pending CN86107991A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853542794 DE3542794A1 (de) 1985-12-04 1985-12-04 Antihypertensives kombinationspraeparat
DEP3542794.9 1985-12-04

Publications (1)

Publication Number Publication Date
CN86107991A true CN86107991A (zh) 1987-08-05

Family

ID=6287544

Family Applications (1)

Application Number Title Priority Date Filing Date
CN198686107991A Pending CN86107991A (zh) 1985-12-04 1986-12-01 抗高血压复合物

Country Status (22)

Country Link
US (1) US4859665A (xx)
EP (1) EP0224810B1 (xx)
JP (1) JPS62132826A (xx)
KR (1) KR870005641A (xx)
CN (1) CN86107991A (xx)
AT (1) ATE44648T1 (xx)
AU (1) AU590030B2 (xx)
DD (1) DD265328A5 (xx)
DE (2) DE3542794A1 (xx)
DK (1) DK581486A (xx)
ES (1) ES2012044B3 (xx)
GB (1) GB2183476B (xx)
GR (1) GR3000188T3 (xx)
HU (1) HU197206B (xx)
IL (1) IL80825A0 (xx)
MT (1) MTP993B (xx)
MW (1) MW7886A1 (xx)
MY (1) MY100256A (xx)
NZ (1) NZ218453A (xx)
PH (1) PH22609A (xx)
PT (1) PT83845B (xx)
ZA (1) ZA869123B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE96322T1 (de) * 1988-03-24 1993-11-15 Hoffmann La Roche Antihypertensives kombinationspraeparat.
IE65902B1 (en) * 1989-03-15 1995-11-29 Boots Co Plc Therapeutic agents
US5350771A (en) * 1989-03-22 1994-09-27 Peter K. T. Pang Method and treatment for hypertension using combination therapy involving exogenous calcium and calcium channel blockers
US5886012A (en) * 1989-03-22 1999-03-23 Peter K. T. Pang Method of treatment for disease associated with excessive PHF using combination therapy involving exogenous calcium and calcium channel blockers
HUT70033A (en) * 1989-03-22 1995-09-28 Pang Process for producing synergetic pharmaceutical composition containing calcium channel blocking agent and calcium compound or vitamin d
US5209933A (en) * 1990-01-10 1993-05-11 Syntex (U.S.A.) Inc. Long acting calcium channel blocker composition
TW216770B (xx) * 1991-07-23 1993-12-01 Hoffmann La Roche
DE4138756A1 (de) * 1991-11-26 1993-05-27 Troponwerke Gmbh & Co Kg Kombination mit neuroprotektiver wirkung
JPH0689761A (ja) * 1992-09-07 1994-03-29 Sumitomo Electric Ind Ltd 平型多心電線
PT634175E (pt) * 1993-07-15 2001-06-29 Hoffmann La Roche Combinacao farmaceutica que contem um inibidor do sistema renina-angiotensina e o antagonista de endotelina

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3932645A (en) * 1971-04-10 1976-01-13 Farbenfabriken Bayer Ag Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylic acid
CH639659A5 (de) * 1978-12-18 1983-11-30 Sandoz Ag Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung.
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4504476A (en) * 1983-09-16 1985-03-12 Arnold Schwartz Method of administering calcium channel blocking agents
US4532237A (en) * 1984-07-30 1985-07-30 Merck & Co., Inc. Substituted and bridged pyridines useful as calcium channel blockers
US4599341A (en) * 1984-10-01 1986-07-08 Merck & Co., Inc. Substituted and bridged pyridines useful as calcium channel blockers
DE3437917A1 (de) * 1984-10-17 1986-04-17 Bayer Ag, 5090 Leverkusen Kombination von dihydropyridinen mit ace-hemmern sowie ihre verwendung in arzneimitteln
US4656188A (en) * 1985-10-09 1987-04-07 Merck & Co., Inc. Ace inhibitors in macular degeneration

Also Published As

Publication number Publication date
PT83845B (en) 1989-01-03
ATE44648T1 (de) 1989-08-15
HUT43787A (en) 1987-12-28
US4859665A (en) 1989-08-22
NZ218453A (en) 1989-01-06
PH22609A (en) 1988-10-17
KR870005641A (ko) 1987-07-06
EP0224810A1 (de) 1987-06-10
PT83845A (en) 1987-01-01
HU197206B (en) 1989-03-28
DE3664409D1 (en) 1989-08-24
DK581486A (da) 1987-06-05
MY100256A (en) 1990-07-28
IL80825A0 (en) 1987-03-31
GR3000188T3 (en) 1990-12-31
JPS62132826A (ja) 1987-06-16
DD265328A5 (de) 1989-03-01
MW7886A1 (en) 1987-12-09
AU6615686A (en) 1987-06-11
GB8628694D0 (en) 1987-01-07
ZA869123B (en) 1987-08-26
GB2183476A (en) 1987-06-10
DE3542794A1 (de) 1987-06-11
MTP993B (en) 1987-08-21
ES2012044B3 (es) 1990-03-01
DK581486D0 (da) 1986-12-03
EP0224810B1 (de) 1989-07-19
AU590030B2 (en) 1989-10-26
GB2183476B (en) 1989-10-25

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication