CN2611051Y - Dual piezoelectric micro-spray atomization device for atomization and administration - Google Patents

Abstract

The utility model belongs to a drug delivery device that micro-sprays drugs or active substances that act on the human body into aerosol forms and then delivers them to the lungs through the nasal cavity or the oral cavity. The utility model is characterized in that two piezoelectric sheets are used to drive the vibrating diaphragm and the atomizing diaphragm that constitute the liquid supply cavity respectively, and the circular piezoelectric sheet and the vibrating diaphragm are bonded to form a piezoelectric transducer, which provides a high-speed longitudinal pressure wave in the liquid spraying direction so that the liquid can be sprayed out at high speed through the micro-spray hole. In order to adapt to various drugs and drug precursors, the vibrating diaphragm and the atomizing diaphragm of the utility model can be made of single crystal silicon sheets or corrosion-resistant metal alloys. By changing the driving voltage and frequency of the annular piezoelectric sheet and the circular piezoelectric sheet, droplet distribution curves of different diameters can be obtained to adapt to different drug delivery purposes. When the diameter of the micro-spray hole is 4-10μm, the droplet diameter is within the range of 1-15μm, and the liquid medicine spray droplets can be small to meet the usual drug delivery requirements.

Description

A dual piezoelectric micro-spray device for nebulized drug delivery

technical field

The utility model belongs to a drug delivery device for injecting medicine or active substances acting on human body into aerosol form through nasal cavity or oral cavity through micro-spraying.

Background technique

At present, there are three common forms of portable medical aerosols.

1. Under finger pressure, press the liquid into a special microporous nozzle and spray it into mist. 2. The two-phase aerosol is filled with high-pressure gas in a pressure container containing liquid medicine. When the valve is pressed with a finger, the liquid is sprayed out at high speed and atomized. 3. The three-phase aerosol is filled with a propellant (such as freon) in a pressure container containing a liquid medicament. When spraying, the freon is quickly vaporized to make the liquid spray out and atomize.

The disadvantage of the above three atomization methods is that the droplets are relatively large, generally 20-80 μm, and it is difficult for such large droplets to reach the bronchioles and even more difficult to reach the alveoli. The pressure vessel is under too high pressure, and the three-phase aerosol has the problem of environmental pollution.

Utility model content

The purpose of the utility model is to solve the problems existing in the existing medical atomization drug delivery device, and to provide a dual piezoelectric micro-spray device with small spray droplets, easy drug delivery, and adapting to different drug delivery purposes.

The utility model is characterized in that two piezoelectric sheets are used to respectively drive the vibrating diaphragm and the atomizing diaphragm forming the liquid supply chamber, and the circular piezoelectric sheet and the vibrating diaphragm are bonded to form a piezoelectric transducer. The ejection direction provides a high-speed longitudinal pressure wave so that the liquid is ejected at a high speed through the micro-orifice. The device comprises an atomized diaphragm with a micro-orifice array bonded to an annular radially polarized piezoelectric film in the middle, a circular corrugated ring on the outer periphery of the micro-orifice array, and a vibrating membrane corresponding to the atomized diaphragm. A circular single-layer or multi-layer longitudinally polarized piezoelectric sheet is glued on the sheet. The vibrating diaphragm has a groove or a gasket to form a liquid chamber with the atomizing diaphragm. A small hole is opened on the edge of the liquid chamber to Connect a dampened supply line. The annular piezoelectric sheet is bonded with the atomizing diaphragm with micro-nozzles to form another piezoelectric transducer, which provides radial vibration waves to the droplets that are about to leave the micro-nozzles to further break the droplets. Adding a loose fiber group in the liquid supply chamber composed of the vibrating diaphragm and the atomizing diaphragm can improve the energy and liquid distribution of each micro-nozzle in the micro-nozzle array and make it tend to be even.

In order to adapt to various medicines and drug precursors in the utility model, the vibrating membrane and the atomizing membrane can be made of single crystal silicon wafers or corrosion-resistant metal alloys. The distribution curves of droplets with different diameters can be obtained by changing the driving voltage and frequency of the annular piezoelectric sheet and the circular piezoelectric sheet, so as to adapt to different drug delivery purposes. When the micro-nozzle diameter is 4-10 μm, the droplet diameter is in the range of 1-15 μm, which can realize the spraying of liquid medicine with small droplets to meet the usual drug delivery requirements.

Description of drawings

Fig. 1 is the front view of the micro-spraying device of the present utility model;

Fig. 2 is a left view of the micro-spraying device of the present invention.

Detailed ways

Referring to FIG. 1 : a liquid supply chamber 7 is composed of an annular piezoelectric film 1 , an atomizing diaphragm 2 with an array of micro-orifices with a corrugated structure 3 , and a circular piezoelectric film 6 and a vibrating diaphragm 5 . When the driving voltage output by the high-frequency generator is applied to the lead wire 9 of the piezoelectric sheet, the circular piezoelectric sheet 6 acts on the liquid in the form of a longitudinal pressure wave in the cavity through the vibrating diaphragm 5, causing the liquid to flow from the micro nozzle hole. 8 high-speed spraying, when the droplets are about to be sprayed, the annular piezoelectric sheet 1 further shears the droplets in the form of radial vibration waves through the atomizing diaphragm 2 with a ring-shaped corrugated structure. The diameter range of the micro spray hole 8 can be between 2-15 μm, and the fiber group 4 is interposed between the vibrating diaphragm and the atomizing diaphragm to ensure that the liquid is distributed in the liquid supply chamber by capillary action, which is conducive to the discharge of air bubbles. The gasket 11 and the indentation 12 determine the volume of the liquid supply chamber. The liquid supply pipe 10 is connected to the liquid storage chamber. Adjusting the driving voltage and frequency of the bimorphs during application can control the atomized droplets between 1-10 μm.

In the utility model, two piezoelectric sheets are respectively driven by alternating current signals to form longitudinal pressure waves and radial vibration waves to extrude liquid from micro-spray holes and atomize it. Each of the two piezoelectric sheets has two piezoelectric signal input terminals, and the frequencies of the piezoelectric signals can be different or consistent. The two piezoelectric sheets are one of PZT, PMN, PNN, PSN, PMN-PT, PNN-PT, PSN-PT, PZN-PT, and have a single-layer structure or a laminated structure of different components. The vibrating diaphragm and the atomizing diaphragm are made of single crystal silicon, and can also be made of corrosion-resistant metals or alloys, such as nickel, nickel-cobalt alloy, nickel-palladium alloy, and nickel-chromium-cobalt-rhodium alloy. The vibrating diaphragm and the atomizing diaphragm are bonded to form a liquid chamber, and there is a liquid supply fiber group made of natural fibers or synthetic fibers in the liquid chamber.

Claims (5)

1. A dual-piezoelectric micro-spraying device for nebulized drug administration, characterized in that the device comprises a piece of adhesive with a ring-shaped radially polarized piezoelectric sheet (1) that has a micro-nozzle (8) array in the middle Atomized diaphragm (2), a circular corrugated ring (3) is arranged on the periphery of the micro-nozzle array, and a circular single-layer or multi-layer vibrating diaphragm (5) corresponding to the atomized diaphragm (2) A longitudinally polarized piezoelectric film (6), the vibrating diaphragm (5) is provided with a groove or a gasket (11) is added to form a liquid chamber (7) with the atomized diaphragm, and the edge of the liquid chamber (7) is opened A small hole is provided to connect the liquid supply pipe (10) with damping effect. 2. The device according to claim 1, wherein the two piezoelectric sheets each have two piezoelectric signal input terminals, and the frequencies of the piezoelectric signals can be different or consistent. 3. The device according to claim 1, wherein the two piezoelectric sheets are one of PZT, PMN, PNN, PSN, PMN-PT, PNN-PT, PSN-PT, PZN-PT, and have a single Layer structure or laminated structure of different components. 4. according to the described device of claim 1, it is characterized in that vibrating diaphragm and atomized diaphragm are processed into by monocrystalline silicon wafer, also available corrosion-resistant metal or alloy are made, as nickel sheet, nickel-cobalt alloy sheet , Nickel-palladium alloy sheet, nickel-chromium-cobalt-rhodium alloy sheet. 5. The device according to claim 1, characterized in that the vibrating diaphragm and the atomizing diaphragm are bonded to form a liquid chamber, and there is a liquid supply fiber group made of natural fiber or synthetic fiber in the liquid chamber.

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