CN222592330U - Serum collecting and buffering device - Google Patents

Abstract

The utility model discloses a serum collection buffer device, which belongs to the field of serum storage equipment, including a collection tank and a buffer tank, wherein the infusion port of the collection tank is connected with the liquid inlet of the buffer tank, the bottom end of the collection tank and the position close to the buffer tank is provided with an infusion port, the top end of the buffer tank facing the collection tank is provided with a liquid inlet, the infusion port is connected with one end of an insertion tube through a reducer, an elbow and a quick connector in sequence, the other end of the insertion tube extends into the interior of the buffer tank through the liquid inlet, and a flow channel is left between the insertion tube and the inner wall of the bottom end of the buffer tank. With the above-mentioned serum collection buffer device, the infusion port of the collection tank is connected with the liquid inlet of the buffer tank through a reducer, an elbow and a quick connector, ensuring that the liquid can be smoothly and quickly transmitted from the collection tank to the interior of the buffer tank, reducing the resistance during the transmission process and improving the transmission efficiency.

Description

Serum collecting and buffering device

Technical Field

The utility model relates to the technical field of serum storage equipment, in particular to a serum collection buffer device.

Background

In biopharmaceutical and cell culture processes, it is often necessary to use a collection tank for receiving serum or other biological fluids from upstream processes (e.g., separation, purification, etc.), while providing a buffer function, regulating the pressure in the system to prevent equipment damage or process instability due to flow fluctuations, and a buffer tank for temporarily storing serum or other biological fluids, ensuring continuous supply during production, and providing a buffer function, balancing flow differences between upstream and downstream processes, and ensuring stability and continuity of the production process.

The existing collecting tanks and buffer tanks are respectively arranged, the middle parts of the existing collecting tanks and the buffer tanks are communicated in a pumping mode, and the defects of energy waste, large occupied area and the like exist.

Disclosure of Invention

The utility model aims to provide a serum collection buffer device which solves the technical problems.

In order to achieve the above purpose, the utility model provides a serum collection buffer device, which comprises a collecting tank and a buffer tank, wherein an infusion port of the collecting tank is communicated with a liquid inlet of the buffer tank, the bottom end of the collecting tank is provided with the infusion port at a position close to the buffer tank, the top end of one side of the buffer tank facing the collecting tank is provided with the liquid inlet, the infusion port is communicated with one end of an insertion pipe sequentially through a reducing joint, an elbow and a quick connector, the other end of the insertion pipe extends into the buffer tank from the liquid inlet, and a circulation channel is reserved between the insertion pipe and the inner wall of the bottom end of the buffer tank.

Preferably, the bottom end of the buffer tank is arranged into a U-shaped structure, and the bottom end of the insertion pipe is arranged into a sharp mouth structure with the same gradient as the U-shaped structure.

Preferably, the top end of the buffer tank is provided with a double-layer annular hole, the double-layer annular hole comprises an inner-layer annular hole and an outer-layer annular hole, the inner-layer annular hole comprises two cleaning and sterilizing holes which are axially symmetrically arranged, and the two cleaning and sterilizing holes are communicated with the CIP cleaning device;

The outer ring hole comprises a feeding hole, a pressure gauge hole, a first differential pressure liquid level gauge hole, a rupture disc hole, a safety valve port, a respirator hole, a first standby hole, a first split-type sight glass mounting hole, a second split-type sight glass mounting hole and a second standby hole which are arranged in a circumferential array;

The bottom central point of buffer vessel puts and is provided with the discharge gate, and the bottom of buffer vessel still is provided with second pressure differential level gauge mouth, thermometer mouth and drain.

Preferably, the two cleaning and disinfecting holes are respectively communicated with a pure water pipe and an alkaline water pipe through three-way pipes, and the pure water pipe and the alkaline water pipe are respectively communicated with the CIP cleaning device;

The drain outlet is communicated with one end of the drain pipe, and the other end of the drain pipe is provided with a conductivity meter;

the conductivity meter is electrically connected with the CIP cleaning device through the PLC.

Preferably, the two cleaning and sterilizing holes and the feeding hole are communicated with the SIP sterilizing device through a steam inlet pipe, one end of the blow-down pipe provided with the conductivity meter is further provided with a thermometer, and the thermometer is electrically connected with the SIP sterilizing device through a PLC.

Therefore, the serum collecting and buffering device has the beneficial effects that:

1. The design of the transfusion port and the liquid inlet is that the transfusion port of the collecting tank is connected with the liquid inlet of the buffer tank through the reducing joint, the elbow and the quick connector, so that the liquid can be smoothly and quickly transferred from the collecting tank to the inside of the buffer tank, the resistance in the transfer process is reduced, and the transfer efficiency is improved;

2. The bottom end of the insertion tube is also designed into a sharp mouth structure with the same gradient as the U-shaped structure, which is beneficial to preventing the foam formed by the injection of the serum with a high distance in the traditional way;

3. The multi-purpose interface is that a double-layer annular hole is arranged at the top end of the buffer tank and comprises a plurality of functional interfaces such as a cleaning and sterilizing hole, a feed inlet, a pressure meter port, a liquid level meter port, a safety valve port and the like, so that the buffer tank can conveniently perform various operations such as cleaning, sterilizing, monitoring pressure, liquid level and the like;

4. The automatic cleaning and disinfection, namely the cleaning and disinfection holes are respectively communicated with the pure water pipe and the alkaline water pipe through the three-way pipe, and the independent design of the pure water pipe and the alkaline water pipe avoids the reduction of the cleaning and disinfection effect caused by pipeline pollution;

5. the buffer tank is provided with a safety valve and a rupture disc opening, and the safety devices can be automatically opened when the pressure exceeds a set value to release redundant pressure so as to ensure the safe operation of the system;

6. The liquid level gauge and the thermometer are arranged in the buffer tank, so that the liquid level and the temperature in the tank can be monitored in real time, and the liquid can be stored and transported under proper conditions;

7. The environmental protection design is that the cleaning effect can be monitored by a conductivity meter, so that the cleaning effect of the CIP cleaning device (in-situ cleaning) is ensured to reach the standard;

8. The sterilizing function is that the feed inlet and the cleaning and sterilizing holes are connected with a SIP (Sterilization In Place in-situ sterilization) sterilizing device through a steam inlet pipe, so that automatic sterilizing operation can be realized, and the sterile state of liquid in the tank is ensured;

9. the cleaning dead angle is avoided by arranging two cleaning ports at the top end of the buffer tank;

10. The top end of the buffer tank is provided with a plurality of standby ports, other functional equipment can be added according to actual requirements, and the flexibility and expansibility of the system are improved.

In conclusion, the serum collection buffer device provided by the utility model has the advantages of high-efficiency transmission, foam prevention, multipurpose interface, automatic cleaning and disinfection, safety, reliability, accurate monitoring, environment-friendly design, sterilization function, convenience in maintenance, multifunctional interface and the like through the optimal design, and is suitable for various high-requirement biopharmaceutical and medical fields.

The technical scheme of the utility model is further described in detail through the drawings and the embodiments.

Drawings

FIG. 1 is a side view of a serum collection buffer according to the present utility model;

FIG. 2 is a top view of a buffer tank of a serum collection buffer device of the present utility model.

Drawings

1. The device comprises a collecting tank, a reducing connector, a 3, an elbow, a 4, a quick connector, a 5, an inserting pipe, a 6, a discharge hole, a 7, a buffer tank, a 8, a spray header, a 9, a cleaning and sterilizing pipe, a 10, a cleaning and sterilizing hole, a 11, a feed port, a 12, a pressure gauge port, a 13, a first differential pressure liquid level meter port, a 14, a rupture disc port, a 15, a safety valve port, a 16, a respirator port, a 17, a first standby port, a 18, a second split-mirror mounting port, and a 19, second standby port.

Detailed Description

In the description of the present utility model, it should be noted that, the azimuth or positional relationship indicated by the terms "upper", "lower", "inner", "outer", etc., are based on the azimuth or positional relationship shown in the drawings, or the azimuth or positional relationship in which the inventive product is conventionally put in use, are merely for convenience of describing the present utility model and simplifying the description, and are not indicative or implying that the apparatus or element to be referred to must have a specific azimuth, be configured and operated in a specific azimuth, and therefore should not be construed as limiting the present utility model. In the description of the present utility model, it should also be noted that, unless explicitly specified and limited otherwise, the terms "configured," "mounted," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, integrally connected, mechanically connected, electrically connected, directly connected, indirectly connected through an intermediate medium, or in communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.

Embodiments of the present utility model will be described in detail below with reference to the accompanying drawings.

As shown in fig. 1 and 2, a serum collection buffer device comprises a collecting tank 1 and a buffer tank 7, wherein an infusion port of the collecting tank 1 is communicated with a liquid inlet of the buffer tank 7, the bottom end of the collecting tank 1 is provided with the infusion port at a position close to the buffer tank 7, the top end of one side of the buffer tank 7, which faces the collecting tank 1, is provided with the liquid inlet, the infusion port is communicated with one end of an insertion tube 5 sequentially through a reducing joint 2, an elbow 3 and a quick connector 4, the other end of the insertion tube 5 extends into the buffer tank 7 through the liquid inlet, and a circulation channel is reserved between the insertion tube 5 and the inner wall of the bottom end of the buffer tank 7. And the bottom end of the buffer tank 7 is provided with a U-shaped structure, and the bottom end of the insertion tube 5 is provided with a sharp mouth structure with the same gradient as the U-shaped structure.

The collecting vat 1 in this embodiment is fixed on the top of the supporting rack, and the bottom of the supporting rack is provided with universal wheels for moving the position of the collecting vat 1.

The top end of the buffer tank 7 is provided with a double-layer annular hole, the double-layer annular hole comprises an inner-layer annular hole and an outer-layer annular hole, the inner-layer annular hole comprises two cleaning and sterilizing holes 10 which are axially symmetrically arranged, the two cleaning and sterilizing holes 10 are communicated with the CIP cleaning device, the outer-layer annular hole comprises a feeding port 11, a pressure gauge port 12, a first differential pressure liquid level gauge port 13, a rupture disc port 14, a safety valve port 15, a respirator port 16, a first standby port 17, a first split-type sight glass mounting port, a second split-type sight glass mounting port 18 and a second standby port 19 which are circumferentially arranged, a discharging port 6 is arranged at the center of the bottom end of the buffer tank 7, and a second differential pressure liquid level gauge port, a thermometer port and a sewage draining port are also arranged at the bottom end of the buffer tank 7.

The two cleaning and disinfecting holes 10 are respectively communicated with a pure water pipe and an alkaline water pipe through three-way pipes, the pure water pipe and the alkaline water pipe are respectively communicated with a CIP cleaning device, a sewage outlet is communicated with one end of the sewage outlet, the other end of the sewage outlet is provided with a conductivity meter, and the conductivity meter is electrically connected with the CIP cleaning device through a PLC (programmable logic controller), so that the change of the ion concentration in water can be reflected by means of the conductivity meter, and the cleaning degree of water quality can be indirectly reflected.

The buffer tank 7 of this embodiment is inside to communicate two cleaning and sterilizing holes 10 respectively through two cleaning and sterilizing pipes 9, and the bottom of cleaning and sterilizing pipe 9 is provided with shower head 8, enlarges the spray area.

The two cleaning and sterilizing holes 10 and the feeding hole 11 are communicated with the SIP sterilizing device through steam inlet pipes, namely, the feeding hole 11 and the cleaning and sterilizing holes 10 are communicated with the SIP sterilizing device through different steam pipes so as to intermittently sterilize a feeding channel by utilizing the SIP sterilizing device, and a thermometer is further arranged at one end of the blow-down pipe, which is provided with a conductivity meter, and is electrically connected with the SIP sterilizing device through a PLC. It should be noted that, the electronic components are all mature products in the market, and the electronic components are only required to be purchased and then connected according to the specification, and are not improved, so that the circuit connection structure and principle of the electronic components are not repeated here.

The use method comprises the steps that serum generated by an upstream process enters the collecting tank 1 and flows into the bottom end of the buffer tank 7 along the reducer union 2, the elbow 3 and the insertion pipe 5 in sequence after being buffered by the collecting tank 1 until all the serum is discharged. When the cleaning agent is used for a period of time, cleaning, disinfection and sterilization are sequentially carried out. The cleaning and disinfecting steps comprise firstly emptying serum in a buffer tank 7, opening a pure water pipe of a CIP cleaning device, spraying pure water into the buffer tank 7 through two cleaning and disinfecting holes 10 and a spray header 8, pre-cleaning by means of the pure water, discharging cleaning sewage by means of a sewage discharge pipe, closing the pure water pipe, opening an alkali water pipe, spraying 2% NaOH solution into the buffer tank 7 through the two cleaning and disinfecting holes 10 and the spray header 8 for alkaline cleaning, pumping the cleaned NaOH solution to an alkali liquid storage tank of the CIP cleaning device by means of a circulating pump, finally opening the pure water pipe again, closing the alkali water pipe for flushing, checking whether the set cleaning effect is achieved by means of a conductivity meter after the flushing is finished, and continuously performing the pure water cleaning until the set cleaning effect is achieved.

The sterilization steps are as follows, the SIP sterilization device is opened, steam is introduced into the buffer tank 7 through the two cleaning and sterilizing holes 10 and the spray header 8, the buffer tank 7 is subjected to SIP sterilization, meanwhile, steam is introduced into the buffer tank 7 through the feed inlet 11 every a period of time to perform SIP sterilization on the feed pipeline, until the temperature acquired by the temperature sensor reaches the set temperature, timing is started, until the set time is reached, and the SIP sterilization device is closed.

It should be noted that the above-mentioned embodiments are merely for illustrating the technical solution of the present utility model and not for limiting the same, and although the present utility model has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present utility model may be modified or substituted by the same, and the modified or substituted technical solution may not deviate from the spirit and scope of the technical solution of the present utility model.

Claims (5)

1. A serum collection buffer device, comprising a collection tank and a buffer tank, wherein the infusion port of the collection tank is connected to the liquid inlet of the buffer tank, and is characterized in that: an infusion port is provided at the bottom end of the collection tank and close to the buffer tank, and a liquid inlet is provided at the top end of the buffer tank facing the collection tank, the infusion port is connected to one end of an insertion tube via a reducer, an elbow and a quick connector in sequence, the other end of the insertion tube extends into the interior of the buffer tank from the liquid inlet, and a flow channel is left between the insertion tube and the inner wall of the bottom end of the buffer tank. 2. A serum collection buffer device according to claim 1, characterized in that the bottom end of the buffer tank is configured as a U-shaped structure, and the bottom end of the insertion tube is configured as a pointed mouth structure with the same slope as the U-shaped structure. 3. A serum collection buffer device according to claim 1, characterized in that: a double-layer ring hole is provided at the top of the buffer tank, the double-layer ring hole comprises an inner ring hole and an outer ring hole, wherein the inner ring hole comprises two cleaning and disinfection holes arranged axially symmetrically, and the two cleaning and disinfection holes are both connected to the CIP cleaning device; The outer ring hole includes a feed port, a pressure gauge port, a first differential pressure level gauge port, a bursting disc port, a safety valve port, a respirator port, a first spare port, a first split sight glass installation port, a second split sight glass installation port, and a second spare port arranged in a circular array; A discharge port is arranged at the center position of the bottom end of the buffer tank, and a second differential pressure level gauge port, a thermometer port and a sewage outlet are also arranged at the bottom end of the buffer tank. 4. A serum collection buffer device according to claim 3, characterized in that: the two cleaning and disinfection holes are connected to the pure water pipe and the alkaline water pipe respectively through a three-way pipe, and the pure water pipe and the alkaline water pipe are connected to the CIP cleaning device; The sewage outlet is connected to one end of the sewage pipe, and the other end of the sewage pipe is provided with a conductivity meter; The conductivity meter is electrically connected to the CIP cleaning device via a PLC controller. 5. A serum collection buffer device according to claim 4, characterized in that: the two cleaning and disinfection holes and the feed port are connected to the SIP sterilization device through the steam inlet pipe, and a thermometer is also provided at one end of the sewage pipe where the conductivity meter is provided, and the thermometer is electrically connected to the SIP sterilization device through a PLC controller.