CN219742971U - Experimental mouse skull observation adapter - Google Patents
Experimental mouse skull observation adapter Download PDFInfo
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- CN219742971U CN219742971U CN202320480781.3U CN202320480781U CN219742971U CN 219742971 U CN219742971 U CN 219742971U CN 202320480781 U CN202320480781 U CN 202320480781U CN 219742971 U CN219742971 U CN 219742971U
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Abstract
The utility model belongs to the technical field of medical appliances, and particularly relates to an experimental mouse skull observation experimental adapter which is mainly applied to: in the observation of the living body of the cranium of the experimental mouse; by setting up: a bottom plate for carrying experimental mice; a fitting for fixing the cranium of the experimental mouse and having an observation hole; connecting the fitting to the base plate and driving the fitting toward or away from the support of the base plate; the limiting rod is connected to the bottom plate, and can not rotate relatively when the accessory is close to or far from the bottom plate, and the limiting rod is connected with the connecting plate of the supporting piece; the method solves the problems: when the experimental mouse skull living body observation experiment is repeated, the fixed position of the mouse head is difficult to ensure, so that the accuracy of the experimental result is difficult to ensure.
Description
Technical Field
The utility model belongs to the technical field of medical appliances, and particularly relates to an experimental mouse skull observation experimental adapter.
Background
As model organisms, rodents are widely used in medical and biological research; in the observation experiment of living brains of experimental mice, a two-photon microscope is widely used for observation, but in the imaging process of the living brains of two photons, firstly, the head of an experimental sample with a skull window is fixed, so that the stability of an animal brain cell observation plane image is ensured, and in the prior experiment, the traditional mode of fixing the brains of the experimental mice after the combination of an ear rod and a dental rod; the fixed position of the head of the mouse is difficult to ensure when the experiment is repeated, so that the accuracy of the experimental result is difficult to ensure.
The utility model aims at the problems and provides an experimental mouse skull observation experimental adapter.
Disclosure of Invention
In order to overcome the problems in the background art, the utility model adopts the following technical scheme:
an experimental mouse skull observation experimental adapter, comprising
A bottom plate for carrying experimental mice;
the accessory is provided with a first end face and a second end face, wherein an observation hole is formed in the first end face, and the accessory is penetrated by the observation hole;
a support for connecting the fitting to the base plate, wherein the support urges the fitting toward or away from the base plate;
the limiting rod is connected to the bottom plate and is positioned on the same end face with the supporting piece, and the accessory is connected with the limiting rod in a sliding mode, so that the accessory can not rotate relatively when being close to or far from the bottom plate;
and the connecting plate is used for connecting the limiting rod with the supporting piece, so that the supporting piece cannot be separated from the bottom plate.
In some embodiments of the present utility model, the bottom plate has a top end surface and a bottom end surface, where the top end surface is provided with a jack, and a portion of the support member is disposed in the jack, so that the support member can rotate about an axis of the jack as a rotation axis.
Further, the support includes: a threaded rod; the threaded rod is provided with a first end and a second end, the first end of the threaded rod is positioned in the jack, and the second end of the threaded rod is attached to the connecting plate.
Further, a rotating button is arranged to penetrate through the connecting plate and connected to the second end of the threaded rod, and when the rotating button is rotated, the threaded rod synchronously rotates along with the rotating button.
In some embodiments of the present utility model, the limit lever is fixedly connected to the top end surface of the bottom plate, and the limit lever is perpendicular to the top end surface of the bottom plate.
In some embodiments of the utility model, the stop bar is integrally connected to the connecting plate, wherein the connecting plate has a through hole, and a portion of the knob is passed through the through hole and connected to the second end of the threaded rod.
Further, the diameter of the through hole is smaller than the diameter of the threaded rod, so that the threaded rod is limited between the connecting plate and the bottom plate.
In some embodiments of the utility model, the fitting has a through hole through which the fitting is connected to the threaded rod and a threaded hole through which the fitting is connected to the stop bar.
In some embodiments of the utility model, the fitting further has opposing first and second faces, the first face being formed with a recess and the second face being formed with a protrusion, the recess being complementary in shape to the protrusion; the groove is provided with a bottom end face, and the observation hole penetrates through the bottom end face towards the second face.
Further, the bottom end face of the bottom plate is provided with an anti-slip layer.
The utility model has the beneficial effects that: through setting up support piece, gag lever post and accessory, can make the accessory directly act on the skull of experimental mouse directly down when using, and then realize that the fixed position of mouse head is unchangeable; and observing brain nerve cells of the experimental mice through observation holes arranged on the accessories; compared with the traditional experimental mouse skull fixing mode, the accuracy of experimental results is improved.
Drawings
FIG. 1 is a schematic diagram of the overall structure of the present utility model;
FIG. 2 is a schematic view of the bottom end of the base of the present utility model;
FIG. 3 is a schematic view of the structure of the threaded rod of the present utility model;
FIG. 4 is a schematic side cross-sectional view of a threaded rod according to the present utility model;
FIG. 5 is a schematic view of a first side of the fitting of the present utility model;
FIG. 6 is a schematic view of a second side of the fitting of the present utility model;
in the figure, 1, a bottom plate; 2. a threaded rod; 21. a rotary knob; 22. a connecting seat; 23. a first baffle; 24. a second baffle; 3. a limit rod; 4. a connecting plate; 5. a fitting; 51. a through hole; 52. a threaded hole; 53. an observation hole; 54. a groove; 55. a protrusion.
Detailed Description
The following detailed description of the embodiments of the present utility model will be made more apparent to those skilled in the art from the following detailed description, in which the utility model is embodied in several, but not all, embodiments of the utility model. The utility model may be embodied or applied in other specific forms and features of the following examples and examples may be combined with each other without conflict, all other examples being contemplated by those of ordinary skill in the art without undue burden from the present disclosure, based on the examples of the utility model.
FIGS. 1-5 show the main technical content of this embodiment, which provides an experimental mouse skull observation experimental adapter, which comprises
A bottom plate 1 for carrying experimental mice;
a fitting 5 having a first end face and a second end face, wherein the first end face is formed with an observation hole 53, and the observation hole 53 penetrates the fitting 5;
a support for connecting the fitting 5 with the base plate 1, wherein the support urges the fitting 5 toward or away from the base plate 1;
the limiting rod 3 is connected to the bottom plate 1 and is positioned on the same end face with the supporting piece, and the accessory 5 is connected with the limiting rod 3 in a sliding way, so that the accessory 5 is close to or far from the bottom plate 1 and cannot rotate relatively;
and the connecting plate 4 is used for connecting the limiting rod 3 with the supporting piece, so that the supporting piece cannot be separated from the bottom plate 1.
Referring to fig. 1-2, in this embodiment, the bottom plate 1 is a rectangular plate, the bottom plate 1 has a top end surface and a bottom end surface, the top end surface is provided with a jack, and a part of the support member is configured in the jack, so that the support member can rotate clockwise and counterclockwise with the axis of the jack as a rotation axis, when the support member rotates clockwise, the fitting 5 is close to the top end surface of the bottom plate 1 along the support member, and when the support member rotates counterclockwise, the fitting 5 is far from the top end surface of the bottom plate 1 along the support member; thereby, the fitting 5 fixes the cranium of the experimental mouse, and the fixing force of the fitting 5 on the cranium of the mice is adjusted.
In order to increase the friction between the bottom plate 1 and the tabletop, so that the bottom plate 1 will not slide during the observation of the experimental mouse skull, in this embodiment, an anti-slip layer is disposed on the second end surface of the bottom plate 1, where the anti-slip layer is selected from: and a rubber layer adhered to the second end surface of the base plate 1 by means of adhesion.
Referring to fig. 1-3, in this embodiment, the support member may be selected from: a threaded rod 2; the threaded rod 2 is provided with a first end and a second end, the first end of the threaded rod 2 is positioned in the jack, and the second end of the threaded rod 2 is attached to the connecting plate 4; more preferably, a knob 21 is arranged to be connected to the second end of the threaded rod 2 through the connecting plate 4, such that the threaded rod 2 rotates synchronously with the knob 21 when the knob 21 is rotated; specifically, a first end of the threaded rod 2 is provided with a connecting seat 22, the connecting seat 22 is rotatably configured in the jack, and a second end of the threaded rod 2 and the rotary knob 21 can be connected by adopting bonding/welding; in use, the knob 21 is rotated clockwise or counter-clockwise so that the threaded rod 2 rotates in synchronism with the knob 21, thereby driving the fitting 5 towards or away from the top end face of the base plate 1.
Referring to fig. 1-2 and 4, in some embodiments of the present utility model, the stop lever 3 is fixedly connected to the top end surface of the base plate 1, and the stop lever 3 is perpendicular to the top end surface of the base plate 1, when the threaded rod 2 drives the fitting 5 to approach or separate from the top end surface of the base plate 1, the fitting 5 slides along the outer wall of the stop lever 3 at the same time, so that no unnecessary rotation occurs during the movement of the fitting 5.
Referring to fig. 1 to 3, in the present embodiment, the stop lever 3 is integrally connected to the connection plate 4, wherein the connection plate 4 has a through hole, and a portion of the knob 21 is passed through the through hole and connected to the second end of the threaded rod 2; more preferably, a connection part is provided between the second end of the threaded rod 2 and the knob 21, wherein the connection part includes: the first baffle 23 and the second baffle 24 have the cylinder axle between the first baffle 23 and the second baffle 24, and the cylinder axle is located between the through-holes of the connecting plate 4, so that the setting can prevent the threaded rod 2 from being separated from the jack when rotating, and make the better drive accessory 5 of the threaded rod 2 move up and down.
Referring to fig. 1-3, in other embodiments of the utility model, it is also possible to set the diameter of the through-hole smaller than the diameter of the threaded rod 2 and to provide a connecting shaft having the same diameter as the through-hole at the first end of the knob, the knob 21 being connected to the second end of the threaded rod 2 by the connecting shaft such that the threaded rod 2 is confined between the connecting plates 4 and the base plate 1.
Referring to fig. 3 and 5, in the present embodiment, the fitting 5 has a through hole 51 and a screw hole 52, wherein the fitting 5 is connected to the threaded rod 2 through the screw hole 52, the fitting 5 is connected to the stopper rod 3 through the through hole 51, and the diameter of the through hole 51 is the same as the diameter of the stopper rod 3.
Referring to fig. 5, in addition, the fitting 5 has a first face and a second face opposite to each other, the first face being formed with a recess 54, the second face being formed with a projection 55, the recess 54 being complementary in shape to the projection 55; wherein, the groove 54 has a bottom end surface, and the observation hole 53 penetrates from the bottom end surface to the second surface direction; more specifically, the centers of the through hole 51, the threaded hole 52 and the observation hole 53 are in the same straight line on the first surface of the fitting 5; and the threaded hole 52 is located between the through hole 51 and the observation hole 53; in use, the observation hole 53 is aligned with the skull window of the experimental mouse, and the edge of the boss 55 is bonded with the skull of the experimental mouse using dental cement; and observing brain nerve cells of the experimental mice through the observation holes 53 under a two-photon microscope; in addition, during the observation, interstitial fluid generated at the skull window of the experimental mouse was stored in the groove 54.
In other embodiments of the present utility model (not shown), the stop lever 3 may be replaced by a rectangular body, wherein the rectangular body is provided with a chute, a sliding protrusion 55 is disposed at one end of the fitting 5, the sliding protrusion 55 is slidably disposed in the chute, and when the threaded rod 2 drives the fitting 5 to approach or separate from the top end surface of the bottom plate 1, the sliding protrusion 55 moves up and down in the chute; so that the fitting 5 does not rotate during the movement.
The application method of the utility model comprises the following steps:
the experimental mouse is placed on the top end face of the bottom plate, the skull of the experimental mouse is placed below the accessory, the accessory is close to the top end face of the bottom plate by rotating the rotating knob clockwise, the position of the skull of the experimental mouse is adjusted when the rotating knob is rotated, so that the skull window is opposite to the observation hole, after the skull of the experimental mouse is fixed by the accessory, the raised edge is adhered to the skull of the mouse by dental cement, and in addition, tissue fluid generated at the skull window of the experimental mouse is stored in the groove in the observation process.
The above description of embodiments is only for the understanding of the present utility model. It should be noted that it will be apparent to those skilled in the art that modifications can be made to the present utility model without departing from the principles of the utility model, and such modifications will fall within the scope of the claims.
Claims (10)
1. An experimental mouse skull observation adapter, comprising:
a bottom plate for carrying experimental mice;
the accessory is provided with a first end face and a second end face, wherein an observation hole is formed in the first end face, and the accessory is penetrated by the observation hole;
a support for connecting the fitting to the base plate, wherein the support urges the fitting toward or away from the base plate;
the limiting rod is connected to the bottom plate and is positioned on the same end face with the supporting piece, and the accessory is connected with the limiting rod in a sliding mode, so that the accessory can not rotate relatively when being close to or far from the bottom plate;
and the connecting plate is used for connecting the limiting rod with the supporting piece, so that the supporting piece cannot be separated from the bottom plate.
2. The experimental mouse skull observation adapter of claim 1, wherein the bottom plate is provided with a top end surface and a bottom end surface, wherein the top end surface is provided with a jack, and a part of the support member is arranged in the jack, so that the support member can rotate by taking the axis of the jack as a rotation axis.
3. The experimental mouse cranium observation adapter according to claim 2 wherein the support comprises: a threaded rod; the threaded rod is provided with a first end and a second end, the first end of the threaded rod is positioned in the jack, and the second end of the threaded rod is attached to the connecting plate.
4. A laboratory mouse skull observation adapter according to claim 3, characterized in that a knob is provided which is connected to the second end of the threaded rod through the connection plate, such that the threaded rod rotates synchronously with the knob when the knob is rotated.
5. The experimental mouse skull observation adapter of claim 1, wherein said stop bar is fixedly connected to the top end surface of said base plate, and said stop bar is perpendicular to the top end surface of said base plate.
6. The experimental mouse skull observation adapter of claim 4, wherein said stop bar is integrally connected to said connecting plate, wherein said connecting plate has a through hole, and wherein a portion of said knob is passed through said through hole and connected to a second end of said threaded rod.
7. The experimental mouse skull observation adapter of claim 6, wherein the diameter of said through-hole is smaller than the diameter of said threaded rod such that said threaded rod is constrained between said connecting plate and said base plate.
8. The experimental mouse skull observation adapter of claim 3, wherein said fitting has a through hole and a threaded hole, wherein said fitting is connected to said threaded rod through said threaded hole, and wherein said fitting is connected to said stop bar through said through hole.
9. The experimental mouse skull observation adapter of claim 8, wherein said fitting further has opposing first and second faces, said first face being formed with a recess, said second face being formed with a protrusion, said recess having a shape complementary to said protrusion shape; the groove is provided with a bottom end face, and the observation hole penetrates through the bottom end face towards the second face.
10. The experimental mouse skull observation adapter of claim 2, wherein the bottom end surface of the bottom plate is provided with an anti-slip layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320480781.3U CN219742971U (en) | 2023-03-14 | 2023-03-14 | Experimental mouse skull observation adapter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320480781.3U CN219742971U (en) | 2023-03-14 | 2023-03-14 | Experimental mouse skull observation adapter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219742971U true CN219742971U (en) | 2023-09-26 |
Family
ID=88092157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320480781.3U Active CN219742971U (en) | 2023-03-14 | 2023-03-14 | Experimental mouse skull observation adapter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219742971U (en) |
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2023
- 2023-03-14 CN CN202320480781.3U patent/CN219742971U/en active Active
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