CN219209903U - Continuous oxidation system for rosuvastatin calcium intermediate - Google Patents
Continuous oxidation system for rosuvastatin calcium intermediate Download PDFInfo
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- CN219209903U CN219209903U CN202320422183.0U CN202320422183U CN219209903U CN 219209903 U CN219209903 U CN 219209903U CN 202320422183 U CN202320422183 U CN 202320422183U CN 219209903 U CN219209903 U CN 219209903U
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Abstract
The utility model provides a continuous oxidation system of a rosuvastatin calcium intermediate, which relates to the technical field of oxidation devices, and comprises a raw material storage device, a nitric acid storage device, a first metering pump, a second metering pump, a preheating component, a reactor and a storage device; the raw material storage device is communicated with the preheating component through a first metering pump, and the nitric acid storage device is communicated with the preheating component through a second metering pump; the preheating component is communicated with the feed inlet of the reactor, the first metering pump and the second metering pump so as to receive raw materials and nitric acid and transfer the raw materials and the nitric acid to the reactor, and is also communicated with the discharge outlet of the reactor and the storage device. The continuous oxidation system can control the metering of reactants through the first metering pump and the second metering pump, the reaction rate is controllable, the operation is safe, and meanwhile, the preheating of raw materials and nitric acid is realized through the reaction liquid, so that the structure is simple, and the cost is saved.
Description
Technical Field
The utility model relates to the technical field of oxidation devices, in particular to a continuous oxidation system of rosuvastatin calcium intermediate.
Background
Rosuvastatin calcium is a selective HMG-CoA reductase inhibitor suitable for use in the adjuvant treatment of patients with primary hypercholesterolemia (type ii a, including heterozygous familial hypercholesterolemia) or mixed dyslipidemia (type ii b) when diet or exercise therapy is not ideal. Rosuvastatin calcium may lower elevated LDL-cholesterol, total cholesterol, triglycerides and ApoB, increasing HDL-cholesterol. Is also suitable for homozygous familial hypercholesterolemia patients, and can be used alone or in combination with diet or other lipid-lowering means (such as LDL removal method).
4- (4-fluorophenyl) -7-isopropyl-2- [ (N-methyl-N-methylsulfonyl) amino ] pyrimidine-5-methanol is a key intermediate for synthesizing rosuvastatin calcium, and has the characteristics of large synthesis difficulty, multiple synthesis steps and higher requirements on production process and technical level. The key steps in the synthesis process are to oxidize concentrated nitric acid at high temperature, the reaction heat release is severe, and the reaction rate needs to be strictly controlled.
And the traditional kettle type reactor is difficult to monitor on line in real time due to the limitation of mass and heat transfer. Meanwhile, the method has the defects of more reaction materials and large quality, potential safety hazard is easy to occur, and the development of the modern industry is difficult to meet.
Disclosure of Invention
The utility model aims to provide a continuous oxidation system of rosuvastatin calcium intermediate, which can control the metering of reactants through a first metering pump and a second metering pump, has controllable reaction rate and safe operation, and simultaneously realizes the preheating of raw materials and nitric acid through reaction liquid, has a simple structure and saves cost.
In order to achieve the above purpose, the present utility model provides the following technical solutions:
the utility model provides a continuous oxidation system of rosuvastatin calcium intermediate, which comprises a raw material storage device, a nitric acid storage device, a first metering pump, a second metering pump, a preheating component, a reactor and a reaction liquid storage device;
the raw material storage device is communicated with the preheating assembly through the first metering pump, and the nitric acid storage device is communicated with the preheating assembly through the second metering pump;
the preheating component is communicated with the feed inlet of the reactor, the first metering pump and the second metering pump so as to receive raw materials and nitric acid and transfer the raw materials and the nitric acid to the reactor, and is also communicated with the discharge outlet of the reactor and the reaction liquid storage device so as to transfer reacted reaction liquid to the reaction liquid storage device after heat exchange between the raw materials and the nitric acid.
Further, the preheating assembly comprises a first preheater and a second preheater;
the first preheater is communicated with a feed inlet of the reactor and the first metering pump so as to receive the raw materials and transfer the raw materials to the reactor, and is also communicated with a discharge outlet of the reactor and the second preheater so as to transfer the reaction liquid to the second preheater after exchanging heat with the raw materials;
the second preheater is communicated with a feed inlet of the reactor and the second metering pump so as to receive the nitric acid and transfer the nitric acid to the reactor, and is also communicated with the reaction liquid storage device so as to transfer the reaction liquid to the reaction liquid storage device after heat exchange with the nitric acid.
Further, the first preheater is connected with a first pipeline for transporting the raw materials, the second preheater is connected with a second pipeline for transporting the nitric acid, and the first pipeline and the second pipeline are connected with the reactor through a main pipeline.
Further, a first conveying pipe and a first cavity arranged around the first conveying pipe are arranged in the first preheater, one of the first conveying pipe and the first cavity is communicated between a feed inlet of the reactor and the first metering pump, and the other is communicated between a discharge outlet of the reactor and the second preheater.
Further, a second conveying pipe and a second cavity arranged around the second conveying pipe are arranged in the second preheater, one of the second conveying pipe and the second cavity is communicated between the feeding port of the reactor and the second metering pump, and the other is communicated between the first preheater and the reaction liquid storage device.
Further, the reaction liquid storage device comprises a storage tank and an exhaust fire-retarding component;
the top of the storage tank is communicated with the preheating component and is used for receiving the reaction liquid discharged by the preheating component;
the exhaust fire-retarding component is communicated with the top of the storage tank and is used for discharging oxygen generated by the reaction and retarding flame.
Further, the exhaust firestop assembly includes a blow-down tube in communication with the top of the storage tank and a flame arrestor mounted on the blow-down tube.
Further, a first valve is arranged between the raw material storage device and the first metering pump.
Further, a second valve is arranged between the nitric acid storage device and the second metering pump.
Further, a third valve is arranged at the discharge hole of the reaction liquid storage device.
The continuous oxidation system of the rosuvastatin calcium intermediate provided by the utility model can produce the following beneficial effects:
when the continuous oxidation system of the rosuvastatin calcium intermediate is used, raw materials in the raw material storage device enter the preheating component through the first metering pump, nitric acid in the nitric acid storage device enters the preheating component through the second metering pump, heat exchange is carried out between the raw materials and nitric acid in the preheating component and reaction liquid after reaction, preheating of the raw materials and the nitric acid is realized, the raw materials and the nitric acid are led into the reactor by the preheating component, reaction of the raw materials and the nitric acid in the reactor releases heat, and finally the reaction liquid is discharged from the reactor to the preheating component to exchange heat with the raw materials and the nitric acid before entering the reactor, and is discharged to the storage device after heat exchange.
Compared with the prior art, the continuous oxidation system provided by the utility model has the advantages that the metering of reactants can be controlled through the first metering pump and the second metering pump, the reaction rate is controllable, the operation is safe, the preheating of raw materials and nitric acid is realized through the reaction liquid, the structure is simple, and the cost is saved.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present utility model, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic structural diagram of a continuous oxidation system of rosuvastatin calcium intermediate provided by the embodiment of the utility model.
Icon: 1-a raw material storage device; 2-nitric acid storage means; 3-a first metering pump; 4-a second metering pump; 5-a preheating assembly; 51-a first preheater; 52-a second preheater; 6-a reactor; 7-a storage device; 71-a storage tank; 72-an exhaust firestop assembly; 721-blow-down pipe; 722—flame arrestor; 8-a first pipe; 9-a second conduit; 10-main pipeline; 011—a first valve; 012-second valve; 013-third valve.
Detailed Description
The following description of the embodiments of the present utility model will be made apparent and fully in view of the accompanying drawings, in which some, but not all embodiments of the utility model are shown. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
In the description of the present utility model, it should be noted that the directions or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present utility model, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model can be understood by those of ordinary skill in the art according to the specific circumstances.
The following describes specific embodiments of the present utility model in detail with reference to the drawings. It should be understood that the detailed description and specific examples, while indicating and illustrating the utility model, are not intended to limit the utility model.
The embodiment aims at providing a continuous oxidation system of rosuvastatin calcium intermediate, as shown in fig. 1, comprising a raw material storage device 1, a nitric acid storage device 2, a first metering pump 3, a second metering pump 4, a preheating component 5, a reactor 6 and a reaction liquid storage device 7;
the raw material storage device 1 is communicated with the preheating component 5 through a first metering pump 3, and the nitric acid storage device 2 is communicated with the preheating component 5 through a second metering pump 4;
the preheating component 5 is communicated with a feed inlet of the reactor 6, the first metering pump 3 and the second metering pump 4 to receive raw materials and nitric acid and transfer the raw materials and the nitric acid to the reactor 6, and the preheating component 5 is also communicated with a discharge outlet of the reactor 6 and the reaction liquid storage device 7 to transfer the reacted reaction liquid to the reaction liquid storage device 7 after exchanging heat between the raw materials and the nitric acid.
The first metering pump 3 and the second metering pump 4 are arranged in the continuous food oxidation system provided by the embodiment, so that the metering of raw materials and nitric acid can be controlled respectively, the quantity of reaction materials is ensured to be controlled within a safe range, and meanwhile, the raw materials and nitric acid are preheated through the reaction liquid, so that the temperature of the reaction liquid is reduced, and meanwhile, the temperature of the raw materials and nitric acid is increased. Has the advantages of simple structure, rapid mass and heat transfer, safe operation, etc.
The reactor 6 may be an existing microchannel reactor.
In some embodiments, as shown in fig. 1, the preheating assembly 5 includes a first preheater 51 and a second preheater 52, wherein:
the first preheater 51 is in communication with the feed inlet of the reactor 6 and the first metering pump 3 to receive and divert feedstock to the reactor 6, and the first preheater 51 is also in communication with the discharge outlet of the reactor 6 and the second preheater 52. When the device is used, raw materials are pumped into the first preheater 51 through the first metering pump 3, heat exchange is carried out between the raw materials and reaction liquid discharged from the reactor 6 in the first preheater 51, the raw materials are preheated, then the raw materials enter the reactor 6, and the reaction liquid enters the second preheater 52.
The second preheater 52 is in communication with the feed inlet of the reactor 6 and the second metering pump 4, and the second preheater 52 is also in communication with the reaction solution storage device 7. When in use, nitric acid is pumped into the second preheater 52 through the second metering pump 4, heat exchange is carried out between the nitric acid and the reaction liquid discharged from the first preheater 51 in the second preheater 52, the preheating of the nitric acid is realized, then the nitric acid enters the reactor 6 to react with raw materials, and the reaction liquid enters the reaction liquid storage device 7.
In some embodiments, as shown in fig. 1, a first preheater 51 is connected to a first pipe 8 for transporting the raw material, a second preheater 52 is connected to a second pipe 9 for transporting the nitric acid, and the first pipe 8 and the second pipe 9 are connected to the reactor 6 through a main pipe 10 to mix the raw material and the nitric acid in the main pipe 10 and then enter the reactor 6.
In some embodiments, the first preheater 51 is provided with a first conveying pipe and a first cavity arranged around the first conveying pipe, one of the first conveying pipe and the first cavity is communicated between the feed inlet of the reactor 6 and the first metering pump 3 to realize the conveying of raw materials, and the other is communicated between the discharge outlet of the reactor 6 and the second preheater 52 to realize the conveying of reaction liquid, and heat exchange is realized through the contact between the outer wall of the first conveying pipe and the materials in the first cavity.
Specifically, the first conveying pipe may be connected between the feed inlet of the reactor 6 and the first metering pump 3, and the first cavity is connected between the discharge outlet of the reactor 6 and the second preheater 52.
The first cavity may be formed on an inner surface of the outer casing of the first preheater 51, and the first transport pipe penetrates the outer casing of the first preheater 51.
In some embodiments, the second preheater 52 is provided with a second conveying pipe and a second cavity arranged around the second conveying pipe, one of the second conveying pipe and the second cavity is communicated between the feed inlet of the reactor 6 and the second metering pump 4 to realize the conveying of nitric acid, and the other is communicated between the first preheater 51 and the reaction solution storage device 7 to realize the conveying of reaction solution, and heat exchange is realized through the contact between the outer wall of the second conveying pipe and materials in the second cavity.
Specifically, a second transporting pipe may be connected between the feed inlet of the reactor 6 and the second metering pump 4, and a second chamber may be connected between the first preheater 51 and the reaction solution storage device 7.
The second cavity may be formed on the inner surface of the outer casing of the second preheater 52, and the second transport pipe penetrates the outer casing of the second preheater 52.
In some other embodiments, the preheating assembly 5 may also comprise only one preheater, through which both the raw material and the nitric acid exchange heat with the reaction solution.
In some embodiments, as shown in fig. 1, the reaction solution storage device 7 includes a storage tank 71 and an exhaust fire retardant assembly 72, the top of the storage tank 71 is in communication with the preheating assembly 5, and the exhaust fire retardant assembly 72 is in communication with the top of the storage tank 71.
In use, the reacted reaction liquid enters the storage tank 71 from the preheating component 5, and the gas generated by the reaction can be discharged through the gas discharge fire-retarding component 72, so that the reaction safety is ensured.
In some embodiments, the exhaust firestop assembly 72 includes a blow-down tube 721 and a flame arrester 722, the blow-down tube 721 being in communication with the top of the storage tank 71, the blow-down tube 721 being capable of exhausting the combustible gases generated by the reaction, the flame arrester 722 being mounted on the blow-down tube 721 to prevent an external open flame from escaping into the blow-down tube 721 because the gases are combustible gases.
In some embodiments, to control the opening and closing of the discharge end of the raw material storage device 1, a first valve 011 is provided between the raw material storage device 1 and the first metering pump 3.
In some embodiments, to control the opening and closing of the discharge end of the nitric acid storage device 2, a second valve 012 is provided between the nitric acid storage device 2 and the second metering pump 4.
In some embodiments, to control the opening and closing of the discharge end of the reaction solution storage device 7, a third valve 013 is disposed at the discharge port of the storage tank 71 in the reaction solution storage device 7.
The first valve 011, the second valve 012 and the third valve 013 may be solenoid valves or manual valves.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present utility model, and not for limiting the same; although the utility model has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the utility model.
Claims (10)
1. The continuous oxidation system of the rosuvastatin calcium intermediate is characterized by comprising a raw material storage device (1), a nitric acid storage device (2), a first metering pump (3), a second metering pump (4), a preheating component (5), a reactor (6) and a reaction liquid storage device (7);
the raw material storage device (1) is communicated with the preheating assembly (5) through the first metering pump (3), and the nitric acid storage device (2) is communicated with the preheating assembly (5) through the second metering pump (4);
the preheating component (5) is communicated with a feed inlet of the reactor (6), the first metering pump (3) and the second metering pump (4) so as to receive raw materials and nitric acid and transfer the raw materials and the nitric acid to the reactor (6), and the preheating component (5) is also communicated with a discharge outlet of the reactor (6) and the reaction liquid storage device (7) so that the reacted reaction liquid exchanges heat with the raw materials and the nitric acid and then transfers the reaction liquid to the reaction liquid storage device (7).
2. The continuous oxidation system of rosuvastatin calcium intermediate according to claim 1, characterized in that said preheating assembly (5) comprises a first preheater (51) and a second preheater (52);
the first preheater (51) is communicated with a feed inlet of the reactor (6) and the first metering pump (3) so as to receive the raw materials and discharge the raw materials to the reactor (6), and the first preheater (51) is also communicated with a discharge outlet of the reactor (6) and the second preheater (52) so as to exchange heat between the reaction liquid and the raw materials and then discharge the reaction liquid to the second preheater (52);
the second preheater (52) is communicated with a feed inlet of the reactor (6) and the second metering pump (4) so as to receive the nitric acid and transfer the nitric acid to the reactor (6), and the second preheater (52) is also communicated with the reaction liquid storage device (7) so as to transfer the reaction liquid to the reaction liquid storage device (7) after heat exchange between the reaction liquid and the nitric acid.
3. The continuous oxidation system of rosuvastatin calcium intermediate according to claim 2, characterized in that said first preheater (51) is connected with a first pipe (8) for transporting said raw material, said second preheater (52) is connected with a second pipe (9) for transporting said nitric acid, said first pipe (8) and said second pipe (9) are connected with said reactor (6) through a main pipe (10).
4. The continuous oxidation system of rosuvastatin calcium intermediate according to claim 2, characterized in that said first preheater (51) has a first transportation pipe and a first cavity arranged around said first transportation pipe, one of said first transportation pipe and said first cavity being in communication between the feed inlet of said reactor (6) and said first metering pump (3), the other being in communication between the discharge outlet of said reactor (6) and said second preheater (52).
5. The continuous oxidation system of rosuvastatin calcium intermediate according to claim 2, characterized in that said second preheater (52) has a second transportation pipe and a second cavity arranged around said second transportation pipe, one of said second transportation pipe and said second cavity being in communication between the feed inlet of said reactor (6) and said second metering pump (4), the other being in communication between said first preheater (51) and said reaction liquid storage means (7).
6. The continuous oxidation system of rosuvastatin calcium intermediate according to claim 1, characterized in that said reaction liquid storage means (7) comprises a storage tank (71) and an exhaust fire retardant assembly (72);
the top of the storage tank (71) is communicated with the preheating component (5) and is used for receiving the reaction liquid discharged by the preheating component (5);
the exhaust fire retardant assembly (72) is in communication with the top of the storage tank (71) for venting oxygen generated by the reaction and for flame retarding.
7. The continuous oxidation system of rosuvastatin calcium intermediate according to claim 6, characterized in that said exhaust firestop assembly (72) comprises a blow down tube (721) and a flame arrestor (722), said blow down tube (721) being in communication with the top of said storage tank (71), said flame arrestor (722) being mounted on said blow down tube (721).
8. Continuous oxidation system of rosuvastatin calcium intermediate according to any of the claims 1-7, characterized in that a first valve (011) is arranged between said raw material storage device (1) and said first metering pump (3).
9. Continuous oxidation system for rosuvastatin calcium intermediate according to any of the claims 1-7, characterized in that a second valve (012) is provided between said nitric acid storage means (2) and said second metering pump (4).
10. The continuous oxidation system of rosuvastatin calcium intermediate according to any of claims 1 to 7, characterized in that a third valve (013) is provided at the discharge port of said reaction liquid storage device (7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320422183.0U CN219209903U (en) | 2023-03-03 | 2023-03-03 | Continuous oxidation system for rosuvastatin calcium intermediate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320422183.0U CN219209903U (en) | 2023-03-03 | 2023-03-03 | Continuous oxidation system for rosuvastatin calcium intermediate |
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| Publication Number | Publication Date |
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| CN219209903U true CN219209903U (en) | 2023-06-20 |
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| CN202320422183.0U Active CN219209903U (en) | 2023-03-03 | 2023-03-03 | Continuous oxidation system for rosuvastatin calcium intermediate |
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