CN219203091U - Ion source gas supply device, collision cell gas supply device and gas circuit system of mass spectrometer - Google Patents
Ion source gas supply device, collision cell gas supply device and gas circuit system of mass spectrometer Download PDFInfo
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- CN219203091U CN219203091U CN202222811568.4U CN202222811568U CN219203091U CN 219203091 U CN219203091 U CN 219203091U CN 202222811568 U CN202222811568 U CN 202222811568U CN 219203091 U CN219203091 U CN 219203091U
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Abstract
The utility model relates to the technical field of mass spectrometers, in particular to an ion source gas supply device, a collision cell gas supply device and a gas circuit system of a mass spectrometer. The ion source air supply device of the mass spectrometer comprises an air source, a first pressure regulating valve sensor, a first air dividing structure and a flowmeter, wherein the first pressure regulating valve sensor is connected with the air source, one end of the air dividing structure is connected with the first pressure regulating valve sensor, and the other end of the air dividing structure is connected with the flowmeter; the collision cell air supply device comprises an air source, a second pressure regulating valve sensor and a flow limiting structure, wherein the air in the air source is divided into two paths after passing through the second pressure regulating valve sensor, one path of the air is introduced into a front-stage buffer cell, the other path of the air is introduced into the collision cell through the flow limiting structure, and the front-stage buffer cell is arranged at the front end of the collision cell; the ion source air supply device and the collision cell air supply device form an air path system, are clear and simple in structure and easy to detach and maintain, and can ensure analysis effect through accurate flow monitoring and pressure feedback, and meanwhile instrument pollution is greatly avoided.
Description
Technical Field
The utility model relates to the technical field of mass spectrometers, in particular to an ion source gas supply device, a collision cell gas supply device and a gas circuit system of a mass spectrometer.
Background
The application of mass spectrometry instruments relates to various fields of medicine, food, environment, materials, energy sources and the like. Mass spectrometry is an analytical method for measuring the mass-to-charge ratio (mass-to-charge ratio) of ions, and the basic principle is that each component in a sample is ionized in an ion source to generate charged ions with different charge-to-mass ratios, and an ion beam is formed by the action of an accelerating electric field and enters a mass analyzer.
The mass spectrometer is composed of the following systems: the device comprises a sample injection device, an ion source, a vacuum system, a mass analyzer, a detector and a data acquisition system. The triple quadrupole mass spectrometer is composed of an ion source, an ion guiding device, a primary quadrupole mass analyzer, a secondary quadrupole mass analyzer/collision reaction cell, a tertiary quadrupole mass analyzer and a detector in sequence from left to right.
In the mass spectrometry process, the correct supply of each gas is an essential component in the experimental process, and in order to meet the requirements of accurate and safe flow control of an ion source and a collision cell, a gas control valve group is used for realizing optimal gas supply. However, the whole mass spectrometer has the advantages that the gas paths are numerous, the circuit design is easy to be confused, so that the disassembly, assembly and maintenance in the actual assembly process are difficult, in addition, the gas path design in the existing triple quadrupole is more problematic in flow monitoring and pressure feedback, the analysis process is difficult to control, the analysis effect is greatly reduced, and the instrument is easy to be polluted.
Disclosure of Invention
In order to achieve the above objects and other advantages in accordance with the purpose of the present utility model, it is an object of the present utility model to provide a triple quadrupole gas path system with a clear and simple design line, easy disassembly and maintenance, which can greatly avoid instrument contamination while ensuring analysis effect through accurate flow monitoring and pressure feedback.
The method comprises the following steps:
the utility model provides an ion source air supply device of a mass spectrometer, which comprises an air source, a first pressure regulating valve sensor, a first air dividing structure and flow meters, wherein the first pressure regulating valve sensor is connected with the air source, one end of the air dividing structure is connected with the first pressure regulating valve sensor, the other end of the air dividing structure is connected with the flow meters, and the number of the flow meters is more than 2.
Further, the flow meter includes a first flow meter, a second flow meter, a third flow meter, and a fourth flow meter.
The first gas distribution structure divides the gas output from the gas source into four parts and respectively supplies the four parts to the flowmeter, the flowmeter comprises a first flowmeter, a second flowmeter, a third flowmeter and a fourth flowmeter, an outlet of the first flowmeter is connected with a gas curtain gas structure of the ion source, and gas curtain gas is output; the outlet of the second flowmeter is connected with an ion source spray needle of the ion source, and auxiliary gas of the ion source spray needle is output;
the outlet of the third flowmeter is connected with an auxiliary gas structure of the ion source, and auxiliary gas is output; the auxiliary gas can remove the solvent, improve ionization efficiency, reduce background noise,
the outlet of the fourth flowmeter is connected with the ion source spray needle, and outputs atomized gas which can vaporize the liquid sample;
and finally, the gas output in the flowmeter is converged into the cavity of the ion source through the gas curtain gas structure, the first auxiliary gas structure, the second auxiliary gas structure and the ion source spray needle.
The auxiliary gas structure comprises a first auxiliary gas structure and a second auxiliary gas structure, a second gas dividing structure is arranged between the third flowmeter and the ion source, the second gas dividing structure divides the gas passing through the third flowmeter into two parts, one part of the gas enters the first auxiliary gas structure, and the other part of the gas enters the second auxiliary gas structure.
On the other hand, the utility model provides a collision cell air supply device which comprises an air source, a second pressure regulating valve sensor and a flow limiting structure, wherein the air in the air source is divided into two paths after passing through the second pressure regulating valve sensor, one path of air is introduced into a front-stage buffer cell at the front end of the collision cell, and the other path of air is introduced into the collision cell through the flow limiting structure.
Further, the flow restricting structure is preferably a needle valve, which can control less gas to enter the collision cell.
Further, the collision cell air supply device further comprises a mechanical pump and a molecular pump, wherein the front-stage buffer cell is connected with the mechanical pump, and the molecular pump is connected with a vacuum cavity for bearing the collision cell.
Further, the device also comprises a pressure detector, wherein the pressure detector is a Pirani gauge or an inverted magnetron vacuum gauge.
Further, the utility model provides a gas path system of the mass spectrometer, which comprises the ion source gas supply device and the collision cell gas supply device.
Further, the gas path system further comprises a third gas distribution structure, the third gas distribution structure divides the gas output by the gas source into two paths, one path enters the ion source through the ion source gas supply device, and the other path enters the collision cell through the collision cell gas supply device.
The utility model uses a clear, simple and easily detachable and maintained triple quadrupole gas path system, and can greatly avoid instrument pollution while guaranteeing analysis effect through accurate flow monitoring and pressure feedback.
The ion source and the mass analyzer share one air source, so that the configuration of an air path system is simplified.
Drawings
Fig. 1: a triple quadrupole internal cavity schematic;
fig. 2: schematic diagram of ion source air supply device of triple quadrupole rods;
fig. 3: a schematic diagram of a collision cell gas supply device of triple quadrupole rods;
fig. 4: a schematic diagram of a collision cell gas supply device of triple quadrupole rods;
fig. 5: schematic diagram of gas circuit system of triple quadrupole rods.
1-air source, 2-first pressure regulating valve sensor, 3-first gas dividing structure, 4-flowmeter, 5-ion source, 6-second pressure regulating valve sensor, 7-preceding buffer pool, 8-current limiting structure, 9-collision pool, 10-mechanical pump, 11-molecular pump.
Detailed Description
Example 1
The triple quadrupole internal cavity is shown in figure 1.
The internal cavity of triple quadrupole rod comprises an ion source cavity, a primary vacuum cavity, a collision pool and a front buffer pool, wherein the primary vacuum cavity and the collision pool jointly form a containing cavity of the triple quadrupole rod mass analyzer, the containing cavity is in a vacuum environment, the ion source cavity is in an atmospheric pressure environment, and the front buffer pool is arranged below the primary vacuum cavity and is used for buffering gas entering the primary vacuum cavity.
The ion source air supply device with triple quadrupole rods comprises an air source 1, a first pressure regulating valve sensor 2, a first air dividing structure 3 and flow meters 4, wherein the first pressure regulating valve sensor 2 is connected with the air source 1, one end of the air dividing structure 3 is connected with the first pressure regulating valve sensor 2, the other end of the air dividing structure is connected with the flow meters 4, and the number of the flow meters 4 is more than 2.
The number of the flow meters is 2, the first gas distribution structure 3 divides the gas output from the gas source 1 into two, the two gas are respectively supplied to the first flow meter 41 and the fourth flow meter 44 in the flow meters 4, the outlet of the first flow meter 41 is connected with the gas curtain gas structure of the ion source to output gas curtain gas, and the outlet of the fourth flow meter 44 is connected with the ion source spray needle to output atomized gas.
The outlet of the first flowmeter is connected with an air curtain air structure of the ion source, and air curtain air is output;
the outlet of the second flowmeter is connected with an ion source spray needle of the ion source, and auxiliary gas of the ion source spray needle is output;
the outlet of the third flowmeter is connected with an auxiliary gas structure of the ion source, and auxiliary gas is output;
the outlet of the fourth flowmeter is connected with the ion source spray needle and outputs atomized gas;
and finally, the gas output in the flowmeter is converged into the cavity of the ion source through the gas curtain gas structure, the first auxiliary gas structure, the second auxiliary gas structure and the ion source spray needle.
Preferably, the first gas dividing structure 3 divides the gas output from the gas source 1 into four, and supplies the four gas to the flow meters 4 respectively, the flow meters 4 include a first flow meter 41, a second flow meter 42, a third flow meter 43 and a fourth flow meter 44, and an outlet of the first flow meter 41 is connected with a gas curtain gas structure of the ion source to output gas curtain gas; the outlet of the second flowmeter 42 is connected with a spray needle of the ion source, and outputs auxiliary gas of the spray needle of the ion source; the outlet of the third flowmeter 43 is connected with an auxiliary gas structure of the ion source, and outputs auxiliary gas, the auxiliary gas can remove solvent, improve ionization efficiency and reduce background noise, and the outlet of the fourth flowmeter 44 is connected with an ion source spray needle, and outputs atomized gas, so that a liquid sample can be vaporized; the gas output from the flow meter 4 is finally converged into the cavity of the ion source 5 through the gas curtain gas structure, the first auxiliary gas structure, the second auxiliary gas structure and the ion source needle.
The first pressure regulating valve sensor 2 can regulate the gas path pressure to the optimal working pressure range of the equipment and has pressure feedback, so that the control of the gas flow can be realized.
Further, the auxiliary gas structure comprises a first auxiliary gas structure and a second auxiliary gas structure, a second gas dividing structure is installed between the third flowmeter 43 and the ion source 5, the second gas dividing structure divides the gas passing through the third flowmeter into two parts, one part enters the first auxiliary gas structure, and the other part enters the second auxiliary gas structure. The two paths of auxiliary gases are controlled by one flowmeter, so that the two paths of auxiliary gases can be ensured to be more uniform.
The second gas dividing structure can be a three-way valve or a multi-way gas dividing block.
Example 2
The utility model provides a triple quadrupole's collision cell air feeder, as shown in fig. 3, includes air supply 1, second air-vent valve sensor 6, restriction structure 8, the gas in the air supply 1 divides into two-way behind the second air-vent valve sensor 6, and preceding stage buffer tank 7 is gone into to the way, and preceding stage buffer tank 7 is gone into collision cell 9 through restriction structure 8, preceding stage buffer tank 7 is at collision cell 9 front end, preceding stage buffer tank 7 can reduce restriction structure 8 front end pressure, reduces the gas flow who gets into the collision cell, improves the stability of collision gas.
The second pressure regulating valve sensor 6 can regulate the optimal working range of the gas path pressure and is provided with pressure feedback.
The flow restricting structure 8 is preferably a needle valve, which allows less gas to enter the collision cell.
Further, as shown in fig. 4, the collision cell air supply device further comprises a mechanical pump 10 and a molecular pump 11, the front buffer cell 7 is connected with the mechanical pump 10, the molecular pump 11 is connected with a vacuum cavity for bearing the collision cell 9, the mechanical pump 10 is used as a front pump of the molecular pump 11, so that a proper front working pressure can be provided for the molecular pump, a vacuum environment is provided for a vacuum cavity in front of the collision cell 9 in the mass analyzer, and the molecular pump 11 provides a proper vacuum environment for the whole mass analyzer.
Further, in order to detect the pressure of each chamber, the steady state of the real-time feedback gas path system may be added with a pressure detector 12, a first pressure detector 121, a second pressure detector 122 and a third pressure detector 123 as shown in the figure, where the pressure detectors are pirani gauges or inverted magnetron vacuum gauges, in the collision cell and the molecular pump.
Example 3
The gas path system of triple quadrupole rod, as shown in fig. 5, includes ion source gas supply unit and collision cell gas supply unit, ion source gas supply unit includes air supply 1, first air-vent valve sensor 2, first minute gas structure 3 and flowmeter 4, first minute gas structure 3 divides the gas of following air supply 1 output into four, supplies flowmeter 4 respectively, flowmeter 4 includes first flowmeter 41, second flowmeter 42, third flowmeter 43 and fourth flowmeter 44, collision cell gas supply unit includes air supply 1, second air-vent valve sensor 6, restriction structure 8, the gas in the air supply 1 divides into two way, and the way lets in preceding buffer cell 7, and the way lets in collision cell 9.
Further, in order to detect the pressure of each chamber, the steady state of the gas path system is fed back in real time, a pressure detector 12 can be added to the collision cell and a molecular pump, and a first pressure detector 121, a second pressure detector 122 and a third pressure detector 123 can be added, wherein the pressure detectors are Pirani gauge or a reverse magnetron vacuum gauge.
The gas path system further comprises a third gas distribution structure 13, wherein the third gas distribution structure 13 divides the gas output by the gas source 1 into two paths, one path enters the ion source through the ion source gas supply device, and the other path enters the collision cell through the collision cell gas supply device.
When the gas circuit system operates, firstly, the gas source 1 is opened, the first pressure regulating valve sensor 2 and the second pressure regulating valve sensor 6 are utilized to detect whether the pressure of the gas source 1 reaches the standard, then, the mechanical pump 10 is opened, the third pressure detector 123 is utilized to detect the vacuum degree, after the vacuum degree reaches the standard, the molecular pump 11 is opened, the first pressure detector 121 is utilized to detect the cavity pressure of the mass analyzer, the sample detection is carried out after the standard reaches the standard, the ion source gas supply device is opened, and the first flowmeter 41, the second flowmeter 42, the third flowmeter 43 and the fourth flowmeter 44 are utilized to output gas curtain gas, auxiliary gas and atomized gas, so that the experimental process is started.
Claims (11)
1. The ion source air supply device of the mass spectrometer is characterized by comprising an air source, a first pressure regulating valve sensor, a first air dividing structure and a flowmeter, wherein the first pressure regulating valve sensor is connected with the air source, one end of the air dividing structure is connected with the first pressure regulating valve sensor, and the other end of the air dividing structure is connected with the flowmeter.
2. The ion source gas supply of claim 1, wherein the flow meter comprises a first flow meter, a second flow meter, a third flow meter, and a fourth flow meter.
3. The ion source gas supply apparatus according to claim 2, wherein the outlet of the first flow meter is connected to a gas curtain gas structure of the ion source, and outputs a gas curtain gas; the outlet of the second flowmeter is connected with a spray needle of the ion source, and the spray needle auxiliary gas is output; the outlet of the third flowmeter is connected with an auxiliary gas structure of the ion source, and auxiliary gas is output; the outlet of the fourth flowmeter is connected with a spray needle of the ion source, and atomized gas is output; and finally, the gas output from the flowmeter is converged into the cavity of the ion source through the gas curtain gas structure, the auxiliary gas structure and the spray needle.
4. The ion source gas supply apparatus according to claim 3, wherein the auxiliary gas structure comprises a first auxiliary gas structure and a second auxiliary gas structure, a second gas dividing structure is installed between the third flowmeter and the ion source, the second gas dividing structure divides the gas passing through the third flowmeter into two parts, one part enters the first auxiliary gas structure, and the other part enters the second auxiliary gas structure.
5. The collision cell air supply device of the mass spectrometer is characterized by comprising an air source, a second pressure regulating valve sensor and a flow limiting structure, wherein the air in the air source is divided into two paths after passing through the second pressure regulating valve sensor, one path of the air is introduced into a front-stage buffer cell, the other path of the air is introduced into the collision cell through the flow limiting structure, and the front-stage buffer cell is arranged at the front end of the collision cell.
6. The collision cell air supply apparatus as defined in claim 5, wherein said flow restricting structure is a needle valve.
7. The crash cell air supply device according to claim 5, further comprising a mechanical pump and a molecular pump, wherein the pre-buffer cell is connected to the mechanical pump and wherein the molecular pump is connected to a vacuum chamber carrying the crash cell.
8. The collision cell air supply apparatus as defined in claim 7, further comprising a pressure detector, wherein the pressure detector is connected to the collision cell or the molecular pump.
9. The collision cell air supply apparatus as defined in claim 8, wherein said pressure detector is a pirani gauge or an inverted magnetron vacuum gauge.
10. A gas circuit system for a mass spectrometer comprising an ion source gas supply as claimed in any one of claims 1 to 4 and a collision cell gas supply as claimed in any one of claims 5 to 9.
11. The gas circuit system of claim 10, further comprising a third gas dividing structure that divides the gas output by the gas source into two paths, one path entering the ion source through the ion source gas supply and one path entering the collision cell through the collision cell gas supply.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222811568.4U CN219203091U (en) | 2022-10-25 | 2022-10-25 | Ion source gas supply device, collision cell gas supply device and gas circuit system of mass spectrometer |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202222811568.4U CN219203091U (en) | 2022-10-25 | 2022-10-25 | Ion source gas supply device, collision cell gas supply device and gas circuit system of mass spectrometer |
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| CN219203091U true CN219203091U (en) | 2023-06-16 |
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| CN202222811568.4U Active CN219203091U (en) | 2022-10-25 | 2022-10-25 | Ion source gas supply device, collision cell gas supply device and gas circuit system of mass spectrometer |
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Address after: No. 45 Shilin Avenue, Tiaodeng Town, Dadukou District, Chongqing 400082 Patentee after: Zhongyuan Huiji Biotechnology Co.,Ltd. Country or region after: China Address before: 400037 1st-4th floor, building 30, No.6 Taikang Road, Zone C, Jianqiao Industrial Park, Dadukou District, Chongqing Patentee before: Zhongyuan Huiji Biotechnology Co.,Ltd. Country or region before: China |