CN218961312U - Quantitative radioactive liquid transferring device of punching injector - Google Patents

Abstract

The utility model relates to a quantitative radioactive liquid transferring device of a perforating injector, which comprises an injector, wherein a hole is formed in the side wall of a cylinder body of the injector, the position of the hole determines the volume of gas or radioactive liquid stored in the cylinder body of the injector, a piston of the injector is arranged at the upper end of the hole, a piston handle is connected with a power device, an injection port of the injector is connected with a middle rotary bottle or a three-way valve, and the middle rotary bottle or the three-way valve is connected with a loop ring. The utility model can prevent the problems of insufficient liquid transfer or overflow caused by insensitive control points when radioactive liquid is transferred by using conventional gas as power, or too complex equipment when the injector is driven by a motor in a reciprocating way, and the like. According to the utility model, through the combination of the air cylinder and the perforating injector, quantitative transfer of radioactive liquid can be realized, equipment is simplified, cost is reduced, and stability is improved.

Description

Quantitative radioactive liquid transferring device of punching injector

Technical Field

The utility model relates to a radioactive liquid transferring device, in particular to a radioactive liquid quantitatively transferring device of a perforated syringe.

Background

In the preparation of radiopharmaceuticals, semi-preparative high-pressure liquid chromatography (Semi-HPLC) is often used for separation and purification to obtain high purity radiopharmaceuticals. After completion of the reaction in the reaction vessel, the radioactive liquid in the vessel is quantitatively transferred into a LOOP Line (LOOP) of HPLC for further separation by loading the LOOP to be separated onto a semi-preparative column. The quantitative radioactive liquid transfer methods commonly used at present include: 1. withdrawing and reloading the LOOP from the reaction vessel with a reciprocating syringe; 2. the liquid in the reaction container is directly pressed onto the LOOP by using gas as power, in order to prevent the liquid in the LOOP from overflowing when the power gas is loaded, the technology of using bubbles and/or radioactive vanishing signals in a pipeline as a cut-off point or a gas/liquid isolating membrane is adopted, and the power gas can not pass through the membrane to be cut off after the liquid transfer is finished.

However, the above method is prone to the following problems in practical use:

1. the reciprocating syringe transfers liquid, and the device has the advantages of controlled and quantitative transfer, but the device for driving the reciprocating syringe is complex, has high precision requirement and has high cost.

2. The gas is used as power, the ultrasonic probe is used as a detector, and the bubbles in the pipeline are cut off after the liquid is transferred; the device has the advantages of simple equipment, easy misjudgment, and incomplete radioactive liquid transfer or overflow of transfer liquid in a LOOP, which causes transfer loss and even failure, because the liquid does not transfer to end to send a cut-off signal or the cut-off signal is not sent all the time because of the decrease of detection sensitivity.

Detecting radioactivity in the transfer pipeline, and taking a radioactivity vanishing signal as a cut-off point; the device has the advantages of simple equipment, but different transfer speeds of radioactive liquid in the pipeline often cause transfer liquid overflow after signal cut-off and in LOOP, and transfer failure is caused.

3. Gas/liquid barrier film technology: before passing through the liquid, the dynamic gas can freely pass through the isolating membrane; once the liquid flows through the isolating membrane, the power gas is blocked by the isolating membrane, and the radioactive liquid in the LOOP does not flow any more; the method is a simple and economical method at present. However, the existing materials of the isolating membrane often cause large adsorption quantity of the radioactive drug on the isolating membrane, and cause large loss and even failure of the transferred radioactivity; it is therefore critical to select an appropriate barrier film. There are still some radiopharmaceuticals that currently do not have a suitable barrier membrane. Meanwhile, before transfer, if a small amount of residual liquid flows into the isolating membrane or the LOOP to flow back, the isolating membrane is blocked in advance, so that the liquid cannot be transferred.

Disclosure of Invention

The utility model aims at overcoming the defects of the prior art, and provides a device for quantitatively transferring radioactive liquid by using a perforated syringe, which is suitable for quantitatively transferring radioactive liquid and ensures that the prepared radioactive liquid is completely transferred to a LOOP.

The technical scheme of the utility model is as follows: the utility model provides a perforating syringe ration shifts radioactive liquid device, includes the syringe be equipped with the hole on the barrel lateral wall of syringe, the position in hole decides the volume of the gas or the radioactive liquid that store in the syringe barrel, and the piston setting of syringe is in the upper end in hole, and the piston handle is connected with power device.

Further, the device for quantitatively transferring radioactive liquid by using the perforated syringe is characterized in that an injection port of the syringe is connected with a transfer bottle or a three-way valve, and the transfer bottle or the three-way valve is connected with a loop ring.

Further, a perforated syringe quantitative transfer radioactive liquid device as described above wherein said holes are located at the volume graduation line of the syringe barrel.

Further, the perforated syringe quantitative radioactive liquid transferring device as described above, wherein the diameter of the hole is 1 to 10mm.

Further, the device for quantitatively transferring radioactive liquid by the perforated injector is characterized in that the power device connected with the piston handle is a cylinder push rod, and the piston is driven by the cylinder to do only single downward pressing movement.

The utility model has the beneficial effects that: the utility model can realize that radioactive liquid enters the injector from the bottom, and redundant gas is discharged from the hole; the piston of the injector only performs single downward pressing action by using the cylinder as power, so that the quantitative automatic transfer of the radioactive liquid is realized; the syringes with different hole positions are replaced, so that quantitative automatic transfer of liquids with different volumes can be realized, and insufficient transfer of radioactive liquid or overflow from a LOOP can not be caused. Compared with a reciprocating injector, the device greatly simplifies equipment, reduces cost and improves stability; compared with other transfer devices, the stability is greatly improved.

Drawings

FIG. 1 is a schematic view of a perforated injector according to the present utility model;

FIG. 2 is a schematic view of a perforated injector of the present utility model in combination with a twist-bottle;

fig. 3 is a schematic view of the combination of the perforated injector of the present utility model and a three-way valve.

Detailed Description

The present utility model will be described in detail with reference to the accompanying drawings and examples.

The utility model provides a quantitative radioactive liquid transferring device of a perforated injector, the structure of which is shown in figure 1, comprising a perforated disposable injector, wherein an air vent hole 2 with the diameter of 1-10 mm is arranged on a cylinder body 1 of the injector, and the position of the air vent hole 2 determines the volume (1-10 mL) of radioactive liquid to be transferred; the piston of the injector is positioned at the upper end of the hole 2, and the piston handle is driven by the cylinder push rod 3; the injection port of the injector is connected with a gas/liquid inlet and outlet 4. When the radioactive liquid is input, gas or radioactive liquid enters the syringe barrel through the injection port, the syringe serves as a temporary container for quantitatively storing a certain volume of gas or radioactive liquid, and when the radioactive liquid enters the syringe barrel, redundant gas overflows from the hole 2. During output, the cylinder is used as power to push out the gas or radioactive liquid stored in the syringe cylinder. If the radioactive liquid is stored, the radioactive liquid is directly extruded, and if the radioactive liquid is stored, the extruding gas is used as power to quantitatively transfer the radioactive liquid in the intermediate transfer bottle. The utility model can prevent the problems of insufficient liquid transfer or overflow caused by insensitivity of an ultrasonic/radioactive probe or transfer failure caused by adsorption or blockage caused by adopting a gas-liquid separation membrane when the radioactive liquid is transferred by using conventional gas as power. The device of the utility model is simpler and more reliable than the device for reciprocally driving the injector by adopting a motor.

Example 1: combination of perforated injector and transfer bottle

On the multifunctional radiopharmaceutical synthesis module, the radioactive liquid after the reaction is transferred to a LOOP of semi-preparative HPLC, and quantitative and automatic transfer can be realized by adopting the perforated injector device provided by the utility model.

As shown in fig. 2, a schematic diagram of the combination of a perforated injector and a medium rotary bottle is shown, an injection port of the injector is connected with the medium rotary bottle 8, the medium rotary bottle 8 is connected with a LOOP 6, in the figure, 5 is an HPLC pump, and 7 is an HPLC column. The gas transfers the reacted radioactive liquid to the transfer bottle 8 and the excess gas escapes from the vent 2. During transfer, the injector is driven by the cylinder push rod 3 to press quantitative gas into the transfer bottle and quantitatively transfer the equal volume of liquid in the transfer bottle to the LOOP 6.

For example, it is desirable to transfer 10ml of radioactive liquid from a transfer bottle to a LOOP, using a perforated syringe with a hole at the 10ml scale on the syringe barrel and a plunger at the upper end of the hole. When the radioactive liquid enters the transfer bottle, the original gas in the bottle overflows from the hole on the syringe barrel. When transferring liquid to the LOOP, the cylinder push rod drives the piston handle to move downwards, 10ml of gas in the syringe cylinder is pressed into the upper part of the intermediate rotary bottle, and 10ml of radioactive liquid at the lower part of the intermediate rotary bottle is transferred to the LOOP.

Example 2: combination of perforated injector and three-way valve

As shown in fig. 3, a schematic diagram of a perforated injector and a three-way valve are combined, an injection port of the injector is connected with a three-way valve 9, the three-way valve 9 is connected with a LOOP 6, in the figure, 5 is an HPLC pump, and 7 is an HPLC column. The gas transfers the reacted radioactive liquid directly to the perforated injector through the three-way valve 9, and the surplus gas overflows from the exhaust hole 2. When transferring, the direction of the three-way valve is switched to enable the injector to be communicated with the LOOP ring, and the injector is driven by the cylinder push rod 3 to directly transfer radioactive liquid in the injector into the LOOP ring.

For example, it is necessary to transfer 5ml of radioactive liquid to the LOOP, first 5ml of radioactive liquid is introduced into the syringe through the three-way valve, and the gas in the syringe overflows from the orifice in the syringe barrel, at which point the syringe piston is located at the upper end of the orifice. When transferring liquid to the LOOP ring, the direction of the three-way valve is switched to enable the injector to be communicated with the LOOP ring, the piston handle is driven by the air cylinder push rod to do pushing movement, and 5ml of radioactive liquid in the injector is directly transferred to the LOOP ring.

It will be apparent to those skilled in the art that the structure of the present utility model is not limited to the details of the above-described exemplary embodiments, but the present utility model may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the utility model being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.

Claims (5)

1. The utility model provides a perforating syringe ration shifts radioactive liquid device, includes the syringe, its characterized in that be equipped with hole (2) on barrel (1) lateral wall of syringe, the volume of gas or radioactive liquid held in syringe barrel (1) is decided to the position of hole (2), and the piston setting of syringe is in the upper end in hole, and the piston handle is connected with power device.

2. The device for quantitatively transferring radioactive liquid by using the perforated syringe according to claim 1, wherein an injection port of the syringe is connected with a transfer bottle (8) or a three-way valve (9), and the transfer bottle (8) or the three-way valve (9) is connected with a loop ring (6).

3. The perforated syringe quantitative radioactive liquid transfer device according to claim 1 or 2, characterized in that the holes (2) are located at the volume graduations of the syringe barrel (1).

4. A device for quantitative transfer of radioactive liquid by a perforated syringe according to claim 3, characterized in that said holes (2) have a diameter ranging from 1 to 10mm.

5. A device for quantitatively transferring radioactive liquid of a perforated syringe according to claim 1 or 2, characterized in that said power means connected to the piston stem is a cylinder push rod (3), the piston being driven by the cylinder with only a single downward pressing movement.

Images