CN218214665U - Lead can and transport container - Google Patents

Abstract

A lead tank and a transport container, used for the transport of radiopharmaceuticals, the lead tank includes: a lead tank body, an open accommodating tank is arranged inside the lead tank body, and the accommodating tank includes The first accommodating space and the second accommodating space adjacent to the bottom of the accommodating tank in sequence; When on the main body, the accommodating groove and the groove form an accommodating part, at least a part of the side wall of the lead can lid is accommodated in the second accommodating space, and the side wall of the lead can body The maximum thickness is less than the maximum thickness of the side wall of the lead can lid.

Description

Lead cans and shipping containers

technical field

The present disclosure relates to the technical field of medicine, in particular to a lead tank and a transport container for transporting radiopharmaceuticals.

Background technique

The half-life of the radionuclide contained in some radiopharmaceuticals is short, which leads to a short period of validity of radiopharmaceuticals. For example, the half-life of ¹⁷⁷ Lu nuclide is only 6.64 days, and the validity period of lutetium oxygen octreotide injection labeled with ¹⁷⁷ Lu nuclide is only 3 sky. These radiopharmaceuticals usually need to be transported and distributed by air transport, and their transport containers need to meet the requirements of radioactive protection and air transport. The existing radiopharmaceutical transport containers are large in size and heavy in weight. The manufacturing cost of the transport container and the transportation The cost is higher.

Utility model content

Some embodiments of the present disclosure provide a lead tank for transporting radiopharmaceuticals, wherein the lead tank includes:

The lead can body, the lead can body is provided with an open accommodating groove, and the accommodating groove includes a first accommodating space and a second accommodating space which are successively away from the bottom of the accommodating tank and successively adjacent to each other; and

a lead can lid, the lead can lid has a groove,

When the lead can lid is fastened on the lead can body, the accommodating groove and the groove form a receiving portion, and at least a part of the side wall of the lead can lid is accommodated in the first In the second accommodating space, the maximum thickness of the side wall of the lead container body is smaller than the maximum thickness of the side wall of the lead container cover.

In some embodiments, in the direction of the axis of the lead can body, the inner sidewall of the second accommodating space gradually converges toward the axis of the lead can body as it gradually approaches the first accommodating space,

The outer surface of the side wall of the lead can lid includes a first outer surface, and in the direction of the axis of the lead can lid, the first outer surface gradually moves away from the top surface of the lead can lid. converges towards the axis of the lead jar lid,

When the lead can body is fastened on the lead can body, the first outer surface is matched with the inner wall of the second accommodating space so that the axis of the lead can body is aligned with the lead can lid The axes of the body are collinear.

In some embodiments, the intersection of the inner surface of the side wall of the lead can lid and the first outer surface has rounded corners.

In some embodiments, the inner surface of the side wall of the lead can lid is parallel to the axis of the lead can lid, the inner wall of the first accommodating space is parallel to the axis of the lead can body,

When the lead can lid is fastened on the lead can body, the inner surface of the side wall of the lead can lid is closer to the inner surface of the lead can body than the inner side wall of the first accommodating space. axis.

In some embodiments, the outer surface of the side wall of the lead can lid further includes a second outer surface and a third outer surface, and the third outer surface is located between the second outer surface and the first outer surface ,

When the lead can lid is fastened on the lead can body, the second outer surface is coplanar with the outer side wall of the lead can body, and the third outer surface is coplanar with the side wall of the lead can body. Matching fit on top of wall.

In some embodiments, the material of the lead can is lead antimony alloy so that the lead can can be manufactured by stamping.

In some embodiments, the outer surface of the lead can is coated with a protective paint.

In some embodiments, the lead can is made of lead-antimony alloy.

Some embodiments of the present disclosure provide a transport container for radiopharmaceuticals, comprising:

a vial configured to hold a radiopharmaceutical;

The lead container described in the foregoing embodiments is configured to accommodate the medicine bottle;

a liquid-absorbing sponge configured to wrap the lead tank to absorb spilled liquid;

a metal airtight tank configured to accommodate the lead tank wrapped by the liquid-absorbent sponge;

a cushioning protective layer configured to wrap the metal canister; and

a corrugated box configured to house said metal sealed can surrounded by said cushioning protective layer,

Wherein, the surface of the lead tank containing the medicine bottle is thermoplastically sealed so that the outer surface of the lead tank is wrapped with a thermoplastic sealing film.

In some embodiments, the material of the metal airtight tank is an anti-corrosion material.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present disclosure or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description These are some embodiments of the present disclosure. For those skilled in the art, other drawings can also be obtained according to these drawings without creative work.

FIG. 1 is a schematic diagram of an exploded structure of a radiopharmaceutical transport container provided by some embodiments of the present disclosure;

Fig. 2 is a schematic structural view of the lead tank in Fig. 1, wherein medicine is accommodated in the lead tank;

Fig. 3 is a schematic cross-sectional structure diagram of the lead tank in Fig. 2, wherein a medicine bottle is accommodated in the lead tank.

detailed description

In order to make the purpose, technical solutions and advantages of the present disclosure clearer, the present disclosure will be further described in detail below in conjunction with the accompanying drawings. Apparently, the described embodiments are only some of the embodiments of the present disclosure, not all of them. Based on the embodiments in the present disclosure, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present disclosure.

Terms used in the embodiments of the present disclosure are for the purpose of describing specific embodiments only, and are not intended to limit the present disclosure. The singular forms "a", "said" and "the" used in the embodiments of this disclosure and the appended claims are also intended to include plural forms, unless the context clearly indicates otherwise, "a plurality" Generally contain at least two.

It should be understood that the term "and/or" used herein is only an association relationship describing associated objects, which means that there may be three relationships, for example, A and/or B, which may mean that A exists alone, and A and B exist simultaneously. B, there are three situations of B alone. In addition, the character "/" in this article generally indicates that the contextual objects are an "or" relationship.

Optional embodiments of the present disclosure will be described in detail below in conjunction with the accompanying drawings.

Fig. 1 is a schematic diagram of an exploded structure of a radiopharmaceutical transport container provided by some embodiments of the present disclosure. Fig. 2 is a schematic structural view of the lead tank in Fig. 1, wherein the lead tank accommodates medicines. Fig. 3 is a schematic cross-sectional structure diagram of the lead tank in Fig. 2, wherein a medicine bottle is accommodated in the lead tank. Some embodiments of the present disclosure provide a transport container for radiopharmaceuticals. As shown in FIGS. , the buffer protection layer 50 and the corrugated cardboard box 60.

The medicine bottle 10 is used to accommodate radiopharmaceuticals, such as lutetium [ ¹⁷⁷ Lu] oxygen octreotide injection, suitable for the treatment of unresectable or metastatic, progressive, well-differentiated (G1 and G2), somatostatin receptors in adults Positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Lutetium [ ¹⁷⁷ Lu ] Oxyoctreotide Injection clinical research showed that the risk of disease progression was reduced by 79% compared with traditional therapy.

Due to its excellent radioactive physical properties, ¹⁷⁷ Lu has obvious advantages in the field of tumor therapy. It has the following advantages when used in clinical diagnosis and treatment:

(1) The β-rays of ¹⁷⁷ Lu have good energy deposition in small-volume tumors, and at the same time, they will not emit high-energy β-rays (76% β-decay (E _β (max)=0.497MeV)) and cause high damage to surrounding healthy tissues. side effect;

(2) Low-energy γ-rays (E _γ = 113keV (6.6%), 208keV (11%) accompanied by β-ray emission can be used for SPECT imaging. This property is used in "precision medicine", "personalized medicine", " It is extremely beneficial in the development strategy of a new generation of radiopharmaceuticals oriented towards the integration of diagnosis and treatment.

(3) In the solution, Lu exists in the +3 oxidation state, which is easy to form a coordination reaction with N, O, so it can be connected to many supports through bifunctional ligands. At the same time, Lu has no other stable valence state, and it is difficult to undergo oxidation-reduction reactions in the solution. It can stably exist in various chemical environments with a +3 valence, which helps to obtain Lu-labeled drugs with high purity and stable chemical properties, and can also be effective. Avoid ¹⁷⁷ Lu off-target during in vivo metabolism research, causing side effects on other tissues.

(4) ¹⁷⁷ Lu has a suitable half-life (6.64 days), which provides convenience for tedious procedures such as radiolabelling, purification, quality control and transportation.

^177Lu Toxicity grouped as poisoned radionuclides. Its half-life is about 6.64 days. Thanks to its decay characteristics, its decayed β-rays have the characteristics of low energy, short range, and no radioactive aerosol. In terms of radiation protection, only good radioactive shielding can achieve the "Radioactive Material Safety Relevant requirements in the Transport Regulations.

The medicine bottle 10 is, for example, a vial, which is, for example, an injection bottle made of borosilicate glass. It includes a medicine bottle body and a rubber stopper matched with the medicine bottle body. The radiopharmaceutical is sealed within the body.

The lead tank 20 is used for accommodating the medicine bottle 10, and is used for isolating the radiation of radiopharmaceuticals and avoiding pollution caused by radiation leakage.

The liquid-absorbing sponge 30 is used to wrap the lead tank 20 to absorb the leaked liquid. Even if the lead tank and the medicine bottle contained therein are damaged, the liquid radiopharmaceutical flowing out of the lead tank will be absorbed by the liquid-absorbing sponge to avoid leakage of the liquid. vent, in line with the requirements of air transport. The liquid-absorbing sponge 30 includes a sponge body 31 and a sponge cover 32. The sponge body 31 is provided with a first groove 311, and the sponge cover 32 is provided with a second groove. When the sponge cover 32 is fastened on the sponge body, The first groove portion 311 is aligned and spliced with the second groove portion, and the two are spliced to form a groove portion for accommodating the lead can 20 . The shape and size of the groove match the shape and size of the lead can, and basically just accommodate the lead can 20. For example, the lead can 20 is cylindrical, and the groove is also called a cylindrical groove. For example, the size of the groove is equal to or slightly smaller than the size of the lead can, so that when the lead can 20 is put into the groove of the liquid-absorbing sponge 30, it can be covered and tightened by the liquid-absorbing sponge 30, preventing the lead can 20 from being placed in the groove of the liquid-absorbing sponge 30. shaking. The liquid-absorbing sponge 30 also plays a role in stabilizing the lead tank. In addition, the elastic properties of the liquid-absorbing sponge 30 can also provide a buffering effect to prevent the lead tank 20 from being damaged.

The metal airtight can 40 accommodates the lead can wrapped by the liquid-absorbent sponge. Metal airtight cans are made of, for example, anti-corrosion materials such as tinplate (tin-plated iron), which have good sealing and anti-corrosion properties, and are cheap. Even if the lead can and the medicine bottle contained therein are damaged, the metal airtight can 40 can seal the liquid-absorbing sponge adsorbed with the radioactive liquid to prevent pollution from leaking out. In some embodiments, the shape and size of the inner space of the metal airtight can 40 match the shape and size of the liquid-absorbing sponge 30 . For example, as shown in FIG. 1 , the shape of the liquid-absorbing sponge 30 is, for example, cylindrical, and the inner space of the metal airtight tank 40 is also cylindrical. The size of the liquid-absorbing sponge 30 is, for example, equal to or slightly larger than the size of the inner space of the metal airtight can 40, so that when the liquid-absorbent sponge 30 wrapped with the lead can 20 is accommodated in the metal airtight can 40, it is possible to avoid wrapping the liquid-absorbent sponge 30 with the lead can 20. The liquid-absorbing sponge 30 shakes in the metal sealed jar 40, which can stabilize the lead jar and the medicine bottle therein.

The buffer protection layer 50 is configured to wrap the metal sealed tank 40 to play a buffer role, and is made of, for example, pearl foam material. The buffer protective layer 50 includes a protective layer body 51 and a protective layer cover 52. The protective layer body 51 is provided with a third groove 511, such as a non-through groove, and the protective layer cover 52 is provided with a fourth groove 521. For example, it is a non-through groove. When the protective layer cover 52 is fastened on the protective layer body 51, the third groove 511 and the fourth groove 521 are aligned and spliced, and the two are spliced into a receiving groove for accommodating metal. Seal the jar 40. The shape and size of the accommodating groove match the shape and size of the metal airtight can 40 , and basically just accommodate the metal airtight can 40 . For example, the metal airtight can 40 is cylindrical, and the accommodating groove is also called a cylindrical groove. For example, the size of the accommodation groove is equal to or slightly smaller than the size of the metal airtight can 40, so that the metal airtight can 40 can be covered and tightened by the buffer protection layer 50 when it is put into the accommodation groove of the buffer protection layer 50, preventing the metal airtight can 40 from being buffered. Shake in the receiving groove of the protective layer 50. The buffer protection layer 50 also plays the role of stabilizing the lead tank, and the elastic performance of the buffer protection layer 50 can also provide a buffer effect to prevent the metal airtight tank 40 from being damaged.

The corrugated box 60 is configured to accommodate the metal airtight can 40 wrapped by the buffer protection layer 50 . The corrugated cardboard box 60 is used as the outermost packaging of the transport container 100, and has the advantages of light weight, good cushioning, low price, and good for recycling. In some embodiments, the shape and size of the inner space of the corrugated box 60 match the shape and size of the buffer protection layer 50 . For example, as shown in FIG. 1 , the shape of the buffer protection layer 50 is, for example, a cube, and the inner space of the corrugated box 60 is also a cube. The size of the buffer protection layer 50 is, for example, equal to or slightly larger than the size of the inner space of the corrugated box 60, so that when the buffer protection layer 50 wrapped with the metal airtight can 40 is accommodated in the corrugated box 60, it is possible to avoid wrapping the metal airtight can 40. The buffer protection layer 50 shakes in the corrugated box 60 and can stabilize the metal airtight can 40 . In some embodiments, the appearance of the corrugated box 60 is, for example, a cube, with a side length of, for example, 25 cm, which is convenient for loading and transportation.

In some embodiments, the surface of the lead can 20 that accommodates the medicine bottle 10 is subjected to thermoplastic sealing so that the outer surface of the lead can 20 is wrapped with a thermoplastic sealing film. Usually, the process of dispensing radiopharmaceuticals into vials and storing the vials in a lead tank needs to be carried out in a radiation-proof environment, such as a radiation-proof box, and the outer surface of the lead tank will inevitably be contaminated with a small amount of radioactive contamination. In order to avoid harm to the operator during the subsequent transportation operation, the lead can containing the medicine bottle taken out from the radioactive environment is formed on the outer surface of the lead can with a thermoplastic sealing film by a thermoplastic sealing process, and the lead can 20 is sealed and wrapped. To isolate radioactive contamination on the outer surface of lead cans.

In addition, the lead can 20 is covered with a thermoplastic sealing film, so that the lead can body and the lead can cover can be sealed together so that the two are not easy to separate, ensuring the tightness of the lead can during transportation.

In the above embodiments, corrugated boxes, liquid-absorbing sponges, etc. are used together with lead cans and medicine bottles to form disposable transport containers, which can reduce costs while meeting the requirements for radioactive protection and air transport. The above-mentioned transport container is small in size, which is conducive to safe loading; light in weight, conducive to air transport; simple in packaging, which can ensure stable and reliable packaging quality; one-time use of transport packaging materials, avoiding the damage of repeated use of transport packaging during use. Unsafe factors used.

In some embodiments, the protective thickness of the lead can is determined in the following manner.

The formula for calculating radiation protection shielding is as follows:

表示比释动能率；in:

Indicates the kerma rate;

A represents the activity of the radioactive source;

Г _k represents the air kerma rate constant (1.19×10 ^-18 Gy·m ² ·Bq ^-1 ·S ^-1 );

r represents the distance from the outer surface of the transport container to the radioactive source, taking a cube with a side length of 25cm as an example,

r can take 0.125m.

Take 250mCi Oxyoctreotide Injection ( ¹⁷⁷ Lu-DOTATATE) as an example

其中，

表示吸收剂量率；because

in,

Indicates the absorbed dose rate;

Wherein, H represents equivalent dose; radiation weight factor Q=1.

If the dose on the outer surface of the transport container is controlled at 0.005mSv/h, then the attenuation factor K=2.54/0.005=508 times, the ray energy is conservatively calculated according to 0.25MeV, the half-valence layer thickness of 0.25MeV lead is 0.88mm, and the calculated lg2(508) is 8.9887, multiplied by the thickness of the half-price layer 0.88mm, the thickness of the lead shielding layer is about 8mm. At the same time, if the lead cans are packed in the secondary transport packaging so that the distance between the transport container and the lead cans is 10cm, the dose rate on the surface of the package will be much lower than 0.005mSv/h.

According to the above calculation, the maximum ¹⁷⁷ Lu activity is 250mCi, the design lead tank thickness is 9mm, and the redundancy is increased. The lead tank is placed in the center of the corrugated box, and the surface of the lead tank is 10cm away from the surface of the transport container (the distance between the surface of the transport container and the center of the radioactive source is 12.5cm). ). Using Rad Pro calculator radiation protection calculation software to calculate, the surface dose rate of the transport container is 0.16μSv/h. It is far lower than the regulation of 0.005mSv/h<H≤0.5mSv/h in the "Regulations for the Safe Transport of Radioactive Materials".

The structure of the lead tank will be described in detail below. As shown in FIGS. 2-3 , the lead tank 20 includes a lead tank body 21 and a lead tank cover 22 .

The lead can body 21 is provided with an open accommodating groove 211 inside the lead can body, and the accommodating groove 211 includes a first accommodating space 2111 and a second accommodating space 2111 which are successively away from the bottom of the accommodating groove and adjacent to each other in sequence. Space 2112 , the accommodating groove 211 is configured to accommodate at least a part of the medicine bottle 10 . The medicine bottle 10 includes, for example, a medicine bottle body 11 and a rubber stopper 12 . The rubber stopper 12 is, for example, a butyl rubber stopper. The rubber stopper 12 can be fastened on the medicine bottle body 11 to realize the sealing of the medicine bottle 10 . In some embodiments, the medicine bottle 10 may also include a sealing cap, such as an aluminum cap, to seal the rubber stopper on the medicine bottle body 11 . As shown in FIGS. 1 to 3 , the neck of the medicine bottle body 11 and its upper part are accommodated in the second accommodation space 2112, for example, and the parts below the neck of the medicine bottle body 11 are accommodated in the first accommodation space, for example. In 2111.

The lead tank cover 22 has a groove 221. When the lead tank cover 22 is fastened on the lead tank body 21, the accommodating groove 211 and the groove 221 form a receiving part for airtight storage. In the medicine bottle 10 , at least a part of the side wall of the lead jar cover 22 is accommodated in the second accommodation space 2112 . That is, a part of the lead can lid 22 is inserted into the accommodating groove 211 , so that the lead can lid 22 is airtightly fastened to the lead can body 21 .

In some embodiments, as shown in FIG. 2 to FIG. 3 , in the direction of the axis m1 of the lead container body 21 , the inner wall of the second accommodating space 2112 gradually approaches the first accommodating space. The space 2111 gradually converges towards the axis m1 of the lead tank body. It is convenient for the medicine bottle 10 to enter into the lead tank body 21 .

The outer surface 222 of the side wall of the lead can lid 22 includes a first outer surface 2221. In the direction of the axis m2 of the lead can lid, the first outer surface 2221 gradually moves away from the lead can The top surface of the cover gradually converges towards the axis m2 of the lead can cover. When the lead can lid 22 is fastened on the lead can body 21, the first outer surface 2221 is matched with the inner side wall of the second accommodating space 2112 so that the axis m1 of the lead can body 21 It is collinear with the axis m2 of the lead can lid 22 . As shown in FIGS. 2 to 3 , the cross section of the first outer surface 2221 is, for example, an inclined plane, and the cross section of the inner wall of the second accommodating space 2112 is also an inclined plane. °～tg70°. With this arrangement, when the lead can lid 22 is fastened on the lead can body 21, under the action of the lead can lid 22's own weight, the lead can lid 22 can be self-aligned and buckled with the lead can body 21, It is convenient for the airtight fastening of the lead can lid body 22 and the lead can body 21 .

In some embodiments, as shown in FIG. 2 to FIG. 3 , the maximum thickness D1 of the side wall of the lead can body 21 is smaller than the maximum thickness D2 of the side wall of the lead can lid 22, and the lead can lid The intersection of the inner surface of the side wall of 22 and the first outer surface 2221 has rounded corners. With this design, it can be avoided that when the maximum thickness of the side wall of the lead can body is equal to the maximum thickness of the side wall of the lead can lid, when the lead can lid and the lead can body are self-aligned and snapped together, A sharp corner is formed at the intersection of the inner surface of the side wall of the lead can lid 22 and the first outer surface 2221 , so that the sharp corner of the lead material is easily damaged.

Specifically, in some embodiments, the inner surface of the side wall of the lead can lid 22 is parallel to the axis m2 of the lead can lid 22, and the inner side wall of the first accommodating space 2111 is parallel to the The axis m1 of the lead can body 21, when the lead can lid 22 is fastened on the lead can body 21, the inner surface of the side wall of the lead can lid 22 is relatively opposite to the first accommodating space The inner wall of 2111 is closer to the axis m2 of the lead tank body.

In some embodiments, the outer surface 222 of the side wall of the lead can lid 22 further includes a second outer surface 2222 and a third outer surface 2223, and the third outer surface 2223 is located between the second outer surface 2222 and the third outer surface 2223. between the first outer surfaces 2221 . When the lead can lid 22 is fastened on the lead can body 21, the second outer surface 2222 is coplanar with the outer side wall of the lead can body 21, and the third outer surface 2223 is in the same plane as the outer side wall of the lead can body 21. The top surface of the side wall of the lead can body 21 is matched and bonded.

In some embodiments, the third outer surface 2223 is, for example, perpendicular to the axis m2 of the lead can body 22 , and the top surface of the side wall of the lead can body 21 is, for example, perpendicular to the axis m1 of the lead can body 21 .

In some embodiments, the material of the lead can is lead antimony alloy so that the lead can can be manufactured by stamping. Specifically, in the lead-antimony alloy, the content of antimony is, for example, between 3% and 4%. The hardness of the lead-antimony alloy with such content is moderate, and lead cans can be manufactured by stamping. Compared with the injection molding process used in the related art, the stamping process in the present disclosure can reduce production cost and improve production efficiency. Moreover, the lead cans manufactured by stamping can also avoid defects such as slag inclusions, air holes and/or shrinkage cavities of the lead cans.

In some embodiments, the outer surface of the lead tank is coated with protective paint to avoid direct exposure of lead to operators and protect operators.

Some embodiments of the present disclosure also provide the use of the container in the foregoing embodiments in transferring radioactive particles, for example, the use of the container in the foregoing embodiments in transferring radioactive particles using a double-needle system.

The flowchart and block diagrams in the Figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to various embodiments of the present disclosure. In this regard, each block in a flowchart or block diagram may represent a module, program segment, or portion of code that contains one or more logical functions for implementing specified executable instructions. It should also be noted that, in some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or they may sometimes be executed in the reverse order, depending upon the functionality involved. It should also be noted that each block of the block diagrams and/or flowchart illustrations, and combinations of blocks in the block diagrams and/or flowchart illustrations, can be implemented by a dedicated hardware-based system that performs the specified functions or operations , or may be implemented by a combination of dedicated hardware and computer instructions.

Finally, it should be noted that each embodiment in this specification is described in a progressive manner, each embodiment focuses on the difference from other embodiments, and the same and similar parts of each embodiment can be referred to each other. As for the system or device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and for relevant details, please refer to the description of the method part.

The above embodiments are only used to illustrate the technical solutions of the present disclosure, rather than to limit them; although the present disclosure has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: it can still be described in the foregoing embodiments The recorded technical solutions are modified, or some of the technical features are replaced equivalently; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present disclosure.

Claims (10)

1. A lead pig for the transport of a radiopharmaceutical, said lead pig comprising:

the lead tank comprises a lead tank body, wherein an open accommodating groove is formed in the lead tank body, and the accommodating groove comprises a first accommodating space and a second accommodating space which are sequentially far away from the bottom of the accommodating groove and are sequentially adjacent; and

a lead can cover body having a groove,

when the lead can cover body is buckled on the lead can body, the accommodating groove and the groove form an accommodating part, at least one part of the side wall of the lead can cover body is accommodated in the second accommodating space, and the maximum thickness of the side wall of the lead can body is smaller than that of the side wall of the lead can cover body.

2. The lead can according to claim 1, wherein, in a direction of an axis of the lead can body, an inner side wall of the second accommodating space gradually converges toward the axis of the lead can body as gradually approaching the first accommodating space,

the outer surface of the side wall of the lead can cover includes a first outer surface that gradually converges toward the axis of the lead can cover as it gradually moves away from the top surface of the lead can cover in the direction of the axis of the lead can cover,

when the lead can cover body is buckled on the lead can body, the first outer surface is matched and attached with the inner side wall of the second accommodating space, so that the axis of the lead can body is collinear with the axis of the lead can cover body.

3. The lead can of claim 2, wherein the intersection of the inner surface of the side wall of the lead can cover and the first outer surface has a rounded corner.

4. The lead can of claim 3, wherein an inner surface of the side wall of the lead can cover is parallel to an axis of the lead can cover, the inner side wall of the first receiving space is parallel to an axis of the lead can body,

when the lead can cover body is buckled on the lead can body, the inner surface of the side wall of the lead can cover body is closer to the axis of the lead can body relative to the inner side wall of the first accommodating space.

5. The lead can of claim 2, wherein the exterior surface of the side wall of the lead can cover further comprises a second exterior surface and a third exterior surface, the third exterior surface being located between the second exterior surface and the first exterior surface,

when the lead can cover body is buckled on the lead can body, the second outer surface is coplanar with the outer side wall of the lead can body, and the third outer surface is matched and attached with the top surface of the side wall of the lead can body.

6. The lead can according to any one of claims 1 to 5, wherein the lead can is made of lead-antimony alloy so that the lead can be manufactured by stamping.

7. The lead can of any one of claims 1 to 5, wherein the outer surface of the lead can is coated with a protective paint.

8. The lead can according to any one of claims 1 to 5, wherein the lead can is made of lead-antimony alloy.

9. A transport container for a radiopharmaceutical, comprising:

a vial configured to hold a radiopharmaceutical;

the lead can of any one of claims 1 to 8, configured to receive the vial;

a liquid-absorbing sponge configured to wrap the lead can to absorb the leaked liquid;

a metal sealed can configured to receive the lead can wrapped by the wicking sponge;

a buffer protective layer configured to wrap the metal can; and

a corrugated carton configured to accommodate the metal sealed can wrapped by the buffer protective layer,

the surface of the lead can containing the medicine bottle is subjected to thermoplastic sealing, so that the outer surface of the lead can is wrapped with a thermoplastic sealing film.

10. The shipping container of claim 9, wherein the material of the metal containment tank is a corrosion resistant material.

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