CN215386905U - A shock wave assisted drug perfusion balloon catheter and medical equipment - Google Patents
A shock wave assisted drug perfusion balloon catheter and medical equipment Download PDFInfo
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- CN215386905U CN215386905U CN202121253412.8U CN202121253412U CN215386905U CN 215386905 U CN215386905 U CN 215386905U CN 202121253412 U CN202121253412 U CN 202121253412U CN 215386905 U CN215386905 U CN 215386905U
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- 239000003814 drug Substances 0.000 title claims abstract description 77
- 229940079593 drug Drugs 0.000 title claims abstract description 66
- 230000035939 shock Effects 0.000 title claims abstract description 47
- 230000010412 perfusion Effects 0.000 title claims abstract description 33
- 239000007788 liquid Substances 0.000 claims abstract description 29
- 238000012377 drug delivery Methods 0.000 claims abstract description 16
- 239000003550 marker Substances 0.000 claims description 7
- 239000011148 porous material Substances 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 abstract description 12
- 230000001988 toxicity Effects 0.000 abstract description 3
- 231100000419 toxicity Toxicity 0.000 abstract description 3
- 238000001802 infusion Methods 0.000 abstract description 2
- 230000003902 lesion Effects 0.000 description 13
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 230000002482 anti-endothelial effect Effects 0.000 description 3
- 239000002872 contrast media Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 210000005077 saccule Anatomy 0.000 description 2
- 208000000575 Arteriosclerosis Obliterans Diseases 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
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Abstract
本实用新型涉及医疗设备技术领域，提供一种冲击波辅助药物灌注球囊导管及医疗设备，该冲击波辅助药物灌注球囊导管包括：外管；球囊，与外管的一端相连，球囊的侧壁上设置有出液孔；内管，依次插置在外管以及球囊内，且内管穿过球囊；内管与外管之间的缝隙形成药物输送通道；冲击波发生器，位于球囊内，且设置在内管的外壁。该冲击波辅助药物灌注球囊导管，在球囊的表面设置有多个出液孔，且通过内管与外管之间的缝隙形成药物输送通道，使得外部的药物可以借助药物输送通道到达球囊，再通过球囊表面的输液孔进入血管内。避免了输送和回撤过程的药物损失，提高了药物利用率，有利于降低药物剂量和毒性风险。
The utility model relates to the technical field of medical equipment, and provides a shock wave auxiliary medicine perfusion balloon catheter and medical equipment. The shock wave auxiliary medicine perfusion balloon catheter comprises: an outer tube; A liquid outlet hole is arranged on the wall; the inner tube is inserted in the outer tube and the balloon in turn, and the inner tube passes through the balloon; the gap between the inner tube and the outer tube forms a drug delivery channel; the shock wave generator is located in the balloon inside, and is arranged on the outer wall of the inner tube. The shock wave-assisted drug perfusion balloon catheter is provided with a plurality of liquid outlet holes on the surface of the balloon, and a drug delivery channel is formed through the gap between the inner tube and the outer tube, so that the external drug can reach the balloon through the drug delivery channel , and then enter the blood vessel through the infusion hole on the surface of the balloon. Drug loss during delivery and withdrawal is avoided, drug utilization is improved, and drug dosage and toxicity risks are reduced.
Description
Technical Field
The utility model relates to the technical field of medical equipment, in particular to a shock wave auxiliary drug perfusion balloon catheter and medical equipment.
Background
In recent years, the drug-coated balloon is increasingly applied to treatment of lower limb arteriosclerosis obliterans, and the drug-coated balloon is loaded with anti-intimal hyperplasia drugs, so that the short-term and long-term patency rates of target lesions can be improved, and the number of implanted stents can be reduced.
However, the existing Drug-coated balloon (DCB) has certain limitations. On one hand, the drug is coated on the surface of the balloon, a large amount of drug is lost to enter blood in the process of balloon conveying, expanding and withdrawing, distal embolism can be caused, the drug utilization rate is low, the dosage is large, and the risk of increasing the death rate is caused. On the other hand, the serious calcification lesion immediate lumen has low acquisition, serious rebound and low drug absorption rate, and influences the prognosis of the drug-coated balloon.
SUMMERY OF THE UTILITY MODEL
Therefore, the technical problem to be solved by the utility model is to overcome the defects that the drug coating balloon in the prior art has low drug utilization rate and large dosage, the mortality is increased, the instant lumen of the serious calcified lesion is low in acquisition and serious in rebound, the drug absorption rate is low, and the prognosis of the drug coating balloon is affected, so that the shock wave assisted drug perfusion balloon catheter and the medical equipment are provided.
In order to solve the technical problems, the technical scheme of the utility model is as follows:
the utility model provides a shock wave auxiliary drug perfusion balloon catheter, which comprises: an outer tube; the balloon is connected with one end of the outer tube, and a liquid outlet hole is formed in the side wall of the balloon; the inner tube is sequentially inserted into the outer tube and the balloon, and the inner tube penetrates through the balloon; a gap between the inner tube and the outer tube forms a drug delivery channel; and the shock wave generator is positioned in the balloon and arranged on the outer wall of the inner tube.
Furthermore, the liquid outlet holes are uniformly distributed on the side wall of the balloon in an array.
Furthermore, the liquid outlet holes are in micron level, and the aperture range of the liquid outlet holes is 1-200 μm.
Further, one end of the inner tube penetrating through the balloon is a flexible hose.
Further, the balloon is a semi-compliant balloon.
Further, the shock wave generator comprises an electrode and a lead; the electrodes are arranged on the outer wall of the inner tube at intervals, and a plurality of electrodes are distributed along the axial direction of the inner tube; one end of the lead is connected with the electrode, and the other end of the lead passes through the drug delivery channel and is suitable for being connected with an external power supply.
Further, the shock wave auxiliary drug perfusion balloon catheter also comprises a catheter seat, the catheter seat is connected with one end, far away from the balloon, of the outer tube, and a plurality of interfaces suitable for being connected with external equipment are arranged on the catheter seat.
Furthermore, the number of the interfaces includes three, which are respectively marked as a first interface, a second interface and a third interface, and the first interface is suitable for wiring of the shock wave generator; the second interface is adapted to connect with a medication storage device; the third port is adapted for passage of a guidewire.
Further, the shock wave auxiliary drug perfusion balloon catheter also comprises a marking ring which is arranged on the outer wall of the inner tube.
The medical equipment is characterized in that the shock wave assists the drug to be infused into the balloon catheter.
The technical scheme of the utility model has the following advantages:
according to the shock wave assisted drug perfusion balloon catheter provided by the utility model, the surface of the balloon is provided with the plurality of liquid outlet holes, and the drug delivery channel is formed through the gap between the inner tube and the outer tube, so that external drugs can reach the balloon through the drug delivery channel and then enter the blood vessel through the infusion holes on the surface of the balloon. Avoids the drug loss in the process of conveying and withdrawing, improves the utilization rate of the drug, and is beneficial to reducing the drug dosage and the toxicity risk. Moreover, before administration, the calcified lesion can be firstly crushed by the shock wave generator, the contact area of the blood vessel and the medicament is increased, the absorption rate of the medicament at the lesion part is improved, and the elastic retraction of the lumen of the blood vessel can be reduced after the calcified lesion is crushed, thereby being beneficial to improving the treatment effect.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a schematic overall structure diagram of a shock wave-assisted drug perfusion balloon catheter in an embodiment of the present invention;
fig. 2 is an enlarged view of a portion of the structure of fig. 1.
Description of reference numerals:
1. an outer tube; 2. A balloon; 3. An inner tube;
4. a catheter hub; 5. A first interface; 6. A second interface;
7. a third interface; 8. A liquid outlet hole; 9. An electrode;
10. the ring is marked.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
In addition, the technical features involved in the different embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Fig. 1 is a schematic overall structure diagram of a shock wave-assisted drug perfusion balloon catheter in an embodiment of the present invention; FIG. 2 is an enlarged view of a portion of FIG. 1; as shown in fig. 1 and fig. 2, the present embodiment provides a shock wave assisted drug perfusion balloon catheter, including: an outer tube 1; the sacculus 2 is connected with one end of the outer tube 1, and a liquid outlet hole 8 is formed in the side wall of the sacculus 2; an inner tube 3 inserted in the outer tube 1 and the balloon 2 in sequence; a gap between the inner tube 3 and the outer tube 1 forms a drug delivery channel; one end of the inner tube 3 far away from the catheter seat 4 penetrates through the balloon 2; and the shock wave generator is positioned in the balloon 2 and arranged on the outer wall of the inner tube 3.
Particularly, the liquid outlet holes 8 can be uniformly arranged on the side wall of the sacculus 2 in an array manner, so that the medicine in the sacculus 2 can be more uniformly acted in the blood vessel, and the treatment effect is improved. Wherein, the liquid outlet 8 can be a micron-scale liquid outlet 8, and the aperture range of the liquid outlet 8 is 1-200 μm. For example, the diameter of the exit openings 8 is 50 μm. Wherein, sacculus 2 can be half compliance sacculus 2, and sacculus 2 is full after through liquid pressurization, can be used to the expansion of stenosis pathological change, and pressure can reach 2-30 atmospheric pressure. The balloon 2 may be inflated and deflated repeatedly for a number of times. The inner tube 3 is inserted into the outer tube 1, and a certain gap exists between the inner tube and the outer tube, and the gap is used as a drug delivery channel, so that external drugs can enter the balloon 2. The drug in this embodiment may be a mixed liquid of physiological saline and a contrast medium, or an anti-endothelial growth drug solution.
When in use, the balloon 2 can be filled with mixed liquid of physiological saline and contrast agent to expand a narrow blood vessel, and then the shock wave generator is excited to crush calcified lesion; after the calcified lesion is smashed, the saccule 2 is contracted, the anti-endothelial proliferation liquid medicine is replaced to fill the saccule 2, and the medicine is delivered to the vascular wall through the liquid outlet hole 8.
According to the shock wave assisted drug perfusion balloon catheter provided by the utility model, the plurality of liquid outlet holes 8 are formed in the surface of the balloon 2, and a drug delivery channel is formed through a gap between the inner tube 3 and the outer tube 1, so that external drugs can reach the balloon 2 through the drug delivery channel and then enter a blood vessel through the liquid outlet holes 88 in the surface of the balloon 2. Avoids the drug loss in the process of conveying and withdrawing, improves the utilization rate of the drug, and is beneficial to reducing the drug dosage and the toxicity risk. Moreover, before administration, the calcified lesion can be firstly crushed by the shock wave generator, the contact area of the blood vessel and the medicament is increased, the absorption rate of the medicament at the lesion part is improved, and the elastic retraction of the lumen of the blood vessel can be reduced after the calcified lesion is crushed, thereby being beneficial to improving the treatment effect.
In this embodiment, one end of the inner tube 3 penetrating through the balloon 2 is a flexible hose, and an adhesive layer may be disposed at a joint of the flexible hose and the balloon 2 for sealing. With this arrangement, the inner tube 3 can be prevented from stabbing the blood vessel when contacting the blood vessel wall.
In this embodiment, the shock wave generator includes an electrode 9 and a lead; the electrodes 9 are arranged on the outer wall of the inner tube 3 at intervals, and a plurality of electrodes 9 are distributed along the axial direction of the inner tube 3; one end of the lead is connected to the electrode 9 and the other end is adapted to be connected to an external power source through the medication delivery channel. Wherein the external power supply may provide a pulsed high voltage. Wherein, the electrodes 9 are applied with pulse high voltage to generate shock wave which can be transmitted through liquid and crush calcified lesion of target blood vessel.
Further, the shock wave assisted drug perfusion balloon catheter further comprises a catheter seat 4, the catheter seat 4 is connected with one end, away from the balloon 2, of the outer tube 1, and a plurality of interfaces suitable for being connected with external equipment are arranged on the catheter seat 4. Wherein, the connection part of the catheter seat 4 and the outer tube 1 can be sealed to prevent liquid leakage. During treatment, the catheter hub 4 is left outside the body, and the outer tube 1 and the balloon 2 are sent into the body.
For example, the interfaces comprise three, wherein the first interface 5 is adapted for wiring of the shock wave generator, i.e. wires extending from the electrodes 9 can be connected to an external power source via the first interface 5.
The second port 6 is adapted to be connected to a drug storage device, the second port 6 is in communication with a drug delivery channel, and upon connection to an external drug storage device, the drug can enter the drug delivery channel through the second port 6 and finally into the balloon 2. The drug storage device can be a device for storing a mixed liquid of physiological saline and a contrast agent, and can also be a device for storing an anti-endothelial proliferation liquid medicine. The second interface 6 may be snap-fit or screw-threaded to the drug storage device.
The third port 7 is adapted for passage of a guide wire, i.e. a guide wire may enter the inner tube 3 through the third port 7 and exit the inner tube 3 at the other end. The guide wire can play a role in guiding the shock wave auxiliary drug perfusion balloon catheter, and can guide the shock wave auxiliary drug perfusion balloon catheter to reach a target treatment position.
In this embodiment, the shock wave assisted drug perfusion balloon catheter further includes a marking ring 10 disposed on the outer wall of the inner tube 3. For example, the marker ring 10 may be a visualization marker ring 10, and the position information of the shockwave-assisted drug perfusion balloon catheter can be acquired in real time through the marker ring 10. For example, there may be two marker rings 10, two marker rings 10 are spaced apart along the axial direction of the inner tube 3, and the marker rings 10 may be disposed near the end of the balloon 2 to better identify the position information of the balloon 2.
The medical equipment is a balloon catheter assisted by drug perfusion through the shock wave.
In conclusion, the shock wave auxiliary drug perfusion balloon catheter provided by the utility model has the functions of shock wave lithotripsy and perfusion drug delivery, can be used for pretreating and delivering a single or multiple calcified lesions for multiple times, and is capable of reducing the number of used instruments, shortening the operation time and reducing the operation cost.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the utility model.
Claims (10)
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| CN202121253412.8U CN215386905U (en) | 2021-06-04 | 2021-06-04 | A shock wave assisted drug perfusion balloon catheter and medical equipment |
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| CN202121253412.8U CN215386905U (en) | 2021-06-04 | 2021-06-04 | A shock wave assisted drug perfusion balloon catheter and medical equipment |
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| CN215386905U true CN215386905U (en) | 2022-01-04 |
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Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113289212A (en) * | 2021-06-04 | 2021-08-24 | 乐普（北京）医疗器械股份有限公司 | Shock wave auxiliary medicine perfusion balloon catheter and medical equipment |
| US11517713B2 (en) | 2019-06-26 | 2022-12-06 | Boston Scientific Scimed, Inc. | Light guide protection structures for plasma system to disrupt vascular lesions |
| US11583339B2 (en) | 2019-10-31 | 2023-02-21 | Bolt Medical, Inc. | Asymmetrical balloon for intravascular lithotripsy device and method |
| US11648057B2 (en) | 2021-05-10 | 2023-05-16 | Bolt Medical, Inc. | Optical analyzer assembly with safety shutdown system for intravascular lithotripsy device |
| US11660427B2 (en) | 2019-06-24 | 2023-05-30 | Boston Scientific Scimed, Inc. | Superheating system for inertial impulse generation to disrupt vascular lesions |
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| US11903642B2 (en) | 2020-03-18 | 2024-02-20 | Bolt Medical, Inc. | Optical analyzer assembly and method for intravascular lithotripsy device |
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| US12102384B2 (en) | 2019-11-13 | 2024-10-01 | Bolt Medical, Inc. | Dynamic intravascular lithotripsy device with movable energy guide |
| US12207870B2 (en) | 2020-06-15 | 2025-01-28 | Boston Scientific Scimed, Inc. | Spectroscopic tissue identification for balloon intravascular lithotripsy guidance |
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| US12295654B2 (en) | 2020-06-03 | 2025-05-13 | Boston Scientific Scimed, Inc. | System and method for maintaining balloon integrity within intravascular lithotripsy device with plasma generator |
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2021
- 2021-06-04 CN CN202121253412.8U patent/CN215386905U/en active Active
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| US11819229B2 (en) | 2019-06-19 | 2023-11-21 | Boston Scientific Scimed, Inc. | Balloon surface photoacoustic pressure wave generation to disrupt vascular lesions |
| US11660427B2 (en) | 2019-06-24 | 2023-05-30 | Boston Scientific Scimed, Inc. | Superheating system for inertial impulse generation to disrupt vascular lesions |
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| US12186499B2 (en) | 2019-06-26 | 2025-01-07 | Boston Scientific Scimed, Inc. | Light guide protection structures for plasma system to disrupt vascular lesions |
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| US11517713B2 (en) | 2019-06-26 | 2022-12-06 | Boston Scientific Scimed, Inc. | Light guide protection structures for plasma system to disrupt vascular lesions |
| US11583339B2 (en) | 2019-10-31 | 2023-02-21 | Bolt Medical, Inc. | Asymmetrical balloon for intravascular lithotripsy device and method |
| US12102384B2 (en) | 2019-11-13 | 2024-10-01 | Bolt Medical, Inc. | Dynamic intravascular lithotripsy device with movable energy guide |
| US12274497B2 (en) | 2019-12-18 | 2025-04-15 | Bolt Medical, Inc. | Multiplexer for laser-driven intravascular lithotripsy device |
| US11672599B2 (en) | 2020-03-09 | 2023-06-13 | Bolt Medical, Inc. | Acoustic performance monitoring system and method within intravascular lithotripsy device |
| US11903642B2 (en) | 2020-03-18 | 2024-02-20 | Bolt Medical, Inc. | Optical analyzer assembly and method for intravascular lithotripsy device |
| US11707323B2 (en) | 2020-04-03 | 2023-07-25 | Bolt Medical, Inc. | Electrical analyzer assembly for intravascular lithotripsy device |
| US12295654B2 (en) | 2020-06-03 | 2025-05-13 | Boston Scientific Scimed, Inc. | System and method for maintaining balloon integrity within intravascular lithotripsy device with plasma generator |
| US12207870B2 (en) | 2020-06-15 | 2025-01-28 | Boston Scientific Scimed, Inc. | Spectroscopic tissue identification for balloon intravascular lithotripsy guidance |
| US12016610B2 (en) | 2020-12-11 | 2024-06-25 | Bolt Medical, Inc. | Catheter system for valvuloplasty procedure |
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| US11648057B2 (en) | 2021-05-10 | 2023-05-16 | Bolt Medical, Inc. | Optical analyzer assembly with safety shutdown system for intravascular lithotripsy device |
| CN113289212A (en) * | 2021-06-04 | 2021-08-24 | 乐普（北京）医疗器械股份有限公司 | Shock wave auxiliary medicine perfusion balloon catheter and medical equipment |
| US11806075B2 (en) | 2021-06-07 | 2023-11-07 | Bolt Medical, Inc. | Active alignment system and method for laser optical coupling |
| US12232753B2 (en) | 2021-12-14 | 2025-02-25 | Bolt Medical, Inc. | Optical emitter housing assembly for intravascular lithotripsy device |
| US11839391B2 (en) | 2021-12-14 | 2023-12-12 | Bolt Medical, Inc. | Optical emitter housing assembly for intravascular lithotripsy device |
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