CN214596603U - A freeze dryer sterilization system for large-scale bacterin production - Google Patents
A freeze dryer sterilization system for large-scale bacterin production Download PDFInfo
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- CN214596603U CN214596603U CN202120142870.8U CN202120142870U CN214596603U CN 214596603 U CN214596603 U CN 214596603U CN 202120142870 U CN202120142870 U CN 202120142870U CN 214596603 U CN214596603 U CN 214596603U
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- pipeline
- freeze
- hydrogen peroxide
- valve
- freeze dryer
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Abstract
The utility model provides a freeze dryer degerming system for large-scale bacterin production, includes first pipeline, second pipeline, third pipeline, fourth pipeline, hydrogen peroxide generating device, freeze-drying equipment, filter, first valve and second valve, and first pipeline, second pipeline and third pipeline form a fluidic circulation route, and the third pipeline is connected with hydrogen peroxide generating device and freeze-drying equipment. The utility model discloses a freeze dryer degerming system for extensive bacterin production communicates clean air, hydrogen peroxide generating device and freeze-drying equipment through pipeline and valve, realizes the online sterilization and the online freeze-drying of freeze-drying equipment, and the replacement of air induction and hydrogen peroxide is more convenient, need not the mobile device, also need not frequent loading and unloading pipeline. In the hydrogen peroxide sterilization process, the pipeline for introducing clean air is also sterilized in advance, so that the hidden danger of bacterial contamination is eliminated.
Description
Technical Field
The utility model relates to a biological product's production is equipped, especially relates to a system that is formed by a plurality of devices interconnect for the extensive freeze-drying of product is realized in bacterin production.
Background
The freeze dryer is important equipment for realizing the freeze drying of biological products, and the freeze-dried biological products are more stable and have longer storage period. The freeze-drying of the vaccine strains and products needs to be carried out in an aseptic environment. In order to ensure the sterile environment of the freeze dryer, the whole system of the box body and the pipeline of the freeze dryer is sterilized before the freeze drying of the product.
At present, a hydrogen peroxide sterilization system and a freeze dryer are generally connected through a standard quick interface in a commercially available small freeze dryer for preparing bacterial seeds, the sterilization of the inner surface of a freeze dryer box body is realized by combining with a vacuum system of the freeze dryer, clean air needs to be collected in the negative pressure process inside the freeze dryer box body, the clean air cannot be sterilized when entering a branch pipeline of the freeze dryer box body, and therefore the entering clean air can have the potential bacteria contamination hazard. Therefore, for the requirement of mass production, a connection scheme for sterilizing the branch pipeline of the freeze dryer is also needed to facilitate the implementation of the freeze drying process.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a freeze dryer degerming system for extensive vaccine production in time provides the connection of online sterilization to freeze dryer branch road pipeline, reduces the degree of difficulty of sterilization.
Another object of the utility model is to provide a freeze dryer degerming system for large-scale bacterin production in time provides the connection of online sterilization to freeze dryer branch road pipeline, improves the efficiency of sterilization.
Another object of the utility model is to provide a freeze dryer degerming system for large-scale vaccine production does benefit to and implements extensive freeze-drying.
The utility model provides a pair of freeze dryer degerming system for large-scale bacterin production, include
A hydrogen peroxide generating device for generating hydrogen peroxide;
a lyophilization apparatus for lyophilizing a vaccine preparation;
a filter for removing impurities in the gas;
the two ends of the first pipeline are respectively connected with the hydrogen peroxide generating device and the filter;
the two ends of the second pipeline are respectively connected with the freeze-drying equipment and the filter;
the third pipeline is communicated with the first pipeline, the second pipeline, the freeze-drying equipment and the hydrogen peroxide generation device;
a fourth pipeline, one end of which is communicated with the second pipeline and guides the clean air into the second pipeline;
a first valve disposed in the third conduit for controlling the flow of fluid in the conduit;
the second valve is arranged on the fourth pipeline and used for controlling the clean air to be introduced into the second pipeline as required;
the first pipeline, the second pipeline and the third pipeline form a fluid circulation passage.
The utility model provides a freeze dryer degerming system for large-scale vaccine production, freeze-drying equipment still include the pump for pump out hydrogen peroxide. The hydrogen peroxide generation device also comprises an electromagnetic valve which is used for controlling the hydrogen peroxide to enter the third pipeline according to the requirement.
The utility model discloses beneficial effect that technical scheme realized:
the utility model provides a freeze dryer degerming system for extensive bacterin production can in time provide the connection of online sterilization to freeze dryer branch road pipeline, reduces the degree of difficulty of sterilization, improves the efficiency of sterilization.
The utility model provides a freeze dryer degerming system for extensive bacterin production has solved the product freeze-drying in-process and has gathered the risk of dying bacteria that the branch road pipeline can not disinfect and exist because of clean air, does benefit to and implements extensive freeze-drying, reduces the risk of dying bacteria of bacterin product, improves the security of product.
Drawings
Fig. 1 is a schematic diagram of an embodiment of a sterilization system of a freeze dryer for mass vaccine production according to the present invention.
Detailed Description
The technical solution of the present invention is described in detail below with reference to the accompanying drawings. The embodiments of the present invention are only used for illustrating the technical solutions of the present invention and not for limiting, although the present invention is described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention can be modified or replaced with other equivalent solutions without departing from the spirit and scope of the present invention, which should be covered by the scope of the claims of the present invention.
Fig. 1 is a schematic diagram of an embodiment of a sterilization system of a freeze dryer for mass vaccine production according to the present invention. As shown in fig. 1, the sterilization system of the freeze dryer for mass vaccine production of the present invention includes a first pipeline 100, a second pipeline 200, a third pipeline 300, a fourth pipeline 400, a hydrogen peroxide generator 500, a freeze drying device 600, a filter 700, a first valve 800 and a second valve 900.
The two ends of the first pipeline 100 are respectively connected with the freeze-drying device 600 and the filter 700, the two ends of the second pipeline 200 are respectively connected with the hydrogen peroxide generation device 500 and the filter 700, the third pipeline 300 is communicated with the first pipeline 100, the second pipeline 200, the hydrogen peroxide generation device 500 and the freeze-drying device 600, and one end of the fourth pipeline 400 is communicated with the second pipeline 200 to guide clean air into the second pipeline 200. The first pipe 100, the second pipe 200, and the third pipe 300 form a circulation path of fluid. A first valve 800 is disposed in the third conduit 300 for controlling the flow of a fluid (e.g., air or hydrogen peroxide) in the conduit. The second valve 900 is disposed on the fourth pipe 400 to control introduction of the clean air into the second pipe 200 as required.
The hydrogen peroxide generator 500 is used for generating hydrogen peroxide, and when sterilizing the freeze-drying apparatus 600, the second valve 900 is closed to prevent air from being introduced, and the hydrogen peroxide generated from the hydrogen peroxide generator 500 enters the third pipeline 300, passes through the first pipeline 100, flows through the filter 700, enters the second pipeline 200, and enters the freeze-drying apparatus 600. Meanwhile, the first valve 800 is also opened, and the hydrogen peroxide generated by the hydrogen peroxide generator 500 can also directly enter the freeze-drying apparatus 600 through the third pipeline 300.
After sterilization, the first valve 800 is closed, hydrogen peroxide in the freeze-drying equipment 600 is pumped out, the second valve 900 is opened, clean air enters the first pipeline 100 from the fourth pipeline 400, flows through the filter 700, and then enters the freeze-drying equipment 600 after entering the second pipeline 200, so that the freeze-drying equipment is ensured to be in a sterile environment, and freeze-drying of vaccines is facilitated.
The system of this embodiment communicates clean air, hydrogen peroxide generating device and freeze-drying equipment through pipeline and valve, realizes the online sterilization and the online freeze-drying of freeze-drying equipment, and the replacement of air introduction and hydrogen peroxide is more convenient, need not the mobile device, also need not frequent loading and unloading pipeline. In the hydrogen peroxide sterilization process, the pipeline (the second pipeline 200) for introducing clean air is also sterilized in advance, so that the hidden danger of bacterial contamination is eliminated.
Claims (3)
1. A lyophilizer sterilization system for large scale vaccine production comprising:
a hydrogen peroxide generating device for generating hydrogen peroxide;
a lyophilization apparatus for lyophilizing a vaccine preparation;
a filter for removing impurities in the gas;
the two ends of the first pipeline are respectively connected with the hydrogen peroxide generating device and the filter;
the two ends of the second pipeline are respectively connected with the freeze-drying equipment and the filter;
a third pipeline which is communicated with the first pipeline, the second pipeline, the freeze-drying equipment and the hydrogen peroxide generating device;
a fourth pipeline, one end of which is communicated with the first pipeline and introduces clean air into the first pipeline;
a first valve disposed in the third conduit for controlling the flow of fluid in the conduit;
the second valve is arranged on the fourth pipeline and used for controlling the clean air to be introduced into the second pipeline according to the requirement;
the first pipeline, the second pipeline and the third pipeline form a fluid circulation passage.
2. The sterilization system of a lyophilizer for large scale vaccine production of claim 1 wherein said lyophilizer further comprises a pump for pumping out hydrogen peroxide.
3. The sterilization system of a freeze dryer for mass production of vaccines as claimed in claim 1, wherein the hydrogen peroxide generator further comprises a solenoid valve for controlling the hydrogen peroxide to enter the third pipeline as required.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120142870.8U CN214596603U (en) | 2021-01-19 | 2021-01-19 | A freeze dryer sterilization system for large-scale bacterin production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120142870.8U CN214596603U (en) | 2021-01-19 | 2021-01-19 | A freeze dryer sterilization system for large-scale bacterin production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN214596603U true CN214596603U (en) | 2021-11-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120142870.8U Active CN214596603U (en) | 2021-01-19 | 2021-01-19 | A freeze dryer sterilization system for large-scale bacterin production |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN214596603U (en) |
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2021
- 2021-01-19 CN CN202120142870.8U patent/CN214596603U/en active Active
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 201108 No. 888 Xiangyang Road, Shanghai, Minhang District Patentee after: Shanghai Rongsheng Biological Pharmaceutical Co.,Ltd. Address before: 201108 No. 888 Xiangyang Road, Shanghai, Minhang District Patentee before: SHANGHAI RONGSHENG BIOTECH CO.,LTD. |
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| CP01 | Change in the name or title of a patent holder |