CN214181158U

CN214181158U - Soft capsule

Info

Publication number: CN214181158U
Application number: CN202020441292.3U
Authority: CN
Inventors: 奈良未沙希; 黑野昌洋; 大川原正喜; 卢翌; 泷口景介; 伊藤圣和; 丰田航平; 冈山智一; 望月雄斗; 酒井理惠; 佐野豪
Original assignee: Sunsho Pharmaceutical Co Ltd
Current assignee: Sunsho Pharmaceutical Co Ltd
Priority date: 2020-01-29
Filing date: 2020-03-31
Publication date: 2021-09-14
Anticipated expiration: 2030-03-31

Abstract

The utility model provides a soft capsule, which has a film and an oily liquid content encapsulated by the film, and is characterized in that: crystalline water-soluble substances are exposed on the outer surface of the soft capsule film in the form of precipitation.

Description

Soft capsule

Technical Field

The utility model relates to a soft capsule which is manufactured in the fields of medicine, quasi-medicine (external medicine of medical department), cosmetics, functional food, health food, common food and the like. More specifically, the present invention relates to a soft capsule comprising a film and an oily liquid content containing a medicinal component or a biofunctional component, wherein the soft capsule is chewed so that the content is scattered in the oral cavity and spread throughout the oral cavity.

Background

In the prior art, there is known a method of preventing and improving oral malodor by adding a medicinal component or a biofunctional component to mouthwash, chewing gum, soft candy, or the like and keeping the mixture in the oral cavity for a certain period of time to sterilize the oral cavity. In addition, soft capsules such as seamless capsules, which can enclose oily liquid components, are often used for oral preparations such as mouth fresheners because they are easily disintegrated in the oral cavity.

However, mouthwashes, chewing gums and fondants are primarily suitable for water-soluble ingredients, whereas for oily ingredients it is difficult to effectively disperse them throughout the oral cavity.

In particular seamless capsules, the size of which, depending on the manufacturing method, is usually as small as a few millimetres. Therefore, in order to disperse an oily liquid containing a pharmaceutical ingredient or a biofunctional ingredient throughout the oral cavity, it is necessary to take a plurality of seamless capsules simultaneously.

SUMMERY OF THE UTILITY MODEL

Problem to be solved by utility model

The present invention has been made in view of the above problems, and an object of the present invention is to provide a soft capsule which can disperse an oily liquid in a wide range in the oral cavity when the soft capsule in which the content of the oily liquid is encapsulated is crushed by squeezing.

Means for solving the problems

Accordingly, the present invention provides a soft capsule having a coating and an oily liquid content encapsulated by the coating, wherein 60% or more of the oily liquid content is scattered to the outside of the soft capsule when the soft capsule is subjected to a crush test using a CE-3000EX-S rheometer manufactured by Sun Kagaku co.

In the present invention, the capsule film preferably contains a base material and a crystalline water-soluble substance.

In the present invention, the base material is at least one selected from gelatin, agar, alginic acid, carrageenan, pectin, curdlan, gellan gum, pullulan, cellulose, chitin, dextrin and soluble starch.

In the present invention, the crystalline water-soluble substance is selected from the group consisting of sorbitol, xylitol, mannitol, erythritol, maltitol, lactitol, arabinose, xylose, glucose, fructose, galactose, mannose, maltose, trehalose, neotrehalose, sucrose, raffinose, sialyllactose, fucosyllactose, malto-oligosaccharide, fructo-oligosaccharide, galacto-oligosaccharide, isomaltulose, xylo-oligosaccharide, and fumaro-oligosaccharide, at least one of agar oligosaccharide, tamarind oligosaccharide, chitosan oligosaccharide, glutamic acid, aspartic acid, glycine, cysteine, cystine, methionine, glutathione, saccharin, sucralose, aspartame, acesulfame potassium, neotame, acetic acid, malic acid, citric acid, lactic acid, ascorbic acid, salt, potassium chloride, amino acid, nucleic acid, caffeine, and tannin.

In the present invention, the crystalline water-soluble substance is preferably exposed as a precipitate on the outer surface of the capsule membrane.

In the present invention, the crystalline water-soluble substance is preferably uniformly exposed as a precipitate on the outer surface of the capsule membrane, and the outer surface of the capsule membrane is apparently separated from the rest thereof into two layers.

In the present invention, it is preferable that the capsule film solution in which the crystalline water-soluble substance is dissolved is used as the encapsulating liquid, the solution is molded and cured into a capsule film in a capsule form, and then the capsule film is dried, and in the middle of the drying step, the ambient environment of the capsule film is once brought into a high humidity atmosphere in which the humidity is higher than the humidity in the drying step, thereby adsorbing water molecules on the outer surface of the capsule film, and the crystalline water-soluble substance is attracted to the outer surface of the capsule film, whereby the precipitate is exposed on the outer surface.

Effect of the utility model

According to the present invention, a soft capsule membrane and a soft capsule can be provided, in which the content liquid of the oily liquid component can be dispersed on a large scale when the soft capsule membrane and the soft capsule are crushed by extrusion.

Drawings

The above and other objects, features, advantages and embodiments of the present invention will be described with reference to the accompanying drawings, in which:

fig. 1 is a schematic cross-sectional view of an example of a soft capsule according to embodiment 2 of the present invention.

Fig. 2 is a schematic cross-sectional view of an example of a soft capsule according to embodiment 2 of the present invention.

Fig. 3 is a schematic cross-sectional view of an example of a soft capsule according to embodiment 2 of the present invention.

Fig. 4 is a schematic cross-sectional view of an example of a soft capsule according to embodiment 2 of the present invention.

Fig. 5 is a schematic cross-sectional view of an example of a soft capsule according to embodiment 2 of the present invention.

Fig. 6 is a schematic cross-sectional view of an example of a soft capsule according to embodiment 2 of the present invention.

Description of the symbols

1. 7, 13, 19, 25, 31. cndot. capsule coating

3. 9, 15, 21, 27, 33. content

5. 11, 17, 23, 29, 35. precipitate

Detailed Description

(embodiment 1)

Hereinafter, the soft capsule according to embodiment 1 of the present invention will be described.

The inventors of the present invention have found, through intensive studies, that when a soft capsule containing an oily liquid content (the oily liquid contains a medicinal component or a biofunctional component) is crushed by pressing with a rheometer at a load of 200N and a speed of 50.0 mm/min, the above soft capsule can scatter more than 60% of the above oily liquid content to the outside, thereby spreading the oily liquid content throughout the entire oral cavity, thereby completing the present invention.

A rheometer is an instrument for measuring viscoelasticity, and is widely used in various industries such as food, medicine, paint, electronics, and battery materials because it can analyze material characteristics based on the molecular structure of an object.

The present invention will be specifically described below with reference to examples and comparative examples, but the present invention is not limited to these examples.

The rheometer used "Sun RHEO METER CE-3000 EX-S" manufactured by Sun Science Co., Ltd. A piece of filter paper having a diameter of 125mm was placed on the sample stage, and a cylindrical paper having a height of about 74.3mm and a width of about 420mm was fixed to the outer periphery of the filter paper. The soft capsule sample was placed in the center of the filter paper, and the soft capsule sample was crushed to scatter the content liquid by moving the sample stage at a speed of 50.0 mm/min under a load of 200N using a cylindrical adapter (No. 3 pressure sensitive shaft) having a diameter of 20mm and a height of 10 mm.

[ examples ] A method for producing a compound

Edible oil and butter oil are used as the content liquid. When the weight portion of the edible oil is 100 portions, 4.2 portions of mastic oil are added. The method comprises the steps of adding 94.1 parts by weight of glycerol, 70.0 parts by weight of water, 20.0 parts by weight of erythritol, 5.0 parts by weight of xylitol and 0.2 part by weight of sucralose to 100.0 parts by weight of acid-treated gelatin (Bloom 200-220) as a reference to prepare a soft capsule membrane liquid, and then forming and curing the soft capsule (OVAL, No.5) encapsulating the content liquid by a conventional method by using a rotary die soft capsule filling machine. Immediately thereafter, the gel was dried by a rotary air dryer, and after standing, the gel was further dried by a rotary air dryer to prepare a soft capsule containing about 250mg of the content liquid, which was left for the test.

[ COMPARATIVE EXAMPLE ]

The content liquid was prepared by adding 88.3 parts by weight of edible oil and fat, 83.3 parts by weight of perfume, 33.3 parts by weight of beeswax, 20.0 parts by weight of menthol, 5.0 parts by weight of aspartame and 3.3 parts by weight of glycerin fatty acid ester to 100 parts by weight of mastic oil. Further, 27.6 parts by weight of acid-treated gelatin (Bloom 250 to 300), 5.5 parts by weight of glycerin, 0.1 part by weight of sucralose, and 0.1 part by weight of acesulfame potassium were added to 100.0 parts by weight of water to prepare a membrane solution, which was then molded into capsules by a conventional method using a seamless capsule filling machine. Next, the capsules were dried (20 ℃ C., humidity 40%) to obtain seamless capsules having a diameter of about 6mm and a content weight of about 103mg, which were left for the test.

< example 1 >

After the content liquid was scattered by crushing the sample using a rheometer, the weight of the filter paper and the roll paper weighed in advance was subtracted from the weight of the filter paper and the roll paper to which the content liquid was adhered, and the weight of the scattered content liquid was calculated. The weight change rate was calculated as the ratio of the content liquid weight of each capsule to the content liquid weight scattered. The larger the weight change rate, the more easily the content liquid in the capsule is scattered to the outside. The results are shown in Table 1.

TABLE 1

From the above results, it was shown that the weight change rate of the example was larger than that of the comparative example, and the content liquid was more easily scattered to the outside when crushed by crushing.

< example 2 >

The sample was crushed with a rheometer to disperse the content liquid, the dispersed filter paper was photographed, the Image was processed with gimp (gnu Image management program)2.10.14, the area value of the dispersed content liquid was measured as the number of pixels, and the degree of dispersion (pixels/mg) with respect to the weight of the content liquid in each capsule was calculated.

The results of the fly-away are shown in table 2.

TABLE 2

From the above results, it was revealed that the scattering area per unit weight of the examples was larger than that of the comparative examples, and the content liquid was more easily scattered to the outside when crushed.

Since a part of the crystalline water-soluble substance is precipitated on the surface of the capsule film, the soft capsule of the present invention is a flexible film. Generally, when a seamless capsule which is easy to break is squeezed, the membrane breaks before the internal pressure of the capsule becomes sufficiently high, but the soft capsule of the present invention has a certain flexibility, so that when the capsule is squeezed, the internal pressure becomes sufficiently high, the membrane breaks in this state, and more content liquid scatters outward more widely.

(embodiment 2)

The soft capsule according to embodiment 2 of the present invention will be described below with reference to the accompanying drawings.

In general, granular materials manufactured in the fields of pharmaceuticals, quasi drugs (quasi drugs), cosmetics, functional foods, health foods, and general foods include capsules, tablets, pills, granular powders, suppositories, troches, capsule bath agents, capsule cosmetics, tablet-shaped candies, sugar-coated candies, snacks such as fructose and chewing gums, granular foods, tablet-shaped foods, and the like. In order to prevent deterioration due to oxidation, browning, moisture absorption, melting, softening, and the like and facilitate storage of the granular material, the granular material is usually stored in a container such as a capsule or covered with a protective film, that is, the granular material is encapsulated and stored.

However, the encapsulating material for encapsulating the content such as the capsule and the protective film is generally gelatin or the like as a base material, and such a base material is generally odorless. Therefore, when such an encapsulating material is used for encapsulating oral medicines, quasi-medicines (quasi drugs) and health foods, candies, etc., it has been proposed to add a flavoring agent and a flavor to the encapsulating material so as to be easily swallowed and eaten. For example, Japanese patent application laid-open No. 61-58537 discloses a method for producing soft capsules by adding a sweetener and taste components of a taste-improving beverage extract such as coffee to a solution of an encapsulating material.

However, the capsule manufactured according to the above method has a disadvantage in that the taste of the taste ingredient and the accompanying flavor and refreshing feeling cannot be instantaneously sensed even if it is contained in the oral cavity. This is because molecules of taste components are contained in a gelatin gel composed of gelatin (base material) molecules, that is, a gelatin network (network structure), and are hardly exposed on the outer surface of the capsule.

In addition, since the outer surface of the encapsulating film is usually exposed to the atmosphere and is affected by the outside such as temperature, humidity and pressure during storage, there is a problem that it is easily deteriorated with time and adhered to each other to cause blocking. This problem is independent of whether the particulate material is intended for oral administration, as is the case with non-oral particulate materials.

In order to prevent such deterioration, it has been proposed to add additives such as calcium-containing substances, wax-like substances such as wax, enzymes such as transglutaminase, mannitol, silicone resin, propylene glycol, emulsifiers, corn starch, and a mixture of cellulose and starch to the surroundings of the encapsulating material or to the solution of the encapsulating material. However, the expected effect is not achieved. In addition, there are other problems in actual production.

Furthermore, to stimulate the consumer's desire to purchase, the granular material preferably has an aesthetic appearance.

The soft capsule of embodiment 2 of the present invention includes an encapsulated "content" and an "encapsulating film".

(Contents)

Examples of the encapsulated contents include capsules, tablets, pills, granulated powders, suppositories, troches, capsule bathing agents, capsule cosmetics, tablet-like candies, sugar-coated candies, snacks such as fructose and chewing gums, and substances such as granular foods and tablet-like foods, which are manufactured in the fields of pharmaceuticals, quasi drugs (quasi drugs for external use), cosmetics, functional foods, health foods, and general foods. They may be in the form of liquid, semi-solid (paste), solid (tablet), powder or granule at room temperature. Further, the gas may be air or oxygen. Or may be an encapsulated multi-layer material. When these materials are in the form of semi-solid, or granular, they can be molded by using a commercially available molding machine such as a pelletizer, or a sugar coating machine (e.g., Revolpan).

(Encapsulated skin) Encapsulated skin composition

The base material for forming the encapsulating film is not particularly limited, and polysaccharides such as gelatin, agar, alginic acid, carrageenan, pectin, curdlan, gellan gum, pullulan, cellulose, chitin, dextrin and soluble starch can be generally used.

As the additives, plasticizers such as glycerin, sorbitol, mannitol, shellac, silicone resin, and fats, stabilizers, preservatives, colorants, and mold release agents can be appropriately added. In addition, coloring agents and perfumes may be added as appropriate.

Crystalline precipitates exposed on the outer surface of the coating

Such precipitates are derived from crystalline water-soluble substances. The kind of the precipitate is not particularly limited, and examples thereof include sugar alcohols such as sorbitol, xylitol, mannitol, erythritol, maltitol and lactitol, monosaccharides such as arabinose, xylose, glucose, fructose, galactose and mannose, disaccharides such as maltose, trehalose, neotrehalose and sucrose, raffinose and sialyllactose, trisaccharides such as fucose galactose, oligosaccharides such as maltooligosaccharide, fructooligosaccharide, galactooligosaccharide, and palatinose, oligosaccharides such as scrotum oligosaccharide, xylooligosaccharide, brass oligosaccharide, agar oligosaccharide, and tamarind oligosaccharide, amino acids such as glutamic acid, aspartic acid, glycine, cysteine, cystine, and methionine, or salts thereof, oligopeptides such as glutathione, and delicious substances such as sweet substances, salty substances, and amino acid nucleic acids, bitter substances such as caffeine, astringent substances such as tannin, and sour substances. Also, two or more of the above substances may be included.

The precipitates need only be exposed on at least a part of the outer surface of the coating. That is, it is not necessary to coat the entire outer surface of the coating with the precipitates, and a part of the precipitates may be present in a state of being completely embedded in the encapsulating coating.

However, the precipitates are preferably uniformly exposed on the outer surface of the film in the form of fine crystals. In this case, the coating and the precipitates appear to be separated into two layers.

The appropriate range of the weight ratio of the precipitates to the remainder of the encapsulating film excluding the precipitates varies depending on the kind of the precipitates. For example, according to experiments performed by the inventors of the present invention, it was confirmed that, when the precipitate is xylitol, it is preferable that xylitol: the rest is 40-200: 130, more preferably xylitol: the rest parts are 80-160: 130. when the educts are caffeine, caffeine is preferred: the balance is 2-50: 130, more preferably caffeine: the balance is 4-20: 130.

the appropriate range of the weight ratio also varies depending on the state of the precipitates exposed on the outer surface of the coating.

Of course, the above range should be a range that does not adversely affect the properties essentially required for the film itself, i.e., the storage stability of the content and the disintegration property required when releasing the content. The form of the coating film may be any form as long as it is in the form of granules in an encapsulated state, and may be, for example, a form of a container such as a soft capsule, a hard capsule, a seamless capsule, or a microcapsule, or a form in which the entire surface of the content such as a tablet or granule is covered with a coating film.

The following is a description of the process for preparing the soft capsules of the present invention.

A film-forming material in a solution state is used. Of course, a crystalline water-soluble substance is dissolved therein. Hot aqueous solutions are commonly used.

When the encapsulated material is in the form of a soft capsule or a seamless capsule, the encapsulated material can be molded while enclosing the contents therein by a commercially available soft capsule filling machine or a seamless capsule filling machine. When the capsule form is a hard capsule, the contents are enclosed after the capsule film in the container form is molded.

If the form of the envelope is a film, the surface of the solid content is covered by a method such as dipping, pulling, dropping, or blowing.

After the capsule is molded or the coating film is coated, the solution-like encapsulating material is cured and dried.

Curing is achieved by gelling. In this case, gelation is mainly performed by forced cooling, but gelation may be performed by a reaction with a salt such as calcium, potassium, or magnesium, or a reaction with an enzyme.

Since the solubility of the solution-like encapsulant-forming material is lowered by cooling, the crystalline water-soluble substance moves from the solution to the outer surface side of the solidified encapsulant.

Thereafter, the cured encapsulant is dried.

When the drying is performed in a blowing manner, the drying may be performed in synchronization with the curing step, but when the drying is performed by heating, the drying is performed after the curing step is completed.

In this drying step, a crystalline water-soluble substance is finally precipitated. Those precipitates on the outer surface will be exposed.

In this drying step, it is preferable to once make the ambient environment a high humidity (humidified) atmosphere. If the humidity of the air in contact with the outer surface of the enclosure is high, water molecules are adsorbed on the outer surface, but the water molecules are less likely to enter the skin. The crystalline water-soluble substance dissolved in the envelope is attracted to the water molecules adsorbed on the outer surface and dissolved in the water molecules in order to eliminate the concentration difference. As a result, a layer of the aqueous solution of the crystalline water-soluble substance is more positively formed on the outer surface. After drying, a large amount of precipitates are exposed on the outer surface.

The above-described humidification treatment and drying treatment in a high humidity atmosphere may be repeated as necessary. Thereby, the precipitates can be uniformly coated on the outer surface without a gap.

The embodiment 2 of the present invention has been described in detail above, but the specific structure thereof is not limited to this embodiment, and changes made to the design within the scope not departing from the gist of the present invention are also included in the present invention.

[ examples ] A method for producing a compound

The following describes example 2 of the present invention, but the scope of the present invention is not limited to the following example.

< example 1 >

An oil or fat containing vitamin E was used as a content, and a solution of 100 parts by weight of alkaline gelatin (Bloom 165 to 185) manufactured by Nippi, Incorporated, 30 parts by weight of glycerin, 1 part by weight of a coloring agent, xylitol (crystalline water-soluble substance, manufactured by Towa Kasei co., ltd., product name "キシリット") 0 (comparative example), 20, 40, 80, 120, 160, 200, 240 parts by weight, and 90 parts by weight of water was used as an encapsulating material solution.

The above solution (70 ℃ C.) was subjected to vacuum degassing and filtration, and then the contents were encapsulated using a rotary mold type soft capsule filling machine, molded and cured into soft capsules (OVAL, No. 5). Immediately thereafter, the mixture was dried for 5 hours using a rotary blower under an air atmosphere having a humidity of 30% and a temperature of 31 ℃ and then left to stand for 3 hours under an air atmosphere having a humidity of 80% and a temperature of 28 ℃. Then, the film was dried in a vacuum atmosphere at a humidity of 30% and a temperature of 31 ℃ for 12 hours by using a rotary dryer, and the moisture content of the film was reduced to about 10%. The results of quality evaluation tests on the 8 samples (soft capsule form) obtained are shown in table 3.

TABLE 3

In table 3, process applicability was determined from product yield. The surface whiteness of the precipitates was determined by visual inspection. Sweetness is determined by inclusion on the tongue. Mutual adhesion was determined by observation after the capsules were stored at 40 ℃ and 75% humidity for 14 days.

The results were expressed as "excellent", "good", "Δ", and "x", in that order.

When the sample is prepared such that the weight ratio of xylitol is 80 to 160 parts by weight, fine white xylitol crystals are uniformly exposed on the outer surface thereof, the appearance is aesthetically pleasing, and a fresh sweet taste of xylitol can be instantly perceived when swallowed or eaten. In addition, even when stored, mutual adhesion phenomenon was hardly observed. Furthermore, since xylitol in the film imparts flexibility to the film, swallowing and eating are facilitated.

Fig. 1 is a schematic cross-sectional view of a sample produced in example 1, wherein numeral 1 denotes a soft capsule-like coating film, numeral 3 denotes a fat or oil (content) containing vitamin E, and numeral 5 denotes an exposed xylitol precipitate.

< example 2 >

In the treatment atmosphere used in example 1, the surface of a commercially available chlorella tablet was uniformly sprayed with the warm skin aqueous solution used in example 1 to form a skin, and then the skin was solidified and dried.

The results of quality judgment tests on the 8 samples (skin forms) obtained showed that these samples had good performance in terms of process applicability, surface whiteness, sweetness and mutual adhesion, and the skin was separated into two layers.

Fig. 2 is a schematic cross-sectional view of a sample produced in example 2, wherein reference numeral 7 denotes a capsule membrane, 9 denotes a chlorella tablet (content), and 11 denotes an exposed xylitol precipitate.

< example 3 >

As the content, a mixed solution of 100 parts by weight of gelatin (basic gelatin (Bloom 165 to 185) produced by Nippi, Incorporated, 30 parts by weight of glycerin, 5 parts by weight of a natural sweetener, 1 part by weight of caramel color, 0 (comparative example) of natural caffeine (crystalline water-soluble substance, manufactured by KOSHIRO COMPANY LIMITED), 5, 10, 50, 100 parts by weight, and 90 parts by weight of water was used as the encapsulating film material solution.

Then, in the treatment atmosphere used in example 1, soft capsules (ROUND, No.3) were molded, cured and dried in accordance with the treatment procedure used in example 1.

The results of the quality judgment test on the 5 samples (soft capsule form) obtained are shown in table 4.

TABLE 4

In table 4, the process applicability, surface whiteness, bitterness and mutual adhesion characteristics were judged in the same manner as in table 3.

In addition, ". cndot. cndot." indicates that the whole dissolved solution could not be prepared, and the test was stopped in the middle.

In the case of the sample containing 5 to 10 parts by weight of caffeine, fine white caffeine crystals are exposed on the outer surface of the coating film, and the sample has an aesthetic appearance when swallowed or eaten, and the bitterness of caffeine can be instantly perceived. Even when stored, the phenomenon of mutual adhesion was hardly observed. These samples, which all have a different chewing mouthfeel from conventional chewing gum, may be referred to as "edible chewing gum".

Fig. 3 is a schematic cross-sectional view of a sample produced in example 3, in which reference numeral 13 denotes a capsule-like coating film, 15 denotes air (content), and 17 denotes an exposed caffeine precipitate.

< example 4 >

As the content, solid chocolate was used, and a mixed solution of 100 parts by weight of gelatin (alkali gelatin (Bloom 165 to 185) manufactured by Nippi, Incorporated), 2 parts by weight of pectin (Sansho co., ltd., HM), 0 part by weight of erythritol (crystal water-soluble substance, manufactured by Niken Kagaku) (comparative example), 50, 100, 150, and 200 parts by weight, and 90 parts by weight of water was used as the encapsulating film material solution. In the treatment atmosphere used in example 1, chocolate was dipped, pulled up, shaped, solidified and dried.

The results of quality judgment tests on the 5 samples (film forms) obtained showed that the films of these samples were separated into two layers, which showed good performance in terms of process applicability, surface whiteness, sweetness and mutual adhesion. The product has no dissolution of the coating even in high temperature environment in summer, so that the chocolate in the product will not flow out and stick to hands.

Fig. 4 is a schematic cross-sectional view of a sample produced in example 4, wherein reference numeral 19 denotes a capsule coating film, 21 denotes chocolate (content), and 23 denotes an exposed erythritol precipitate.

< example 5 >

As the encapsulating film material solution, a solution of 100 parts by weight of a gelatin solution (basic gelatin (Bloom 165 to 185) manufactured by Nippi, Incorporated, glycerin 30 parts by weight, maltose (crystalline water-soluble substance, NIHON SHOKUHIN KAKO co., LTD.)50 parts by weight, and water 90 parts by weight was used as the content.

The solution was subjected to soft capsule (ROUND, No.160) molding, curing and drying in the treatment atmosphere used in example 1 according to the treatment procedure used in example 1.

The results of the quality judgment tests on the obtained samples (soft capsule form) revealed that not only the mutual adhesion between capsules during storage and the blocking phenomenon were smaller than those of the conventional samples, but also the capsules immediately disintegrated in hot bath water to release the contents.

Fig. 5 is a schematic sectional view of a sample produced in example 5, in which 25 denotes a soft capsule coating film, 27 denotes a bath agent (content), and 29 denotes an exposed maltose precipitate.

< example 6 >

Aloe powder having strong bitterness was used as a content, and a solution of 100 parts by weight of gelatin (basic gelatin (Bloom 165 to 185) manufactured by Nippi, Incorporated, 1.0 part by weight of an emulsifier, 20.0 parts by weight of fructose (crystalline water-soluble substance, Kato Kagaku co., Ltd.) and 150 parts by weight of water was used as an encapsulating membrane material solution.

The above solution (70 ℃ C.) was degassed under vacuum and adjusted in viscosity, and a stainless pin was immersed in the solution, pulled up while rotating, molded and cured. Immediately thereafter, the resultant was dried in an air atmosphere having a humidity of 30% and a temperature of 25 ℃ until the moisture content of the coating was reduced to about 12%, thereby obtaining a coating in the form of a container. Then, after the aloe powder is put therein, it is sealed.

The obtained sample (hard capsule form) was subjected to a quality judgment test, and the results showed that not only mutual adhesion and blocking adhesion during storage were reduced, but also swallowing was facilitated, as compared with the conventional sample. Meanwhile, the capsule skin is separated into two layers.

Fig. 6 is a schematic cross-sectional view of a sample produced in example 6, in which 31 denotes a hard capsule coating film, 33 denotes aloe powder (content), and 35 denotes exposed fructose precipitates.

As described above, in addition to the effects of embodiment 1, the soft capsule of embodiment 2 of the present invention has an effect that the precipitates exposed on the outer surface are dissolved at the time of swallowing and eating, and the taste, aroma, cooling feeling, and the like associated therewith can be instantly perceived. Also, the precipitate can prevent mutual adhesion and caking between the grains upon storage. In addition, since the precipitates are uniformly exposed on the outer surface, a good product appearance is exhibited. In addition, since a part of the precipitates remains in the film, the flexibility thereof is increased and the precipitates are easily disintegrated.

Claims

1. a soft capsule, has skin film and the oily liquid content encapsulated by this skin film, it is characterized in that:

The crystalline water-soluble substance is exposed on the outer surface of the soft capsule film in the form of precipitation.

2. soft capsule as claimed in claim 1, is characterized in that,

The crystalline water-soluble substance uniformly covers the outer surface of the capsule membrane in the form of precipitation, and is separated from the outer surface of the membrane into two layers.