Background
Extracorporeal membrane oxygenation (extracorporeal membrane oxygenation) is an extracorporeal circulation technique that is removed from the heart operating room. The principle is that the venous blood in vivo is led out of the body, and is injected into the artery or vein system of a patient after being oxygenated by an artificial cardiopulmonary bypass made of special materials, so that the function of partial cardiopulmonary replacement is achieved, the oxygenation blood supply of the visceral organs of the human body is maintained, the existing extracorporeal circulation system pipeline is easy to coagulate blood and infect, and the probability of causing thrombus and infection is greatly increased particularly after extracorporeal circulation operation for more than 6 hours.
SUMMERY OF THE UTILITY MODEL
Therefore, the embodiment of the utility model provides a heat preservation blood transfusion pipeline for external circulation system for solve the technical problem of easy blood coagulation and infection of external circulation pipeline.
In order to achieve the above object, the embodiment of the present invention provides the following technical solutions:
the embodiment of the invention provides a blood transfusion pipeline for an extracorporeal circulation system, which comprises:
a blood delivery tract;
and the coating is arranged on the inner wall of the blood transfusion pipeline and is used for resisting bacteria and blood coagulation.
Preferably, the coating comprises a first coating and a second coating, wherein the first coating is an antibacterial layer, and the second coating is an anti-blood coagulation layer.
Preferably, the first coating and the second coating are disposed on the inner wall of the blood transport vessel in a spiral or ring shape.
Preferably, the first coating and the second coating are alternately arranged on the inner wall of the blood conveying pipeline respectively.
Preferably, the inner wall of the blood conveying pipeline is provided with an antibacterial layer and an anti-blood coagulation layer along the direction of the blood conveying pipeline.
Preferably, the area of each of the antibacterial layer and the anti-blood coagulation layer accounts for half of the inner wall of the blood conveying pipeline.
Preferably, the antimicrobial layer comprises an antibiotic and the anti-clotting layer comprises an anti-coagulant heparin.
Preferably, the antibacterial layer and the anti-blood coagulation layer each include a sustained-release agent.
In another aspect, the invention also provides an extracorporeal circulation apparatus which uses the above-described blood conveying pipeline.
The embodiment of the utility model provides a have following advantage:
the embodiment of the utility model provides a pair of a keep warm blood transfusion way and extracorporeal circulation equipment for extracorporeal circulation system has realized blood when extracorporeal circulation, has guaranteed that blood reduces the internal thrombus of extracorporeal circulation blood reflux and infects the risk at the circulation in-process.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It should be apparent that the drawings in the following description are merely exemplary, and that other embodiments can be derived from the drawings provided by those of ordinary skill in the art without inventive effort.
The structure, ratio, size and the like shown in the present specification are only used for matching with the content disclosed in the specification, so as to be known and read by people familiar with the technology, and are not used for limiting the limit conditions which can be implemented by the present invention, so that the present invention has no technical essential significance, and any structure modification, ratio relationship change or size adjustment should still fall within the scope which can be covered by the technical content disclosed by the present invention without affecting the efficacy and the achievable purpose of the present invention.
Fig. 1 is a perspective view of a heat-preservation blood transfusion tube for an extracorporeal circulation system according to embodiment 1 of the present invention;
fig. 2 is a cross-sectional view of a thermal insulation blood transfusion tube for an extracorporeal circulation system according to embodiment 1 of the present invention;
fig. 3 is a partial enlarged view of a thermal insulation blood conveying pipeline for an extracorporeal circulation system according to embodiment 1 of the present invention;
fig. 4 is a cross-sectional view of a thermal insulation blood transfusion tube for an extracorporeal circulation system according to embodiment 2 of the present invention;
fig. 5 is a partial enlarged view of a thermal insulation blood conveying pipeline for an extracorporeal circulation system according to embodiment 2 of the present invention;
fig. 6 is a cross-sectional view of a thermal insulation blood transfusion tube for an extracorporeal circulation system according to embodiment 3 of the present invention;
fig. 7 is a partial enlarged view of a thermal insulation blood transportation vessel for an extracorporeal circulation system according to embodiment 3 of the present invention;
in the figure: 01-the blood conveying vessel, 02-the first coating, 03-the second coating.
Detailed Description
The present invention is described in terms of specific embodiments, and other advantages and benefits of the present invention will become apparent to those skilled in the art from the following disclosure. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
It should be noted that the terms "first," "second," and the like in the description and claims of this application and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the application described herein are capable of operation in sequences other than those illustrated or described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
Example 1
As shown in fig. 1 to 3, the embodiment of the utility model discloses a heat preservation blood transportation pipeline for an extracorporeal circulation system, a blood transportation pipeline 01; the coating is arranged on the inner wall of the blood transfusion pipeline, the coating is used for antibiosis and anti-blood coagulation, the coating comprises a first coating 02 and a second coating 03, the first coating 02 is an antibacterial layer, the second coating 03 is an anti-blood coagulation layer, the first coating 02 and the second coating 03 are alternately arranged on the inner wall of the blood transfusion pipeline 01 in a ring shape, other arrangement modes can be adopted, the invention is not limited to the above, the final purpose is that the main coating is contacted with blood, the antibacterial layer comprises antibiotic, the anti-blood coagulation layer comprises anti-blood coagulation agent heparin, the antibiotic can be used as an antibacterial layer by being mixed with a fixing agent, or can be used as an antibacterial layer alone, the anti-blood coagulation agent heparin can be used as an antibacterial layer by being mixed with a fixing agent, or can be used as an antibacterial layer alone, and the invention is not limited to the above.
Preferably, the antibacterial layer and the anti-blood coagulation layer respectively comprise a slow release agent, the slow release agent cannot perform chemical reaction with the material of the antibacterial layer and the material of the anti-blood coagulation layer, and the slow release agent can slowly release the material of the antibacterial layer and the material of the anti-blood coagulation layer, so that better antibacterial and anti-blood coagulation effects can be achieved, and the antibacterial material and the anti-blood coagulation material can be effectively utilized.
In the embodiment of the invention, the following three skeleton type sustained-release agents are used as carriers according to different chemical characteristics of the antibacterial layer so as to achieve the purpose of sustained release. 1. The hydrophilic gel skeleton material mainly comprises sodium carboxymethylcellulose CMC-Na, hydroxypropyl methylcellulose HPMC, polyvinylpyrrolidone PVP, alginate, chitosan and the like; 2. insoluble framework material: ethyl cellulose EC, polymethacrylate, and the like; 3. bioerodible matrix material: carnauba oil, animal fats, hydrogenated vegetable oils, beeswax, glyceryl monostearate and the like.
According to the different chemical properties of the anti-blood coagulation layer, a sustained-release agent consistent with the antibacterial layer can be adopted, or the sustained-release agent can be inconsistent with the antibacterial layer.
The blood conveying pipeline disclosed by the embodiment can effectively solve the technical problems of easy coagulation and infection of extracorporeal circulation pipelines.
Example 2
As shown in fig. 4 to 5, the embodiment 2 is different from the embodiment 1 in that the first coating layer 02 and the second coating layer 03 are alternately disposed on the inner wall of the blood transportation channel 01 in a spiral shape, and other disposition manners are also possible, and the present invention is not limited thereto, and it is only necessary that the final objective main coating layer is in contact with blood, the antibiotic layer includes antibiotic, the anticoagulant layer includes anticoagulant heparin, the antibiotic may be mixed with a fixative as the antibiotic layer, or may be used alone as the antibiotic layer, the anticoagulant heparin may be mixed with a fixative as the antibiotic layer, or may be used alone as the antibiotic layer, and the present invention is not limited thereto.
Preferably, the antibacterial layer and the anti-blood coagulation layer respectively comprise a slow release agent, the slow release agent cannot perform chemical reaction with the material of the antibacterial layer and the material of the anti-blood coagulation layer, and the slow release agent can slowly release the material of the antibacterial layer and the material of the anti-blood coagulation layer, so that better antibacterial and anti-blood coagulation effects can be achieved, and the antibacterial material and the anti-blood coagulation material can be effectively utilized.
In the embodiment of the invention, the following three skeleton type sustained-release agents are used as carriers according to different chemical characteristics of the antibacterial layer so as to achieve the purpose of sustained release. 1. The hydrophilic gel skeleton material mainly comprises sodium carboxymethylcellulose CMC-Na, hydroxypropyl methylcellulose HPMC, polyvinylpyrrolidone PVP, alginate, chitosan and the like; 2. insoluble framework material: ethyl cellulose EC, polymethacrylate, and the like; 3. bioerodible matrix material: carnauba oil, animal fats, hydrogenated vegetable oils, beeswax, glyceryl monostearate and the like.
According to the different chemical properties of the anti-blood coagulation layer, a sustained-release agent consistent with the antibacterial layer can be adopted, but the embodiment of the invention is not limited thereto, and the invention can be applied to the technical scheme of the invention as long as the sustained-release effect can be achieved and the sustained-release agent does not have chemical reaction with the antibacterial layer and the anti-blood coagulation layer.
The blood conveying pipeline disclosed by the embodiment can effectively solve the technical problems of easy coagulation and infection of extracorporeal circulation pipelines.
Example 3
As shown in fig. 6 to 7, the embodiment 3 is different from the embodiments 1 and 2 in that the first coating 02 and the second coating 03 are disposed along the inner wall of the blood transfusion channel 01, the areas of the first coating 02 and the second coating 03 respectively occupy half of the inner wall of the blood transfusion channel 01, or other ratios, which are not limited herein, and are adjusted according to actual requirements, the antibiotic layer includes antibiotic, the anticoagulant layer includes anticoagulant heparin, the antibiotic can be used as the antibiotic layer by being mixed with a fixative, or can be used as the antibiotic layer alone, the anticoagulant heparin can be used as the antibiotic layer by being mixed with a fixative, or can be used as the antibiotic layer alone, which is not limited herein.
In the embodiment of the invention, the following three skeleton type sustained-release agents are used as carriers according to different chemical characteristics of the antibacterial layer so as to achieve the purpose of sustained release. 1. The hydrophilic gel skeleton material mainly comprises sodium carboxymethylcellulose CMC-Na, hydroxypropyl methylcellulose HPMC, polyvinylpyrrolidone PVP, alginate, chitosan and the like; 2. insoluble framework material: ethyl cellulose EC, polymethacrylate, and the like; 3. bioerodible matrix material: carnauba oil, animal fats, hydrogenated vegetable oils, beeswax, glyceryl monostearate and the like.
According to different chemical properties of the anti-blood coagulation layer, a sustained-release agent consistent with the antibacterial layer can be adopted, and the embodiment of the invention is not limited in comparison, and can be applied to the technical scheme of the invention as long as the sustained-release effect can be achieved and the sustained-release agent does not have chemical reaction with the antibacterial layer and the anti-blood coagulation layer.
The blood conveying pipeline disclosed by the embodiment can effectively solve the technical problems of easy coagulation and infection of extracorporeal circulation pipelines.
In another aspect, an embodiment of the present invention further provides an extracorporeal circulation apparatus, where the extracorporeal circulation apparatus uses the blood transportation vessels disclosed in embodiment 1, embodiment 2, and embodiment 3.
The extracorporeal circulation device disclosed by the embodiment can effectively solve the technical problems of easy coagulation and infection of extracorporeal circulation pipelines.
Although the invention has been described in detail with respect to the general description and the specific embodiments, it will be apparent to those skilled in the art that modifications and improvements can be made based on the invention. Therefore, such modifications and improvements are intended to be within the scope of the invention as claimed.