CN211741318U - Washing device for chemiluminescence immunoassay analyzer - Google Patents

Abstract

The utility model relates to the technical field of production and manufacture of chemiluminescence immunoassay analyzers, in particular to a washing device for a chemiluminescence immunoassay optical analyzer which can effectively improve the washing effect on the premise of not adding washing times, which is characterized in that the magnetic beads The adsorption mechanism is provided with a magnet mounting plate. The magnet mounting plate is provided with more than two magnet mounting slots. Two magnets are arranged side by side in each magnet mounting slot. The magnetic poles of the two magnets located in the same magnet mounting slot are opposite. The magnetic attraction directions of two magnets at the same height in the adjacent magnet installation slots are also reversed; there is also a pre-adsorption magnet installation slot at the corresponding starting position of the adsorption process on the magnet installation plate or the inner side wall of the rotating disk, and the pre-adsorption magnet is installed A magnet is installed in the slot.

Description

Washing device for chemiluminescence immunoassay analyzer

technical field

The utility model relates to the technical field of production and manufacture of chemiluminescence immunoassay analyzers, in particular to a washing device for a chemiluminescence immunoassay analyzer which can effectively improve the washing effect on the premise of no washing times.

Background technique

Fully automatic chemiluminescence immunoassay analyzer is an ultra-micro analysis device established by combining immune reaction and luminescence analysis. However, in the actual use process, we found that such existing products have the following defects: (1) The position of the lower needle of the cleaning needle is located in the center of the cuvette, so a small amount of magnetic beads carrying effective substances will be absorbed when the waste liquid is sucked. Suction away, resulting in the loss of magnetic beads and the risk of cross-contamination; (2) The magnetic bead adsorption device used adopts a single-magnet structure, and the suction force is weak, so the magnetic beads are adsorbed slowly, and the single-magnet structure causes the magnetic beads to be adsorbed in dots or strips. , so the magnetic beads are easy to form a multi-interlayer adsorption structure, resulting in the impurity in the adjacent interlayers cannot be removed.

SUMMARY OF THE INVENTION

Aiming at the shortcomings and deficiencies in the prior art, the utility model proposes a washing device for a chemical immunoassay optical analyzer which can effectively improve the washing effect without adding washing times.

The utility model can be achieved through the following measures:

A washing device for a chemical immunoassay optical analyzer is provided with a magnetic bead adsorption mechanism. Two magnets are arranged side by side in the slot, the magnetic pole directions of the two magnets in the same magnet installation slot are reversed, and the magnetic attraction directions of the two magnets at the same height in the adjacent magnet installation slot are also reversed; the magnet installation plate Or a pre-adsorption magnet installation slot is further provided on the inner side wall of the rotary disk corresponding to the initial position of the adsorption treatment, and a magnet is installed in the pre-adsorption magnet installation slot.

According to the utility model, two pre-adsorption magnet installation grooves are arranged in parallel on the magnet installation plate at the starting position of the adsorption treatment along the rotation and advance direction of the rotating plate of the reaction cup, and each pre-adsorption magnet installation groove is respectively provided with a magnet for Before the washing process starts, the magnetic beads in the reaction cup are pre-adsorbed to improve the adsorption and cleaning effect.

The utility model is further provided with a reaction cup rotating plate and a lifting needle holder, the reaction cup rotating plate is provided with a channel for passing the sample, the magnetic bead adsorption mechanism is arranged on the side of the channel, and the lifting needle holder is arranged above the channel.

The lifting needle holder of the utility model is provided with at least two groups of combined liquid injection and suction needles. It is lower than the tip of the lower end of the liquid injection needle, and the tip of the liquid injection needle is bent in the direction close to the suction needle, so as to ensure that the tip of the suction needle can reach the bottom of the sample in the reaction cup when sucking waste liquid, and fully absorb impurities. When the cleaning solution is injected, the tip of the injection needle is located above the tip of the aspiration needle, and the cleaning solution injected by the injection needle can flush the aspiration needle to avoid contamination of different samples.

The liquid suction needle and the liquid injection needle of the utility model are both arranged on the side of the reaction cup above the reaction cup which deviates from the magnet adsorption mechanism through the lifting needle frame, so as to ensure that the liquid suction needle is lowered to the point where the magnetic beads in the reaction cup are adsorbed and agglomerated during liquid suction. on the opposite side to avoid bead loss.

The magnet mounting plate of the utility model is composed of a vertical plate and a bottom plate. The vertical plate and the bottom plate are vertically and fixedly connected, and the cross section is L-shaped. The side of the vertical plate is provided with more than two U-shaped grooves for placing magnets. The opening direction is upward, the top of the vertical plate is provided with a pressing plate for closing the openings of more than two U-shaped grooves, the pressing plate is fixedly connected with the top of the vertical plate by screws, and the bottom plate is provided with a split tooth for fitting with the rotating chassis; There are two magnets placed side by side in the U-shaped groove, and a rust-proof iron plate is set on the outside of the magnet to strengthen the magnetism. Further, the outer side of the rust-proof iron plate is covered with shading tape to improve the protection of the whole mechanism from light. Both the vertical plate and the bottom plate are in arc shape suitable for the inner side of the main body of the rotating disk. The rotating disk is provided with a cuvette carrying track, and on the inner wall corresponding to the washing position, a cuvette carrying track for assembling the magnet mounting plate is opened through the cuvette carrying track. The installation notch is provided with an installation groove matched with the split teeth.

In the process of using the utility model, the cuvette rotating disk drives two or more cuvettes containing the samples to be tested to advance in the set direction, and the driving mechanism for driving the cuvette rotating disk to rotate can drive the cuvette rotating disk every time Advance one cuvette position, when the washing process starts, the cuvette first enters the pre-adsorption processing area driven by the rotating disk, and the magnetic beads in the cuvette are pre-adsorbed by a single magnet in the pre-adsorption magnet installation slot on the magnet mounting plate. Adsorption treatment, so that the magnetic beads originally scattered in the whole space of the cuvette approach the side where the magnetic bead adsorption mechanism is located. When the rotating disk drives the cuvette into the double magnet adsorption area, the magnetic beads are quickly adsorbed to the cuvette close to the magnet. On one side of the cup wall, at this time, due to the use of double magnet adsorption, the magnetic beads in the cuvette are spread on the cuvette cup wall, the agglomeration phenomenon is effectively reduced, and the multi-layer agglomerated magnetic beads wrapped in impurities can affect the cleaning effect; here At the same time, the lifting needle holder is driven up and down by the needle holder drive mechanism to complete the injection of cleaning fluid and the suction of waste fluid. The direction of the needle is bent, so as to ensure that the tip of the aspiration needle can reach the bottom of the sample in the cuvette when the waste liquid is sucked, and the impurities can be fully absorbed. The cleaning solution injected by the liquid injection needle can rinse the liquid suction needle to avoid contamination of different samples; in addition, the liquid suction needle and the liquid injection needle are set on the side of the reaction cup away from the magnet adsorption mechanism through the lifting needle holder, so as to ensure the liquid suction needle When aspirating liquid, descend to the opposite side of the cuvette where the magnetic beads are adsorbed and agglomerated to avoid the loss of magnetic beads.

Compared with the prior art, the utility model can effectively improve the cleaning effect and reduce the loss of magnetic beads without increasing the number of cleanings, and has the obvious advantages of reasonable structure, simple operation, reliable operation and the like.

Description of drawings:

Accompanying drawing 1 is the structural schematic diagram of the present invention.

Figure 2 is a schematic structural diagram of the combined needle for liquid injection and suction in the present invention.

FIG. 3 is a cross-sectional view along the line A-A in FIG. 2 .

Figure 4 is a schematic structural diagram of the magnet mounting plate in the present invention.

Reference signs: Rotating disk 1, lifting needle holder 2, magnet 3, pre-adsorption magnet mounting slot 4, magnet mounting plate 5, liquid injection and suction combination needle 6, liquid suction needle 7, liquid injection needle 8, vertical plate 9, Bottom plate 10 , magnetic bead adsorption surface 11 , U-shaped groove 12 , pressing plate 13 , and split teeth 14 .

Detailed ways:

The utility model will be further described below in conjunction with the accompanying drawings.

As shown in Figure 1, the present utility model proposes a washing device for a chemical immunoassay optical analyzer, which is provided with a cuvette rotating disk 1, a lifting needle holder 2, and a magnetic bead adsorption mechanism, which is characterized in that the magnetic bead adsorption The mechanism is provided with a magnet mounting plate 5, and the magnet mounting plate 5 is provided with more than two magnet mounting slots, and two magnets 3 are arranged side by side in each magnet mounting slot, and the magnetic poles of the two magnets 3 located in the same magnet mounting slot are opposite. The magnetic attraction directions of the two magnets 3 located at the same height in the adjacent magnet installation slots are also reversed; the magnet installation plate 5 or the inner side wall of the rotary disk 1 is also provided with a pre-adsorption magnet installation at the corresponding starting position of the adsorption process Slot 4, a magnet is installed in slot 4 for pre-adsorption magnet installation.

According to the present invention, two pre-adsorption magnet installation grooves 4 are arranged in parallel along the rotation and advance direction of the cuvette rotating plate at the starting position of the magnet installation plate 5, and each pre-adsorption magnet installation groove 4 is respectively provided with a magnet. , which is used to pre-adsorb the magnetic beads in the cuvette before the washing process starts, so as to improve the adsorption and cleaning effect.

As shown in FIG. 2 , at least two groups of combined liquid injection and suction needles 6 are arranged on the lifting needle holder 2 of the present invention, and the combined liquid injection and suction needles 6 are composed of a liquid suction needle 7 and a It consists of a liquid needle 8, wherein the position of the lower end of the liquid suction needle 7 is lower than the position of the lower end of the liquid injection needle 8, and the needle tip of the liquid injection needle 8 is bent in the direction close to the liquid suction needle 7, so as to ensure that when the waste liquid is sucked, the liquid is sucked. The tip of the needle 7 can reach the bottom of the sample in the cuvette 9 to fully absorb the impurities. When the cleaning solution is injected, the tip of the injection needle 8 is located above the tip of the aspiration needle 7, and the cleaning solution injected into the injection needle 8 can rinse the suction. The tip of the liquid needle 7 to avoid contamination of different samples.

As shown in FIG. 3 , both the liquid suction needle 7 and the liquid injection needle of the present invention are arranged on the side of the reaction cup that deviates from the magnet adsorption mechanism through the lifting needle holder 2, so as to ensure that the liquid suction needle 7 is not sucked when the liquid is sucked. Descend to the opposite side of the cuvette where the magnetic beads are adsorbed and agglomerated to avoid the loss of magnetic beads.

As shown in FIG. 4 , the magnet mounting plate 5 of the present invention is composed of a vertical plate 9 and a bottom plate 10 . The vertical plate 9 and the bottom plate 10 are vertically and fixedly connected, and the cross-section is L-shaped. The side of the vertical plate 9 is provided with more than two The U-shaped groove 12 for placing the magnets, the opening direction of the U-shaped groove 12 is upward, the top of the vertical plate 9 is provided with a pressure plate 13 for closing the openings of more than two U-shaped grooves 12, and the pressure plate 13 is fixed with the top of the vertical plate 9 by screws Connection, the bottom plate 10 is provided with a split tooth 14 for fitting with the rotary disk 1; the U-shaped groove on the side of the vertical plate 9 is provided with two magnets placed side by side, and a rust-proof iron plate is set on the outside of the magnet. In order to strengthen the magnetism, further, the outer side of the rust-proof iron plate is covered with light-shielding tape to improve the light-shielding property of the whole mechanism; The one-piece structure with the bottom plate 10, a cuvette carrying track is set on the rotating disk 1, and a mounting gap that is used to assemble the magnet mounting plate and is connected to the cuvette carrying track is opened at the corresponding position of the washing position on the inner wall. The mounting grooves in which the split teeth 14 are matched.

In the process of using the utility model, the cuvette rotating disk drives two or more cuvettes containing the samples to be tested to advance in the set direction, and the driving mechanism for driving the cuvette rotating disk to rotate can drive the cuvette rotating disk every time Advance one cuvette position, when the washing process starts, the cuvette first enters the pre-adsorption processing area driven by the rotating disk, and the magnetic beads in the cuvette are pre-adsorbed by a single magnet in the pre-adsorption magnet installation slot on the magnet mounting plate. Adsorption treatment, so that the magnetic beads originally scattered in the whole space of the cuvette approach the side where the magnetic bead adsorption mechanism is located. When the rotating disk drives the cuvette into the double magnet adsorption area, the magnetic beads are quickly adsorbed to the cuvette close to the magnet. On one side of the cup wall, at this time, due to the use of double magnet adsorption, the magnetic beads in the cuvette are spread on the cuvette cup wall, the agglomeration phenomenon is effectively reduced, and the multi-layer agglomerated magnetic beads wrapped in impurities can affect the cleaning effect; here At the same time, the lifting needle holder is driven up and down by the needle holder drive mechanism to complete the injection of cleaning fluid and the suction of waste fluid. The direction of the needle is bent, so as to ensure that the tip of the aspiration needle can reach the bottom of the sample in the cuvette when the waste liquid is sucked, and the impurities can be fully absorbed. The cleaning solution injected by the liquid injection needle can rinse the liquid suction needle to avoid contamination of different samples; in addition, the liquid suction needle and the liquid injection needle are set on the side of the reaction cup away from the magnet adsorption mechanism through the lifting needle holder, so as to ensure the liquid suction needle When aspirating liquid, descend to the opposite side of the cuvette where the magnetic beads are adsorbed and agglomerated to avoid the loss of magnetic beads.

Compared with the prior art, the utility model can effectively improve the cleaning effect and reduce the loss of magnetic beads without increasing the number of cleanings, and has the obvious advantages of reasonable structure, simple operation, reliable operation and the like.

Claims (7)

1. a washing device for chemical immunoassay light analyzer is provided with a magnetic bead adsorption mechanism, it is characterized in that the magnetic bead adsorption mechanism is provided with a magnet mounting plate, and the magnet mounting plate is provided with more than two magnet mounting grooves, each Two magnets are arranged side by side in the magnet installation slot, the magnetic pole directions of the two magnets in the same magnet installation slot are reversed, and the magnetic attraction directions of the two magnets at the same height in the adjacent magnet installation slot are also reversed. 2. The washing device for a chemical immunoassay light analyzer according to claim 1, wherein the magnet mounting plate or the inner side wall of the rotating disk is also provided with a pre-adsorption magnet mounting groove at the corresponding adsorption treatment starting position, and the pre-adsorption magnet mounting groove is provided. Install a magnet in the suction magnet mounting slot. 3. The washing device for a chemical immunoassay light analyzer according to claim 1, characterized in that at the magnet mounting plate corresponding to the initial position of adsorption treatment, along the rotating advance direction of the cuvette rotating disk, two parallel arranging Pre-adsorption magnet installation grooves, each pre-adsorption magnet installation groove is provided with a magnet, which is used to pre-adsorb the magnetic beads in the cuvette before the washing process starts, so as to improve the adsorption and cleaning effect. 4. The washing device for a chemical immunoassay light analyzer according to claim 1, characterized in that it is also provided with a cuvette rotating disk, a lifting needle holder, and a channel for passing the sample is provided on the cuvette rotating disk, and the magnetic beads The adsorption mechanism is arranged on the side of the channel, and the lifting needle frame is arranged above the channel. 5 . The washing device for a chemical immunoassay optical analyzer according to claim 4 , wherein at least two groups of combination needles for injection and suction are provided on the lifting needle frame, and the combination needles for injection and suction are 5 . It consists of a suction needle and a liquid injection needle, wherein the position of the lower end of the suction needle is lower than the position of the lower end of the liquid injection needle, and the needle tip of the liquid injection needle is bent toward the direction close to the liquid suction needle. 6 . The washing device for a chemical immunoassay light analyzer according to claim 5 , wherein the suction needle and the liquid injection needle are both arranged on the side of the reaction cup that deviates from the magnet adsorption mechanism through a lifting needle holder. 7 . . 7. The washing device for a chemical immunoassay light analyzer according to claim 1, wherein the magnet mounting plate is composed of a vertical plate and a bottom plate, and the vertical plate and the bottom plate are vertically fixedly connected, and the cross section is L-shaped, There are two or more U-shaped grooves on the side of the vertical plate for placing magnets. The opening direction of the U-shaped groove is upward. The top of the vertical plate is provided with a pressure plate for closing the openings of more than two U-shaped grooves. The pressure plate is connected to the top of the vertical plate through screws. Fixed connection, the bottom plate is provided with split teeth for fitting with the rotating chassis; two magnets placed side by side are set in the U-shaped groove on the side of the vertical plate, and a rust-proof iron plate is set on the outside of the magnet to strengthen the magnetism , the outside of the rust-proof iron plate is covered with light-shielding tape to improve the light-proof property of the whole mechanism; the vertical plate and the bottom plate are arc shapes suitable for the inner side of the main body of the rotating disk. Corresponding to the upper washing position, there is a mounting notch which is used for assembling the magnet mounting plate and communicates with the carrying track of the reaction cup.

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