CN211676417U - Chromatographic column and combined chromatographic column - Google Patents
Chromatographic column and combined chromatographic column Download PDFInfo
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- CN211676417U CN211676417U CN201921971112.6U CN201921971112U CN211676417U CN 211676417 U CN211676417 U CN 211676417U CN 201921971112 U CN201921971112 U CN 201921971112U CN 211676417 U CN211676417 U CN 211676417U
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Abstract
The utility model provides a chromatography column and combination chromatography column, the chromatography column includes chromatography column body filling opening, the chromatography column body, chromatography column body discharging pipe, the three-way valve, first communicating pipe, first pipeline, second communicating pipe and second pipeline, the one end of chromatography column body is located to chromatography column body filling opening, the other end of chromatography column body is located to chromatography column body discharging pipe, be equipped with the three-way valve on the chromatography column body discharging pipe, the three-way valve is through first communicating pipe and first pipeline intercommunication, the chromatography column body, partial chromatography column body discharging pipe, first communicating pipe forms U type nest of tubes with first pipeline, first pipeline is through second communicating pipe and second pipeline intercommunication and form the type of falling U nest of tubes. The utility model discloses chromatographic column and combination chromatographic column be convenient for the control flow.
Description
Technical Field
The utility model belongs to organic compound, natural product's extraction, separation and purification device in chemistry, chemical industry and pharmacy field, concretely relates to chromatographic column and combination chromatographic column.
Background
Column chromatography is widely used for extraction, separation and purification of organic compounds and natural products in the fields of chemistry, chemical industry and pharmacy due to its advantages of simplicity, economy, good separation effect and the like.
In the process of extracting, separating or purifying substances, the substances need to be extracted at a certain temperature, while the existing chromatographic column can only be performed at room temperature and cannot meet the experimental requirements. The existing common chromatographic column mainly controls the flow rate by rotating the opening degree of a lower piston, so that the flow rate is very complicated and fussy to adjust.
SUMMERY OF THE UTILITY MODEL
In view of the above shortcoming of the prior art, the utility model aims at providing a chromatographic column and combination chromatographic column, very complicated and loaded down with trivial details, unable control temperature etc. in the time of aiming at solving among the prior art chromatographic column regulation flow at least one problem. The chromatography column includes chromatography column body filling opening, chromatography column body discharging pipe, three-way valve, first communicating pipe, first pipeline, second communicating pipe and second pipeline, the one end of chromatography column body is located to chromatography column body filling opening, the other end of chromatography column body is located to chromatography column body discharging pipe, be equipped with on the chromatography column body discharging pipe the three-way valve, the three-way valve warp first communicating pipe with first pipeline intercommunication, chromatography column body, partial chromatography column body discharging pipe first communicating pipe with first pipeline forms U type nest of tubes, first pipeline warp the second communicating pipe with second pipeline intercommunication and formation type of falling U nest of tubes. The utility model discloses chromatography column and combination chromatography column be convenient for the control flow, and simple structure, simple operation, practicality are strong, are fit for using widely in relevant laboratories such as hospital, institute, colleges and universities.
For realizing above-mentioned purpose and other relevant purpose, the utility model discloses the first aspect provides a chromatography column, including chromatography column body filling opening, chromatography column body discharging pipe, three-way valve, first connecting pipe, first pipeline, second communicating pipe and second pipeline, the one end of chromatography column body is located to chromatography column body filling opening, the other end of chromatography column body is located to chromatography column body discharging pipe, be equipped with on the chromatography column body discharging pipe the three-way valve, the three-way valve warp first connecting pipe with first pipeline intercommunication, chromatography column body, partial chromatography column body discharging pipe first connecting pipe with first pipeline forms U type nest of tubes, first pipeline warp second communicating pipe with second pipeline intercommunication and formation type of falling U nest of tubes.
Preferably, at least one of the following technical features is also included:
1) the free end of the discharge pipe of the chromatographic column body is a discharge hole of the chromatographic column body;
2) the free end of the second pipeline is a second pipeline liquid outlet.
Preferably, the chromatography column further comprises a filtration unit, and the filtration unit is arranged in the chromatography column body.
More preferably, the filter unit is a sand core filter unit.
Preferably, when the chromatographic column body is vertically placed, the highest point of the chromatographic column body is higher than that of the inverted U-shaped tube group.
Preferably, the chromatographic column further comprises a fixing unit for connecting the first communicating pipe, the first pipeline, the second communicating pipe and the second pipeline which are communicated with the chromatographic column body.
Preferably, the chromatographic column further comprises a heat exchange layer, the heat exchange layer is arranged outside the chromatographic column body, a space for heat exchange is formed between the heat exchange layer and the chromatographic column body, and the heat exchange layer is provided with a heat exchange medium inlet for inputting a heat exchange medium and a heat exchange medium outlet for outputting the heat exchange medium.
More preferably, the heat exchanger further comprises a fixing unit for connecting the first communicating pipe, the first pipeline, the second communicating pipe and the second pipeline which are communicated with each other with the heat exchange layer.
The second aspect of the utility model provides a combined chromatographic column, which comprises two or more than three series-connected chromatographic columns.
Preferably, between adjacent chromatographic columns, the liquid outlet of the second pipeline of the first chromatographic column is positioned above the liquid adding port of the chromatographic column body of the second chromatographic column.
As mentioned above, the utility model provides a chromatographic column and combination chromatographic column has at least one in following technological effect:
1) in the test, the three-way valve can be controlled to sample from the outlet of the discharging pipe of the chromatographic column body, namely the discharging port of the chromatographic column body, or the outlet of the second pipeline, namely the liquid outlet of the second pipeline when the sampling is needed; when the continuous operation can control the three-way valve and carry out the ejection of compact through the export of second pipeline promptly second pipeline liquid outlet, this chromatographic column need not come flow control through adjusting the three-way valve, because the principle of intercommunication, ejection of compact flow need not adjust, and is the same with the input flow, convenient control.
2) The utility model provides a heat transfer layer can let in heat transfer liquid to required temperature when controlling the column chromatography.
3) When the experiment is established ties to needs, only need insert the export of the second pipeline of last chromatographic column with the chromatographic column body filling opening of next chromatographic column promptly the second pipeline liquid outlet, can realize that a plurality of chromatographic columns establish ties, and every chromatographic column liquid level and flow all do not need artificial control. When two or three above chromatography columns establish ties the experiment, if need take a sample in every chromatography column, only need the control three-way valve pass through the export of chromatography column body discharging pipe promptly chromatography column body discharge gate sample can accomplish, easy and simple to handle.
4) The utility model has the advantages of being simple in structure and simple in operation, the practicality is strong, is fit for using widely in medical experiment related laboratories such as hospital, institute, colleges and universities.
Drawings
Fig. 1 shows a schematic structural diagram of the chromatography column of the present invention.
Fig. 2 shows a schematic structural diagram of the combined chromatographic column of the present invention.
Reference numerals:
1 chromatographic column body liquid adding port
2 chromatography column body
3 chromatography column body discharging pipe
31 chromatography column body discharge port
4 three-way valve
5 first communicating pipe
6 first pipeline
7 second communicating pipe
8 second pipeline
81 second pipe liquid outlet
9 Filter unit
10 fixing unit
11 heat exchange layer
111 heat exchange medium inlet
112 heat exchange medium outlet
Detailed Description
The following description is provided for illustrative purposes, and other advantages and features of the present invention will become apparent to those skilled in the art from the following detailed description.
Please refer to fig. 1 and fig. 2. It should be understood that the structure, ratio, size and the like shown in the drawings attached to the present specification are only used for matching with the content disclosed in the specification, so as to be known and read by those skilled in the art, and are not used for limiting the limit conditions that the present invention can be implemented, so that the present invention has no technical essential meaning, and any structure modification, ratio relationship change or size adjustment should still fall within the scope that the technical content disclosed in the present invention can cover without affecting the function that the present invention can produce and the purpose that the present invention can achieve. Meanwhile, the terms such as "upper", "lower", "left", "right", "middle" and "one" used in the present specification are for convenience of description, and are not intended to limit the scope of the present invention, and changes or adjustments of the relative relationship thereof may be made without substantial technical changes, and the present invention is also regarded as the scope of the present invention.
As shown in fig. 1, a chromatographic column, including chromatographic column body filling opening 1, chromatographic column body 2, chromatographic column body discharging pipe 3, three-way valve 4, first communicating pipe 5, first pipeline 6, second communicating pipe 7 and second pipeline 8, chromatographic column body filling opening 1 is located the one end of chromatographic column body 2, chromatographic column body discharging pipe 3 is located the other end of chromatographic column body 2, be equipped with on chromatographic column body discharging pipe 3 three-way valve 4, three-way valve 4 warp first communicating pipe 5 with first pipeline 6 intercommunication, chromatographic column body 2, partial chromatographic column body discharging pipe first communicating pipe 5 with first pipeline 6 forms the U type nest of tubes, first pipeline 6 warp second communicating pipe 7 with second pipeline 8 intercommunication and formation fall the U type nest of tubes.
The first pipeline 6 is communicated with the second pipeline 8 through the second communicating pipe 7 to form an inverted U-shaped pipe group, which is convenient for sampling and is also convenient for the use of chromatographic columns in series connection (as shown in fig. 2).
The chromatographic column body 2, part of the chromatographic column body discharge pipe, the first communication pipe 5 and the first pipeline 6 form a U-shaped pipe group to form a communicator; the first pipeline 6 is communicated with the second pipeline 8 through the second communicating pipe 7 to form an inverted U-shaped pipe group, so that a communicating vessel is formed. In the test, the three-way valve can be controlled to sample from the outlet of the discharging pipe of the chromatographic column body, namely the discharging port of the chromatographic column body, or the outlet of the second pipeline, namely the liquid outlet of the second pipeline when the sampling is needed; when the continuous operation can control the three-way valve and carry out the ejection of compact through the export of second pipeline promptly second pipeline liquid outlet, this chromatographic column need not come flow control through adjusting the three-way valve, because the principle of intercommunication, ejection of compact flow need not adjust, and is the same with the input flow, convenient control. The utility model discloses the chromatography column is convenient for the control flow, and simple structure, simple operation, practicality are strong, are fit for using widely in relevant laboratories such as hospital, institute, colleges and universities.
In a preferred embodiment, the free end of the chromatography column body outlet pipe 3 is a chromatography column body outlet 31.
In a preferred embodiment, the free end of the second pipe 8 is a second pipe outlet 81.
In a preferred embodiment, the chromatography column further comprises a filter unit 9, the filter unit 9 being provided within the chromatography column body 2.
In a preferred embodiment, the filter unit 9 is a sand core filter unit.
In a preferred embodiment, when the chromatographic column body is vertically placed, the highest point of the chromatographic column body is higher than that of the inverted U-shaped tube group, and the liquid flows by utilizing the pressure difference formed by the height difference.
In a preferred embodiment, the chromatographic column further comprises a fixing unit 10 for connecting the first communicating pipe 5, the first pipeline 6, the second communicating pipe 7 and the second pipeline 8 which are communicated with each other with the chromatographic column body 2, for example, the fixing unit 10 may be a glass rod, and the first communicating pipe 5, the first pipeline 6, the second communicating pipe 7 and the second pipeline 8 which are communicated with each other are connected with the chromatographic column body 2 by sintering, so as to perform a fixing function.
In a preferred embodiment, the heat exchange layer 11 is further included, the heat exchange layer 11 is disposed outside the chromatographic column body 2, and a space for heat exchange is formed between the heat exchange layer 11 and the chromatographic column body 2, and the heat exchange layer 11 is provided with a heat exchange medium inlet 111 for inputting a heat exchange medium and a heat exchange medium outlet 112 for outputting the heat exchange medium. The heat exchange layer can be filled with heat exchange liquid so as to control the temperature required during column chromatography.
In a preferred embodiment, a fixing unit 10 is further included for connecting the first communicating pipe 5, the first duct 6, the second communicating pipe 7 and the second duct 8, which are communicated, with the heat exchange layer 11.
A combined chromatographic column, as shown in FIG. 2, comprises two or more than three of the above chromatographic columns connected in series.
In a preferred embodiment, between adjacent chromatographic columns, the second pipeline liquid outlet of the first chromatographic column is positioned above the liquid adding port of the chromatographic column body of the second chromatographic column.
When the experiment is established ties to needs, only need insert the export of the second pipeline of last chromatographic column with the chromatographic column body filling opening of next chromatographic column promptly the second pipeline liquid outlet, can realize that a plurality of chromatographic columns establish ties, and every chromatographic column liquid level and flow all do not need artificial control. When two or three above chromatography columns establish ties the experiment, if need take a sample in every chromatography column, only need the control three-way valve pass through the export of chromatography column body discharging pipe promptly chromatography column body discharge gate sample can accomplish, easy and simple to handle.
The chromatographic column and the combined chromatographic column are applied to adsorbing iodine element in acetic acid:
the catalyst used for preparing acetic acid from synthesis gas contains iodine element, which can cause that the acetic acid product contains a small amount of iodine element and influences the product quality. Therefore, the utility model is used for filling resin and adsorbing iodine element in acetic acid.
Because the temperature of the acetic acid needs to be controlled to be about 80 ℃, the temperature of the chromatographic column needs to be controlled to be about 80 ℃, hot water is generally adopted for heating, the hot water enters from the heat exchange medium inlet 111 and flows out from the heat exchange medium outlet 112, and then a certain amount of resin is filled in the chromatographic column body 2.
Acetic acid containing iodine element is added from chromatographic column body filling opening 1, through resin adsorption, then gets into first communicating pipe 5, first pipeline 6, second communicating pipe 7, second pipeline 8 through three-way valve 4 in proper order, flows out from second pipeline liquid outlet 81 at last. In the experimental process, due to the principle of the communicating vessel, the flow of the second pipeline liquid outlet 81 can be controlled only by adjusting the flow of the chromatographic column body liquid adding port 1.
In order to improve the removal of iodine element in the experiment, two chromatographic columns are connected in series, see fig. 2, the second pipeline liquid outlet 81 of the chromatographic column can be connected into the chromatographic column body liquid adding port 1 of the next chromatographic column to realize series connection, and when the effect of iodine element in resin adsorption acetic acid in the first chromatographic column needs to be analyzed, the three-way valve 4 can be controlled to sample from the chromatographic column body discharge port 31 for analysis.
The above embodiments are merely illustrative of the principles and effects of the present invention, and are not to be construed as limiting the invention. Modifications and variations can be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which may be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (10)
1. The utility model provides a chromatographic column, its characterized in that, includes chromatographic column body filling opening (1), chromatographic column body (2), chromatographic column body discharging pipe (3), three-way valve (4), first communicating pipe (5), first pipeline (6), second communicating pipe (7) and second pipeline (8), the one end of chromatographic column body (2) is located to chromatographic column body filling opening (1), the other end of chromatographic column body (2) is located to chromatographic column body discharging pipe (3), be equipped with on chromatographic column body discharging pipe (3) three-way valve (4), three-way valve (4) warp first communicating pipe (5) with first pipeline (6) intercommunication, chromatographic column body (2), partial chromatographic column body discharging pipe first communicating pipe (5) with first pipeline (6) form U type nest of tubes, first pipeline (6) warp second communicating pipe (7) with second pipeline (8) intercommunication and formation fall U type nest of tubes A tube set.
2. The chromatography column of claim 1, further comprising at least one of the following technical features:
1) the free end of the chromatographic column body discharge pipe (3) is a chromatographic column body discharge hole (31);
2) the free end of the second pipeline (8) is a second pipeline liquid outlet (81).
3. A chromatography column according to claim 1, further comprising a filtration unit (9), the filtration unit (9) being provided within the chromatography column body (2).
4. A chromatography column according to claim 3, wherein the filter unit (9) is a sand core filter unit.
5. A chromatography column according to claim 1, characterized in that the highest point of the column body (2) is higher than the highest point of the inverted U-shaped tube set when the column body (2) is placed vertically.
6. A chromatography column according to any of claims 1 to 5, further comprising a fixing unit (10) for connecting the communicating first communication tube (5), first tubing (6), second communication tube (7) and second tubing (8) with the chromatography column body (2).
7. A chromatography column according to any one of claims 1 to 5, further comprising a heat exchange layer (11), wherein the heat exchange layer (11) is arranged outside the chromatography column body (2) and forms a space for heat exchange with the chromatography column body, and the heat exchange layer (11) is provided with a heat exchange medium inlet (111) for inputting a heat exchange medium and a heat exchange medium outlet (112) for outputting the heat exchange medium.
8. The chromatography column according to claim 7, further comprising a fixing unit (10) for connecting the first communicating tube (5), the first conduit (6), the second communicating tube (7) and the second conduit (8) in communication with the heat exchange layer (11).
9. A combined chromatography column comprising two or more chromatography columns according to any one of claims 1 to 8 connected in series.
10. The combination chromatography column of claim 9, wherein between adjacent columns, the second conduit outlet of a first column is positioned above the column body inlet of a second column.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921971112.6U CN211676417U (en) | 2019-11-13 | 2019-11-13 | Chromatographic column and combined chromatographic column |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921971112.6U CN211676417U (en) | 2019-11-13 | 2019-11-13 | Chromatographic column and combined chromatographic column |
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| CN211676417U true CN211676417U (en) | 2020-10-16 |
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| CN201921971112.6U Active CN211676417U (en) | 2019-11-13 | 2019-11-13 | Chromatographic column and combined chromatographic column |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113577824A (en) * | 2021-09-02 | 2021-11-02 | 温州市金榜轻工机械有限公司 | Double-stage chromatographic column separation system for purifying cannabidiol in industrial cannabis sativa |
| CN116392854A (en) * | 2023-06-07 | 2023-07-07 | 江中药业股份有限公司 | Full-automatic chromatographic device and analysis system |
-
2019
- 2019-11-13 CN CN201921971112.6U patent/CN211676417U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113577824A (en) * | 2021-09-02 | 2021-11-02 | 温州市金榜轻工机械有限公司 | Double-stage chromatographic column separation system for purifying cannabidiol in industrial cannabis sativa |
| CN116392854A (en) * | 2023-06-07 | 2023-07-07 | 江中药业股份有限公司 | Full-automatic chromatographic device and analysis system |
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