CN211482642U - Isolated lung storage and perfusion device - Google Patents

Abstract

The utility model relates to an isolated lung storage perfusion device, which comprises a storage perfusion box; a perfusion circulation mechanism and a breathing circulation mechanism are arranged in the storage perfusion box; the perfusion circulation mechanism and the breathing circulation mechanism are both connected with the storage perfusion box. The perfusion breathing controller in the body is electrically connected; after the perfusion circulation mechanism is adapted and connected with the pulmonary artery and pulmonary vein of the isolated lung, the perfusion breathing controller controls the perfusion circulation mechanism to continuously perfuse the connected isolated lung, and in the In the process of perfusion fluid perfusion, the metabolites produced by the isolated lung can be removed; the perfusion breathing controller controls the breathing and circulation mechanism to assist the isolated lung respiration, so that the isolated lung can maintain a normal breathing state. The utility model can effectively realize the cleaning and perfusion of the isolated lung during the transport process, effectively remove the metabolites generated during the transport process of the isolated lung, provide the breathing cycle of the isolated lung during the transport process, and ensure that the transported lungs are transported by the isolated lung. Functional, safe and reliable.

Description

Isolated lung storage perfusion device

technical field

The utility model relates to a storage perfusion device, in particular to an isolated lung storage perfusion device, which belongs to the technical field of isolated lung storage.

Background technique

During lung transplantation, the isolated lung needs to be removed first. After the isolated lung is taken out, it is put into the isolated lung transport box after perfusion with perfusate, and then the isolated lung transport box and the isolated lung are transported to the destination. Generally, the transfer time of the isolated lung can reach 6 to 7 hours or even longer. However, during the transfer of the isolated lung, since the perfusion operation cannot be performed in the transfer box, the metabolites of the isolated lung will be lost in the isolated lung. It cannot be excreted from the lungs. Following transplantation in the isolated lung, metabolites in the isolated lung follow the body's circulation into the recipient's blood, resulting in an even more severe response in the isolated lung recipient.

In addition, the isolated lung is in a stable state under the low temperature environment of the transfer box, which makes the isolated lung unable to maintain the normal breathing state, which will also cause greater damage to the isolated lung and reduce the function of the isolated lung. lead to the failure of lung transplantation.

SUMMARY OF THE INVENTION

The purpose of the present utility model is to overcome the deficiencies in the prior art, and provide an isolated lung storage perfusion device, which can effectively realize the cleaning and perfusion of the isolated lung during the transport process, and effectively remove the generation of the isolated lung during the transport process. The metabolites of the isolated lung provide the respiratory circulation during the transport process of the isolated lung, and ensure the transport function of the isolated lung, which is safe and reliable.

According to the technical solution provided by the present utility model, the isolated lung storage perfusion device includes a storage perfusion box that can be used for storage and transport of the isolated lung; the storage perfusion box is provided with a suitable connection with the isolated lung. The perfusion circulation mechanism and the breathing circulation mechanism that can be adapted and connected to the isolated lung, the perfusion circulation mechanism and the breathing circulation mechanism are all electrically connected with the perfusion breathing controller in the storage perfusion box, and the perfusion circulation can be controlled by the perfusion breathing controller. The corresponding working status of the mechanism and the breathing and circulation mechanism;

After the perfusion circulation mechanism is adapted and connected to the pulmonary artery and pulmonary vein of the isolated lung, the perfusion breathing controller controls the perfusion circulation mechanism to continuously perfuse the connected isolated lung, and can remove the isolated lung during the perfusion process. The metabolites produced by the lung; the perfusion breathing controller controls the breathing circulation mechanism to assist the isolated lung respiration, so that the isolated lung can maintain a normal breathing state.

An insulating layer is arranged in the storage perfusion box, and a storage and transport refrigeration source capable of providing a low temperature environment required for storage and transportation of isolated lungs is also arranged in the storage perfusion box.

The storage and transport refrigeration source includes ice cubes placed in the storage perfusion box or a semiconductor refrigerator that can realize working refrigeration, the semiconductor refrigerator is connected with a perfusion breathing controller that controls the working state of the semiconductor refrigerator, and the perfusion The breathing controller can collect the temperature in the storage perfusion box in real time through the temperature sensor, and the perfusion breathing controller can make the storage perfusion box reach the temperature environment of the isolated lung transport through the temperature sensor and the semiconductor refrigerator.

The perfusion circulation mechanism includes a perfusate device capable of accommodating perfusate, a perfusion driver adapted to the perfusate device, and a first pulmonary vein connecting pipe, a second pulmonary vein connecting pipe, and a pulmonary artery first connecting pipe, which can be communicated with the perfusion liquid device. The first connecting tube and the second connecting tube of the pulmonary artery;

The first connecting tube of the pulmonary vein and the second connecting tube of the pulmonary vein can be adapted to connect with the pulmonary vein, the first connecting tube of the pulmonary artery and the second connecting tube of the pulmonary artery can be connected to the pulmonary artery, and the perfusion fluid in the perfusion device can be driven by the perfusion driver. Enter the pulmonary artery of the isolated lung through the first connecting tube of the pulmonary artery and the second connecting tube of the pulmonary artery, and the perfusate entering the isolated lung can be returned to the perfusate again through the first connecting tube of the pulmonary vein and the second connecting tube of the pulmonary vein, so that To achieve continuous perfusion circulation of isolated lungs.

It also includes a perfusion liquid outlet pipe and a perfusion liquid inlet pipe that can be adapted and connected with the perfusion liquid device. The second connecting pipe is connected and communicated, one end of the perfusion outlet pipe is connected with the perfusate device, and the other end of the perfusion outlet pipe is connected and communicated with the first connecting pipe of the pulmonary artery and the second connecting pipe of the pulmonary artery;

A filter remover for removing metabolites in the isolated lung is provided on the perfusate outflow pipe, and a gas separator for discharging gas in the perfusate is provided on the perfusion liquid inlet pipe.

An outlet one-way valve is arranged in the end of the perfusion outlet pipe adjacent to the perfusate, and an inlet check valve is arranged in the end of the perfusion inlet pipe adjacent to the perfusate;

The perfusion liquid container includes a perfusion liquid container capable of accommodating perfusion liquid and a perfusion driving elastic ring arranged in the upper part of the perfusion liquid container. It can drive the perfusion driving elastic ring to reciprocate in the perfusion liquid container. When the perfusion driving elastic ring reciprocates in the perfusion liquid container, the perfusion liquid in the perfusion liquid inlet pipe can enter the perfusion liquid storage cavity at the lower part of the perfusion liquid container. inside, and can make the perfusate in the perfusate receiving cavity enter into the perfusate outlet pipe.

The gas separator includes a plurality of exhaust holes arranged on the perfusion liquid inlet pipe and a water blocking gas permeable membrane arranged in the exhaust holes, and the filter remover includes an adsorption filter membrane body capable of adsorbing and separating metabolites.

A first connecting tube clip is set on the first connecting tube of the pulmonary vein, a second connecting tube clip is set on the second connecting tube of the pulmonary vein, a third connecting tube clip is set on the first connecting tube of the pulmonary artery, and a second connecting tube is set on the pulmonary artery. A fourth connecting pipe clamp is set on the upper part.

The breathing cycle mechanism includes a gas generator capable of extracting gas in the storage and perfusion box, an extraction driver capable of driving the gas generator, and a gas filter capable of filtering the gas extracted by the gas generator. A tracheal intubation tube that can be adapted to the trachea of the isolated lung is provided, the extraction driver is electrically connected to the perfusion breathing controller, and the perfusion breathing controller can control the extraction driver to drive the gas generator to enter a required working state.

The gas generator comprises a generator housing, a gas extraction elastic ring arranged in the generator housing, and a filter air inlet arranged at the bottom of the generator housing; the extraction driver can drive the gas extraction elastic ring When the gas extraction elastic ring reciprocates in the generator casing, the gas in the storage perfusion box can enter the generator casing through the filter air inlet, and the gas in the generator casing can pass through the gas Filters and endotracheal tubes are inserted into the trachea of the isolated lung.

The advantages of the utility model: the storage and transport of the isolated lung can be realized through the storage perfusion box, the continuous perfusion of the isolated lung during the storage and transport process can be realized through the perfusion circulation mechanism in the storage perfusion box, and the breathing cycle can be used to achieve continuous perfusion of the isolated lung. The mechanism can realize the respiratory support during the storage and transport process of the isolated lung, effectively realize the perfusion cleaning of the isolated lung during the transport process, effectively remove the metabolites generated during the transport process of the isolated lung, and provide the isolated lung with the The breathing cycle during the transfer process ensures the transport function of the isolated lung, which is safe and reliable.

Description of drawings

Figure 1 is a schematic structural diagram of the utility model.

FIG. 2 is a schematic structural diagram of the first box cover of the present invention.

FIG. 3 is a schematic structural diagram of the second box cover of the present invention.

FIG. 4 is a schematic diagram of the perfusion circulation mechanism of the present invention.

FIG. 5 is a schematic diagram of the specific implementation of the perfusion circulation mechanism of the present invention.

FIG. 6 is a schematic diagram of the breathing circulation mechanism of the present invention.

Description of reference numerals: 1- storage perfusion box, 2- heat insulation layer, 3- box body pull ring, 4- box body power supply, 5- perfusion circulation mechanism, 6- breathing circulation mechanism, 7- first box cover , 8-perfusion circulation placement area, 9-perfusion elastic ring drive body, 10-perfusion elastic ring drive plate, 11-second box cover, 12-breathing cycle placement area, 13-extraction elastic ring drive body, 14-extraction Elastic ring drive plate, 15- 1st pulmonary vein connecting pipe, 16- 2nd pulmonary vein connecting pipe, 17- 1st connecting pipe clamp, 18- 2nd connecting pipe clamp, 19- perfusion inlet pipe, 20- gas separation container, 21- Water blocking breathable membrane, 22- Inlet check valve, 23- Perfusion device, 24- Outlet check valve, 25- Filter remover, 26- Perfusion outlet pipe, 27- Third connecting pipe clamp, 28- The fourth connecting pipe clamp, 29- The first connecting pipe of the pulmonary artery, 30- The second connecting pipe of the pulmonary artery, 31- The injection port, 32- The perfusate container, 33- The perfusion driving elastic ring, 34- The perfusion liquid receiving cavity , 35-filter removal container, 36-adsorption filter membrane body, 37-generator shell, 38-gas extraction elastic ring, 39-filter air inlet, 40-gas filter, 41-tracheal tube, 42-trachea Insert end and 43-exhaust valve.

Detailed ways

The utility model will be further described below in conjunction with the specific drawings and embodiments.

As shown in Figure 1, Figure 2 and Figure 3: In order to realize the perfusion cleaning of the isolated lung during the transport process, effectively remove the metabolites generated during the transport process of the isolated lung, and provide the breathing of the isolated lung during the transport process. The utility model includes a storage perfusion box 1 that can be used for storage and transport of the isolated lung; a storage perfusion box 1 that can be adapted and connected to the isolated lung is arranged in the storage perfusion box 1 A perfusion circulation mechanism 5 and a breathing circulation mechanism 6 that can be adapted and connected to the isolated lung, the perfusion circulation mechanism 5 and the breathing circulation mechanism 6 are both electrically connected to the perfusion breathing controller in the storage perfusion box 1, and are controlled by perfusion breathing The device can control the corresponding working states of the perfusion circulation mechanism 5 and the breathing circulation mechanism 6;

After the perfusion circulation mechanism 5 is adapted and connected to the pulmonary artery and pulmonary vein of the isolated lung, the perfusion breathing controller controls the perfusion circulation mechanism 5 to perform continuous perfusion perfusion to the connected isolated lung, and can be removed during the perfusion perfusion process. The metabolites produced by the isolated lung; the perfusion breathing controller controls the breathing circulation mechanism 6 to assist the isolated lung respiration, so that the isolated lung can maintain a normal breathing state.

Specifically, the storage perfusion box 1 is made of materials that meet medical standards, and the specific material types can be selected according to needs, which are well known to those skilled in the art, and will not be repeated here. The storage and transfer of the isolated lung can be realized by the storage perfusion box 1 . In specific implementation, a perfusion circulation mechanism 5, a breathing circulation mechanism 6 and a perfusion breathing controller are set in the storage perfusion box 1, and the perfusion circulation mechanism 5 and the breathing circulation mechanism 6 can be used to counteract the storage and perfusion box 1. The isolated lung is connected and matched, and the perfusion breathing controller can be electrically connected with the perfusion circulation mechanism 5 and the breathing circulation mechanism 6, that is, the perfusion breathing controller can control the corresponding working states of the perfusion circulation mechanism 5 and the breathing circulation mechanism 6.

In specific implementation, the perfusion circulation mechanism 5 can be adapted to connect with the pulmonary artery and pulmonary vein of the isolated lung, and the perfusion circulation mechanism 5 can realize continuous perfusion of the connected isolated lung, and during the perfusion process, the isolated lung can be removed. At the same time, the metabolites produced by the lung can also separate and discharge the gas in the perfusate, which can effectively reduce the reaction of the isolated lung after transplantation and ensure the reliability of the isolated lung after transplantation. The respiration and circulation mechanism 6 can assist the respiration of the isolated lung, maintain the breathing state of the isolated lung during the transfer process, and ensure the function of the isolated lung during the transfer process.

Specifically, the perfusion respiration controller may adopt the existing commonly used micro-processing form, such as using a single-chip microcomputer, etc., which may be selected according to needs, and will not be repeated here. Generally, in order to adapt to the storage of isolated lungs, the storage perfusion box 1 includes a first box cover 7 and a second box cover 11 adapted to the first box cover 7 . The first box cover 7 , When the second box cover 11 is close to each other, the storage perfusion box 1 can be formed, so that the isolated lung can be sealed and stored; when the first box cover 7 and the second box cover 11 are separated from each other, it can be The isolated lungs are placed in the storage perfusion box 1 . The first box cover 7 and/or the second box cover 11 is provided with a box pull ring 3 , and the storage and pouring box 1 can be easily held through the box pull ring 3 .

In the embodiment of the present invention, the perfusion cycle mechanism 5 is arranged in the perfusion cycle placement area 8 in the first box cover 7, the breathing cycle mechanism 6 is arranged in the breathing cycle placement area 12 in the second box cover 11, A cavity suitable for the isolated lung can be formed between the first case cover 7 and the second case cover 11, so that when the isolated lung is placed between the first case cover 7 and the second case cover 11, the perfusion circulation mechanism 5. The respiration and circulation mechanism 6 can be adapted to connect with the isolated lung to realize continuous perfusion and auxiliary respiratory support for the isolated lung. The storage perfusion box 1 also needs to be provided with a box power supply 4 that can provide the operation of the perfusion breathing controller. The box power supply 4 can be a lithium battery or other power supply forms, and the box power supply 4 can be rechargeable or In an interchangeable form, a common connection form can be used between the box body power supply 4 and the perfusion breathing controller, which is well known to those skilled in the art, and will not be repeated here.

Further, an insulating layer 2 is arranged in the storage perfusion box 1, and a storage and transport refrigeration source capable of providing a low temperature environment required for in vitro lung storage and transportation is also arranged in the storage perfusion box 1. In the embodiment of the present invention, the temperature conditions required by the isolated lung in the storage perfusion box 1 can be provided by storing and transporting the refrigeration source, so as to ensure the safety and reliability of the isolated lung in the storage perfusion box 1 . The thermal insulation layer 2 can reduce the heat exchange of the storage and transport refrigeration source in the outside world, and ensure the stability of the temperature in the storage and pouring box 1. The thermal insulation layer 2 is located in the first box cover 7 and the second box cover 11. The thermal layer 2 may adopt the existing commonly used form, as long as the purpose of heat insulation can be achieved, and the specific situation will not be repeated.

The storage and transport refrigeration source includes ice cubes placed in the storage perfusion box 1 or a semiconductor refrigerator that can realize working refrigeration, and the semiconductor refrigerator is connected to the perfusion breathing controller that controls the working state of the semiconductor refrigerator. The perfusion breathing controller can collect the temperature in the storage perfusion box 1 in real time through the temperature sensor, and the perfusion breathing controller can make the storage perfusion box 1 reach the temperature environment of the isolated lung transport through the temperature sensor and the semiconductor refrigerator.

In the embodiment of the present invention, when ice cubes are arranged in the storage perfusion box 1, the low temperature of the ice cubes can make the temperature conditions in the storage perfusion box 1 meet the temperature conditions required for the storage and transportation of isolated lungs. The form of block refrigeration is consistent with the existing refrigeration method in the storage and transportation of isolated lungs. Of course, in the specific implementation, a semiconductor refrigerator can also be used, and the semiconductor refrigerator can adopt the existing common form. The semiconductor refrigerator is electrically connected to the perfusion breathing controller. When the semiconductor refrigerator is working, it can make the storage perfusion box 1 The temperature conditions are maintained at -5°C to 10°C. Of course, other refrigeration forms can also be used in the storage and perfusion box 1, as long as the temperature environment of the isolated lung during storage and transportation in the storage and perfusion box 1 can be met, and will not be listed here.

As shown in FIG. 4 and FIG. 5 , the perfusion circulation mechanism 5 includes a perfusate container 23 capable of accommodating perfusate, a perfusion driver adapted to the perfusion set 23 , and a pulmonary vein that can communicate with the perfusion set 23 . The first connecting tube 15, the second connecting tube 16 of the pulmonary vein, the first connecting tube 29 of the pulmonary artery, and the second connecting tube 30 of the pulmonary artery;

The first connecting tube 15 of the pulmonary vein and the second connecting tube 16 of the pulmonary vein can be adapted to connect with the pulmonary vein, the first connecting tube 29 of the pulmonary artery and the second connecting tube 30 of the pulmonary artery can be connected to the pulmonary artery, and the perfusion device can be driven by the perfusion driver. The perfusate in 23 enters the pulmonary artery of the isolated lung through the first pulmonary artery connecting pipe 29 and the second connecting pipe 30 of the pulmonary artery, and the perfusate entering the isolated lung can pass through the first connecting pipe 15 of the pulmonary vein and the second connecting pipe 16 of the pulmonary vein. Return to the perfusate set 23 again to achieve a continuous perfusate perfusion cycle for the isolated lung.

In the embodiment of the present invention, the perfusate can be accommodated by the perfusate device 23. The perfusate can be placed in the perfusate device 23 by means of pre-filling or perfusion. The perfusate is the existing liquid that can perfuse the isolated lung. , the specific form of the perfusate is well known to those skilled in the art, and will not be repeated here. The perfusion driver is adapted to the perfusate device 23, and the perfusion driver can provide the power for the perfusion solution circulation in the perfusion solution device 23 to realize the perfusion cycle of the perfusion solution. In order to cooperate with the isolated lung, the first connecting tube 15 of the pulmonary vein and the second connecting tube 16 of the pulmonary vein can be connected with the pulmonary vein of the isolated lung, and the first connecting tube 29 of the pulmonary artery and the second connecting tube 30 of the pulmonary artery can be connected with the isolated lung. pulmonary artery adapter connection. After the perfusate device 23 is adapted and connected to the isolated lung and driven by the perfusion driver, the perfusate in the perfusate device 23 can enter the pulmonary artery of the isolated lung via the first connecting tube 29 of the pulmonary artery and the second connecting tube 30 of the pulmonary artery, and enter the The perfusate in the isolated lung can be returned to the perfusate device 23 through the first pulmonary vein connecting pipe 15 and the second pulmonary vein connecting pipe 16. With the continuous cooperation of the perfusion driver and the perfusate device 23, the circulation of the perfusate can be continuously realized. exercise, so as to achieve a continuous perfusion cycle of the isolated lung.

Further, it also includes a perfusion outlet pipe 26 and a perfusion inlet pipe 19 that can be adapted and connected to the perfusion liquid device 23. One end of the perfusion liquid inlet pipe 19 is connected to the perfusion liquid device 23, and the other end of the perfusion liquid inlet pipe 19 is One end is connected and communicated with the first connecting pipe 15 of the pulmonary vein and the second connecting pipe 16 of the pulmonary vein, one end of the perfusion liquid pipe 26 is connected with the perfusate device 23, and the other end of the perfusion liquid pipe 26 is connected with the first connecting pipe 29 of the pulmonary artery and the pulmonary artery. The second connecting pipe 30 is connected and communicated;

A filter remover 25 for removing metabolites in the isolated lung is provided on the perfusate outlet pipe 26 , and a gas separator for discharging the gas in the perfusate is provided on the perfusion fluid inlet pipe 19 .

In the embodiment of the present invention, the diameter of the perfusion liquid inlet pipe 19 is larger than the diameter of the first pulmonary vein connecting pipe 15 and the second pulmonary vein connecting pipe 16, and the length direction of the first pulmonary vein connecting pipe 15 and the second pulmonary vein connecting pipe 16 is the same as The length directions of the perfusion liquid inlet pipe 19 are consistent, and the first pulmonary vein connecting pipe 15 and the second pulmonary vein connecting pipe 16 can communicate with the perfusion liquid device 23 through the perfusion liquid inlet pipe 19 . Similarly, the diameter of the perfusion outlet pipe 26 is larger than the diameter of the first pulmonary artery connecting pipe 29 and the diameter of the second pulmonary artery connecting pipe 30. The diameters of the first pulmonary artery connecting pipe 29 and the second pulmonary artery connecting pipe 30 are perfused The liquid outlet pipe 26 can communicate with the perfusate 23 .

A filter remover 25 is provided on the perfusion liquid outlet pipe 26 , and a gas separator is provided on the perfusion liquid inlet pipe 19 . The gas separator includes a plurality of exhaust holes arranged on the perfusion liquid inlet pipe 19 and a water-blocking gas-permeable membrane 21 arranged in the exhaust holes. The filter remover 25 includes an adsorption filter membrane capable of adsorbing and separating metabolites. body 36. Specifically, the gas separator includes a gas separation container 20 that can be communicated with the perfusion liquid inlet pipe 19, a plurality of exhaust holes are arranged on the gas separation container 20, and a water-blocking gas permeable membrane 21 is arranged in each exhaust hole. The perfusion liquid entering the perfusion liquid device 23 from the liquid inlet pipe 19 first enters the gas separation container 20. When there is gas in the perfusion liquid, the gas in the perfusion liquid can be discharged through the water blocking gas permeable membrane 20, and the gas in the perfusion liquid can be discharged through the water blocking gas permeable membrane 20. It can prevent the perfusate from being discharged from the exhaust hole following the gas. After the gas is discharged, the perfusate enters the perfusate device 23 again. As the perfusion continues, the gas can be effectively discharged to avoid the existence of gas in the perfusate. Air embolism problem. Generally, a liquid injection port 31 may also be provided at the bottom of the gas separation container 20, and through the liquid injection port 31, the required liquid medicine can be injected into the gas separation container 20, such as injection of physiological saline, injection of perfusion liquid, etc. The liquid can mix with the perfusate within the gas separation vessel 20 and follow the perfusion cycle of the perfusate.

In the embodiment of the present invention, the filter removal device 25 further includes a filter removal container 35, and the adsorption filter membrane body 36 is arranged in the filter removal container 35. The perfusate entering the pulmonary artery from the perfusate device 23 will first enter the filter removal container 35. After the perfusate is in full contact with the adsorption filter membrane body 36 in the filter removal container 35, it enters the pulmonary artery through the first pulmonary artery connecting tube 29 and the second pulmonary artery connecting tube 30, and the isolated lung can be produced by the adsorption filter membrane body 36. The metabolites are adsorbed and removed, and the adsorption filter membrane body 36 can be perpendicular to the filter removal container 35. At this time, the perfusate in the perfusate device 23 first enters the lower part of the adsorption filter membrane body 36, and the perfusate passes through the adsorption filter membrane body 36. The filter removal container 35 flows out through the upper part of the filter removal container 35; of course, the adsorption filter membrane body 36 can also adopt other distribution forms, as long as the perfusate can be fully contacted. The adsorption filter membrane body 36 can adopt the combination form of the existing commonly used filter mesh membrane and the medical adsorbent. The metabolites generated during the body-lung perfusion process can be adsorbed or filtered, and will not be described in detail.

Further, an outlet check valve 24 is provided in the end of the perfusion outlet pipe 26 adjacent to the perfusate 23, and an inlet check valve 22 is arranged in the end of the perfusion inlet pipe 19 adjacent to the perfusate 23;

The perfusion liquid container 23 includes a perfusion liquid container 32 capable of accommodating perfusion liquid, and a perfusion driving elastic ring 33 disposed in the upper part of the perfusion liquid container 32. The perfusion driving elastic ring 33 is adapted to the perfusion liquid container 32. With the connection, the perfusion drive elastic ring 33 can be driven to reciprocate in the perfusate container 32 through the perfusion driver, and the perfusion drive elastic ring 33 can reciprocate in the perfusion container The perfusate enters the perfusate containing cavity 34 at the lower part of the perfusate container 32 , and enables the perfusate in the perfusate containing cavity 34 to enter the perfusate outlet pipe 26 .

In the embodiment of the present invention, the liquid outlet one-way valve 24 and the liquid inlet one-way valve 22 can adopt the existing common forms, and the one-way flow of the perfusion liquid can be realized through the liquid inlet one-way valve 22 and the liquid outlet one-way valve 24 , the liquid inlet check valve 22 is located between the gas separation container 20 and the perfusion liquid container 23, the liquid outlet check valve 24 is located between the perfusion liquid container 23 and the filter removal container 35, through the liquid inlet check valve 22, the liquid outlet check valve 24 Valve 24 ensures reliable flow of perfusate during perfusion.

The perfusion liquid container 23 can accommodate the perfusion liquid through the perfusion liquid receiving container 32, and the perfusion driving elastic ring 33 is located in the upper part of the perfusion liquid receiving container 32. The perfusion driving elastic ring 33 can be made of elastic components such as springs. The length direction is consistent with the length direction of the perfusate container 32, and the upper part of the perfusion container 32 can follow the perfusion drive elastic ring 33 to reciprocate, that is, the upper part of the perfusion container 32 can be made of an elastic film, so that the The perfusion driving elastic ring 33 is accommodated in the perfusion liquid container 32, and can also ensure the reciprocating motion of the perfusion driving elastic ring 33 in the perfusion liquid container 32. The reciprocating direction of the perfusion driving elastic ring 33 is the perfusion driving elastic ring 33. length direction. When the elastic ring 33 is compressed and perfused, a negative pressure can be generated in the perfusion liquid container 32, so that the perfusion liquid in the perfusion liquid inlet pipe 19 can enter the perfusion liquid storage container at the lower part of the perfusion liquid container 32 through the liquid inlet check valve 22. In the cavity 34 , when the perfusion driving elastic ring 33 is reset, the perfusion liquid in the perfusion liquid receiving cavity 34 can enter the perfusion liquid outlet pipe 26 through the liquid outlet one-way valve 24 .

When the perfusion liquid device 23 adopts the above structure, the perfusion driver can drive the perfusion driving elastic ring 33 to reciprocate; in specific implementation, the perfusion driver includes the perfusion elastic ring driving body 9 and the perfusion elastic ring driving plate 10, and the perfusion elastic ring driving body 9 Installed on the first box cover 7, the perfusion elastic ring driving plate 10 is located directly above the perfusion driving elastic ring 33, the perfusion elastic driving body 9 can be a linear motor, and the perfusion elastic ring driving plate 10 is adapted to the perfusion elastic driving body 9 In connection, the perfusion elastic driving body 9 can drive the perfusion driving elastic ring 33 to reciprocate through the perfusion elastic ring driving plate 10 . Of course, the perfusion elastic drive body 9 can also be in the form of a motor and a screw nut, etc., as long as the perfusion elastic ring drive plate 10 can be used to drive the reciprocating motion of the perfusion driving elastic ring 33. Specifically, it can be selected according to needs. It will not be repeated here. The perfusion elastic driving body 9 is electrically connected with the perfusion breathing controller, and the perfusion breathing controller can control the working state of the perfusion elastic driving body 9 , thereby realizing the driving control of the reciprocating motion of the perfusion driving elastic ring 33 .

Further, a first connecting tube 17 is set on the first connecting tube 15 of the pulmonary vein, a second connecting tube 18 is set on the second connecting tube 16 of the pulmonary vein, and a third connecting tube is set on the first connecting tube 29 of the pulmonary artery. The clip 27 is set, and the fourth connecting tube clip 28 is set on the second connecting tube 30 of the pulmonary artery.

In the embodiment of the present invention, the state of the perfusate flowing in the first connecting tube 15 of the pulmonary vein can be controlled by the first connecting tube clip 17. The first connecting tube clip 17 can be a commonly used medical clip, which can be carried out according to needs. selection, which will not be repeated here. Similarly, the specific functions of the second connecting pipe clamp 18 , the third connecting pipe clamp 27 and the fourth connecting pipe clamp 28 are the same as those of the first connecting pipe clamp 17 . For details, please refer to the description of the first connecting pipe clamp 17 .

Further, the breathing cycle mechanism 6 includes a gas generator capable of extracting the gas in the storage perfusion box 1, an extraction driver capable of driving the gas generator, and a gas filter 40 capable of filtering the gas extracted by the gas generator. The air outlet of the gas filter 40 is provided with a tracheal intubation tube 41 that can be adapted to the trachea of the isolated lung. The extraction driver is electrically connected to the perfusion breathing controller, and the perfusion breathing controller can control the extraction driver to drive the gas generator into the body. required working status.

In the embodiment of the present invention, the gas in the storage perfusion box 1 can be extracted by the gas generator, the gas generator can be driven by the extraction driver, and the gas entering the trachea of the isolated lung can be filtered by the gas filter 40 , to avoid impurities in the gas entering the trachea of the isolated lung. The tracheal intubation tube 41 is adapted to the isolated lung, and the tracheal intubation tube 41 has a tracheal intubation end 42 , that is, the tracheal intubation tube 41 can be inserted into the trachea of the isolated lung through the tracheal intubation end 42 . The extraction driver is electrically connected with the perfusion breathing controller. When the perfusion breathing controller controls the extraction driver to work, the extraction driver can cooperate with the gas generator to extract the gas in the storage perfusion box 1 and send it into the trachea of the isolated lung. It can assist the breathing of the isolated lung and maintain the function of the isolated lung during operation. Generally, the extraction driver and gas generator cooperate with the trachea frequency of the isolated lung, which is generally lower than the normal breathing frequency of the isolated lung. After the isolated lung breathes, the gas is directly discharged into the storage perfusion box 1 to realize Gas recycling.

As shown in FIG. 6 , the gas generator includes a generator casing 37 , a gas extraction elastic ring 38 disposed in the generator casing 37 , and a filter air inlet disposed at the bottom of the generator casing 37 . 39; The extraction driver can drive the gas extraction elastic ring 37 to reciprocate in the generator housing 37, and when the gas extraction elastic ring 38 reciprocates in the generator housing 37, the gas in the storage perfusion box 1 can pass through the filter. The air inlet 39 enters the generator housing 37 and enables the gas in the generator housing 37 to enter the trachea of the isolated lung through the gas filter 40 and the tracheal tube 41 .

In the embodiment of the present invention, the gas generator can take the form of a conventional foot pump. Specifically, the gas generator includes a generator casing 37 and a gas extraction elastic ring 38 arranged in the generator casing. And the filter air inlet 39, the filter air inlet 39 is the air inlet for setting the gas filter membrane, the gas extraction elastic ring 38 can reciprocate in the generator housing 37, and the length direction of the gas extraction elastic ring 38 is the same as that of the generator housing. The length direction of the body 37 is consistent, and the generator casing 37 can generally be made of a flexible film, that is, the gas extraction elastic ring 38 can be accommodated in the generator casing 37, and the elastic ring can be extracted following the gas extraction. For the reciprocating motion of 38, the gas extraction elastic ring 38 can generally be a spring coil. When the gas extraction elastic ring 38 is compressed in the generator casing 37, a negative pressure can be generated in the generator casing 37, and the gas in the storage perfusion box 1 can enter the generator casing 37 through the filter air inlet 39; When the gas extraction elastic ring 38 is reset, the gas in the generator housing 37 can enter the gas filter 40 . The gas filter 40 can be in the form of conventional gas filtration, such as carbon dioxide absorbent.

After the gas is fully filtered by the gas filter 40, it enters the trachea of the isolated lung through the endotracheal tube 41 to ensure the cleanliness of the gas entering the trachea of the isolated lung. Generally, the diameter of the endotracheal tube 41 can be smaller than the trachea of the isolated lung, so that after breathing in the isolated lung, the breathed gas or the unbreathed gas can pass through the gap between the endotracheal tube 41 and the trachea of the isolated lung It is directly discharged into the storage perfusion box 1. During specific implementation, an exhaust valve 43 can also be provided on the tracheal tube 41, and the exhaust valve 43 can be a commonly used overflow valve, that is, when there is a lot of gas in the generator housing 37, it can be discharged through the exhaust valve 43. Excess gas, or the gas in the airway of the isolated lung can be discharged through the exhaust valve 43 through the exhaust valve 43, so as to realize the support of the breathing process of the isolated lung.

When the gas generator adopts the above-mentioned structural form, the extraction driver includes an extraction elastic ring driving body 13 and an extraction elastic ring driving plate 14. The extraction elastic ring driving body 13 can be in the form of a linear motor, etc., the extraction elastic ring driving plate 14 and the extraction The output end of the elastic ring driving body 13 is connected. The extracting elastic ring driving body 13 cooperates with the extracting elastic ring driving plate 14 to realize the reciprocating motion of the driving gas to extract the elastic ring 38. The extracting elastic ring driving body 13 is installed on the second case cover 11 Inside, the extraction elastic ring drive plate 14 is located directly above the gas extraction elastic ring 38 . The specific form and driving process of extracting the elastic ring driving body 13 and the extracting elastic ring driving plate 14 in cooperation with the driving gas to extract the elastic ring 38 are the same as the specific form of the above-mentioned injecting elastic ring driving body 9 and injecting elastic ring driving plate 10 for driving the perfusion elastic ring 33 And the driving process is similar, for details, please refer to the above description, which will not be repeated here.

Claims (10)

1. An isolated lung storage perfusion device, comprising a storage perfusion box (1) that can be used for isolated lung storage and transport; it is characterized in that: in the storage perfusion box (1), a storage perfusion box (1) that can be used for storage and perfusion is provided. A perfusion circulation mechanism (5) adapted to connect with a lung and a breathing circulation mechanism (6) adapted to be connected to an isolated lung, wherein the perfusion circulation mechanism (5) and the breathing circulation mechanism (6) are both connected to the storage perfusion box ( 1) The perfusion breathing controller is electrically connected, and the perfusion breathing controller can control the corresponding working states of the perfusion circulation mechanism (5) and the breathing circulation mechanism (6); After the perfusion circulation mechanism (5) is adapted and connected to the pulmonary artery and pulmonary vein of the isolated lung, the perfusion breathing controller controls the perfusion circulation mechanism (5) to continuously perfuse the connected isolated lung with perfusion fluid, and the perfusion fluid perfusion is performed. During the process, the metabolites produced by the isolated lung can be removed; the perfusion breathing controller controls the breathing circulation mechanism (6) to assist the isolated lung respiration, so that the isolated lung can maintain a normal breathing state. 2 . The isolated lung storage perfusion device according to claim 1 , wherein a thermal insulation layer ( 2 ) is arranged in the storage perfusion box ( 1 ), and in the storage perfusion box ( 1 ). 3 . A storage and transport refrigeration source that can provide the cryogenic environment required for ex vivo lung storage and transportation is also provided. 3. The isolated lung storage perfusion device according to claim 2, wherein the storage and transport refrigeration source comprises ice cubes placed in the storage perfusion box (1) or a semiconductor refrigerator capable of working refrigeration, The semiconductor refrigerator is connected to a perfusion breathing controller that controls the working state of the semiconductor refrigerator. The perfusion breathing controller can collect and store the temperature in the perfusion box (1) in real time through a temperature sensor. The sensor and the semiconductor refrigerator can make the storage and perfusion box (1) reach the temperature environment for the transport of the isolated lung. 4. The isolated lung storage perfusion device according to claim 1, wherein the perfusion circulation mechanism (5) comprises a perfusate container (23) capable of accommodating perfusate, and the perfusion container (23) An adapted perfusion driver and a first pulmonary vein connecting tube (15), a second pulmonary vein connecting tube (16), a first pulmonary artery connecting tube (29), and a second pulmonary artery connecting tube that can communicate with the perfusate (23) (30); The first pulmonary vein connecting tube (15) and the second pulmonary vein connecting tube (16) can be adapted and connected to the pulmonary vein, and the first pulmonary artery connecting tube (29) and the second pulmonary artery connecting tube (30) can be adapted and connected to the pulmonary artery, The perfusion fluid in the perfusate device (23) can be driven by the perfusion driver to enter the pulmonary artery of the isolated lung through the first pulmonary artery connecting pipe (29) and the second pulmonary artery connecting pipe (30), and the perfusate entering the isolated lung can be The first connecting pipe (15) and the second connecting pipe (16) of the pulmonary vein are returned to the perfusate device (23) again, so as to realize the continuous perfusion circulation of the isolated lung. 5. The isolated lung storage perfusion device according to claim 4, characterized in that: it further comprises a perfusion liquid outlet pipe (26) and a perfusion liquid inlet pipe (19) that can be adapted and connected with the perfusion liquid device (23), One end of the perfusion liquid inlet pipe (19) is connected to the perfusion liquid device (23), and the other end of the perfusion liquid inlet pipe (19) is connected to the first connecting pipe (15) of the pulmonary vein and the second connecting pipe (16) of the pulmonary vein, and One end of the perfusion liquid pipe (26) is connected with the perfusate device (23), and the other end of the perfusion liquid pipe (26) is connected with the first connecting pipe (29) of the pulmonary artery and the second connecting pipe (30) of the pulmonary artery. connected; A filter remover (25) for removing metabolites in the isolated lung is arranged on the perfusate outlet pipe (26), and a gas separator for discharging gas in the perfusate is arranged on the perfusion inlet pipe (19). 6. The isolated lung storage perfusion device according to claim 5, characterized in that: an outlet check valve (24) is provided in the end of the perfusion outlet pipe (26) adjacent to the perfusate device (23), A liquid inlet check valve (22) is arranged in the end of the liquid inlet pipe (19) adjacent to the perfusion liquid device (23); The perfusion liquid container (23) comprises a perfusion liquid container (32) capable of accommodating perfusion liquid, and a perfusion driving elastic ring (33) arranged in the upper part of the perfusion liquid container (32), the perfusion driving elastic ring (33) is adapted to be connected with the perfusion liquid container (32), the perfusion driving elastic ring (33) can be driven to reciprocate in the perfusion liquid container (32) by the perfusion driver, and the perfusion driving elastic ring (33) can be driven in the perfusion liquid container (32). When the container (32) reciprocates, the perfusion liquid in the perfusion liquid inlet pipe (19) can enter the perfusion liquid storage cavity (34) at the lower part of the perfusion liquid storage container (32), and the perfusion liquid storage cavity (34) can be made to enter the perfusion liquid storage cavity (34). ) into the perfusion outlet pipe (26). 7. The isolated lung storage perfusion device according to claim 5 or 6, wherein the gas separator comprises a plurality of exhaust holes arranged on the perfusion liquid inlet pipe (19) and arranged in the exhaust holes The water-blocking and gas-permeable membrane (21) is provided, and the filter remover (25) includes an adsorption filter membrane body (36) capable of adsorbing and separating metabolites. 8. The isolated lung storage perfusion device according to claim 4, 5 or 6, characterized in that: a first connecting pipe clamp (17) is provided on the first connecting pipe (15) of the pulmonary vein, and a second connecting pipe (17) is arranged on the first connecting pipe (15) of the pulmonary vein. A second connecting pipe clamp (18) is arranged on the connecting pipe (16), a third connecting pipe clamp (27) is arranged on the first connecting pipe (29) of the pulmonary artery, and a fourth connecting pipe is arranged on the second connecting pipe (30) of the pulmonary artery. Pipe clamp (28). 9. The isolated lung storage perfusion device according to claim 1, characterized in that: the breathing cycle mechanism (6) comprises a gas generator capable of extracting gas in the storage perfusion box (1), a gas generator capable of driving The extraction driver and the gas filter (40) capable of filtering the gas extracted by the gas generator, the air outlet of the gas filter (40) is provided with a tracheal intubation tube (41) that can be adapted to the trachea of the isolated lung The extraction driver is electrically connected with the perfusion breathing controller, and the perfusion breathing controller can control the extraction driver to drive the gas generator to enter a required working state. 10. The isolated lung storage perfusion device according to claim 9, wherein the gas generator comprises a generator housing (37), and a gas extraction elastic provided in the generator housing (37) A ring (38) and a filter air inlet (39) arranged at the bottom of the generator housing (37); the extraction driver can drive the gas extraction elastic ring (38) to reciprocate in the generator housing (37) , when the gas extraction elastic ring (38) reciprocates in the generator casing (37), the gas in the storage perfusion box (1) can enter the generator casing (37) through the filter air inlet (39), And the gas in the generator housing (37) can enter the trachea of the isolated lung through the gas filter (40) and the tracheal intubation tube (41).

Images