CN211432840U

CN211432840U - Eyepiece formula pupil light reflex automated inspection equipment

Info

Publication number: CN211432840U
Application number: CN201920629782.3U
Authority: CN
Inventors: 陈伟; 刘志勇; 刘建仁
Original assignee: Isen Tech & Trading Co ltd; Ninth Peoples Hospital Shanghai Jiaotong University School of Medicine
Current assignee: Isen Tech & Trading Co ltd; Ninth Peoples Hospital Shanghai Jiaotong University School of Medicine
Priority date: 2019-05-05
Filing date: 2019-05-05
Publication date: 2020-09-08
Anticipated expiration: 2029-05-05

Abstract

The utility model relates to an ocular pupil light reflex automatic detection device, which comprises a camera for acquiring human eye images; a light stimulus source providing at least one stimulus light source to a user; a distance measuring sensor for measuring a distance from the camera to the human eye; and the data analysis module acquires pupil data according to the numerical value of the data measurement sensor and the supplemented pupil image. The utility model has the advantages that: the carrying is convenient, and the compatibility is good; various light sources and sound sources are provided, so that the stimulation type can be conveniently selected, the requirement of a darkroom is met through a half reflector, the pupil is supplemented with light through an infrared light supplementing lamp, and a clear image can be conveniently obtained; accurately acquiring the distance between the pupil and the detection equipment through a distance measurement sensor; through a completion algorithm, objective parameters of pupillary light reflex can be accurately extracted, and the method is very suitable for clinical and scientific research needs of neurology department, ophthalmology department and psychiatric department.

Description

Eyepiece formula pupil light reflex automated inspection equipment

Technical Field

The utility model relates to a pupil physiological data acquisition equipment technical field especially relates to an eyepiece formula pupil light reflex automated inspection equipment.

Background

The pupil light reflex is a physiological phenomenon, which means that when the pupil is irradiated by visible light, the pupil shrinks, and after the light source is removed, the pupil rapidly recovers to the original shape. Pupil detection typically requires that it be performed in a dark room, preferably with a totally enclosed, light-shielded environment.

As a classic neurology simple bedside examination method, pupillary light reflex plays an important role in the judgment of nerve injury, disturbance of consciousness and brain dysfunction. With the development of modern neuroscience, more and more evidences suggest that the examination has important reference value in aspects of Parkinson's disease, cognitive impairment, autonomic nerve dysfunction assessment and the like, and is expected to become an electrophysiological marker capable of objectively reflecting disease subtypes. Traditionally, pupil light reflex mainly depends on a flashlight and an inspector to finish evaluation through manual inspection and visual observation, the result is relatively subjective, quantitative analysis cannot be realized, and multi-center data homogenization management is inconvenient. At present, quantitative pupil light reflex inspection equipment in the market mainly comes from Europe and America countries, is high in price, and is lack of instruments with independent intellectual property rights in China.

Under normal conditions, the pupil of a person is generally circular with the diameter of 2-6 mm, the pupils on two sides are basically the same in size, and when the pupil is stimulated by illumination, a certain algorithm is used for analyzing the change process of the pupil diameter to obtain a plurality of parameters such as latency, stable diameter, minimum diameter, maximum acceleration when the pupil contracts, maximum speed when the pupil contracts and the like. These data have significant clinical significance.

The pupil light reflex quantitative detection usually uses a camera to collect pupils, calculates the pupil diameter D with pixels as a unit by an image analysis technology, and then uses the formula F: pupil true size (M, in millimeters) = pupil diameter (D) × pupil true physical size (K, in millimeters/pixel, related to the distance from the camera to the pupil) represented by each pixel, resulting in the physical size of the pupil. Electronically detecting the pupil diameter, the actual physical size of the pupil must be obtained according to the aforementioned formula F. However, in the existing equipment, no matter a fixed detection box or a handheld detector, the distance between the camera and the pupil is not a stable value, and different tested objects cannot achieve the consistent distance between the pupil and the camera due to various reasons, so that the problem is caused that the diameter of the pupil detected by the existing equipment cannot be a fixed value due to the fact that K is a fixed value, but according to the reasons, K cannot be a fixed value actually, and the real size of the pupil and a test value have an error which is difficult to eliminate.

In addition, the prior art has the following problems:

1. the existing detection equipment requires the completeness of the pupil in the collected image when processing the pupil, so that the pupil diameter can be effectively calculated, and the pupil cannot be completely exposed in the test process in the actual clinical environment, so that the pupil diameter cannot be accurately calculated

2. The stimulation light source is fixed singly, and the switching of a plurality of color light sources can not be realized

3. Fail to provide acoustic stimulation

4. The fixed detection box has larger volume, has certain requirements on the inspection site and has no portability.

5. The hand-held test meter does not have light-shielding properties.

SUMMERY OF THE UTILITY MODEL

In view of the above, the present application provides a pupil detection apparatus capable of eliminating the influence of distance change on pupil measurement.

The present application solves the above technical problems by the following technical solutions.

An automatic eye lens type pupil light reflex detection device comprises

A camera for acquiring an image of a human eye;

a light stimulus source providing at least one stimulus light source to a user;

a distance measuring sensor for measuring a distance from the camera to the human eye;

an image analysis module for completing the pupil and a data analysis module for acquiring pupil data according to the numerical value of the distance measuring sensor and the pupil image after completion;

the signal output end of the camera is in communication connection with the signal input end of the image analysis module, the signal output end of the distance measurement sensor is in communication connection with the signal input end of the data analysis module, and the signal output end of the image analysis module is in communication connection with the signal input end of the data analysis module.

Preferably, the system also comprises a parameter setting module and a single chip microcomputer, wherein the signal input end of the single chip microcomputer is in communication connection with the signal output ends of the parameter setting module, the camera and the distance measuring sensor, and the signal output end of the single chip microcomputer is in communication connection with the signal input ends of the optical stimulus source, the image analysis module and the data analysis module; the parameter setting module can be used for sending instructions to change the light intensity, time and frequency generated by the light stimulation source like a single chip microcomputer.

Preferably, the optical stimulus source further comprises three groups of filters of red, green and blue; the pupil detection equipment further comprises an infrared light supplementing lamp and a semi-reflecting and semi-transparent lens, the semi-reflecting and semi-transparent lens reflects light of the infrared light supplementing lamp to a pupil area, when the front of the pupil is viewed in an orthographic mode, the included angle between the normal direction of the semi-reflecting and semi-transparent lens and a sight line is 30-60 degrees, and the wavelength of infrared light emitted by the infrared light supplementing lamp is 850-940 nm.

Preferably, the sound stimulation device further comprises a sound stimulation source, wherein the signal input end of the sound stimulation source is in communication connection with the signal output end of the single chip microcomputer, and the sound stimulation source can send out a stimulation sound source according to an instruction of the parameter setting module.

The utility model provides an eyepiece formula pupil light reflex automated inspection equipment's advantage lies in: the eyepiece is used as a base, so that the portable mobile phone is convenient to carry and has good compatibility; various light sources and sound sources are provided, so that the stimulation type can be conveniently selected, the requirement of a darkroom is met through a half reflector, the pupil is supplemented with light through an infrared light supplementing lamp, and a clear image can be conveniently obtained; the distance between the pupil and the detection equipment is accurately acquired through the distance measuring sensor, and errors are eliminated; by the aid of a completion algorithm, pupil data can be accurately extracted, objective parameters of light reflex can be accurately obtained, and clinical and scientific research requirements of neurology department, ophthalmology department and psychiatric department are met.

Drawings

Fig. 1 is a schematic diagram of a pupil detection device according to an embodiment of the present invention.

Detailed Description

As shown in fig. 1, an ocular pupil light reflex automatic detection device includes a camera 1 for acquiring an image of a human eye, a light stimulus source 2 for providing a stimulus light source for a user, a distance measurement sensor 3 for measuring a relative distance from the camera 1 to the human eye, an image analysis module 41 for complementing a pupil image, and a data analysis module 42 for acquiring pupil data according to a numerical value of the distance measurement sensor 3 and the complemented image; when the device is used, the detection device is placed in front of eyes, a lens of the camera 1 is aligned to a pupil, light is emitted through the light stimulation source 2 to stimulate the eyes, the camera 1 records the change process of the pupil and sends an image to the image analysis module 41, the image analysis module 41 completes an incomplete pupil image and sends the incomplete pupil image to the data analysis module 42, meanwhile, the distance measurement sensor 3 transmits acquired data to the data analysis module 42, in the preferred embodiment, the distance measurement sensor 3 adopts an infrared sensor for ranging, the directly obtained data is the distance between the distance measurement sensor 3 and the pupil, and as the relative position of the camera 1 and the distance measurement sensor 3 is determined, the distance between the pupil and the camera 1 can be calculated by using the relative distance between the pupil and the distance measurement sensor 3; and then obtaining the data of the pupil through the distance and the complemented image.

By introducing the distance measuring module 3, the relative distance between the pupil and the camera 1 can be respectively determined for different users, and the precision of measured data is improved; in a preferred embodiment, the camera 1 is an infrared camera to improve the imaging quality.

Further, the pupil detection apparatus provided by the present embodiment further has an acoustic stimulus source 6 so as to study the influence of the acoustic stimulus on the pupil constriction. In order to explore the influence of light rays with different colors on pupil constriction, the light stimulus source 2 can adopt a variable light lamp, and the light-emitting color is selected according to the requirement; the optical filter can also be arranged between the light stimulus source 2 and the pupil, and the optical filter comprises three groups of red, green and blue, so that light rays of four colors of red, green, blue and white can be provided for a user, and if other colors are needed, the corresponding optical filter or the combination of a plurality of optical filters can be selected.

In order to further improve the imaging quality of the camera 1, the pupil detection device further comprises an infrared light supplement lamp (not shown) and a semi-reflecting and semi-transmitting lens (not shown) which reflects light rays of the infrared light supplement lamp to a pupil area, and when the pupil is looking forward, an included angle between the normal direction of the semi-reflecting and semi-transmitting lens and a sight line is 30-60 degrees, preferably 45 degrees; the infrared light supplement lamp provides infrared light with the wavelength of 850-940 nm.

The pupil detection device further comprises a parameter setting module 43 and a single chip microcomputer 5, wherein a signal input end of the single chip microcomputer 5 is in communication connection with signal output ends of the parameter setting module 43, the camera 1 and the distance measuring sensor 3, a signal output end of the single chip microcomputer 5 is in communication connection with signal input ends of the light stimulus source 2, the sound stimulus source 6, the image analysis module 41 and the data analysis module 42, and a signal output end of the image analysis module 41 is in communication connection with a signal input end of the data analysis module 42. The parameter setting module 43 sends an instruction to the single chip microcomputer 5, and the single chip microcomputer 5 controls the on and off of the light stimulation source 2 and the sound stimulation source 6, the light intensity, the time, the frequency and corresponding sound parameters according to the instruction.

The method for completing the pupil by the image analysis module 41 comprises the following steps:

step A: acquiring an image, extracting the edge of a pupil, if the area of the pupil point set envelope region is less than 100 pixels, considering that the pupil is shielded, and skipping to the step B, otherwise skipping to the step E;

and B: calculating the center and radius of a circle where the pupil is located by taking any three pixel points on the edge of the pupil, and repeating the step until all the pixel points on the edge of the pupil are traversed;

and C: c, performing minimum two-way fitting on all circle centers and radiuses obtained in the step B to obtain the circle center and the radius of a fitting circle;

step D: carrying out variance analysis on the fitting circle and the pupil edge, judging whether the fitting precision meets the requirement, if not, adjusting fitting parameters, and skipping to the step C; if the fitting precision meets the requirement, jumping to the step E;

step E: and transmitting the pupil edge data to a data analysis module.

And when the variance confidence coefficient of the fitting circle and the pupil edge is greater than 0.95, the fitting precision is considered to meet the requirement.

The pupil data acquired by the data analysis module 42 includes a latency period, a stable diameter, a minimum diameter, a maximum acceleration and a maximum speed when the pupil contracts, and the like in the pupil change process, and the method for acquiring the data by the data analysis module 42 is as follows:

step 1: setting filter parameters to filter the pupil data in the complete stimulation process, and calculating the stable diameter in a normal state and the minimum diameter when the pupil is minimum;

step 2: calculating the speed and the acceleration of two corresponding points on the continuous images, traversing all diameter data of the whole stimulation process, and obtaining the maximum speed and the maximum acceleration of the stress change of the pupil; if a point with the speed of more than 10mm/s for three times continuously exists, recording the position data as the time when the stress reaction starts; the latency period of the stress response of the pupil can be obtained by comparing the time for providing the stimulus with the time for starting the stress response;

and step 3: outputting the pupil data.

The image analysis module 41, the data analysis module 42 and the parameter setting module 43 may use a conventional controller to write in a related algorithm to realize a corresponding function, or may integrate them into computer software to perform processing by calling a processor of the electronic device itself; the computer software is computer software, mobile phone software, embedded software or a webpage.

Claims

1. The utility model provides an eyepiece formula pupil light reflex automatic check out test equipment which characterized in that: comprises that

A camera for acquiring an image of a human eye;

a light stimulus source providing at least one stimulus light source to a user;

2. The ocular pupil automatic detection device for light reflex according to claim 1, wherein: the device comprises a parameter setting module and a single chip microcomputer, wherein the signal input end of the single chip microcomputer is in communication connection with the signal output ends of the parameter setting module, a camera and a distance measuring sensor, and the signal output end of the single chip microcomputer is in communication connection with the signal input ends of a light stimulus source, an image analysis module and a data analysis module; the parameter setting module can be used for sending instructions to change the light intensity, time and frequency generated by the light stimulation source like a single chip microcomputer.

3. The ocular pupil automatic detection device for light reflex according to claim 1, wherein: the light stimulus source also comprises three groups of filters of red, green and blue; the eyepiece type automatic pupil light reflection detection equipment further comprises an infrared light supplementing lamp and a semi-reflecting and semi-transparent lens, wherein light rays of the infrared light supplementing lamp are reflected to the pupil area, when the front of the pupil is viewed, the included angle between the normal direction of the semi-reflecting and semi-transparent lens and a sight line is 30-60 degrees, and the wavelength of infrared light emitted by the infrared light supplementing lamp is 850-940 nm.

4. The ocular pupil automatic detection device for light reflex according to claim 1, wherein: the sound stimulation source is in communication connection with the signal output end of the single chip microcomputer, and can send out a stimulation sound source according to an instruction of the parameter setting module.