Reaction generating mechanism in biochemical analyzer
Technical Field
The utility model relates to a biochemical analysis appearance technical field especially relates to reaction among biochemical analysis appearance and takes place mechanism.
Background
The medical diagnosis and treatment needs to use a biochemical analyzer to carry out biochemical inspection and analysis on a patient sample. Biochemical analyzers generally consist of a housing, a mechanical transport system, a stirring system, a cleaning system, a reagent loading system, a detection system, a control system, a reaction system, and the like. The reaction system generally comprises a reaction disc and a reaction cup, and is a main component of biochemical reaction and detection. The reaction disc bears the reaction cup, it is constructed as to have a plurality of discs used for inserting the open pore of reaction cup on it, the centre of a circle has spindles connected to biochemical apparatus, the work is that the spindle is controlled by the control system of biochemical apparatus to rotate, thus make the position of the reaction cup on the rotary table change in order to realize the detection; the reaction cup is generally a cuboid with an opening at the top end, a closed bottom end and four closed surfaces, and two opposite surfaces of the cuboid are transparent and are used for observing and detecting the change of the transmittance of an object to be detected in the reaction cup before and after the reaction with a reagent, so that a detection result is obtained. The other two opposite surfaces are opaque, so that the hand-held mounting, dismounting and cleaning are convenient.
At present, a biochemical analyzer detects the change of transmittance of a specimen and a reagent before and after reaction according to the Lambert-beer law, and then a control system carries out statistical calculation to obtain a detection result, so that the specimen and the reagent are required to react uniformly, the specimen and the reagent are required to be fully mixed, a stirring system is required to be matched, and a stirring needle of the stirring system can enable reaction liquid of the specimen and the reagent to be fully mixed. However, in practice, the use of a stirring pin may affect the reaction in many ways, resulting in inaccurate test results or a biological safety hazard:
1. in order to improve the inspection speed of modern biochemical analysis, reaction cups as many as possible are loaded on a reaction disc to respectively inspect different items, and generally, only two sets of stirring systems are provided, so that stirring pins can be used in different reaction cups in a crossed manner, which may cause cross contamination between different samples and different inspection items due to unclean cleaning of the stirring pins, and thus, the accuracy of the inspection result is affected.
2. The stirring pin rotating at high speed stirs in the reaction liquid, and micro bubbles may be generated due to vortex action, which affects the transmittance of the reaction liquid and the accuracy of the test result.
3. The stirring needle has a certain volume, the reaction cup is generally small in volume, the stirring needle extends into the reaction liquid to lift the liquid level, the stirring needle rotates at a high speed, the reaction liquid is easy to splash out of the reaction cup, on one hand, the reaction in the adjacent reaction cup is polluted, the result accuracy is influenced, and on the other hand, the reaction liquid splashes possibly to have biological potential safety hazards (a sample may carry germs and the like).
SUMMERY OF THE UTILITY MODEL
The utility model discloses the technical problem that will solve is: provided is a reaction generation mechanism in a biochemical analyzer, which can improve the detection accuracy of the biochemical analyzer.
In order to solve the technical problem, the utility model discloses a technical scheme be: the reaction generating mechanism in the biochemical analyzer comprises a reaction cup and a reaction disc with a socket, wherein one end of the reaction cup penetrates through the socket, the reaction generating mechanism also comprises a reaction cup accessory fixedly connected with the reaction cup, and the reaction cup accessory is suspended on the reaction disc; the reaction cup accessory comprises a permanent magnet assembly, an electromagnet assembly matched with the permanent magnet assembly is arranged at a socket of the reaction disc, alternating current is conducted to the electromagnet assembly, and the electromagnet assembly is used for driving the reaction cup accessory to rotate.
Furthermore, the reaction cup accessory also comprises a first permanent magnet positioned below the permanent magnet assembly, and a second permanent magnet with the same polarity as the first permanent magnet is arranged on the reaction disc.
Furthermore, the reaction cup accessory further comprises a supporting sleeve body, the permanent magnet assembly and the first permanent magnet are respectively arranged on the supporting sleeve body, and the supporting sleeve body is sleeved on the reaction cup.
Furthermore, the permanent magnet assembly comprises two third permanent magnets which are oppositely arranged, and the magnetic force of the two third permanent magnets is not equal.
Furthermore, the electromagnet assembly comprises a first electromagnet and a second electromagnet which are oppositely arranged, the first electromagnet and the second electromagnet are respectively communicated with alternating current, and the permanent magnet assembly is located between the first electromagnet and the second electromagnet.
Furthermore, the electromagnet assembly comprises a U-shaped iron core and a winding wound on the iron core, the winding is electrified with alternating current, and the permanent magnet assembly is positioned in the iron core.
Further, the reaction disc comprises a body and a reaction disc accessory detachably mounted on the body, the socket is arranged on the body, the electromagnet assembly and the second permanent magnet are respectively arranged on the reaction disc accessory, the body is provided with a conductive circuit and a first electrode point connected with the conductive circuit, the reaction disc accessory is provided with a second electrode point electrically connected with the electromagnet assembly, and the second electrode point is in contact conduction with the first electrode point.
The device further comprises a rack, a rotating shaft and a conductive sliding ring, wherein the fixed end of the conductive sliding ring is installed on the rack, the sliding end of the conductive sliding ring is installed on the body, the conductive sliding ring is electrically connected with the conductive circuit, and the body is connected with the rotating shaft.
Furthermore, the output end of the conductive slip ring is provided with a first conductive terminal, and one end of the conductive circuit, which is far away from the first electrode point, is provided with a second conductive terminal which is in plug-in fit with the first conductive terminal.
Furthermore, the reaction disc is formed by splicing a plurality of fan-shaped blocks.
The beneficial effects of the utility model reside in that: the reaction generating mechanism enables the reaction cup to suspend and rotate under the action of magnetic force, effectively avoids the problem of cross contamination caused by the cross use of the stirring needles, is beneficial to improving the accuracy of the detection result of the biochemical analyzer, and in addition, no stirring needle is inserted into the reaction liquid in the rotating and stirring process, so that the occurrence of bubbles can be reduced or even eliminated, the influence on the transmittance of the reaction liquid is avoided, and the accuracy of the detection result of the biochemical analyzer is further improved; meanwhile, the liquid level of the reaction liquid is lifted due to the fact that no stirring needle is inserted, the reaction liquid cannot splash all around in the process of rotary stirring, the situation that the reaction liquid pollutes detection liquid in adjacent reaction cups is effectively avoided, accuracy of detection results is guaranteed, and moreover, the reaction liquid cannot splash and biological safety can be guaranteed.
Drawings
Fig. 1 is a schematic view of the overall structure of a reaction generation mechanism in a biochemical analyzer according to a first embodiment of the present invention;
fig. 2 is a partial sectional view of a reaction generation mechanism in a biochemical analyzer according to a first embodiment of the present invention;
fig. 3 is a schematic structural diagram of a reaction cup accessory in a reaction generating mechanism according to a first embodiment of the present invention;
fig. 4 is a schematic structural diagram of a reaction disk accessory in a reaction generating mechanism according to a first embodiment of the present invention;
fig. 5 is a top view of a spliced reaction disc in a reaction generating mechanism according to a first embodiment of the present invention;
fig. 6 is a schematic view of the reaction cup attachment and the reaction plate attachment in the reaction generating mechanism according to the second embodiment of the present invention;
fig. 7 is a schematic view showing the reaction cup attachment and the reaction plate attachment in the reaction generating mechanism according to the third embodiment of the present invention.
Description of reference numerals:
1. a reaction cup; 2. a reaction disc; 3. a reaction cup accessory; 4. a permanent magnet assembly; 5. an electromagnet assembly; 6. a shoulder portion; 7. a first permanent magnet; 8. a second permanent magnet; 9. a supporting sleeve body; 10. a third permanent magnet; 11. A first electromagnet; 12. a second electromagnet; 13. a body; 14. a reaction disk accessory; 15. a rotating shaft; 16. A sector block; 17. a socket; 18. an iron core; 19. winding; 20. and a third electromagnet.
Detailed Description
In order to explain the technical content, the objects and the effects of the present invention in detail, the following description is made with reference to the accompanying drawings in combination with the embodiments.
The utility model discloses the most crucial design lies in: the reaction cup accessory of fixed reaction cup suspends in the setting of reaction plate, sets up the electro-magnet subassembly of circular telegram on the reaction plate, the reaction cup accessory including have with electro-magnet subassembly complex permanent magnet subassembly, utilize the magnetic force effect between electro-magnet subassembly and the permanent magnet subassembly to order about the reaction cup accessory rotation in order to drive the reaction cup and rotate, and the change that utilizes the electric current flow direction of alternating current lets the direction of rotation of reaction cup change, thereby makes the reaction liquid in the reaction cup obtain the stirring.
Referring to fig. 1 to 7, a reaction generating mechanism in a biochemical analyzer includes a reaction cup 1 and a reaction tray 2 having a socket 17, one end of the reaction cup 1 passes through the socket 17, and further includes a reaction cup attachment 3 fixedly connected to the reaction cup 1, the reaction cup attachment 3 is suspended on the reaction tray 2; reaction cup annex 3 includes permanent magnet subassembly 4, the socket 17 department of reaction dish 2 be equipped with permanent magnet subassembly 4 matched with electromagnet assembly 5, electromagnet assembly 5 circular telegram alternating current, electromagnet assembly 5 is used for driving about reaction cup annex 3 rotatory.
The structure/working principle of the utility model is as follows: the reaction cup accessory 3 is driven to rotate by utilizing the magnetic action between the electromagnet assembly 5 and the permanent magnet assembly 4 so as to drive the reaction cup 1 to rotate, and the rotating direction of the reaction cup 1 is changed by utilizing the change of the current flow direction of alternating current, so that the reaction liquid in the reaction cup 1 is stirred.
From the above description, the beneficial effects of the present invention are: the reaction generating mechanism enables the reaction cup 1 to suspend and rotate under the action of magnetic force, effectively avoids the problem of cross contamination caused by the cross use of stirring needles, is beneficial to improving the accuracy of the detection result of the biochemical analyzer, and in addition, no stirring needle is inserted into the reaction liquid in the rotating and stirring process, so that the occurrence of bubbles can be reduced or even eliminated, the influence on the transmittance of the reaction liquid is avoided, and the accuracy of the detection result of the biochemical analyzer is further improved; meanwhile, the liquid level of the reaction liquid is lifted due to the fact that no stirring needle is inserted, the reaction liquid cannot splash all around in the process of rotary stirring, the situation that the reaction liquid pollutes detection liquid in the adjacent reaction cups 1 is effectively avoided, accuracy of detection results is guaranteed, and moreover, the reaction liquid cannot splash and biological safety can be guaranteed.
Further, the reaction cup accessory 3 further comprises a first permanent magnet 7 positioned below the permanent magnet assembly 4, and a second permanent magnet 8 with the same polarity as the first permanent magnet 7 is arranged on the reaction disk 2.
As can be seen from the above description, the cuvette attachment 3 fixedly connected to the cuvette 1 is suspended with respect to the reaction plate 2 by the cooperation of the first and second permanent magnets (using the principle that like magnetic poles repel each other).
Further, the reaction cup accessory 3 further comprises a supporting sleeve body 9, the permanent magnet assembly 4 and the first permanent magnet 7 are respectively arranged on the supporting sleeve body 9, and the supporting sleeve body 9 is sleeved on the reaction cup 1.
As can be seen from the above description, the supporting sleeve body 9 can be detachably connected with the reaction cup 1 or detachably connected with the reaction cup 1, and preferably, the supporting sleeve body and the reaction cup are detachably connected through interference fit.
Further, the permanent magnet assembly 4 includes two third permanent magnets 10 disposed oppositely, and the magnetic forces of the two third permanent magnets 10 are not equal.
As can be seen from the above description, when the electromagnet assembly 5 is energized, the magnetic forces exerted on the two third permanent magnets 10 are different due to the different magnitudes of the magnetic forces exerted on the two third permanent magnets 10, so that the reaction cup accessories 3 can rotate.
Further, the electromagnet assembly 5 comprises a first electromagnet 11 and a second electromagnet 12 which are oppositely arranged, the first electromagnet 11 and the second electromagnet 12 are respectively electrified with alternating current, and the permanent magnet assembly 4 is located between the first electromagnet 11 and the second electromagnet 12.
As can be known from the description, at the same moment, the first electromagnet and the second electromagnet are close to the same polarity at one end of the permanent magnet component 4, so that the response speed of the reaction generating mechanism can be increased, the stirring efficiency is increased, the displacement of the reaction cup accessory 3 in the horizontal plane can be avoided, and the improvement of the working stability of the reaction generating mechanism is facilitated.
Further, the electromagnet assembly 5 comprises a U-shaped iron core 18 and a winding 19 wound on the iron core 18, the winding 19 is electrified with alternating current, and the permanent magnet assembly 4 is located in the iron core 18.
As can be seen from the above description, the electromagnet assembly 5 has a simple structure and low manufacturing cost, and is beneficial to controlling the manufacturing cost of the reaction generating mechanism.
Further, the reaction disk 2 comprises a body 13 and a reaction disk accessory 14 detachably mounted on the body 13, the socket 17 is formed in the body 13, the electromagnet assembly 5 and the second permanent magnet 8 are respectively arranged on the reaction disk accessory 14, a conductive circuit and a first electrode point connected with the conductive circuit are arranged on the body 13, a second electrode point electrically connected with the electromagnet assembly 5 is arranged on the reaction disk accessory 14, and the second electrode point is in point contact conduction with the first electrode point.
As can be seen from the above description, when the electromagnet assembly 5 or the second permanent magnet 8 is damaged, the above structure can bring great convenience to maintenance work; meanwhile, when a manufacturer assembles the reaction generating mechanism, the structure can accelerate the assembly efficiency and reduce the assembly cost.
Further, the device comprises a rack, a rotating shaft 15 and a conductive slip ring, wherein the fixed end of the conductive slip ring is installed on the rack, the sliding end of the conductive slip ring is installed on the body 13, the conductive slip ring is electrically connected with the conductive circuit, and the body 13 is connected with the rotating shaft 15.
As can be seen from the above description, the conductive slip ring can enable the body 13 to rotate for a long time in the clockwise or counterclockwise direction without the phenomenon of intertwining of the wires, which is beneficial to ensuring the working stability of the reaction generating mechanism.
Furthermore, the output end of the conductive slip ring is provided with a first conductive terminal, and one end of the conductive circuit, which is far away from the first electrode point, is provided with a second conductive terminal which is in plug-in fit with the first conductive terminal.
From the above description, the electrical connection between the conductive slip ring and the body 13 is simple and stable.
Further, the reaction disc 2 is formed by splicing a plurality of fan-shaped blocks 16.
From the above description, the user can assemble the reaction disk 2 with different number of the sockets 17 according to the requirement, which is beneficial to improving the universality of the reaction generating mechanism and reducing the machine purchasing cost of the user.
Example one
Referring to fig. 1 to 5, a first embodiment of the present invention is: referring to fig. 1 and 2, a reaction generating mechanism in a biochemical analyzer includes a reaction cup 1 and a reaction plate 2 having a socket 17, one end of the reaction cup 1 passes through the socket 17, and further includes a reaction cup attachment 3 fixedly connected to the reaction cup 1, the reaction cup attachment 3 is suspended on the reaction plate 2; reaction cup annex 3 includes permanent magnet subassembly 4, the socket 17 department of reaction dish 2 be equipped with permanent magnet subassembly 4 matched with electromagnet assembly 5, electromagnet assembly 5 circular telegram alternating current, electromagnet assembly 5 is used for driving about reaction cup annex 3 rotatory.
In this embodiment, the reaction cup 1 is made of transparent material, and the cross section of the reaction cup 1 is T-shaped, so that the reaction cup 1 has a shoulder portion 6.
Optionally, reaction cup 1 is including having the open-ended supporting body and sealing the open-ended lid, and the supporting body is used for splendid attire reaction liquid, and the lid can be dismantled with the supporting body and be connected, so, can ensure that the reaction liquid in reaction cup 1 can not accidentally swing out when stirring, does benefit to the accuracy of further assurance testing result.
As shown in fig. 2, the reaction cup accessory 3 further includes a first permanent magnet 7 located below the permanent magnet assembly 4, a second permanent magnet 8 having the same polarity as the first permanent magnet 7 is disposed on the reaction disk 2, and the first permanent magnet 7 is located right above the second permanent magnet 8. As the polarities of the first and second permanent magnets are the same, a repulsive force exists between the first and second permanent magnets, so that the reaction cup accessories 3 can be suspended relative to the reaction disk 2.
Referring to fig. 2 and 3, in this embodiment, the reaction cup accessory 3 further includes a supporting sleeve 9, the permanent magnet assembly 4 and the first permanent magnet 7 are respectively disposed on the supporting sleeve 9, the supporting sleeve 9 is sleeved on the reaction cup 1 and is located below the shoulder 6, specifically, the first and second permanent magnets are respectively annular, and the first permanent magnet 7 is sleeved on the supporting sleeve 9. In order to avoid relative rotation between the reaction cup 1 and the supporting sleeve body 9, optionally, the top surface of the supporting sleeve body 9 is provided with a protrusion extending upwards, and the bottom surface of the shoulder 6 of the reaction cup 1 is provided with a groove matched with the protrusion.
As shown in fig. 3, the permanent magnet assembly 4 includes two third permanent magnets 10 disposed oppositely, the two third permanent magnets 10 repel each other, and the magnetic forces of the two third permanent magnets 10 are not equal. When the two third permanent magnets 10 are made of the same material, the two third permanent magnets 10 may have different magnetic forces by setting the contour sizes of the two third permanent magnets 10 to be different.
Referring to fig. 2 and 4, in the present embodiment, the electromagnet assembly 5 includes a first electromagnet 11 and a second electromagnet 12 that are oppositely disposed, the first electromagnet 11 and the second electromagnet 12 are respectively energized with alternating current, and the permanent magnet assembly 4 is located between the first electromagnet 11 and the second electromagnet 12.
Referring to fig. 1, 2 and 4, for convenience of maintenance and assembly, the reaction disk 2 includes a main body 13 and a reaction disk accessory 14 detachably mounted on the main body 13, the socket 17 is disposed on the main body 13, the electromagnet assembly 5 and the second permanent magnet 8 are respectively disposed on the reaction disk accessory 14, the main body 13 is provided with a conductive circuit and a first electrode point connected to the conductive circuit, the reaction disk accessory 14 is provided with a second electrode point electrically connected to the electromagnet assembly 5, and the second electrode point is in contact conduction with the first electrode point. Optionally, at least a portion of the reaction disk attachment 14 is insert-mounted within the socket 17.
The conductive slip ring is characterized by further comprising a rack, a rotating shaft 15 and a conductive slip ring, wherein the fixed end of the conductive slip ring is installed on the rack, the sliding end of the conductive slip ring is installed on the body 13, the conductive slip ring is electrically connected with the conductive circuit, the body 13 is connected with the rotating shaft 15, and preferably, the body 13 is detachably connected with the rotating shaft 15.
The output end of the conductive slip ring is provided with a first conductive terminal, and one end of the conductive circuit, which is far away from the first electrode point, is provided with a second conductive terminal which is in plug-in fit with the first conductive terminal.
As shown in fig. 5, optionally, the reaction disk 2 is formed by splicing a plurality of segments 16, in this embodiment, each segment 16 is provided with at least one socket 17; two adjacent fan-shaped blocks 16 are connected through a buckle structure or a magnetic attraction structure to improve the structural stability of the reaction disc 2; in other embodiments, the socket 17 is provided on a portion of the segments 16, and the socket 17 is not provided on another portion of the segments 16.
The structure enables a user to rapidly assemble a plurality of fan-shaped blocks 16 with different sizes of the socket 17 (the fan-shaped blocks 16 are provided with the second conductive terminals) to form the reaction disc 2, or form the reaction discs 2 with different sizes to be matched with biochemical analyzers of different models, so that diversification of the reaction discs 2 is favorably realized, the universality of the reaction generating mechanism is enhanced, and the machine purchasing cost of the user is saved.
The operation of the reaction generating mechanism of this embodiment is briefly described as follows: firstly, the reaction cup 1 is put into the supporting sleeve body 9 of the reaction cup accessory 3, then the supporting sleeve body 9 is placed above the socket 17 of the reaction disc 2, the reaction cup accessory 3 is suspended by utilizing repulsion force between the first permanent magnet and the second permanent magnet, then the electromagnet assembly 5 is conducted to generate magnetic force, so that the permanent magnet assembly 4 drives the reaction cup 1 to rotate, the rotation direction of the reaction cup 1 is changed by the change of the magnetic force direction of the electromagnet assembly 5, and the aim of stirring reaction liquid in the reaction cup 1 is fulfilled.
Example two
Referring to fig. 1 to 6, another technical solution proposed by the second embodiment of the present invention is a structure of an electromagnet assembly 5 on the basis of the first embodiment, which is different from the first embodiment in that: the electromagnet assembly 5 comprises an iron core 18 in a U shape and a winding 19 wound on the iron core 18, the winding 19 is electrified with alternating current, and the permanent magnet assembly 4 is positioned in the iron core 18 and close to an opening of the iron core 18.
EXAMPLE III
Referring to fig. 1 to 5 and 7, a third embodiment of the present invention is another technical solution provided for a structure of the electromagnet assembly 5, a structure of the permanent magnet assembly 4 and a cooperation therebetween on the basis of the first embodiment, and is different from the first embodiment in that: the electromagnet assembly 5 comprises a third electromagnet 20, the permanent magnet assembly 4 comprises a third permanent magnet 10 arranged on the outer side of the supporting sleeve body 9, the magnetic pole orientation of the third electromagnet 20 is arranged in a tangent manner with the motion track of the third permanent magnet 10, it should be noted that, because the electromagnet assembly 5 can drive the reaction cup accessory 3 to rotate, the motion track of the third permanent magnet 10 is a circular ring (as shown by a dotted line in the figure), and the magnetic pole orientation of the third electromagnet 20 is in a tangent manner with the circular ring. In addition, it is also different from the first embodiment in that the number of the third permanent magnets 10 may be only one.
In addition, since the third electromagnet 20 is energized with ac current, the third electromagnet 20 can repel and attract the third permanent magnet 10, thereby rotating the cuvette attachment 3. Optionally, the third electromagnet 20 is intermittently turned on (or called as pulse type conduction), so that loss of the rotational kinetic energy of the cuvette accessory 3 caused by the third electromagnet 20 is avoided, and the rotational speed of the cuvette accessory 3 is slowed down, so that the cuvette accessory 3 can more smoothly change the rotational direction.
To sum up, the reaction generating mechanism in the biochemical analyzer provided by the utility model can effectively improve the accuracy of the detection result of the biochemical analyzer; the reaction disk accessory electrically connected with the reaction disk body is arranged, so that subsequent maintenance is facilitated; the reaction disc is formed by splicing a plurality of fan-shaped blocks, and the fan-shaped blocks are respectively connected with the conductive slip ring in an inserting mode, so that the universality of the reaction generating mechanism is improved to a great extent, and the machine purchasing cost of a user is reduced.
The above mentioned is only the embodiment of the present invention, and not the limitation of the patent scope of the present invention, all the equivalent transformations made by the contents of the specification and the drawings, or the direct or indirect application in the related technical field, are included in the patent protection scope of the present invention.