CN210078552U - Delivery and application system for local anesthesia sustained-release drug-coated stents - Google Patents

Abstract

A delivery and application system of a local anesthesia slow-release drug coating stent; the utility model comprises a film coating layer and a conduit mechanism for conveying the film coating layer into a tube cavity and clinging to a bracket; a drug application layer for attaching a solid slow-release anesthetic and a particle bin layer for loading radioactive particles are uniformly distributed on the film coating layer; the catheter mechanism comprises a first sleeve, a second sleeve and a third sleeve, a guide wire penetrates through the third sleeve, and the laminating layer is sleeved in the first sleeve and is positioned between the second sleeve and the third sleeve; the utility model discloses in, through second sleeve pipe and the sheathed tube extension of third in the pipe mechanism, will overlap the laminating layer between them and pull open and paste on the support, utilize the medicine on the laminating layer to paste the layer on slowly-releasing anesthetic and carry out anesthesia and the intraformational radiation particle in particle storehouse and carry out radiotherapy, need not to take out original support and change iodine particle support, can not cause the secondary damage.

Description

Delivery and application system for local anesthesia sustained-release drug-coated stents

technical field

The utility model relates to the field of medical devices, in particular to a delivery and application system for a local anesthesia sustained-release drug-coated stent.

Background technique

Surgical resection is still the only radical approach for luminal tumors (luminal cancer, cholangiocarcinoma, intestinal tumor, intratracheal tumor, intravascular tumor thrombus, ureteral cancer, etc.). However, local infiltration and metastasis of distant organs have already occurred in most patients. For such patients, improving the quality of life and prolonging the survival period has become the main treatment goal. For example, metal stents are implanted in the lumen to open the narrow lumen to palliatively relieve the clinical symptoms of patients. The implanted metal stents often need to exceed the two ends of the tumor tissue by at least 2 cm. The physical expansion of the stent pushes the tumor tissue to the outside of the tube wall. The continuous expansion of metal stents leads to local discomfort in some patients. For example, tracheal stents cause continuous coughing, especially at night, which seriously affects the quality of life. The high-level luminal stent causes severe foreign body sensation in the patient, the intestinal stent causes the patient to experience severe abdominal pain, and the ureteral stent causes the patient to experience severe discomfort in the lumbosacral region. The use of local anesthetics (such as bupivacaine/lidoca) can significantly reduce the local discomfort of patients and improve the quality of life. Using modern coating drug-loading technology, such as PGLA, nano-coating, graphene, etc. as the carrier, the outer membrane of the local drug-carrying stent is released. After the metal stent is released, the local anesthetic drug is slowly released to reduce the stent implantation compression For symptoms such as related discomfort caused by tumors, because the drug is locally and continuously released in low doses, it will not cause related complications such as drug accumulation, which is worthy of further clinical promotion.

In addition, liver cancer is also a common clinical malignant tumor. Patients with liver cancer often form portal vein tumor thrombus due to tumor invasion of the portal vein, resulting in rapid disease progression and poor long-term survival. Therefore, the treatment of portal vein tumor thrombus plays a decisive role in the long-term survival of patients with liver cancer. External radiotherapy is often used clinically to treat portal vein tumor thrombi. However, due to the wide spread of tumor thrombus and its distribution along the tortuous vascular system, it is difficult to locate radiotherapy, and the patient’s liver moves due to breathing motion. In order to cover the tumor, it is necessary to expand external radiotherapy exposure. range and cause greater damage to the liver. Clinically, the palliative treatment plan mainly focuses on opening the portal vein lumen to restore the blood flow into the liver, thereby improving the quality of life of patients. It is necessary to use minimally invasive puncture techniques to implant portal vein stents to open blood vessels, but the stents can only open the lumen and have no therapeutic effect on the tumor. With the progress of the tumor, more than 50% of patients will have intra-stent resection within 3 months. Blockage occurs. Therefore, some domestic scholars use the short-range radioactive particles to form a chain structure, and use the interventional technology to press the 125I particle chain outside the stent, and control part of the tumor thrombus through the brachytherapy of the particles, thereby prolonging the patency time of the stent. However, due to the randomness of the implanted particle chains, often the particle chains are implanted into a non-tumor once, resulting in failure of brachytherapy. And clinical studies have shown that the use of particle chains can only prolong the patency time of 2-3 months. The reasons for the analysis are as follows: the number of particles is small, resulting in excessive dose cold zone; the particle chain is located on the opposite side of the tumor tissue, and after the stent is expanded, the particles are farther away from the tumor and cannot exert a better anti-tumor effect. Therefore, it is urgent to develop a complete set of helical 125I seed implantation system, on the one hand, to solve the problem of uneven dose distribution and reduce the dose cold zone. On the one hand, the tumor can be fully contacted with the particles, and the curative effect of brachytherapy can be improved.

SUMMARY OF THE INVENTION

In order to solve the above-mentioned problems, the purpose of this utility model is to provide a delivery and application system for a local anesthesia sustained-release drug-coated stent, which, through the elongation of the second cannula and the third cannula in the catheter mechanism, will be sleeved therebetween. The coating layer is pulled and attached to the stent, and the sustained-release anesthetic on the drug application layer on the coating layer is used for anesthesia and the radioactive particles in the particle chamber layer for radiotherapy without removing the original stent and replacing the iodine 125 particles. The bracket will not cause secondary damage.

The purpose of this utility model is to realize through the following technical solutions:

The utility model provides a delivery and application system for a local anesthesia sustained-release drug-coated stent, which comprises a film covering layer for tightly adhering to the stent and a film covering layer used for transporting the film covering layer into the lumen to be closely adhered In the catheter mechanism of the stent; the coating layer is evenly distributed with a drug application layer for attaching solid sustained-release anesthetics and a particle warehouse layer for loading radioactive particles; the catheter mechanism includes a first sleeve, a sleeve A second sleeve connected to the first sleeve and a third sleeve sleeved to the second sleeve, a guide wire is inserted through the third sleeve, and the coating layer is sleeved on the second sleeve. Inside the first sleeve and between the second sleeve and the third sleeve, after the third sleeve protrudes from the second sleeve, the coating layer is pulled apart and attached to the stent .

As an improvement of the present invention, the first sleeve is provided with a retraction cavity, the outer wall of the lower end of the second sleeve is connected with an upper layer balloon, and the outer wall of the lower end of the third sleeve is connected with a lower layer balloon The upper layer balloon and the lower layer balloon can be folded in the retracting cavity; a first airway is arranged in the first sleeve, a first inflation tube is arranged in the first airway, and the upper layer balloon passes through The first inflatable tube is communicated with the first inflatable one-way valve joint; the third sleeve is provided with a second airway, the second airway is provided with a second inflatable tube, and the lower-layer balloon passes through the The second inflation tube communicates with the second inflation check valve joint.

As a further improvement of the present invention, both the upper-layer balloon and the lower-layer balloon are provided with two balloon cavities.

As a further improvement of the present invention, the upper and lower ends of the coating layer are provided with clamp rings, and the clamp rings are provided with bracket clamping grooves for being clamped on the support.

As a further improvement of the present utility model, two sustained-release anesthetic chambers for storing sustained-release anesthetics are provided on the collar, and a collar penetration hole is provided on the sustained-release anesthetic chambers.

As a further improvement of the present invention, the two sustained-release anesthetic chambers are communicated through a communication groove.

As a further improvement of the present invention, the collar is provided with an inclined surface, and the outer rings of the upper-layer balloon and the lower-layer balloon are provided with a receding groove surface matching the inclined surface.

As a further improvement of the present invention, the drug application layer is provided with a plurality of membrane permeable holes.

As a further improvement of the present invention, the first sleeve is provided with a helical retracting tube, the lower end of the third sleeve is provided with a catheter head, and a tightening sleeve is coaxially connected to the catheter head, and the first sleeve is A clamping bracket is sheathed between the two sleeves and the tightening sleeve, the helical retracting tube can sheath the clamping bracket, and the coating layer is sheathed between the clamping bracket and the spiral retracting tube.

As a further improvement of the present invention, the first sleeve, the second sleeve and the third sleeve are all provided with handle ends.

In the present utility model, through the extension of the second sleeve and the third sleeve in the catheter mechanism, the film covering between them is pulled apart and attached to the stent, and the drug application layer on the film is used to slow down the Release anesthesia for anesthesia and radioactive particles in the particle compartment layer for radiotherapy without removing the original stent and replacing the iodine particle stent, which will not cause secondary damage.

Description of drawings

The accompanying drawings described here are used to provide further understanding of the present invention and constitute a part of the present application. The schematic embodiments and descriptions of the present invention are used to explain the present invention and do not constitute an improper limitation of the present invention. In the attached image:

Fig. 1 is the structural representation of the utility model;

Fig. 2 is the front view of the utility model;

FIG. 3 is a schematic diagram 1 of the close contact structure between the coating layer and the stent of the present invention;

FIG. 4 is a second schematic diagram of the close contact structure between the coating layer and the stent of the present invention;

Fig. 5 is the first structural schematic diagram of the coating layer of the present invention;

Fig. 6 is the structural schematic diagram 1 of the collar of the utility model;

Fig. 7 is the structural representation 2 of the collar of the utility model;

8 is a second structural schematic diagram of the coating layer of the present invention;

Fig. 9 is the structural schematic diagram three of the coating layer of the present invention;

10 is a schematic diagram 1 of the internal structure of the catheter mechanism of the present invention;

11 is a second schematic diagram of the internal structure of the catheter mechanism of the present invention;

12 is a schematic diagram three of the internal structure of the catheter mechanism of the present invention;

13 is a schematic diagram 4 of the internal structure of the catheter mechanism of the present invention;

14 is a schematic diagram five of the internal structure of the catheter mechanism of the present invention;

15 is a schematic diagram of the connection structure of the upper layer balloon and the collar of the present invention;

16 is a schematic structural diagram 1 of Embodiment 1 of the present invention;

17 is a second schematic structural diagram of Embodiment 1 of the present invention;

FIG. 18 is a schematic diagram 1 of the development of Embodiment 1 of the present invention;

Fig. 19 is the expanded schematic diagram 2 of Embodiment 1 of the present utility model;

20 is a schematic diagram of the connection structure of the clamping bracket and the bracket of the present invention;

FIG. 21 is a schematic diagram 1 of the connection structure of the clamping bracket of the present invention;

Figure 22 is a second schematic diagram of the connection structure of the clamping bracket of the present invention;

Fig. 23 is the first structural schematic diagram of the clamping bracket, the coating layer and the bracket of the clamping bracket of the present invention;

24 is a second structural schematic diagram of the clamping bracket, the coating layer and the bracket of the clamping bracket of the present invention;

25 is an exploded schematic diagram of the connection structure of the clamping bracket, the coating layer and the bracket of the clamping bracket of the present invention;

Figure 26 is the first structural schematic diagram of the spiral retractable tube of the present invention;

Fig. 27 is the second structural schematic diagram of the helical retracting tube of the present invention;

Fig. 28 is an internal schematic view of the helical retracting tube of the present invention.

The reference numerals are: 1-coating layer, 11-drug application layer, 111-membrane permeation hole, 12-particle storage layer, 13-clamping ring, 131-support clamping groove, 132-sustained-release anesthetic Cavity, 133-communication groove, 134-bevel, 135-collar penetration hole, 2-catheter mechanism, 21-first sleeve, 211-retraction cavity, 212-first airway, 213-first inflation tube, 214 -The first inflatable one-way valve joint, 215-the second airway, 216-the second inflatable tube, 217-the second inflatable one-way valve joint, 218-spiral retracting tube, 22-the second sleeve, 221-the upper ball Balloon, 222-Balloon cavity, 223-Give way groove surface, 23-Third cannula, 231-Lower balloon, 24-Guide wire, 25-Handle end, 3-Stand.

Detailed ways

In order to enable those skilled in the art to better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention will be described clearly and completely below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described The embodiments are only some of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.

As shown in Fig. 1 to Fig. 28 , a delivery and application system for a local anesthesia sustained-release drug-coated stent of the present invention includes a coating layer 1 for closely adhering to the stent 3 and a coating layer 1 for attaching the coating layer 1 to the stent 3. It is delivered to the catheter mechanism 2 that is closely attached to the stent 3 in the lumen.

As shown in FIG. 5 , a drug application layer 11 for attaching solid sustained-release anesthetics and a particle chamber layer 12 for loading radioactive particles are uniformly distributed on the coating layer 1 .

The catheter mechanism 2 includes a first sleeve 21 , a second sleeve 22 sleeved in the first sleeve 21 and a third sleeve 23 sleeved in the second sleeve 22 , and the third sleeve 23 penetrates therethrough. The guide wire 24, the coating layer 1 is sheathed in the first cannula 21 and between the second cannula 22 and the third cannula 23, and the third cannula 23 extends from the second cannula 22 to cover the film Layer 1 is pulled apart and attached to bracket 3.

In the present invention, through the elongation of the second sleeve 22 and the third sleeve 23 in the catheter mechanism 2, the covering layer 1 between them is pulled apart and attached to the stent 3, and the The sustained-release anesthetic on the drug application layer 11 is used for anesthesia and the radioactive particles in the particle storage layer 12 are used for radiotherapy. There is no need to take out the original stent and replace the iodine 125 particle stent, which will not cause secondary damage.

The stent 3 is originally existing in the inner wall of the patient's lumen to function as a channel, the structure of the stent 3 is of a braided type, and the braided wire mesh of the stent 3 is made of a nickel-titanium alloy material. The length and circumference of the stent 3 are matched with a coating layer 1 . The coating layer 1 is cylindrical and can be closely attached to the inner side of the stent 3 when it is opened. The coating layer 1 is formed of a polymer flexible material. On the coating layer 1 of the mesh of the stent 3, a drug application layer 11 and a particle storage layer 12 are arranged at circumferential intervals. The drug application layer 11 and the particle storage layer 12 are uniformly distributed in several circumferential spirals along the axial direction of the outer wall of the stent 3 on the membrane of the mesh hole of the stent 3 . Bar-shaped iodine 125 particles are loaded in the particle warehouse layer 12, and a solid sustained-release anesthetic is attached to the inside of the drug application layer 11. The sustained-release anesthetic is in the shape of a round cake, which can make the surface fit to the patient's lumen wall to the greatest extent possible. anesthesia on. The particle compartment layer 12 adopts a single helix to be evenly distributed at the mesh hole of the stent 3, and this design enables the drugs covered by the stent and the iodine 125 particles to perform radiotherapy and drug-assisted treatment on the tumor site in the lumen area as a whole; The outer layer of the drug application layer 11 of the coating layer 1 is provided with a plurality of coating permeation holes 111 , and the membrane permeation holes 111 are conducive to the penetration of drugs, making it more convenient for drug treatment of tumors in the lumen area.

As shown in FIG. 3 , FIG. 6 and FIG. 7 , the upper and lower ends of the coating layer 1 are provided with collars 13 , and the collars 13 are provided with bracket clamping grooves 131 for clamping on the bracket 3 ; There are two sustained-release anesthetic chambers 132 for storing sustained-release anesthetics, and the sustained-release anesthetic chambers 132 are provided with collar penetration holes 135; the two sustained-release anesthetic chambers 132 communicate with each other through a communication groove 133; The layer 11 is provided with a number of membrane permeable holes 111; specifically, an annular collar 13 is connected to the upper and lower end ports of the cylindrical membrane layer 1, and the collar 13 is made of a medical polymer material with elastic deformation characteristics. to make. A ring-shaped bracket clamping groove 131 is circumferentially provided on the corresponding end surfaces of the collar 13 toward the upper and lower end surfaces of the bracket 3, and the bracket clamping groove 131 is provided with a gap on the circumference of the facing surface of the upper and lower end surfaces of the bracket 3, and the bracket clamping groove 131 clamps the cross-section It exceeds the semicircular area and matches the thickness of the braided mesh of the stent 3, so that the stent clamping groove 131 can clamp the stent mesh at the upper and lower ports of the stent 3. After tightening, the coating layer 1 can be tightened to closely fit the inner side wall of the bracket 3; as shown in Figures 6 and 7, the outer side and the upper side bevel of the bracket clamping groove 131 inside the collar 13 There are respectively designed annular cavities as slow-release anesthetic chambers 132. Slow-release anesthetics are housed in the sustained-release anesthetic chambers 132. A number of cards are evenly opened on the outer side walls of the two annular slow-release anesthetic chambers 132. The ring penetration hole 135, the collar penetration hole 135 can allow the internal sustained-release anesthetic to penetrate into the patient's lumen wall to achieve anesthesia effect. A space is set between the two slow-release anesthetic chambers 135 in the oblique angle of the collar 13 and in the outer side wall, and a plurality of communication grooves 133 are evenly arranged on the circumference of the spaced surface, so that the internal liquid state of the two slow-release anesthetic chambers 132 is convenient. The sustained-release anesthetic liquid can penetrate and communicate with each other, preventing one cavity of the liquid from drying up and unable to anesthetize the lumen wall.

As shown in FIG. 10 to FIG. 14 , a retraction cavity 211 is arranged in the first sleeve 21 , an upper layer balloon 221 is connected to the outer wall of the lower end of the second sleeve 22 , and a lower layer ball is connected to the outer wall of the lower end of the third sleeve 23 The bag 231, the retracting cavity 211 can retract the upper layer balloon 221 and the lower layer balloon 231; the first sleeve 21 is provided with a first airway 212, the first airway 212 is provided with a first inflation tube 213, and the upper layer balloon 221 The first inflation tube 213 communicates with the first inflation check valve joint 214; the third sleeve 21 is provided with a second air passage 215, the second air passage 215 is provided with a second inflation tube 216, and the lower layer balloon 231 passes through The second inflatable tube 216 communicates with the second inflatable one-way valve joint 217; as shown in FIG. 10 and FIG. 15, the upper layer balloon 221 and the lower layer balloon 231 are both provided with two balloon cavities 222; specifically, the catheter mechanism 2. The outermost layer is the first sleeve 21. The lower end surface of the first sleeve 21 is provided with a retracting cavity 211 with a certain depth of blind holes in the axial direction. A font-shaped handle end 25 is fixedly arranged on the outer wall of the upper end of the first sleeve 21, and the handle end 25 is convenient for hand-held control of push-pull and anti-rotation functions. A second sleeve 22 is sleeved at the through hole at the axial center of the first sleeve 21. The outer wall of the upper end of the second sleeve 22 is provided with a handle end 25 that is the same as that of the first sleeve 21. An upper layer balloon 221 is arranged on the outer wall of the lower end port of the tube 22, the upper layer balloon 221 is in the shape of a round cake when inflated and filled, and a spacer layer is arranged at the middle height of the upper layer balloon 221 to be separated into two balloon cavities 222, respectively. There are one cavity for the upper balloon and two cavities for the upper balloon. The purpose of arranging two cavities through the spacer layer is to support the spacer layer, so that the upper layer balloon 221 has a certain strength in the middle position of the outer ring after filling, which is not as easy as other areas of the upper layer balloon 221 after being pressed. Sag deformation. A first airway 212 is axially opened inside the side wall of the first sleeve 21 . The lower end of the first airway 212 is provided with ventilation holes in the first cavity and the second cavity of the upper layer balloon, respectively. A first inflation tube 213 is connected to the port of an airway 212 , and a first inflation check valve joint 214 is connected to the end of the first inflation tube 213 . The chambers are inflated simultaneously. A third sleeve 23 is sleeved inside the second sleeve 22 , a font handle end 25 is also provided on the side wall of the upper end of the third sleeve 23 , and a lower layer is provided on the outer wall of the lower end of the third sleeve 23 The structure of the balloon 231 and the lower layer balloon 231 is the same as that of the upper layer balloon 221. The lower layer balloon 231 is also divided into two cavities through the middle spacer layer, and the outer ring circumferential abdication groove surface 223 is the same after the lower layer balloon 231 is inflated and filled. It can be stuck at the inclined surface 134 of the lower collar 13 . The retraction cavity 211 at the lower end of the first sleeve 21 has a certain length, and can receive and retract the upper layer balloon 221 , the related structures of the membrane layer 1 , and the lower layer balloon 231 in sequence. A second airway 215 is axially arranged inside the tube wall of the third sleeve 23 , and the second airway 215 has small holes as ventilation holes at the tube walls of the two cavities of the lower layer balloon 231 . A second inflation tube 216 and a second inflation one-way valve joint 217 are connected to the upper end of the lower layer balloon 231 for inflation. A guide wire 24 is inserted through the axial center of the third cannula 23 for guiding when the catheter is advanced in the body.

In the present utility model, the bevel 134 is provided on the collar 13, and the outer rings of the upper layer balloon 221 and the lower layer balloon 231 are provided with a receding groove surface 223 that matches the bevel 134; specifically, between the collar 13 and the bracket The angle of the end face away from the 3 ports is set as the slope 134, and the outside is long and the inside is short, so that the slope 134 is inclined from the outside to the inside. The circumferential outer ring of the upper layer balloon 221 is designed as an abdication groove surface 223 that matches the inclined surface 134 of the clip ring 13, so that the upper layer balloon 221 can fit the clip ring 13 after being inflated, and the upper layer balloon 223 The spacer layer is located at the height of the circumferential groove surface, which can stabilize the collar.

When it is necessary to perform iodine 125 particle radiation therapy on 3 parts of the stent inside the patient's lumen, the first cannula 21, the second cannula 22, the third cannula 23, and the guide wire 25 are inserted in sequence in the initial state, and the first cannula Between the upper layer balloon 221 and the lower layer balloon 231 folded in the lower section of the tube 21, the relevant structure of the covering layer 1 is filled, and when the tube is transported to the catheter mechanism 2 to the position of the patient stent 3, the first sleeve 21 is pulled upward to make the first sleeve 21. Both the lower ends of the second sleeve 22 and the third sleeve 23 can be exposed. First inflate the second inflatable one-way valve joint 217, the gas enters the lower layer balloon 231 through the second airway 215 inside the tube wall of the third sleeve 23 to expand and fill, and the lower layer balloon 231 drives the lower collar 13 to support to a circular shape, and clamp the bracket clamping groove 131 of the collar 13 at the port of the bracket 3 . When the lower collar 13 clamps the lower end of the bracket 3, the upper upper layer balloon 221 is inflated and inflated through the same operation as above, and the upper collar 13 is clamped to the port on the upper end of the bracket 3, and the collar 13 is clamped and fixed. During the process, it should be noted that the particle warehouse 12 of the coating layer 1 and the drug application layer 11 are corresponding to the braided mesh of the stent 3, so that the particle warehouse layer 12 and the drug application layer 11 can contact the lumen wall tissue so as to prevent them from being damaged. Peripheral tumor with particle radiation therapy and anesthesia sustained release effect. After the upper and lower collars 13 are clamped and fixed, the coating layer 1 can be closely attached to the inner wall of the bracket, and the upper and lower clamps face each other to make the entire structure more stable. The sustained-release anesthetic cavity 132 of the upper and lower collars 13 can always release anesthetic liquid to the patient's lumen wall while being firmly clamped. The iodine 125 in layer 12 treats the tumor.

The delivery and application system of the local anesthesia sustained-release drug-coated stent has the following advantages:

1. The coating layer 1 exists separately from the stent 3, so that the patient can treat the tumor at the inner wall of the lumen by keeping the coating layer 1 and the original stent 3 relatively fixed without replacing the stent 3, thus avoiding the need for the replacement of the stent 3. Unnecessary injury to patients and an increase in surgical treatment costs are caused; at the same time, this design also enables the covering layer 1 to be easily replaced or withdrawn, which provides great convenience for subsequent surgical operations. Several spirally-arranged particle warehouse layers 12 evenly distributed on the circumference of the coating layer 1 and the drug application layer 11 designed with a number of membrane permeable holes 111 can be loaded with iodine 125 particles and slow-release anesthetics to treat tumors.

2. The bracket clamping groove 131 provided on the collar 13 connecting the upper and lower ends of the coating layer 1 is convenient for clamping the upper and lower ports of the bracket 3, so that the coating layer 1 and the bracket 3 are clamped and fixed in the opposite direction and cannot be loosened. 13. The two interconnected slow-release anesthetic chambers 132 designed at the upper and lower positions on the outer side pass through the collar penetration holes 135 on the outer side wall, so that the sustained-release anesthetic in the chamber can continuously and stably play a sustained-release anesthetic effect on the inner wall of the lumen.

3. The inclined surfaces 134 at the ports of the upper and lower collars 13 are designed to fit the upper and lower balloons 221 and 231 in the middle of the abdication groove surface 223 of the outer ring. The collar 13 is fastened at the port of the bracket 3 . The purpose of setting two cavities through the spacer layer is to support the spacer layer, so that the upper layer balloon 221 has a certain strength in the middle position of the outer ring after filling, which is not as easy as other areas of the upper layer balloon 231 after being pressed. Sag deformation.

In the present invention, as shown in FIGS. 15 to 28 , the present invention provides a first embodiment. In the first embodiment, the first sleeve 21 is provided with a helical retracting tube 218 , and the third sleeve 23 is provided with a helical retracting tube 218 . The lower end is provided with a catheter head 232, the catheter head 232 is coaxially connected with a tightening sleeve 233, a clamping bracket 224 is sleeved between the second sleeve 22 and the tightening sleeve 233, and the spiral retracting tube 218 can be sleeved on the clamping bracket 224 , the coating layer 1 is sheathed between the clamping bracket 224 and the helical retracting tube 218; the first sleeve 21, the second sleeve 22 and the third sleeve 23 are all provided with a handle end 25; specifically, the catheter mechanism 2 From the outside to the inside, the first sleeve 21 is also sheathed with the second sleeve 22 and the third sleeve 23 in sequence, and the first sleeve 21, the second sleeve 22 and the third sleeve 23 are set at the rear of the operating end. The type handle end 25 is consistent with the aforementioned catheter mechanism 2 . The inside of the retracting cavity 211 at the lower end of the first sleeve 21 is provided with a spiral retracting tube 218. The spiral retracting tube 218 is cylindrical as a whole, and the inner wall of the spiral retracting tube 218 is in the shape of a number of spiral ridges that are evenly distributed around the axis. . The length of the spirally retracting tube 218 is longer than that of the clamping bracket 224 in an elongated and tightened state, so that the clamping bracket 224 can be completely retracted into the inside of the spirally retracting tube 218 . The inner wall at the front end port of the second sleeve 22 sheathed inside the first sleeve 21 is designed as a stepped structure to a certain depth inward, so that the wall thickness of the inner wall at the front end port of the second sleeve 22 is smaller than the rest of the positions. A third sleeve 23 is sleeved inside the second sleeve 22, the front section of the third sleeve 23 can extend out of the second sleeve 22 and a certain distance, and a conical shape is coaxially and fixedly connected at the front end port of the third sleeve 23 The catheter head 232 is coaxially fixed with a tightening sleeve 233 on the rear end surface of the catheter head 232. The tightening sleeve 233 is in the shape of a sleeve as a whole, and the tightening sleeve 233 is clearance fit on the third sleeve 23. The inner wall is connected to the third sleeve. The tube wall of the sleeve 23 is spaced apart. A clamping bracket 224 is sleeved between the front section of the second sleeve 22 sleeved on the third sleeve 23 and the inner wall of the tightening sleeve 233 and the tube wall of the third sleeve 23 , and the clamping bracket 224 is longer than the bracket 3 . The front end of the second sleeve 22 and the tightening sleeves 233 are respectively fastened to the two ends of the clamping bracket 224. When the first sleeve 21 is pushed forward to the catheter head 232, the spiral retracting tube 218 at the front end of the first sleeve 21 It can be sleeved on the outside of the clamping bracket 224 . When the spiral retracting tube 218 is withdrawn to expose the clamping bracket 224, the relative distance between the second sleeve 22 and the tightening sleeve 233 is increased by controlling the handle ends of the second sleeve 22 and the third sleeve 23 by hand. The clamping bracket 224 can be released. The coating layer 1 is sheathed between the clamping bracket 224 and the spiral retracting tube 218 , and the structure of the coating layer 1 in the first embodiment is the same as that of the coating layer 1 described above, and will not be repeated here.

In the first embodiment, in the initial state, the clamping bracket 224 is first pulled to a slender shape, and the two ends are respectively wrapped around the front section of the second sleeve 22 and the rear end of the catheter head 232. Wrap it around the outer periphery of the clamping bracket 224 , and push the first sleeve 21 forward so that the clamping bracket 224 and the coating layer 1 are both retracted and sleeved inside the spiral retracting tube 218 . The spiral ridge-shaped sharp corners on the inner wall of the spiral retracting tube 218 evenly distributed in the axial direction can prevent the relative slippage or even slippage of the coating layer 1 and the clamping bracket 224. When the second sleeve 22 and the third sleeve 23 are pulled backwards to drive the helical retracting tube 218 to gradually release the coating layer 1 and the clamping bracket 224, the spiral ridge-type sharp corners on the inner wall of the spiral retracting tube 218 can always be used to release the unreleased The film layer 1 and the clamping bracket 224 of the segment play a stabilizing role, and the film layer 1 and the clamping bracket 224 can be kept relatively fixed until the film layer 1 and the clamping bracket 224 are completely separated from the spiral retractable tube 218 . When the helical retracting tube 218 follows the first sleeve 21 and is pulled back to completely release the tightening sleeve and the clamping bracket 224 , only the front end stage of the second sleeve 22 and the tightening sleeve 233 are left to tighten the two ends of the clamping bracket 224 , while pushing the second sleeve 22 forward and pulling the third sleeve 23 backward, so that the relative distance between the second sleeve 22 and the tightening sleeve 233 becomes smaller, and the end face of the second sleeve 22 and the tightening sleeve 233 Under the pushing action of the rear end surface of the front-end catheter head 232, the middle section of the clamping bracket 224 expands and bulges, so that the clamping bracket 223 is formed into a shape with two ends thin and thick in the middle, and the middle section of the clamping bracket 224 supports the coating layer 1 to the same position as the other. The intraluminal stent 3 is tightly attached. After the relative position of the coating layer 1 and the stent 3 is determined correctly, the third sleeve 23 is pushed forward, and the third sleeve 23 drives the tightening sleeve 233 to push forward, so that the front end port of the clamping bracket 224 is gradually separated from the tightening 233 Finally, the front end of the clamping bracket 224 is completely released to the inner wall of the lumen, so that the clamping bracket 224 is relatively fixed to the lumen wall. At this time, the second sleeve 22 is pulled back, and the other end of the clamping bracket 224 is released, so that the clamping bracket 224 is fully supported on the inner wall of the lumen, and the coating layer 1 is completely clamped between the bracket 3 and the clamping bracket 224 Tightly fix it, so that the cake-shaped solid sustained-release anesthetic of the coating layer 1 is combined with iodine 125 particles to treat the tumor on the inner wall of the lumen.

The first embodiment has the following advantages:

1. Use the clamping bracket 224 longer than the bracket 3 to clamp the covering layer 1 between the bracket 3 and the clamping bracket 224, so that the covering layer 1 is completely fixed so as to perform radiotherapy on the inner wall of the lumen. This method can According to the length and specifications of the original stent 3, the corresponding clamping stent can be arbitrarily replaced. It has a universal type and is convenient for doctors to treat. When the conventional covered stent sticks to the original stent because the length of the covered stent is too short, the treatment is insufficient or the coverage is too short. The too long membrane stent causes the drug to be suspended and cannot fit to the inner wall of the lumen and cannot be adequately treated.

2. The stage stage of the second sleeve 22 and the tightening sleeve 233 tighten the two ends of the clamping bracket 224, and the spiral retracting tube 218 tightens the middle section of the clamping bracket 224, so that the clamping bracket 224 can be completely tightened , and the helical ridge-type sharp corners on the inner wall of the helical retracting tube 218 play a stabilizing role in the unreleased section of the coating layer and the clamping bracket 224, which can be completely separated from the spiral retracting tube 218 when the coating layer 1 and the clamping bracket 224 are completely separated. The above two can be kept relatively fixed before, so that the clamping bracket 224 can control the coating layer 1 to fit to the exact position of the bracket 3, and the end face of the second sleeve 22 and the rear end face of the front end of the catheter head of the tightening sleeve 233 are pushed up. effect.

3. The middle section of the clamping stent 224 can be controlled to expand and bulge when released, so that the clamping stent 224 is formed into a shape with two thin ends and a thick middle. 3. It is closely attached, so that the coating layer 1 is closely attached to the alignment position and then completely released, which has a high fault tolerance rate, avoiding the situation that the traditional stent release method is directly released from the slender tightening state, and it cannot be slipped after the position is deviated. .

The above are only the preferred embodiments of the present invention. It should be pointed out that for those skilled in the art, without departing from the principles of the present invention, several improvements and modifications can be made. These improvements and Retouching should also be regarded as the protection scope of the present invention.

Claims (10)

1. the delivery and application system of the local anesthesia sustained-release drug-coated stent, is characterized in that, comprises the coating layer for being close to the stent and the coating layer for being transported to the lumen and being close to the stent. A catheter mechanism; a drug application layer for attaching solid sustained-release anesthetics and a particle chamber layer for loading radioactive particles are evenly distributed on the film layer; the catheter mechanism includes a first sleeve, sleeved on the A second sleeve in the first sleeve and a third sleeve sleeved in the second sleeve, a guide wire is inserted through the third sleeve, and the coating layer is sleeved on the first sleeve inside the tube and between the second sleeve and the third sleeve. After the third sleeve extends from the second sleeve, the coating layer is pulled apart and attached to the stent. 2 . The delivery and application system for a local anesthesia sustained-release drug-coated stent according to claim 1 , wherein the first sleeve is provided with a retraction cavity, and the outer wall of the lower end of the second sleeve is connected with a The upper-layer balloon, the lower-layer balloon is connected to the outer wall of the lower end of the third sleeve, and the retracting cavity can retract the upper-layer balloon and the lower-layer balloon; the first sleeve is provided with a first airway, so A first inflation tube is arranged in the first airway, and the upper layer balloon is communicated with the first inflation check valve joint through the first inflation tube; a second airway is arranged in the third sleeve, and the first inflation tube is A second inflation tube is arranged in the second air passage, and the lower-layer balloon communicates with the second inflation one-way valve joint through the second inflation tube. 3 . The delivery and application system for a local anesthesia sustained-release drug-coated stent according to claim 2 , wherein the upper-layer balloon and the lower-layer balloon are each provided with two balloon cavities. 4 . 4 . The delivery and application system for a local anesthesia sustained-release drug-coated stent according to claim 3 , wherein the upper and lower ends of the coating layer are provided with collars, and the collars are provided with The bracket clamping slot that snaps onto the bracket. 5 . The delivery and application system for a local anesthesia sustained-release drug-coated stent according to claim 4 , wherein two sustained-release anesthetic chambers for storing sustained-release anesthetics are provided on the collar, so the The said sustained-release anesthetic cavity is provided with a collar penetration hole. 6 . The delivery and application system for a local anesthetic sustained-release drug-coated stent according to claim 5 , wherein the two sustained-release anesthetic cavities communicate with each other through a communication groove. 7 . 7 . The delivery and application system for a local anesthesia sustained-release drug-coated stent according to claim 6 , wherein the collar is provided with a slope, and the outer rings of the upper-layer balloon and the lower-layer balloon An abdication groove surface matching the inclined surface is provided. 8 . The delivery and application system for a local anesthesia sustained-release drug-coated stent according to claim 7 , wherein the drug application layer is provided with a plurality of membrane-coated infiltration holes. 9 . 9 . The delivery and application system for a local anesthesia sustained-release drug-coated stent according to claim 1 , wherein the first sleeve is provided with a helical retracting tube, and the lower end of the third sleeve is provided with a catheter. 10 . A tightening sleeve is coaxially connected to the catheter head, a clamping bracket is sleeved between the second sleeve and the tightening sleeve, and the spiral shrinking tube can cover the clamping bracket. The coating layer is sheathed between the clamping bracket and the helical retracting tube. 10 . The delivery and application system for a local anesthesia sustained-release drug-coated stent according to claim 1 , wherein the first sleeve, the second sleeve and the third sleeve are all provided with handle ends. 11 .

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