CN210020444U - Composite disposable efficient and rapid liquid sterilization and purification device - Google Patents
Composite disposable efficient and rapid liquid sterilization and purification device Download PDFInfo
- Publication number
- CN210020444U CN210020444U CN201920138251.4U CN201920138251U CN210020444U CN 210020444 U CN210020444 U CN 210020444U CN 201920138251 U CN201920138251 U CN 201920138251U CN 210020444 U CN210020444 U CN 210020444U
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- Prior art keywords
- liquid
- composite
- purification device
- sterilization
- injection cup
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- 239000007788 liquid Substances 0.000 claims abstract description 69
- 239000012528 membrane Substances 0.000 claims abstract description 52
- 238000001914 filtration Methods 0.000 claims abstract description 40
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 26
- 238000002347 injection Methods 0.000 claims abstract description 24
- 239000007924 injection Substances 0.000 claims abstract description 24
- 230000001954 sterilising effect Effects 0.000 claims abstract description 21
- 238000000746 purification Methods 0.000 claims abstract description 19
- 150000001875 compounds Chemical class 0.000 claims abstract description 9
- 239000002131 composite material Substances 0.000 claims description 27
- 239000000463 material Substances 0.000 claims description 15
- 239000011148 porous material Substances 0.000 claims description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 5
- 238000002955 isolation Methods 0.000 claims description 5
- 230000002209 hydrophobic effect Effects 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 4
- 239000013060 biological fluid Substances 0.000 abstract description 3
- 239000002158 endotoxin Substances 0.000 abstract description 3
- 238000000926 separation method Methods 0.000 abstract description 3
- 239000003124 biologic agent Substances 0.000 abstract description 2
- 230000009849 deactivation Effects 0.000 abstract description 2
- 101100327917 Caenorhabditis elegans chup-1 gene Proteins 0.000 description 10
- 239000000523 sample Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 6
- 241000700605 Viruses Species 0.000 description 4
- 239000012488 sample solution Substances 0.000 description 4
- 230000004071 biological effect Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
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- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The utility model discloses a be applied to compound, multi-functional, simple and easy efficient integrated device of effects such as biological fluid or biological agent filtration, purification, disinfection, deactivation, the liquid can reach aseptic, virus-free, the ultra-clean state of no endotoxin after the filtration, and its technical scheme main points compound disposable high-efficient quick liquid sterilization purifier, including liquid injection cup, compound filtration membrane and collecting pipe, compound filtration membrane arranges liquid in and pours into the cup, and the collecting pipe is arranged liquid in and is poured into the bottom of the cup portion and pour into the cup intercommunication with liquid, the utility model is suitable for a biological fluid operation sterilization separation purification technical field.
Description
Technical Field
The utility model belongs to the technical field of biological liquid operation sterilization separation and purification.
Background
Liquid operation is the most extensive operation in the fields of life science and medicine research and development, and the separation and purification of reagents or cell, germ and virus culture media applied to various organisms belong to sterilization and purification treatment. The liquid with biological activity, such as bovine serum, vaccine and the like, needs to be sterilized at room temperature and cannot be sterilized by high temperature and high pressure. The most common operations in the market at present adopt a filter membrane with a certain pore size, such as a filter membrane with a permeation pore size of 0.2 micron, and the sample liquid is collected under an aseptic condition to achieve the sterilization effect, but in many cases, the virus or small active molecules, such as inflammatory factors, cannot be removed only through the filter membrane with the pore size of 0.2 micron, and the like, and at the moment, a new vessel and the filter membrane are replaced and filtered again for one to three times, so that the whole filtering process is time-consuming, labor-consuming and expensive, and many solutions with biological activity, such as antibody preparations, may be inactivated or denatured when the above operations are performed at room temperature.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a be applied to compound, multi-functional, simple and easy efficient integrated device of effects such as biological fluid or biological agent filtration, purification, disinfection, deactivation, the liquid can reach aseptic, no virus, no endotoxin's super clean state after the filtration.
The purpose of the utility model is realized like this: the utility model provides a compound disposable high-efficient quick liquid sterilization purifier which characterized in that: the device comprises a liquid injection cup, a composite filtering membrane and a collecting pipe, wherein the composite filtering membrane is arranged in the liquid injection cup, and the collecting pipe is arranged at the bottom of the liquid injection cup and is communicated with the liquid injection cup.
The utility model discloses further set up to: the composite filtering membrane comprises an upper filtering membrane, a support and a lower filtering membrane which are sequentially arranged from top to bottom.
The utility model discloses further set up to: the pore diameter of the upper filter membrane is 0.2-0.8 μm, and the pore diameter of the lower filter membrane is 0.1 μm.
The utility model discloses further set up to: the material of the support is one or a combination of more of inert materials, hydrophilic materials, hydrophobic materials or activated carbon.
The utility model discloses further set up to: the liquid injection cup is internally provided with a liquid collection plate arranged below the composite filtering membrane, the upper surface of the liquid collection plate is provided with a plurality of micro channels with annular structures and a plurality of radially arranged sub channels, and a main channel communicated with the centers of the sub channels is also arranged below the liquid collection plate.
The utility model discloses further set up to: and a vacuumizing connecting device is arranged on the collecting pipe.
The utility model discloses further set up to: the top of the liquid injection cup is provided with an isolation cover.
The utility model discloses further set up to: and the inner wall of the collecting pipe is provided with a connecting part.
The use method of the composite disposable high-efficiency rapid liquid sterilization and purification device is characterized in that: the method comprises the following steps:
connecting a collecting bottle on a collecting pipe, connecting an air pump on a vacuumizing connecting device, injecting sample liquid into a liquid injection cup, and covering an isolation cover;
and secondly, starting the air pump, sequentially filtering the sample liquid by the upper filter membrane and the lower filter membrane, entering the micro channel, further entering the sub channel, further entering the main channel, and finally entering the collecting bottle to finish the disinfection and sterilization purification process.
By adopting the technical scheme, the method has the following advantages: the device has simple structure, can complete the sample treatment with various requirements such as filtration, purification, disinfection and sterilization, inactivation and the like by one-step filtration, is simple and quick, and is suitable for the treatment of any aqueous solution, biological reagent or biological solution; composite filtration is a sandwich design so that filtration can be performed at high pressure.
Drawings
FIG. 1 is a schematic sectional view of the present invention;
FIG. 2 is a schematic view of the sectional three-dimensional structure of the present invention;
FIG. 3 is a schematic structural diagram of the composite filtering membrane of the present invention;
FIG. 4 is a schematic structural view of the liquid collecting plate of the present invention;
the reference numbers in the figures are: 1. a liquid injection cup; 2. compounding a filtering membrane; 3. a collection pipe; 4. an upper filter membrane; 5. a support; 6. a lower layer filter membrane; 7. a liquid collecting plate; 8. micro-channel; 9. dividing channels; 10. a main channel; 11. a canal pipe; 12. a vacuum connection device; 13. an isolation cover; 14. a connecting portion.
Detailed Description
The invention will be further described in the following with reference to specific embodiments thereof, with reference to the accompanying drawings, in which figures 1 to 4:
the utility model provides a compound disposable high-efficient quick liquid sterilization purifier which characterized in that: the device comprises a liquid injection cup 1, a composite filtering membrane 2 and a collecting pipe 3, wherein the composite filtering membrane 2 is arranged in the liquid injection cup 1, and the collecting pipe 3 is arranged at the bottom of the liquid injection cup 1 and is communicated with the liquid injection cup 1.
The composite filtering membrane 2 comprises an upper filtering membrane 4, a support 5 and a lower filtering membrane 6 which are arranged from top to bottom in sequence.
The pore diameter of the upper filter membrane 4 is 0.2-0.8 μm, and the pore diameter of the lower filter membrane 6 is 0.1 μm.
The composite filtering membrane 2 adopts a multilayer sandwich structure design, the upper filtering membrane 4 is used for removing bacterial pollution, and the lower filtering membrane 6 is used for removing pollution such as endotoxin and virus.
The material of support 5 is one or more combinations in inert material, hydrophilic material, hydrophobic material or active carbon, the material of support 5 can be selected according to sample solution needs, and be the network structure by above-mentioned material preparation, be used for being in the same place with upper filter membrane 4 and lower floor's filter membrane 6 complex, support 5 plays the supporting role to upper filter membrane 4 and lower floor's filter membrane 6, make between upper filter membrane 4 and the lower floor's filter membrane 6 for separate the state, be convenient for sample solution flow to lower floor's filter membrane 6 by upper filter membrane 4 with higher speed, and above-mentioned material can remain stable in biological environment, can not take place chemical reaction, can not pollute sample solution.
The liquid injection cup 1 is internally provided with a liquid collection plate 7 arranged below the composite filtering membrane 2, the upper surface of the liquid collection plate 7 is provided with a plurality of micro channels 8 with annular structures and a plurality of radially arranged sub channels 9, the lower part of the liquid collection plate 7 is also provided with a main channel 10 communicated with the centers of the sub channels 9, each micro channel 8 is a plurality of small annular channels, bulges among the annular channels support and support the composite filtering membrane 2, each sub channel 9 is a plurality of strip-shaped channels, the sub channels 9 and the micro channels 8 are mutually staggered, the main channel 10 is positioned at the center of the liquid collection plate 7, sample liquid filtered by the composite filtering membrane 2 can enter the micro channels 8 and then converge into the sub channels 9 and finally converge into the main channels 10 and flow into the collecting bottles in the collecting pipe 3, the bottom of the liquid injection cup 1 is also provided with a channel pipe 11 communicated with the main channel 10 to play a role in guiding liquid, and the filtered sample liquid is prevented from being attached to the pipe wall of the collecting pipe, the collection effect is influenced, and the influence on the air pump is also avoided.
The collecting pipe 3 is provided with a vacuumizing connecting device 12, and the vacuumizing connecting device 12 can be a connecting pipe and is arranged on the pipe wall of the collecting pipe 3 and used for being connected with an air pump, so that the liquid injection cup 1 can be subjected to suction filtration, and the filtering speed is improved.
The top that the liquid pours into cup 1 is equipped with keeps apart lid 13, and the top that the liquid pours into cup 1 is open structure, and the easy to assemble collects liquid board 7 and compound filtration membrane 2 also conveniently pours into sample solution into.
Be equipped with connecting portion 14 on the inner wall of collecting pipe 3, connecting portion 14 can be thread structure or buckle structure, conveniently connects the receiving flask, improves and connects the leakproofness.
A use method of a composite disposable high-efficiency rapid liquid sterilization and purification device comprises the following steps:
firstly, a collecting bottle is connected on a collecting pipe 3, an air pump is connected on a vacuumizing connecting device 12, sample liquid is injected into a liquid injection cup 1, and an isolation cover 13 is covered;
and secondly, starting the air pump, sequentially filtering the sample liquid by the upper filter membrane 4 and the lower filter membrane 6, entering the micro channel 8, further entering the sub channel 9, further entering the main channel 10, and finally entering the collecting bottle to finish the disinfection and sterilization purification process.
The device has the advantages of simple use method, high efficiency and good applicability.
The above-mentioned embodiment is only the preferred embodiment of the present invention, and does not limit the protection scope of the present invention according to this, so: all equivalent changes made according to the structure, shape and principle of the utility model are covered within the protection scope of the utility model.
Claims (8)
1. The utility model provides a compound disposable high-efficient quick liquid sterilization purifier which characterized in that: the device comprises a liquid injection cup (1), a composite filtering membrane (2) and a collecting pipe (3), wherein the composite filtering membrane (2) is arranged in the liquid injection cup (1), and the collecting pipe (3) is arranged at the bottom of the liquid injection cup (1) and is communicated with the liquid injection cup (1).
2. The composite disposable high-efficiency rapid liquid sterilization and purification device according to claim 1, which is characterized in that: the composite filtering membrane (2) comprises an upper filtering membrane (4), a support (5) and a lower filtering membrane (6) which are sequentially arranged from top to bottom.
3. The composite disposable high-efficiency rapid liquid sterilization and purification device according to claim 2, which is characterized in that: the pore diameter of the upper filter membrane (4) is 0.2-0.8 μm, and the pore diameter of the lower filter membrane (6) is 0.1 μm.
4. The composite disposable high-efficiency rapid liquid sterilization and purification device according to claim 2, which is characterized in that: the material of the support (5) is one or more of inert material, hydrophilic material, hydrophobic material or activated carbon.
5. The composite disposable high-efficiency rapid liquid sterilization and purification device according to claim 1, which is characterized in that: the liquid injection cup is characterized in that a liquid collection plate (7) arranged below the composite filtering membrane (2) is arranged in the liquid injection cup (1), a plurality of micro channels (8) of annular structures and a plurality of radially arranged sub channels (9) are arranged on the upper surface of the liquid collection plate (7), and a main channel (10) communicated with the centers of the sub channels (9) is further arranged below the liquid collection plate (7).
6. The composite disposable high-efficiency rapid liquid sterilization and purification device according to claim 1, which is characterized in that: and a vacuumizing connecting device (12) is arranged on the collecting pipe (3).
7. The composite disposable high-efficiency rapid liquid sterilization and purification device according to claim 1, which is characterized in that: the top of the liquid injection cup (1) is provided with an isolation cover (13).
8. The composite disposable high-efficiency rapid liquid sterilization and purification device according to claim 1, which is characterized in that: and a connecting part (14) is arranged on the inner wall of the collecting pipe (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920138251.4U CN210020444U (en) | 2019-01-26 | 2019-01-26 | Composite disposable efficient and rapid liquid sterilization and purification device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920138251.4U CN210020444U (en) | 2019-01-26 | 2019-01-26 | Composite disposable efficient and rapid liquid sterilization and purification device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210020444U true CN210020444U (en) | 2020-02-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920138251.4U Active CN210020444U (en) | 2019-01-26 | 2019-01-26 | Composite disposable efficient and rapid liquid sterilization and purification device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210020444U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109731107A (en) * | 2019-01-26 | 2019-05-10 | 临海市科晶生物科技有限公司 | A composite disposable high-efficiency and rapid liquid sterilization and purification device and its use method |
-
2019
- 2019-01-26 CN CN201920138251.4U patent/CN210020444U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109731107A (en) * | 2019-01-26 | 2019-05-10 | 临海市科晶生物科技有限公司 | A composite disposable high-efficiency and rapid liquid sterilization and purification device and its use method |
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