CN209797999U - Extraction and purification device for biochemical molecules - Google Patents
Extraction and purification device for biochemical molecules Download PDFInfo
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- CN209797999U CN209797999U CN201822153615.4U CN201822153615U CN209797999U CN 209797999 U CN209797999 U CN 209797999U CN 201822153615 U CN201822153615 U CN 201822153615U CN 209797999 U CN209797999 U CN 209797999U
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Abstract
The utility model discloses a biochemical molecule's extraction and purification device belongs to experiment consumptive material field. The device comprises: draw the post, draw the membrane, the interim block mechanism of liquid, and executive component, the one end of drawing the post is provided with the inlet, the other end of drawing the post is provided with the liquid outlet, draw membrane and the interim block mechanism of liquid and all install in drawing the post, the interim block mechanism of liquid is located the inlet and draws between the membrane, the interim block mechanism of liquid includes horizontal support portion and at least one portion that can break away from, the inner wall of drawing the post is located to the horizontal support portion card, be equipped with at least one mounting hole on the horizontal support portion, the quantity of mounting hole is the same with the quantity that can break away from the portion, install one in every mounting hole can break away from the portion, can break away from corresponding mounting hole with executive component phase-match and. The device does not need a manual liquid transfer device or an automatic mechanical arm and a mechanical liquid transfer device in the process of transferring liquid for extracting and purifying molecules such as nucleic acid.
Description
Technical Field
the utility model relates to an experiment consumptive material field, in particular to biochemical molecule draw purification device.
Background
Nucleic acid is a biological macromolecular compound formed by polymerizing a plurality of nucleotides and is widely existed in all animal and plant cells and microorganisms. Nucleic acids are widely used, and generally, a column method is used to extract and purify nucleic acids from biological tissues.
The column method comprises: firstly, adding liquid cells and various chemical reagents (such as cell lysis solution, nucleic acid release solution and the like) into a test tube, uniformly mixing, standing until the liquid cells are broken and nucleic acid in the cells is released into the solution so as to form a nucleic acid solution to be extracted; secondly, transferring the nucleic acid solution to be extracted from the test tube to a nucleic acid filter column or an adsorption column; the filter column and the adsorption column are respectively provided with a nucleic acid filtering membrane and an adsorption membrane, impurities in the nucleic acid solution to be extracted are filtered by the filter column or the nucleic acid is adsorbed by the adsorption column to obtain the extracted nucleic acid, and the extracted nucleic acid is purified by subsequent rinsing and elution.
In the process of implementing the present invention, the inventor finds that the prior art has at least the following problems: in the conventional column method, it is necessary to transfer a nucleic acid solution to be extracted from a test tube to a filter column or an adsorption column. Manual operation or a manipulator is needed to complete the transfer process, the manual liquid transfer increases the workload of operators, and certain accuracy is required; the manipulator has high cost and slow operation, and reduces the efficiency of extracting and purifying nucleic acid.
SUMMERY OF THE UTILITY MODEL
The embodiment of the utility model provides a biochemical molecule draws purification device, when adopting the device to draw molecules such as purification nucleic acid, need not to carry out the transfer of nucleic acid solution, can reduce operating personnel's work load, reduces the degree of difficulty of drawing purification nucleic acid, saves the cost, improves the efficiency of drawing purification nucleic acid. The technical scheme is as follows:
The utility model provides a biochemical molecule's extraction and purification device, the device includes: draw the post, draw membrane, the interim block mechanism of liquid and executive component, the one end of drawing the post is provided with the inlet, the other end of drawing the post is provided with the liquid outlet, draw the membrane with the interim block mechanism of liquid all install in draw in the post, the interim block mechanism of liquid is located the inlet with draw between the membrane, the interim block mechanism of liquid includes lateral support portion and at least one detachable portion, the lateral support portion card is located draw the inner wall of post, be equipped with at least one mounting hole on the lateral support portion, the quantity of mounting hole with the quantity of detachable portion is the same, every install one in the mounting hole detachable portion, detachable portion with executive component phase-match and under executive component's the effect break away from corresponding mounting hole.
Optionally, the detachable portion is a sheet or a round plug, and the lateral support portion is a sheet or a cylinder.
Optionally, the temporary liquid blocking mechanism further includes an outer longitudinal support portion, the outer longitudinal support portion is fixed to the outer side of the transverse support portion and perpendicular to the transverse support portion, and the transverse support portion is clamped on the inner wall of the extraction column through the outer longitudinal support portion.
Optionally, the detachable portion is sheet-shaped, and a plurality of discontinuous first strip-shaped holes are arranged between the detachable portion and the transverse support portion.
optionally, the detachable portion is a circular piece, and a plurality of discontinuous second strip-shaped holes are formed in the detachable portion in the radial direction.
Optionally, the detachable portion includes a first outer ring and a first inner ring, the first outer ring is provided with the plurality of discontinuous second strip-shaped holes along the radial direction, and a plurality of discontinuous third strip-shaped holes are provided between the first outer ring and the first inner ring.
Optionally, the widths of the first bar-shaped hole, the second bar-shaped hole and the third bar-shaped hole are all less than or equal to 0.2 mm.
Optionally, the transverse supporting portion is a circular plate, the outer longitudinal supporting portion includes an upper circular ring and a lower circular ring, and the transverse supporting portion is clamped between the upper circular ring and the lower circular ring.
Optionally, the detachable portion is a round plug, the transverse support portion is a round piece, the temporary liquid blocking mechanism further includes an inner longitudinal support portion, the inner longitudinal support portion is located inside the outer longitudinal support portion, the inner longitudinal support portion is fixed to an inner ring of the transverse support portion and perpendicular to the transverse support portion, the inner longitudinal support portion is a cylinder, and the detachable portion is clamped inside the inner longitudinal support portion.
Optionally, the inner longitudinal support portion is a bottom-sealed cylinder, the detachable portion is clamped in an opening of the inner longitudinal support portion, and at least one window hole is formed in an inner wall of the inner longitudinal support portion.
The embodiment of the utility model provides a beneficial effect that technical scheme brought is: through set up the temporary stop gear of liquid between inlet and extracting the membrane of extracting the column, the temporary stop gear of liquid includes horizontal supporting part and at least one can break away from the part, can break away from the part and install in the mounting hole that matches on the horizontal supporting part, like this, when each can break away from the part and all lie in corresponding mounting hole, the temporary stop gear of liquid forms the stock solution chamber with extracting the column, extract the column and have the function of the test tube, make it can hold liquid and realize the pretreatment of nucleic acid extraction purification, namely realize the course that the cell breaks; when the detachable part is detached from the corresponding mounting hole under the action of the execution part, the corresponding mounting hole forms a liquid leakage hole, and the liquid containing the nucleic acid flows down through the liquid leakage hole and passes through the extraction membrane to realize the extraction and purification of the nucleic acid. In the device, the liquid transfer process does not need to be completed by manually matching a liquid transfer device or using an automatic manipulator and a mechanical liquid transfer device. The device greatly reduced molecules such as nucleic acid and extracted the cost and accelerated the speed of extracting the purification, compare and moved the liquid and reduced operating personnel to nucleic acid extraction purification's work load in manual, reduce the degree of difficulty of extracting the purification nucleic acid, and the device small in size is light, saves the cost to the efficiency of nucleic acid extraction purification has been improved.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a schematic structural diagram of an apparatus for extracting and purifying biochemical molecules according to an embodiment of the present invention;
Fig. 2-11 are schematic structural diagrams of a temporary liquid blocking mechanism according to an embodiment of the present invention.
In the drawings, the parts are numbered as follows:
The device comprises a 1 extraction column, a 1a liquid inlet, a 1b liquid outlet, a 1c mounting hole, a 2 extraction film, a 3 liquid temporary blocking mechanism, a 31 transverse supporting part, a 31a second outer ring, a 31b second inner ring, a 31f inner longitudinal supporting part, a 31g window hole, a 32 detachable part, a 32b first strip-shaped hole, a 32c first outer ring, a 32d first inner ring, a 32f second strip-shaped hole, a 32g third strip-shaped hole, a 4 execution part and a 5 outer longitudinal supporting part.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer, embodiments of the present invention will be described in further detail below with reference to the accompanying drawings.
FIG. 1 is a device for extracting and purifying biochemical molecules according to an embodiment of the present invention. Referring to fig. 1, the apparatus includes: an extraction column 1, an extraction membrane 2, a liquid temporary blocking mechanism 3, and an actuator 4. Wherein, one end of the extraction column 1 is provided with a liquid inlet 1a, and the other end of the extraction column 1 is provided with a liquid outlet 1 b; the extraction membrane 2 and the liquid temporary blocking mechanism 3 are both arranged in the extraction column 1, and the liquid temporary blocking mechanism 3 is positioned between the liquid inlet 1a and the extraction membrane 2. Referring to fig. 2, the liquid temporary blocking mechanism 3 includes a lateral support 31 and at least one detachable portion 32; the lateral support 31 is engaged with the inner wall of the extraction column 1. Referring to fig. 3, the lateral support portion 31 is provided with at least one mounting hole 1c, the number of the mounting holes 1c is the same as the number of the detachable portions 32, and each mounting hole 1c is provided with one detachable portion 32; the disengageable portion 32 is fitted to the actuator 4 and disengaged from the corresponding mounting hole 1c by the actuator 4.
Through set up the temporary block mechanism 3 of liquid between loading port 1a and extraction membrane 2 of the extraction column 1, the temporary block mechanism 3 of liquid includes the horizontal support 31 and at least one can break away from the portion 32, can break away from the portion 32 and install in the mounting hole 1c that matches on the horizontal support 31, like this, when each can break away from the portion 32 and locate at corresponding mounting hole 1c, the temporary block mechanism 3 of liquid forms the liquid storage chamber with the extraction column 1, the extraction column 1 has the function of the test tube, make it can hold liquid and realize the pretreatment of nucleic acid extraction purification, namely realize the course of cell rupture; when the detachable part 32 is detached from the corresponding mounting hole 1c by the actuator 4, the corresponding mounting hole 1c forms a weep hole through which the nucleic acid-containing liquid flows down and passes through the extraction membrane 2, thereby extracting and purifying the nucleic acid. In the process, the liquid is transferred to the extraction membrane 2 from the liquid storage cavity, so that the liquid can be quickly and easily transferred. The device greatly reduced molecules such as nucleic acid and extracted the cost and accelerated the speed of extracting the purification, compare and moved the liquid and reduced operating personnel to nucleic acid extraction purification's work load in manual, reduce the degree of difficulty of extracting the purification nucleic acid, and the device small in size is light, saves the cost to the efficiency of nucleic acid extraction purification has been improved.
Illustratively, the material from which the detachable portion 32 and/or the lateral support portion 31 is made may be various plastics, rubbers, papers, glasses, leathers, resins, metals or alloys, aluminum foils, and the like.
Among them, the present embodiment provides the liquid temporary blocking mechanism 3 of two structures.
In the first structure, the liquid temporary blocking mechanism 3 is constituted only by the lateral support portion 31 and the detachable portion 32. The first structure is divided into two cases (a case and B case) again according to the structure of the detachable portion 32, and in the a case, the detachable portion 32 may be sheet-shaped (see fig. 1); in case B, the disengageable portion 32 may be a round plug.
In case a, the detachable portion 32 and the lateral support portion 31 are made of the same material and are integrated, and in this case, the whole liquid temporary blocking mechanism 3 may be shaped like a sheet. Illustratively, the detachable portion 32 may be a disk (see fig. 2), a triangular piece (see fig. 1), a snowflake-shaped piece (see fig. 3), or other various shaped pieces.
In case B, referring to fig. 4, the disengageable portion 32 may be a round plug, and the lateral support portion 31 may be a cylinder. The outer diameter of the detachable portion 32 is equal to or slightly smaller than the inner diameter of the corresponding mounting hole 1c, and the detachable portion 32 is caught in the corresponding mounting hole 1 c. Illustratively, referring to fig. 4, the transverse support 31 has a certain longitudinal thickness and is the same as the longitudinal thickness of the detachable portion 32. Furthermore, the bottom of the detachable portion 32 may have 1 or more protrusions to prevent the detachable portion 32 from coming off and reducing the contact between the lower surface thereof and the nucleic acid extracting membrane 2, which affects the extraction efficiency.
In a second structure, referring to fig. 5, the liquid temporary blocking mechanism 3 further includes an outer longitudinal support portion 5, the outer longitudinal support portion 5 is fixed on the outer side of the transverse support portion 31 and is perpendicular to the transverse support portion 31, and the transverse support portion 31 is clamped on the inner wall of the extraction column 1 through the outer longitudinal support portion 5 (see fig. 1). At this time, the liquid temporary blocking mechanism 3 is similar to a bottle cap or a cylinder in appearance.
The introduction of the outer longitudinal support 5 can provide a strong supporting force. The embodiment of the present invention does not limit the fixing manner of the outer longitudinal supporting portion 5 and the lateral supporting portion 31. Illustratively, when the materials of the outer longitudinal supporting portion 5 and the transverse supporting portion 31 are the same, such as plastics, the outer longitudinal supporting portion 5 and the transverse supporting portion 31 may be integrally formed into a cylinder or other shapes; when the material of the outer longitudinal support portion 5 is different from that of the transverse support portion 31, for example, the outer longitudinal support portion 5 is made of plastic, and the transverse support portion 31 is made of paper, a clamping member may be used to clamp the transverse support portion 31 to the outer longitudinal support portion 5. Based on this, the outer longitudinal support portion 5 includes an upper ring and a lower ring, and the lateral support portion 31 is interposed between the upper ring and the lower ring. In this way, the outer longitudinal support portion 5 has a double-ring structure, and the lateral support portion 31 is clamped between the double rings of the outer longitudinal support portion 5, so that the lateral support portion 31 can be fixed more favorably.
Wherein, the second structure is divided into two cases according to the structure of the detachable part 32, and in the first case, the detachable part 32 can be sheet-shaped; in the second case, the disengageable portion 32 can be a round plug.
In the first case, when the detachable portion 32 is in a sheet shape, the detachable portion 32 is easily detached from the mounting hole 1c by the actuator 4. Illustratively, referring to fig. 6, the detachable portion 32 is sheet-shaped, and a plurality of discontinuous first strip-shaped holes 32b are provided between the detachable portion 32 and the lateral support portion 31. When implemented, the transverse support 31 and the detachable portion 32 may be formed with various shapes of minute slits or dotted slits, but are not completely separated from each other. The width of the slit is determined according to specific conditions, and the principle is that the molecular solution cannot drip through the slit. Because the water molecules have a certain tension and if the gap is too small, it will not be permeable for a short time, so the width of the slit is related to the amount of solution in the column, the specific gravity and the pressure of the local air pressure on the slit, and in addition to the time the solution needs to stay in the column. When the width of the first stripe hole 32b is less than or equal to 0.2 mm, that is, the width of the slit is less than or equal to 0.2 mm, the test proves that the slit does not bleed out the molecular solution. Moreover, the slit liquid temporary blocking mechanism 3 is suitable for use in a high-throughput nucleic acid extraction apparatus such as a 96-throughput nucleic acid extraction apparatus in which the detachable portion 32 can be easily broken by the actuator 4 while being impermeable to liquid (i.e., the detachable portion 32 can be used as a test tube without being broken), because it is possible to simultaneously break the detachable portions 32 in a plurality of (e.g., 96) nucleic acid extraction cartridges 1, and if the liquid temporary blocking mechanism 3 is so constructed, the detachable portion 32 can be easily broken because the connecting portion between the detachable portion 32 and the lateral support portion 31 is actually partially separated.
Illustratively, referring to fig. 7, the detachable portion 32 is a circular plate, and a plurality of discontinuous second strip-shaped holes 32f are radially formed on the detachable portion 32. The detachable part 32 is easy to break at a plurality of positions through a plurality of discontinuous second strip-shaped holes 32f after being stressed, thereby forming a flow passage for liquid to pass through.
accordingly, when the detachable portion 32 is a circular piece, the lateral support portion 31 is a circular piece, while the lateral support portion 31 is a cylindrical or other shape integrated with the longitudinal support portion 5.
Based on the fact that the detachable portion 32 is provided with a plurality of discontinuous second strip-shaped holes 32f along the radial direction, for example, referring to fig. 7, the detachable portion 32 comprises a first outer ring 32c and a first inner ring 32d, the first outer ring 32c is provided with a plurality of discontinuous second strip-shaped holes 32f along the radial direction, and a plurality of discontinuous third strip-shaped holes 32g are provided between the first outer ring 32c and the first inner ring 32 d.
Illustratively, the widths of the first, second, and third bar apertures 32b, 32f, and 32g are each less than or equal to 0.2 millimeters.
Illustratively, when the detachable portion 32 is a circular disc and the lateral support portion 31 is a circular disc, referring to fig. 9, the lateral support portion 31 includes a second outer ring 31a and a second inner ring 31b, an outer edge of the second outer ring 31a contacts with an inner wall of the extraction column 1, a thickness of the second inner ring 31b is smaller than, greater than or equal to a thickness of the second outer ring 31a, and a thickness of the detachable portion 32 is smaller than, greater than or equal to a thickness of the second inner ring 31 b.
The user can act on the disengageable part 32 by means of the actuating member 4. Since the connection between the detachable portion 32 and the lateral support portion 31 is actually partially separated, the detachable portion 32 is likely to be broken at a plurality of positions by force, and thus a flow path for liquid to pass through is more easily formed.
In the second case, the disengageable portion 32 can be a round plug. Exemplarily, referring to fig. 10, when the detachable portion 32 is a round plug and the transverse support portion 31 is a round piece, the liquid temporary blocking mechanism 3 further includes an inner longitudinal support portion 31f, the inner longitudinal support portion 31f is located in the outer longitudinal support portion 5, the inner longitudinal support portion 31f is fixed to an inner ring of the transverse support portion 31 and is perpendicular to the transverse support portion 31, the inner longitudinal support portion 31f is a cylinder, and the detachable portion 32 is clamped in the inner longitudinal support portion 31 f.
Wherein, the space between the inner longitudinal support part 31f and the outer longitudinal support part 5 is hollow. Thus, the wall of the inner longitudinal supporting portion 31f has a transverse extensibility, and when the detachable portion 32 is detached from the hollow cylinder by an external force, the inner wall of the inner longitudinal supporting portion 31f can be extended to the outer hollow portion to make the detachable portion 32 easily detached.
Based on the introduction of the inner longitudinal support portion 31f, exemplarily, referring to fig. 11, the inner longitudinal support portion 31f is a bottom-sealed cylinder, the detachable portion 32 is clamped in the opening of the inner longitudinal support portion 31f, and the inner wall of the inner longitudinal support portion 31f is opened with at least one window hole 31 g. When the detachable portion 32 is detached from the corresponding mounting hole 1c, it will fall down to the bottom of the bottomed cylinder, and the molecular solution will flow out through the window hole 31 g. Such a design will avoid the detachable part 32 falling on the extraction membrane 2 and affecting the extraction and purification effect.
In the present embodiment, the extraction membrane 2 may be, for example, a filtration membrane or an adsorption membrane; the actuating member 4 may be a rod.
An exemplary operation of the device for extracting and purifying biochemical molecules provided in this embodiment is briefly described as follows: a user adds liquid cells and various chemical reagents (such as cell lysate and the like) into the extraction column 1, uniformly mixes the liquid cells and various chemical reagents through the execution component 4, and then stands the extraction column, so that after the cells are broken, nucleic acid in the cells is released into the solution to form a nucleic acid solution to be extracted and purified, the execution component 4 enables the detachable part 32 to be partially or completely detached from the mounting hole 1c, the nucleic acid solution to be extracted flows downwards to the extraction membrane 2 through the mounting hole 1c, impurities are filtered out by the extraction membrane 2 (a filtering membrane) or the nucleic acid is adsorbed by the extraction membrane 2 (an adsorption membrane), and the purpose of extracting the nucleic acid is realized through rinsing and eluting processes of the extraction membrane 2. The device is not only suitable for extracting and purifying nucleic acid molecules, but also suitable for extracting and purifying various biochemical molecules.
The above description is only for the preferred embodiment of the present invention, and is not intended to limit the present invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included within the protection scope of the present invention.
Claims (10)
1. An apparatus for extracting and purifying biochemical molecules, the apparatus comprising: extract post (1), extract membrane (2), liquid temporary blocking mechanism (3), and executive component (4), the one end of extracting post (1) is provided with inlet (1a), the other end of extracting post (1) is provided with liquid outlet (1b), it all installs in to extract membrane (2) and liquid temporary blocking mechanism (3) extract post (1), liquid temporary blocking mechanism (3) are located inlet (1a) with extract between the membrane (2), liquid temporary blocking mechanism (3) include horizontal supporting part (31) and at least one can break away from portion (32), horizontal supporting part (31) card is located extract the inner wall of post (1), be equipped with at least one mounting hole (1c) on horizontal supporting part (31), the quantity of mounting hole (1c) and the quantity of can break away from portion (32) the same, each mounting hole (1c) is internally provided with a detachable part (32), and the detachable part (32) is matched with the actuating component (4) and is detached from the corresponding mounting hole (1c) under the action of the actuating component (4).
2. Device according to claim 1, characterized in that said detachable portion (32) is a sheet or a plug and said transversal support (31) is a sheet or a cylinder.
3. The device according to claim 1, characterized in that the temporary liquid blocking means (3) further comprise an outer longitudinal support (5), the outer longitudinal support (5) being fixed outside the transverse support (31) and perpendicular to the transverse support (31), the transverse support (31) being clamped to the inner wall of the extraction column (1) by means of the outer longitudinal support (5).
4. Device according to claim 3, characterized in that said detachable portion (32) is sheet-like, and in that between said detachable portion (32) and said transverse support (31) there are provided several first strip-like holes (32b) which are not continuous.
5. The device according to claim 4, characterized in that said detachable portion (32) is a circular disk, said detachable portion (32) being provided with a plurality of second non-continuous holes (32f) along the radial direction.
6. Device according to claim 5, characterized in that said detachable portion (32) comprises a first outer ring (32c) and a first inner ring (32d), said first outer ring (32c) being provided with said plurality of second non-continuous strip-shaped holes (32f) in a radial direction, and said first outer ring (32c) and said first inner ring (32d) being provided with a plurality of third non-continuous strip-shaped holes (32g) therebetween.
7. The device according to claim 6, wherein the width of each of the first strip aperture (32b), the second strip aperture (32f), and the third strip aperture (32g) is less than or equal to 0.2 mm.
8. Device according to claim 3, characterized in that said transversal support (31) is a disc, said outer longitudinal support (5) comprising an upper ring and a lower ring, said transversal support (31) being interposed between said upper ring and said lower ring.
9. A device according to claim 3, wherein the disengageable portion (32) is a round plug, the transverse support (31) is a round disc, the temporary liquid blocking means (3) further comprise an inner longitudinal support (31f), the inner longitudinal support (31f) being located inside the outer longitudinal support (5), the inner longitudinal support (31f) being fixed to the inner ring of the transverse support (31) and perpendicular to the transverse support (31), the inner longitudinal support (31f) being a cylinder, the disengageable portion (32) being engaged inside the inner longitudinal support (31 f).
10. The device according to claim 9, characterized in that said inner longitudinal support (31f) is a closed bottom cylinder, said detachable portion (32) being engaged in an opening of said inner longitudinal support (31f), said inner longitudinal support (31f) having at least one window (31g) opened in its inner wall.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822153615.4U CN209797999U (en) | 2018-12-20 | 2018-12-20 | Extraction and purification device for biochemical molecules |
| PCT/CN2019/077621 WO2019174539A1 (en) | 2018-03-13 | 2019-03-11 | Nucleic acid extraction and purification device and biochemical molecule extraction and purification device |
| US16/971,652 US11680233B2 (en) | 2018-03-13 | 2019-03-11 | Nucleic acid extraction and purification device and biochemical molecule extraction and purification device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822153615.4U CN209797999U (en) | 2018-12-20 | 2018-12-20 | Extraction and purification device for biochemical molecules |
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| Publication Number | Publication Date |
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| CN209797999U true CN209797999U (en) | 2019-12-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201822153615.4U Active CN209797999U (en) | 2018-03-13 | 2018-12-20 | Extraction and purification device for biochemical molecules |
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| CN (1) | CN209797999U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023160091A1 (en) * | 2022-02-25 | 2023-08-31 | 武汉医蒂生物科技有限公司 | Purification column |
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2018
- 2018-12-20 CN CN201822153615.4U patent/CN209797999U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023160091A1 (en) * | 2022-02-25 | 2023-08-31 | 武汉医蒂生物科技有限公司 | Purification column |
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