CN209485981U - A kind of full-automatic SPR analyzer - Google Patents
A kind of full-automatic SPR analyzer Download PDFInfo
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- CN209485981U CN209485981U CN201822102822.7U CN201822102822U CN209485981U CN 209485981 U CN209485981 U CN 209485981U CN 201822102822 U CN201822102822 U CN 201822102822U CN 209485981 U CN209485981 U CN 209485981U
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- 239000007921 spray Substances 0.000 claims abstract description 83
- 238000004458 analytical method Methods 0.000 claims abstract description 20
- 238000005192 partition Methods 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims description 7
- 229910001209 Low-carbon steel Inorganic materials 0.000 claims description 4
- 238000012806 monitoring device Methods 0.000 abstract description 2
- 239000012472 biological sample Substances 0.000 description 14
- 238000010586 diagram Methods 0.000 description 3
- 230000001678 irradiating effect Effects 0.000 description 3
- 239000012528 membrane Substances 0.000 description 2
- 239000012491 analyte Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000012455 bioassay technique Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000009878 intermolecular interaction Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 239000002094 self assembled monolayer Substances 0.000 description 1
- 239000013545 self-assembled monolayer Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
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- Testing Resistance To Weather, Investigating Materials By Mechanical Methods (AREA)
Abstract
The utility model discloses a kind of full-automatic SPR analyzers, including work box, the front of work box is provided with station and observation platform, the outer surface of station is provided with display screen and indicator light, control panel and power switch are provided at the top of observation platform, work box is internally provided with baffle, the bottom of baffle is provided with partition, analysis plates are provided at the top of partition, first rotating shaft and the second shaft, pressure-sensitive diaphragm is provided at the top of analysis plates, the outer surface of first rotating shaft is provided with the first cylindrical lens, the outer surface of second shaft is provided with the second cylindrical lens, work roof box is provided at the top of work box, the bottom of work roof box is provided with prism and rotating disk, the outer surface of prism is provided with metallic film, the bottom of rotating disk is provided with spray tube, the bottom of spray tube is provided with spray head, the bottom of spray head is arranged There is spray port, therefore this kind of full-automatic SPR analyzer solves the problems, such as that staff is unable to real-time monitoring device operation conditions using indicator light.
Description
Technical field
The utility model relates to bioassay technique field, specially a kind of full-automatic SPR analyzer.
Background technique
Spr physically refers to surface plasma body resonant vibration, surface (interface usually between solid phase and liquid phase) plasma
Resonance is the optics professional technique for characterizing the change of surface refraction coefficient, and SPR can observe molecule combination, film shape in real time
At etc. superficial phenomena, and the signal of highly sensitive, highly selective while the smallest non-specific binding can be provided, application field includes
The formation and property of film, self assembled monolayer, the intermolecular interaction such as protein, nucleosides, pharmaceuticals, surfactant are made
With.
But it is existing, when staff carries out analysis work to biological sample, need manually fully to soak buffer
Enter in biological sample, complex for operation step, device not enough automates, and staff can not be to the analysis of biological sample
Variation in journey is observed work, various situations when device is run, and staff can not timely have found.
So how to design a kind of full-automatic SPR analyzer, becoming us will currently be solved the problems, such as.
Utility model content
The purpose of this utility model is to provide a kind of full-automatic SPR analyzers, to solve to propose in above-mentioned background technique
Staff the problem of being unable to real-time monitoring device operation conditions.
To achieve the above object, the utility model provides the following technical solutions: a kind of full-automatic SPR analyzer, including work
Make case, the bottom of the work box is provided with supporting leg, and the front of the work box is provided with station and observation platform, the behaviour
The outer surface for making platform is provided with display screen and indicator light, and control panel and power switch, institute are provided at the top of the observation platform
Power switch is stated to be flexibly connected with observation platform, the work box is internally provided with baffle, the bottom of the baffle be provided with every
Plate is provided with analysis plates, first rotating shaft and the second shaft at the top of the partition, is provided with sensing membrane at the top of the analysis plates
Piece, the pressure-sensitive diaphragm are combined closely with analysis plates, and the outer surface of the first rotating shaft is provided with the first cylindrical lens, and described
The outer surface of two shafts is provided with the second cylindrical lens, and work roof box, the work box are provided at the top of the work box
Buffer storage case is provided at the top of top plate, the buffer storage case is fixedly connected with work roof box, the work box
The bottom of top plate is provided with prism and rotating disk, and the outer surface of the prism is provided with metallic film, the bottom of the rotating disk
It is provided with spray tube, the bottom of the spray tube is provided with spray head, and the bottom of the spray head is provided with spray port.
Further, the spray tube includes the rotating disk of spray tube tail end and the spray head on spray tube top, described
Hollow out inside spray tube.
Further, there are four the supporting leg settings, and four supporting legs are located at the quadrangle of work box, together
When four supporting legs one end be fixedly connected with work box.
Further, the spray port is provided with multiple, and multiple spray ports are evenly distributed on the appearance of spray head
Face, while the diameter of multiple spray ports is five millimeters.
Further, the baffle is process by mild steel, and there are two the baffle plate settings, while two gears
Plate is symmetric.
Further, there are three the indicator light settings, and three indicator light sizes are identical, while three fingers
Show that lamp is arranged in " "-" type ".
Compared with prior art, the utility model has the beneficial effects that this kind of full-automatic SPR analyzer, in original base
It improves and promotes on plinth, be provided with spray tube, spray tube includes rotating disk and the spray tube top of spray tube tail end
Spray head, hollow out inside spray tube, the buffer stored in buffer storage case can be sprayed at by spray tube using spray port
On biological sample, spray port is provided with multiple, and multiple spray ports are evenly distributed on the outer surface of spray head, while multiple sprays
The diameter of mouth is five millimeters, and rotating disk is capable of the position that 360 deg adjusts spray tube, while the setting of multiple spray ports, energy
Enough make buffer is more full and uniform to be sprayed on biological sample, be provided with first rotating shaft and the second shaft, can be passed through
One shaft arbitrarily adjusts the position of the first cylindrical lens, and the position of the second cylindrical lens is arbitrarily adjusted by the second shaft, reduces
The step of staff manually adjusts, improves the working efficiency of staff, is provided with mild steel and is process baffle, and
There are two baffle plate settings, while two baffles are symmetric, and two be symmetric baffle can be by point of biological sample
Analysis environmental protection is got up, and is provided good biological sample analysis environment to device, is provided with indicator light, indicator light is provided with three
It is a, and three indicator light sizes are identical, while three indicator lights are arranged in " "-" type ", fill as work light is able to reflect out
It sets whether normal operation, carries out real-time monitoring work convenient for operation conditions of the staff to device.
Detailed description of the invention
Fig. 1 is the overall structure diagram of the utility model；
Fig. 2 is the schematic diagram of the section structure of utility model works case；
Fig. 3 is the partial structural diagram of the utility model rotating disk.
In figure: 1, supporting leg, 2, work box, 201, partition, 202, baffle, 203, first rotating shaft, the 204, first cylinder are saturating
Mirror, 205, metallic film, 206, prism, 207, rotating disk, 208, work roof box, the 209, second cylindrical lens, 210, second
Shaft, 211, analysis plates, 212, pressure-sensitive diaphragm, 213, spray tube, 214, spray head, 215, spray port, 3, station, 4, observation
Platform, 5, display screen, 6, indicator light, 7, buffer storage case, 8, control panel, 9, power switch.
Specific embodiment
It is in the description of the present invention, it should be noted that term " center ", "upper", "lower", "left", "right", " perpendicular
Directly ", the orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" is to be based on the orientation or positional relationship shown in the drawings, and is only
For ease of description the utility model and simplify description, rather than the device or element of indication or suggestion meaning must have it is specific
Orientation, be constructed and operated in a specific orientation, therefore should not be understood as limiting the present invention.In addition, term " the
One ", " second ", " third " are used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " is pacified
Dress ", " connected ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integrally
Connection；It can be mechanical connection, be also possible to be electrically connected；Can be directly connected, can also indirectly connected through an intermediary,
It can be the connection inside two elements.For the ordinary skill in the art, above-mentioned art can be understood with concrete condition
The concrete meaning of language in the present invention.
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
Every other embodiment obtained, fall within the protection scope of the utility model.
Fig. 1-3 is please referred to, the utility model provides a kind of technical solution: a kind of full-automatic SPR analyzer, including supporting leg
1, work box 2, partition 201, baffle 202, first rotating shaft 203, the first cylindrical lens 204, metallic film 205, prism 206, rotation
Turntable 207, work roof box 208, the second cylindrical lens 209, the second shaft 210, analysis plates 211, pressure-sensitive diaphragm 212, spray
Pipe 213, spray head 214, spray port 215, station 3, observation platform 4, display screen 5, indicator light 6, buffer storage case 7, control
Panel 8 and power switch 9, the bottom of work box 2 are provided with supporting leg 1, and the front of work box 2 is provided with station 3 and observation
Platform 4, the outer surface of station 3 are provided with display screen 5 and indicator light 6, and the top of observation platform 4 is provided with control panel 8 and power supply
Switch 9, power switch 9 are flexibly connected with observation platform 4, and work box 2 is internally provided with baffle 202, the bottom setting of baffle 202
There is partition 201, the top of partition 201 is provided with analysis plates 211, first rotating shaft 203 and the second shaft 210, the top of analysis plates 211
Portion is provided with pressure-sensitive diaphragm 212, and pressure-sensitive diaphragm 212 is combined closely with analysis plates 211, and the outer surface of first rotating shaft 203 is provided with
First cylindrical lens 204, the outer surface of the second shaft 203 are provided with the second cylindrical lens 209, and the top of work box 2 is provided with
Work roof box 208, and the top of work roof box 208 is provided with buffer storage case 7, buffer storage case 7 and work box top
Plate 208 is fixedly connected, and the bottom of work roof box 208 is provided with prism 206 and rotating disk 207, the outer surface setting of prism 206
There is metallic film 205, the bottom of rotating disk 207 is provided with spray tube 213, and the bottom of spray tube 213 is provided with spray head 214,
The bottom of spray head 214 is provided with spray port 215.
For the utility model by rotating disk 207 and spray port 215, rotating disk 207 adjusts the position of spray tube 213, multiple
Spray port 215 is evenly distributed on the outer surface of spray head 214, so that the buffer stored in buffer storage case 7 can be uniform
It is sprayed on biological sample, reduces the immersion liquid step that staff manually completes biological sample, pass through first rotating shaft 203 and
Two shafts 210 can arbitrarily adjust the irradiating angle of the first cylindrical lens 204 and the second cylindrical lens 209, be not necessarily to staff
It manually adjusts, improves the analysis efficiency of biological sample.
Specifically, spray tube 213 includes the spray head on 213 top of rotating disk 207 and spray tube of 213 tail end of spray tube
214,213 inside hollow out of spray tube, rotating disk 207 is capable of the position of the adjusting spray tube 213 of 360 deg.
The spray tube 213 that the utility model is rotated by 360 deg uniformly sprays away buffer.
Specifically, there are four the settings of supporting leg 1, and four supporting legs 1 are located at the quadrangle of work box 2, while four
One end of supporting leg 1 is fixedly connected with work box 2, and supporting leg 1 supports whole device.
The utility model improves the stability of device by four supporting legs 1 for being located at 2 four jiaos of work box.
Specifically, spray port 215 is provided with multiple, and multiple spray ports 215 are evenly distributed on the appearance of spray head 214
Face, while the diameter of multiple spray ports 215 is five millimeters, buffer can be sprayed away by spray port 215.
The utility model is uniformly sprayed buffer by multiple spray ports 215 being evenly distributed on spray head 214
It goes out.
Specifically, baffle 202 is process by mild steel, and there are two the settings of baffle 202, while two baffles 202 are in
It is symmetrical, baffle 202 can analysis environment to biological sample carry out protected working.
It is that device has built good analysis environment that the utility model, which passes through the baffle 202 being symmetric,.
Specifically, there are three the settings of indicator light 6, and three 6 sizes of indicator light are identical, while three indicator lights 6 are arranged in
The operation conditions of " "-" type ", device can be reflected by different indicator lights 6.
The utility model by three indicator lights 6 staff can see in real time to the operation conditions of device
Survey work.
Working principle: firstly, staff checks whether all parts performance is normal, if finding some component capabilities not just
After often, it should be repaired or replaced in time, after device all parts performance to be checked is normal, device is placed in specified work
Industry place, powers on for device, turns on the power switch 9, and corresponding indicator light 6 lights, and biological sample is placed on sensing membrane
On piece 212, the buffer in buffer storage case 7 can enter spray tube 213, then pass through the spray port on 214 surface of spray head
215 spray, while the spray angle of spray tube 213 is constantly regulate by rotating disk 207, and buffer is uniformly sprayed at biological sample
On, the irradiating angle of the first cylindrical lens 204 is adjusted by first rotating shaft 203, while the second column is adjusted by the second shaft 210
The irradiating angle of face lens 209, the first cylindrical lens 204 can be irradiated respectively with the second cylindrical lens 209 together with light, twice
Light is radiated on the metallic film 205 of 206 outer surface of prism, generates surface plasma-wave, can be with if having in biological sample
The molecule that pressure-sensitive diaphragm 212 interacts can cause 205 surface refractive index of metallic film to change, and eventually lead to the variation of the angle SPR,
By detecting SPR angle change, the information such as concentration, affinity, kinetic constant and the specificity of analyte are obtained, are detected
The data come can be conducted to display screen 5, convenient for staff's observation experiment as a result, device operation finishes, close power supply.
While there has been shown and described that the embodiments of the present invention, for the ordinary skill in the art,
It is understood that these embodiments can be carried out with a variety of variations in the case where not departing from the principles of the present invention and spirit, repaired
Change, replacement and variant, the scope of the utility model is defined by the appended claims and the equivalents thereof.
Claims (6)
1. a kind of full-automatic SPR analyzer, including work box (2), it is characterised in that: the bottom of the work box (2) is provided with
Supporting leg (1), the front of the work box (2) are provided with station (3) and observation platform (4), the outer surface of the station (3)
It is provided with display screen (5) and indicator light (6), is provided with control panel (8) and power switch (9) at the top of the observation platform (4),
The power switch (9) is flexibly connected with observation platform (4), and the work box (2) is internally provided with baffle (202), the gear
The bottom of plate (202) is provided with partition (201), is provided with analysis plates (211), first rotating shaft at the top of the partition (201)
(203) and the second shaft (210) pressure-sensitive diaphragm (212), the pressure-sensitive diaphragm, are provided at the top of the analysis plates (211)
(212) it combines closely with analysis plates (211), the outer surface of the first rotating shaft (203) is provided with the first cylindrical lens (204),
The outer surface of second shaft (210) is provided with the second cylindrical lens (209), is provided with work at the top of the work box (2)
Make roof box (208), is provided with buffer storage case (7) at the top of the work roof box (208), the buffer storage case
(7) it is fixedly connected with work roof box (208), the bottom of the work roof box (208) is provided with prism (206) and rotating disk
(207), the outer surface of the prism (206) is provided with metallic film (205), and the bottom of the rotating disk (207) is provided with spray
The bottom of shower pipe (213), the spray tube (213) is provided with spray head (214), and the bottom of the spray head (214) is provided with
Spray port (215).
2. a kind of full-automatic SPR analyzer according to claim 1, it is characterised in that: the spray tube (213) includes spray
The rotating disk (207) of shower pipe (213) tail end and the spray head (214) on spray tube (213) top, the spray tube (213) are interior
Portion's hollow out.
3. a kind of full-automatic SPR analyzer according to claim 1, it is characterised in that: the supporting leg (1) is provided with four
It is a, and four supporting legs (1) are located at the quadrangle of work box (2), at the same one end of four supporting legs (1) with
Work box (2) is fixedly connected.
4. a kind of full-automatic SPR analyzer according to claim 1, it is characterised in that: the spray port (215) is provided with
It is multiple, and multiple spray ports (215) are evenly distributed on the outer surface of spray head (214), while multiple spray ports
(215) diameter is five millimeters.
5. a kind of full-automatic SPR analyzer according to claim 1, it is characterised in that: the baffle (202) is by mild steel
It is process, and there are two the baffle (202) settings, while two baffles (202) are symmetric.
6. a kind of full-automatic SPR analyzer according to claim 1, it is characterised in that: the indicator light (6) is provided with three
It is a, and three indicator light (6) sizes are identical, while three indicator lights (6) are arranged in " "-" type ".
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822102822.7U CN209485981U (en) | 2018-12-14 | 2018-12-14 | A kind of full-automatic SPR analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822102822.7U CN209485981U (en) | 2018-12-14 | 2018-12-14 | A kind of full-automatic SPR analyzer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209485981U true CN209485981U (en) | 2019-10-11 |
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ID=68127608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201822102822.7U Active CN209485981U (en) | 2018-12-14 | 2018-12-14 | A kind of full-automatic SPR analyzer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209485981U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113030027A (en) * | 2021-03-29 | 2021-06-25 | 上海工程技术大学 | SPR sensor device can be regulated and control to hand-held type |
-
2018
- 2018-12-14 CN CN201822102822.7U patent/CN209485981U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113030027A (en) * | 2021-03-29 | 2021-06-25 | 上海工程技术大学 | SPR sensor device can be regulated and control to hand-held type |
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