CN209203290U - A kind of heparin tube with degreasing material - Google Patents
A kind of heparin tube with degreasing material Download PDFInfo
- Publication number
- CN209203290U CN209203290U CN201821835335.5U CN201821835335U CN209203290U CN 209203290 U CN209203290 U CN 209203290U CN 201821835335 U CN201821835335 U CN 201821835335U CN 209203290 U CN209203290 U CN 209203290U
- Authority
- CN
- China
- Prior art keywords
- heparin tube
- lipid
- tube
- heparin
- connection carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims abstract description 38
- 229960002897 heparin Drugs 0.000 title claims abstract description 38
- 229920000669 heparin Polymers 0.000 title claims abstract description 38
- 239000000463 material Substances 0.000 title claims abstract description 24
- 238000005238 degreasing Methods 0.000 title claims abstract description 15
- 150000002632 lipids Chemical class 0.000 claims abstract description 18
- 229920003023 plastic Polymers 0.000 claims abstract description 12
- 239000004033 plastic Substances 0.000 claims abstract description 12
- 239000007799 cork Substances 0.000 claims abstract description 7
- 238000007789 sealing Methods 0.000 claims abstract description 6
- 238000010241 blood sampling Methods 0.000 claims abstract description 3
- 239000011347 resin Substances 0.000 claims description 20
- 229920005989 resin Polymers 0.000 claims description 20
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 18
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 18
- 239000004743 Polypropylene Substances 0.000 claims description 10
- SEOVTRFCIGRIMH-UHFFFAOYSA-N indole-3-acetic acid Chemical group C1=CC=C2C(CC(=O)O)=CNC2=C1 SEOVTRFCIGRIMH-UHFFFAOYSA-N 0.000 claims description 9
- -1 polypropylene Polymers 0.000 claims description 9
- 239000004745 nonwoven fabric Substances 0.000 claims description 8
- 229920001155 polypropylene Polymers 0.000 claims description 8
- 238000004132 cross linking Methods 0.000 claims description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 239000005864 Sulphur Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract description 13
- 210000004369 blood Anatomy 0.000 abstract description 13
- 238000002844 melting Methods 0.000 abstract description 9
- 230000008018 melting Effects 0.000 abstract description 9
- 238000001514 detection method Methods 0.000 abstract description 6
- 210000002966 serum Anatomy 0.000 abstract description 4
- 238000005119 centrifugation Methods 0.000 abstract description 3
- 239000000969 carrier Substances 0.000 abstract 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 8
- 229960003080 taurine Drugs 0.000 description 4
- 208000032928 Dyslipidaemia Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 208000017170 Lipid metabolism disease Diseases 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000003463 adsorbent Substances 0.000 description 2
- 150000001718 carbodiimides Chemical class 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009435 amidation Effects 0.000 description 1
- 238000007112 amidation reaction Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model discloses a kind of heparin tubes with degreasing material, heparin tube tube body including having sealed plastic bottle cap, sealing is embedded with cork in the middle part of the plastic bottle closure, is provided with connection carrier in the heparin tube tube body, is crosslinked with lipid oriented attachment material on the connection carrier.The utility model has the advantage of the setting connection carriers in heparin tube tube body, lipid oriented attachment material is crosslinked on connection carrier, blood sample after the completion of blood sampling is by being mixed by inversion, come into full contact with the fat melting sample in sample with carrier is connect, the carrier that lipid is attached with after centrifugation can be in clot layer or tube bottom, lipid is separated from serum sample, ensure that the accuracy of subsequent detection.
Description
Technical field
The utility model relates to heparin tubes, and the heparin tube of degreasing material is had more particularly, to a kind of inside.
Background technique
Heparin tube collecting blood sample usually in clinical chemistry, serology and immunology detection is used.Due to economical fast
Speed development, resident's eating habit and life style also change correspondingly, Chinese (including mid-aged population even some young men)
Blood lipid level and dyslipidemia illness rate it is significantly raised, and the rate of climb is speeded.2010, Chinese adult was overweight and fat
Person's prevalence proportions account for 27.9% and 5.1%.Investigation result is shown within 2012, and Blood Lipid Abnormality in Chinese Adults illness rate is up to
40.40%.Meanwhile since two thousand and ten, angiocarpy case in China's increases by 9,200,000, implies following China's dyslipidemia illness rate
It will be further aggravated.
Along with the increase of people with hyperlipidemia, fat melting probability is sharply increased in serum specimen, and blood fat melting is for subsequent
The interference of detection mainly includes two aspects: 1, interference of the uniform state serum fat melting to detection system；2, the blood after being centrifuged
Clear fat melting layering, fat melting layer are in top layer, and in full-automatic chemical analysis instrument or automatic lmunoassays analyzer device Instrumental
Can not identify whether upper layer is fat melting layer, is likely to result in unnecessary sample transfer step, or even in the state of untreated
Cause measurement deviation and medical tangle.
Different from haemolysis, hemolytic jaundice, easily occur non-uniform state after fat melting specimen centrifuge, it is easy for full-automatic instrument
Cause measurement the situations such as exception or instrument specimen needle plug-hole, in today that dyslipidemia rate increasingly aggravates, provide it is a kind of can be to blood
Lipid in liquid sample is adsorbed then to be very necessary with the heparin tube for guaranteeing the accuracy of testing result.
Summary of the invention
The purpose of this utility model is that in view of the deficiencies in the prior art, providing a kind of adopting with degreasing material
Blood vessel can be oriented absorption to the lipid in blood sample, ensure that the accuracy of subsequent detection result.
To achieve the above object, the utility model can take following technical proposals:
Heparin tube described in the utility model with degreasing material, the heparin tube pipe including having sealed plastic bottle cap
Body, sealing is embedded with cork in the middle part of the plastic bottle closure, and connection carrier is provided in the heparin tube tube body, and the connection carries
Lipid oriented attachment material is crosslinked on body.
The connection carrier is to be placed in the intracorporal netted, column of the pipe or spheroid carrier, fixes or is not fixed in tube wall
On.
When specific production, the connection carrier is the polypropylene non-woven fabric for being placed in heparin tube bottom of the tube, the lipid orientation
Adsorbent material is taurine of the crosslinking on polypropylene non-woven fabric.
The connection carrier can also use the polyvinyl alcohol macropore dropwise resin being fixed on the blood sampling tube wall,
The polyvinyl alcohol macropore dropwise resin surface is crosslinked with heteroauxin.
The connection carrier is the polyvinyl alcohol macropore dropwise resin balls being placed in the heparin tube, in the polyethylene
Heteroauxin is crosslinked in alcohol macropore dropwise resin balls.The diameter of the polyvinyl alcohol macropore dropwise resin balls is 0.3 ~ 1.0mm.
It is fixed that lipid is crosslinked with the utility model has the advantage of the setting connection carrier in heparin tube tube body, on connection carrier
To adsorbent material, blood sample after the completion of taking a blood sample by being mixed by inversion, make fat melting sample in sample with to connect carrier abundant
Lipid can be separated from serum sample in clot layer or tube bottom, be protected by contact, the carrier that lipid is attached with after centrifugation
The accuracy of subsequent detection is demonstrate,proved.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the utility model embodiment 1.
Fig. 2 is the top perspective view of Fig. 1.
Fig. 3 is the structural schematic diagram of the utility model embodiment 2.
Fig. 4 is the structural schematic diagram of the utility model embodiment 3.
Specific embodiment
More detailed explanation is done to the utility model below by specific embodiment, in order to those skilled in the art's
Understand.
Embodiment 1 prepares the internal heparin tube for being filled with polyvinyl alcohol macropore dropwise resin balls
As shown in Figure 1, 2, the heparin tube with degreasing material of the utility model, including having sealed plastic bottle cap 1
Heparin tube tube body 2, in the middle part of plastic bottle closure 1 sealing be embedded with cork 3, be filled in heparin tube tube body 2 diameter be 0.3 ~
The polyvinyl alcohol macropore dropwise resin balls 4 of 1.0mm, under normal circumstances, the charging quantity of polyvinyl alcohol macropore dropwise resin balls 4 are pipe
The 1/10 of body capacity, polyvinyl alcohol macropore dropwise resin balls 4 it is surface-crosslinked have heteroauxin (when actual fabrication, can be by poly- second
Enol macropore dropwise resin balls 4 are dipped in 30 min are impregnated in heteroauxin solution after add two hexamethylenes with heteroauxin equivalent
Base carbodiimide, it is normal temperature crosslinked overnight, screen out the byproduct of reaction of fine particle size, and using using after ethanol washing).
Heparin tube is made of vacuum technology according to a conventional method, and using negative pressure in pipe, blood taking needle is pierced by cork 3, is adopted
It needs to mix well blood in heparin tube after the completion of blood, connects lipid in sample sufficiently with polyvinyl alcohol macropore dropwise resin balls 4
Touching, the polyvinyl alcohol macropore dropwise resin balls 4 that lipid is adhered to after centrifugation should be at clot layer or tube bottom.
Embodiment 2 prepares the heparin tube that inner wall is fixed with polyvinyl alcohol macropore dropwise resin layer
As shown in figure 3, the heparin tube with degreasing material of the utility model, including adopting with sealed plastic bottle cap 1
Blood vessel tube body 2, sealing is embedded with cork 3 in the middle part of plastic bottle closure 1, fixes polyvinyl alcohol macropore on 2 inner wall of heparin tube tube body
Bead-like resin layer (with a thickness of 0.3 ~ 1.0mm) 5 is crosslinked with heteroauxin (coating in polyvinyl alcohol macropore dropwise resin layer surface
There is heteroauxin solution).
Application method is the same as embodiment 1.
Embodiment 3 prepares the heparin tube that bottom is placed with polypropylene non-woven fabric
As shown in figure 4, the heparin tube with degreasing material of the utility model, including adopting with sealed plastic bottle cap 1
Blood vessel tube body 2, sealing is embedded with cork 3 in the middle part of plastic bottle closure 1, is placed with polypropylene non-woven fabric in 2 bottom of heparin tube tube body
6, taurine is crosslinked on polypropylene non-woven fabric 6 (when actual fabrication, can be dipped in polypropylene non-woven fabric 6 in taurine solution
Carbodiimide is added in 30min, normal temperature crosslinked overnight, and it is anti-that amidation occurs for the amino in the carboxyl and taurine of PP nonwoven surface
It answers, so that sulfonic group can be introduced in PP nonwoven surface).
Application method is the same as embodiment 1.
When practical preparation, other similar materials can also be used by connecting carrier and lipid oriented attachment material, as long as energy
It serves the same role.
Claims (6)
1. a kind of heparin tube with degreasing material, the heparin tube tube body including having sealed plastic bottle cap, in the plastic bottle
The sealing of lid middle part is embedded with cork, it is characterised in that: connection carrier is provided in the heparin tube tube body, on the connection carrier
It is crosslinked with lipid oriented attachment material.
2. the heparin tube according to claim 1 with degreasing material, it is characterised in that: the connection carrier is is placed in
State the intracorporal netted, column of pipe or spheroid carrier.
3. the heparin tube according to claim 1 or 2 with degreasing material, it is characterised in that: the connection carrier is to set
In the polypropylene non-woven fabric of heparin tube bottom of the tube, the lipid oriented attachment material is ox sulphur of the crosslinking on polypropylene non-woven fabric
Acid.
4. the heparin tube according to claim 1 or 2 with degreasing material, it is characterised in that: the connection carrier is solid
The polyvinyl alcohol macropore dropwise resin being scheduled on the blood sampling tube wall, is crosslinked in the polyvinyl alcohol macropore dropwise resin surface
There is heteroauxin.
5. the heparin tube according to claim 1 or 2 with degreasing material, it is characterised in that: the connection carrier is to put
The polyvinyl alcohol macropore dropwise resin balls in the heparin tube are set, are crosslinked in the polyvinyl alcohol macropore dropwise resin balls
Heteroauxin.
6. the heparin tube according to claim 5 with degreasing material, it is characterised in that: the polyvinyl alcohol macropore dropwise
The diameter of resin balls is 0.3 ~ 1.0mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821835335.5U CN209203290U (en) | 2018-11-08 | 2018-11-08 | A kind of heparin tube with degreasing material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821835335.5U CN209203290U (en) | 2018-11-08 | 2018-11-08 | A kind of heparin tube with degreasing material |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209203290U true CN209203290U (en) | 2019-08-06 |
Family
ID=67458659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821835335.5U Active CN209203290U (en) | 2018-11-08 | 2018-11-08 | A kind of heparin tube with degreasing material |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209203290U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109222999A (en) * | 2018-11-08 | 2019-01-18 | 郑州安图生物工程股份有限公司 | A kind of heparin tube with degreasing material |
-
2018
- 2018-11-08 CN CN201821835335.5U patent/CN209203290U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109222999A (en) * | 2018-11-08 | 2019-01-18 | 郑州安图生物工程股份有限公司 | A kind of heparin tube with degreasing material |
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|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |