CN208989123U

CN208989123U - A frequency-selectable radio frequency ablation signal generation and control circuit

Info

Publication number: CN208989123U
Application number: CN201820961339.1U
Authority: CN
Inventors: 邹金成; 张爱丽
Original assignee: Shanghai Jiao Tong University
Current assignee: Shanghai Jiao Tong University
Priority date: 2018-06-21
Filing date: 2018-06-21
Publication date: 2019-06-18
Anticipated expiration: 2028-06-21

Abstract

Occur the utility model discloses a kind of optional RF ablation signal of frequency and control circuit, the circuit occur circuit, rf power amplifier circuit, radio frequency signal detecting circuitry, frequency selective network and output isolation circuit etc. by microprocessor, radio frequency power controlling circuit, controllable direct current power supply, fundamental frequency signal and constitute.The circuit of the utility model can satisfy the requirement that the required radio frequency of high-end clinic is precisely controlled, it realizes in tissue ablation process, reaches the accurate treatment to target tissue with the frequency of control RF ablation signal by selecting, and circuit is simple, debugging is convenient, control is flexible, and complexity is low.

Description

A kind of optional RF ablation signal of frequency occurs and control circuit

Technical field

The utility model relates to medical instruments fields, relate more specifically to a kind of optional RF ablation signal generation of frequency With control circuit.

Background technique

Based on the RF ablation of radio frequency electromagnetic field bio-heating effectiveness, i.e. radio frequency hatching in situ is outside oncotherapy, ambition It is all widely used in section, neurosurgery, gynaecology and Urology Surgery etc. clinic, all kinds of corresponding Medical Devices are also Largely occurred.In radio-frequency ablation procedure, radiofrequency ablation therapy system output power properly whether it is most important, it is too low, reach It is excessively high and target tissue can be made to gasify because of high temperature and be carbonized less than the purpose of ablation, while good ablation effect is not achieved, And target tissue is in irregular shape, in order to consider the conformal therapy to target tissue, it is necessary to consider that the reality of tissue Border structure carries out research heating means from the basic principle of radio frequency heating, to realize the preferably ablation to each tissue, especially For heating to treat for the small patch in angiocarpy inside.

The radio frequency of different frequency is all different to the ablation size and depth of ablation of target tissue in radiofrequency ablation procedures, Haemmerich et al. modeling analysis tumor tissues and normal tissue are inside 10kHz and 500kHz rf frequency effect undertissue The distribution of current field and temperature field has obtained may be implemented preferentially heating tumour at a lower frequency without injuring normal tissue As a result；Ekstrand et al. to how using radio frequency preferentially heat the tumor tissues in breast cancer without injure around fatty exhibition Open research；Franco et al. studies ability fatty in RF ablation biological tissue, and which employs 500kHz and 4MHz Rf frequency heats pork, it is found that the radio frequency heating range of 500kHz is bigger, but heating speed is slower, the radio frequency of 4MHz With faster heating speed but heated perimeter it is relatively small.Blenky et al. has studied different radio frequency frequency and wears to biological tissue The influence of saturating depth, and experiments prove that penetration depth reduces with the increase of frequency.Therefore, different radio frequency frequency melts The ablation range and depth of ablation of target tissue can be changed, can be realized by control therapeutic strategy to the thorough of target tissue Bottom ablation.

Therefore, this field still lacks a kind of radio-frequency signal generating circuit, which can according to need selection specific frequency It is operated, to realize effective ablation to target tissue.

Utility model content

The purpose of this utility model is to provide a kind of optional RF ablation signal generation of frequency and control circuit, the electricity Road can be used in the laboratory apparatus of different frequency radiofrequency ablation therapy, provide circuit support and technical solution for it.By this reality It can be simultaneously emitted by the RF therapy signal of multi-frequency with novel circuit, then cooperate control method appropriate, realization pair again Effective ablation of target tissue and precisely treatment.

The utility model provides that a kind of optional RF ablation signal of frequency occurs and control circuit, the circuit include micro- Circuit, rf power amplifier circuit, radio frequency letter occur for processor, radio frequency power controlling circuit, controllable direct current power supply, fundamental frequency signal Number detection circuit, frequency selective network and radio frequency output isolation circuit；The fundamental frequency signal occurs circuit and receives micro- place The high-frequency square-wave signal that the fundamental frequency that device issues controls generation corresponding frequencies after signal is managed, power amplifier tube driving electricity is transferred to Lu Hou exports the pumping signal of corresponding frequencies, is transferred to the fundamental frequency input terminal of the rf power amplifier circuit；The frequency choosing The frequency request that circuit receives the microprocessor is selected, the impedance matching in the rf power amplifier circuit under the frequency is adjusted Network generates the RF ablation signal of corresponding frequencies；The radio frequency power controlling circuit receives the power control of the microprocessor Signal processed converts thereof into corresponding controllable direct current power supply control signal, controls the adjustable DC power supply output corresponding power Power supply, load in the rf power amplifier circuit, the RF ablation signal of corresponding power occurs, and pass through radio frequency isolation Circuit function in treatment probe, by RF ablation signal function in treatment tissue, the radio frequency isolation circuit using transformer every From.

In another preferred example, over the course for the treatment of, in the radio frequency signal detecting circuitry real-time monitoring therapeutic process Radio-frequency power and tissue impedance.

In another preferred example, the radio frequency power controlling circuit receives the pwm signal that the microprocessor occurs, and will The pwm signal turns potential circuit by PWM, and the variable DC voltage control signal of output amplitude acts on described controllable straight The control signal in galvanic electricity source exports the adjustable DC voltage control signal of more powerful amplitude, acts on the radio frequency function The power input of rate amplifying circuit.

In another preferred example, the rf power amplifier circuit includes filter circuit, series resonance power amplification circuit, Impedance matching circuit.

In another preferred example, parameter can pass through the frequency selective network in the series resonance power amplification circuit It is adjusted, the resonance circuit of respective radio-frequency occurrence frequency occurs；The impedance matching circuit is by the frequency selective network tune Corresponding frequencies are saved with matching network.

In another preferred example, the series resonance power amplification circuit uses LC series resonance.

In another preferred example, the capacitor C in the resonance circuit is fixed value, and inductance L has adjustable output, can pass through The frequency selective network is selected, while selecting impedance matching network parameter appropriate by the frequency selective network, So that the circuit carries out resonance under intrinsic frequency, and then issue radiofrequency signal.

In another preferred example, the radio frequency signal detecting circuitry includes isolation coupling circuit, current rectifying and wave filtering circuit, signal Amplifying circuit and photoelectric isolating circuit, the radio frequency signal detecting circuitry can be realized the electricity of different frequency RF ablation signal Pressure, current detecting.

In another preferred example, the isolation coupling circuit uses the electric current of coupling inductance isolation coupling RF output end, Current signal is converted into voltage signal again, after being rectified by the current rectifying and wave filtering circuit, is put by the signal amplification circuit Greatly, it is then output to the microprocessor A/D by the photoelectric isolating circuit to convert, sensed current signal；The detection of voltage It is directly detected in high-frequency isolation transformer input terminal, later by the current rectifying and wave filtering circuit, signal amplification circuit, described Photoelectric isolating circuit is input to the microprocessor A/D conversion, detects radio-frequency voltage；What the last microprocessor will test Voltage and electric current calculate radio-frequency power and tissue impedance according to Ohm's law.

In another preferred example, the optional radiofrequency signal reference frequency output of the circuit is between 100KHz-3MHz It is one or more.

In another preferred example, the circuit can only have a kind of optional radiofrequency signal, can also there are many optional Radiofrequency signal.

It should be understood that in the scope of the utility model, above-mentioned each technical characteristic of the utility model and below (such as implementation Example) in specifically describe each technical characteristic between can be combined with each other, to form a new or preferred technical solution.It is limited to Length, not repeated them here.

Detailed description of the invention

In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment Or attached drawing needed to be used in the description of the prior art does and simply introduces, it should be apparent that, the accompanying drawings in the following description is only It is some embodiments of the utility model, for those of ordinary skill in the art, in the premise not made the creative labor Under, it is also possible to obtain other drawings based on these drawings.

Fig. 1 is that the optional RF ablation signal of one of one example of the utility model frequency occurs and control circuit Structural schematic diagram.

Fig. 2 is the circuit of frequency optional RF ablation the signal generation and control circuit in one example of the utility model Figure.

Fig. 3 is the structural schematic diagram of the radio frequency signal detecting circuitry in one example of the utility model.

Specific embodiment

The present inventor after extensive and in-depth study, by largely screening, develops a kind of frequency for the first time and optionally penetrates Frequency ablation signal occurs and control circuit, a variety of different frequencies of generation that especially can be selective in same system are penetrated Frequency ablation signal, compared with prior art, the RF ablation signal generating circuit of the utility model can effectively overcome existing list The deficiency of one RF ablation signal generating circuit can form a treatment system by the radio-frequency signal generating circuit of the utility model System, the treatment system can issue the RF therapy signal of multi-frequency, then cooperate control method appropriate again, quickly control not The radio frequency of same frequency realizes effective ablation to target tissue, while advantageously accounting for needing to use different radio frequency ablation frequency The research and development for realizing the instruments such as influence research of the accurate treatment or different frequency radio frequency to tissue to therapeutic effect, in this base The utility model is completed on plinth.

The utility model provides a kind of optional RF ablation signal of frequency and occurs and control circuit, it is that one kind has The circuit of specific structure.

Typically, the optional RF ablation signal generation of the frequency of the utility model and control circuit, including microprocessor, Circuit, rf power amplifier circuit, radio-frequency signal detection occur for radio frequency power controlling circuit, controllable direct current power supply, fundamental frequency signal Circuit, frequency selective network and radio frequency output isolation circuit.The selection of radio frequency selection circuit, which is controlled, by microprocessor adjusts phase It answers the impedance matching network of frequency and adjusts resonant circuit parameters, and control fundamental frequency signal and circuit generation corresponding frequencies occur Pumping signal；The radio-frequency power of microprocessor control simultaneously adjusts circuit and issues radio-frequency power adjustment signal, controls controllable direct current The output in source, the pumping signal that then fundamental frequency signal occurs that circuit generates acts on simultaneously with controllable direct current power supply control output penetrates The radiofrequency signal of corresponding frequencies occurs by frequency selective network, radiofrequency signal is finally passed through output for frequency power amplification circuit Isolation circuit is transferred to rf probe, acts on tissue and is treated.Over the course for the treatment of, instrument is examined by radiofrequency signal Impedance and power in slowdown monitoring circuit real-time monitoring therapeutic process.

In another preferred example, radio frequency power controlling circuit includes that circuit occurs for PWM, pwm signal turns potential circuit, electricity Press amplifying circuit.

In another preferred example, controllable direct current power supply is 0-100V controllable linear out-put supply

In another preferred example, rf power amplifier circuit includes chokes filter circuit, rf power amplifier circuit, series connection Resonance circuit, impedance matching circuit.

In another preferred example, radio frequency output isolation circuit primarily to prevent radio circuit directly with human contact and The spacing output circuit done, plays the protective effect to human body, mainly uses transformer isolation mode

In another preferred example, radio frequency signal detecting circuitry includes radiofrequency signal coupling circuit, current rectifying and wave filtering circuit, letter Number amplifying circuit, photoelectric isolating circuit

In another preferred example, the circuit side of including wave generation circuit, power tube drive circuit occur for fundamental frequency signal, can be with It needs the square wave of frequency that a variety of different crystal oscillators also can be used using programmable logic device generation to be divided to obtain, then will The square wave of generation is transferred to power tube drive circuit, pumping signal needed for issuing power amplifier tube.

The major advantage of the utility model includes:

(a) it can be used for ablation instrument, realize effective ablation to target tissue；

(b) research influenced for different frequency for RF ablation pushes Developments；

(c) structure is simple, and complexity is low, practical；

(d) accurate treatment of the frequency realization to tissue is melted by different radio frequency.

Therefore, the optional RF ablation signal generating circuit of the frequency of the utility model and relevant control circuit, energy It is enough applied in the instrument research for carrying out ablation using the advantage of different frequency or different frequency disappears for radio frequency Melt in the correlative study of influence, to realize effective ablation to target tissue and the accurate treatment etc. to tissue.

The present invention will be further illustrated below in conjunction with specific embodiments.It should be understood that these embodiments are merely to illustrate this Utility model rather than limitation the scope of the utility model.In addition, attached drawing is schematic diagram, therefore utility model device and set Standby is not limited by the size or ratio of the schematic diagram.

It should be noted that in the claim and specification of this patent, such as first and second or the like relationship Term is only used to distinguish one entity or operation from another entity or operation, without necessarily requiring or implying There are any actual relationship or orders between these entities or operation.Moreover, the terms "include", "comprise" or its Any other variant is intended to non-exclusive inclusion so that include the process, methods of a series of elements, article or Equipment not only includes those elements, but also including other elements that are not explicitly listed, or further include for this process, Method, article or the intrinsic element of equipment.In the absence of more restrictions, being wanted by what sentence " including one " limited Element, it is not excluded that there is also other identical elements in the process, method, article or apparatus that includes the element.

Embodiment one

The optional radiofrequency signal of the frequency of the present embodiment occurs and control circuit includes microprocessor, radio-frequency power control Circuit, rf power amplifier circuit, radio frequency signal detecting circuitry, frequency selection occur for circuit, controllable direct current power supply, fundamental frequency signal Circuit and output isolation circuit.

Microprocessor utilizes Programmed control, sends frequency required for work at present to fundamental frequency signal and circuit occurs, so The frequency request that circuit receives control signal occurs for fundamental frequency signal afterwards, issues the square wave of corresponding frequencies, is transferred to power tube drive Dynamic circuit, issues fundamental frequency pumping signal, is transferred to the pumping signal input terminal of rf power amplifier circuit.

Microprocessor regulates and controls radio frequency power controlling circuit by the control mode of PWM, then radio frequency power controlling circuit, hair Corresponding control signal out, control controllable direct current power supply export a certain size direct current signal, act on rf power amplifier circuit.

Microprocessor sends frequency selection control signal, and then frequency selective network receives the control signal of corresponding frequencies Afterwards, the parameter in the series resonant network in rf power amplifier circuit, and the impedance spectrum net of selection corresponding frequencies are adjusted Network.

Rf power amplifier circuit mainly by the way of E power-like amplifier, controllable direct current power supply is exported controllable DC power supply is filtered by chokes, amplification, series resonance, and the circuits such as impedance matching network generate corresponding frequencies and certain amplitude Radiofrequency signal, then radiofrequency signal is output in human body by output isolation circuit and is accurately treated, and is believed by radio frequency Number detection circuit treats the electric-physiology parameter of tissue during real-time detection feedback treating.

Embodiment two

As shown in Figure 1, the optional RF ablation signal of the frequency of the present embodiment occurs with control circuit to include microprocessor A, circuit C, frequency selective network D, rf power amplifier circuit E, controllable straight occurs for radio frequency power controlling circuit B, fundamental frequency signal Galvanic electricity source F, radio frequency signal detecting circuitry G and radio frequency output isolation circuit H.

Microprocessor A exports work at present rf frequency and controls signal, is transmitted to fundamental frequency signal and circuit C occurs, then base Frequency signal generating circuit C issues the high frequency square wave pumping signal of corresponding frequencies, and the fundamental frequency for being linked into rf power amplifier circuit E is defeated Enter signal end；Microprocessor A issues work at present radio-frequency power and controls signal simultaneously, is transmitted to radio frequency power controlling circuit B, then The control signal for issuing controllable direct current power supply by radio frequency power controlling circuit B exports corresponding size to controllable direct current power supply F Controllable direct current signal is transferred to the power input of rf power amplifier circuit E；And at the same time frequency selective network D, selection are penetrated In frequency power amplifier E, impedance matching network under corresponding present operating frequency, finally by the output of radio-frequency power amplifier The radiofrequency signal of end output corresponding frequencies is output to treatment tissue by radio frequency output isolation circuit H and carries out RF therapy.And Radiofrequency signal during radio frequency signal detecting circuitry G real-time detection Current therapeutic, the related physiological parameters with treatment tissue Information, feedback are handled to microprocessor A, and then microprocessor A adjusts radio frequency output according to the treatment signal of feedback.

The rf power amplifier circuit E of the present embodiment is not limited to single-ended mainly using E class power amplification circuit The E class power amplification circuit of input or double-width grinding.Power amplification type metal-oxide-semiconductor is mainly used in power amplification circuit as function Rate amplifier.As shown in Fig. 2, circuit C sending high frequency square wave pumping signal, which occurs, for fundamental frequency signal acts on power amplifier tube AQ1's Grid, to provide fundamental frequency signal, the voltage signal that then controllable constant-current source issues is accessed after filter circuit in high frequency choke Enclose L1.The high frequency choke coil L1 plays the role of constant current in circuit, according to the working principle of E class power amplification circuit, High frequency choke coil L1, which can be calculated, should meet formula (1):

In above formula, L1 is the inductance value of high frequency choke coil；F is rf frequency；C3 is the capacitance of capacitor.To meet electricity The bandwidth requirement of selected radio frequency in road, the value of capacitor C3 is fixed, and sets minimum frequency f for the value of high frequency choke coil L1_minWhen Corresponding inductance value complies with the design requirement of all optional rf frequencies.The power supply signal in controllable constant-current source is by filtering Circuit is connected to the source level of power amplifier tube AQ1, the capacitor being connected in LC series resonant circuit with after high frequency choke coil L1 C4, C4 connect with series resonance inductor L2.The series resonance inductor L2 is variable inductance, by frequency selective network C root It requires to carry out selection adjusting according to the rf frequency of work at present.The signal that series resonance comes out accesses impedance matching network, described Impedance matching network devise the impedance matching networks of a variety of different frequencies, and using frequency selective network C to its frequency Under impedance network selected.The signal come out from impedance matching network is the radiofrequency signal of sine wave.Last radiofrequency signal By output isolation circuit H, it is output to RF therapy probe, acts on treatment tissue, the output isolation circuit is mainly adopted With transformer isolation.In the input front end of output isolation circuit, by radio-frequency voltage incoming radio frequency signal detection circuit G, and By the way of inductive coupling, by current coupling to the radio-frequency current coupling circuit, the sampling of RF therapy electric current is carried out.

Shown in attachment 3, radio frequency signal detecting circuitry mainly has radio frequency voltage signal detection circuit and current radio frequency signal inspection Slowdown monitoring circuit composition, wherein radio-frequency current detection circuit first passes around isolation coupling circuit, then turns potential circuit G1 by electric current The current signal of coupling is converted into voltage signal, is converted into d. c. voltage signal using half-wave precise rectification circuit G21, is passed through Micro- place is linked into after crossing filter circuit G31, DC voltage amplifying circuit G41, signal isolation circuit G51, A/D conversion circuit G61 It manages device A and carries out signal acquisition process, the current signal value in the real-time detection course of work.The radio-frequency voltage detection circuit, The voltage signal for directly acquiring the front end radio frequency output isolation circuit G, then passes through half-wave precise rectification circuit G22, filter circuit Be linked into after G32, DC voltage amplifying circuit G42, signal output isolation circuit G52, A/D conversion circuit G62 microprocessor A into Row signal acquisition.Last microprocessor A calculates real-time treatment power and tissue according to the current signal and voltage signal of acquisition Impedance, and monitor treatment energy.

Rf power amplifier circuit B receives the pulse width modulation (PWM) signal that microprocessor A is issued, then by pwm signal Turn potential circuit by pwm signal and is converted into corresponding adjustable dc voltage signal.Adjustable dc voltage in the present embodiment The value of signal is 0~5V, is the change with PWM duty cycle and changes, and the frequency of pwm signal can be arbitrarily to conform to The frequency asked.Adjustable dc voltage signal is input to the control signal of controllable direct current power supply F later.The controllable direct current Source is using switch DC regulated power supply, and voltage output end is linked into radio frequency power controlling circuit E, and voltage is with input The variation of control voltage changes linearly, and improves control precision.

Occur and control circuit in conclusion the utility model provides a kind of optional RF ablation signal of frequency, energy It is enough applied to the Instrument Design that different radio frequency frequency signal is precisely treated, and the RF ablation for being not limited to tumour is controlled Treat instrument, radio frequency defibrillation, cardiovascular disease radiofrequency ablation therapy.

It is incorporated herein by reference in all documents that the utility model refers to, just as each document quilt It is individually recited as with reference to such.In addition, it should also be understood that, after having read the above-mentioned teaching content of the utility model, this field skill Art personnel can make various changes or modifications the utility model, and such equivalent forms equally fall within the application appended claims Book limited range.

Claims

1. a frequency-selectable radio frequency ablation signal generation and control circuit, is characterized in that, described circuit comprises microprocessor, radio frequency power control circuit, controllable DC power supply, fundamental frequency signal generation circuit, radio frequency power amplifier circuit, radio frequency Signal detection circuit, frequency selection circuit, and radio frequency output isolation circuit;

The fundamental frequency signal generating circuit receives the fundamental frequency control signal sent by the microprocessor and generates a high-frequency square wave signal of the corresponding frequency, which is transmitted to the power amplifier tube driving circuit, and outputs the excitation signal of the corresponding frequency, which is transmitted to the the fundamental frequency input end of the radio frequency power amplifier circuit;

The frequency selection circuit receives the frequency request of the microprocessor, adjusts the impedance matching network in the radio frequency power amplifier circuit under the frequency, and generates the radio frequency ablation signal of the corresponding frequency;

The radio frequency power control circuit receives the power control signal of the microprocessor, converts it into a corresponding controllable DC power supply control signal, and controls the adjustable DC power supply to output a power supply of corresponding power, which is loaded on the radio frequency power amplifier. The circuit generates a radio frequency ablation signal of corresponding power, and acts on the treatment probe through a radio frequency isolation circuit, and the radio frequency ablation signal acts on the treatment tissue, and the radio frequency isolation circuit is isolated by a transformer.

2 . The circuit according to claim 1 , wherein, during the treatment process, the radio frequency signal detection circuit monitors the radio frequency power and tissue impedance of different frequencies in the treatment process in real time. 3 .

3. The circuit according to claim 1, wherein the radio frequency power control circuit receives the PWM signal generated by the microprocessor, and converts the PWM signal through a PWM-to-voltage circuit to output a variable amplitude PWM signal. The DC voltage control signal acts on the control input terminal of the controllable DC power supply, and outputs a DC voltage control signal with adjustable amplitude of greater power, which acts on the power supply input terminal of the radio frequency power amplifier circuit.

4. The circuit of claim 1, wherein the radio frequency power amplifier circuit comprises a filter circuit, a series resonance power amplifier circuit, and an impedance matching circuit.

5. The circuit according to claim 4, wherein the parameters in the series resonant power amplifier circuit can be adjusted by the frequency selection circuit to generate a resonant circuit with a corresponding radio frequency generation frequency; the impedance matching circuit is determined by the The frequency selection circuit adjusts the corresponding frequency.

6. The circuit according to claim 4 or 5, wherein the series resonance power amplifier circuit adopts LC series resonance.

7. The circuit according to claim 1, wherein the radio frequency signal detection circuit comprises an isolation coupling circuit, a rectification filter circuit, a signal amplification circuit and an optoelectronic isolation circuit, and the radio frequency signal detection circuit is used for radio frequency ablation of different frequencies Signal voltage and current detection.

8 . The circuit according to claim 1 , wherein the optional radio frequency signal output frequency range of the circuit is one or more of 100KHz-3MHz. 9 .