CN208552669U - A kind of Almightiness type plasma purification system based on centrifugal separation plasma method - Google Patents
A kind of Almightiness type plasma purification system based on centrifugal separation plasma method Download PDFInfo
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Abstract
本实用新型公开了一种基于离心分离血浆法的全能型血浆净化系统，包括血浆置换装置和血浆透析滤过吸附装置，所述血浆置换装置包括离心式血浆分离器，所述血浆净化系统还包括血浆转移装置，所述血浆转移装置包括血浆转移袋和废浆袋，所述血浆置换装置的血浆输出端与所述血浆转移袋之间设有血浆转移管路，所述血浆转移袋和所述废浆袋之间设有血浆排出管路，所述血浆透析滤过吸附装置的输出端与所述血浆排出管路之间设有血浆循环管路。本实用新型的血浆净化系统能充分发挥离心式血浆置换、血浆透析滤过、血浆双重吸附治疗的优势，并满足离心式血浆置换、血浆透析滤过及血浆吸附对不同血浆流速需求，具有功能更全面、适用范围更广等优点。
The utility model discloses an all-purpose plasma purification system based on a centrifugal plasma separation method, comprising a plasma exchange device and a plasma diafiltration adsorption device, the plasma exchange device includes a centrifugal plasma separator, and the plasma purification system further includes A plasma transfer device, the plasma transfer device includes a plasma transfer bag and a waste plasma bag, a plasma transfer pipeline is arranged between the plasma output end of the plasma exchange device and the plasma transfer bag, the plasma transfer bag and the plasma transfer bag are A plasma discharge pipeline is arranged between the waste pulp bags, and a plasma circulation pipeline is arranged between the output end of the plasma diafiltration adsorption device and the plasma discharge pipeline. The plasma purification system of the utility model can give full play to the advantages of centrifugal plasma exchange, plasma diafiltration and plasma double adsorption treatment, and can meet the requirements of centrifugal plasma exchange, plasma diafiltration and plasma adsorption for different plasma flow rates, and has more functions. It has the advantages of comprehensiveness and wider application.
Description
Technical field
The utility model relates to Medical Instruments for blood purification more particularly to a kind of based on centrifugal separation plasma method
Almightiness type plasma purification system (versatile plasma purification system, VPPS).
Background technique
Acute hepatic failure or acute-on-chronic liver failure state of an illness weight and rapid, the easy complicated with multiple system organ failure that is in progress, it is short
If disease progression cannot be prevented in the phase, by threat to life, urgent liver transfer operation is needed.Acute or acute-on-chronic liver failure patient's body
There are a large amount of toxin, and with coagulation disorders, advanced stage hepatic failure patients hemorrhagic tendency is even more serious.Artificial liver is that one kind is used for
The blood purification method for treating liver failure.Domestic and international basic artificial liver method has 4 kinds at present: plasma exchange, blood plasma are inhaled
Attached, haemodialysis and blood filtering.Artificial liver in treatment is carried out to serious hepatic failure patients, the risk of its bleeding should be scrupled, again
Each toxoid accumulated in vivo, including protein binding toxin and soluble toxins are removed comprehensively.Different blood purification modes
The hepatic failure toxin of removing is different, and combination therapy can remove more toxin, enhances clean-up effect.
Albumin dialysis is adsorbed with molecular adsorbent recirculation system (MARS) for representative, its working principle is that saturating in albumin
Analysis circulation in using 20% albumin liquid (500 ~ 600ml) as combination, transport protein toxin medium, make in blood samples of patients with
Protein bound toxin and other kinds of lps molecule, are transferred in albumin liquid, through protein liquid by MARS dialysis membrane
Purifying regeneration circulation, sequentially passes through dialysis, resin and activated carbon adsorption and is purified, purified albumin liquid can repeat again
It is recycled；Absorber absorption, which reaches saturation postalbumin, cannot reuse and abandon.MARS is due to using albumin transhipment poison
Indirect attachment toxin that is plain and realizing absorber, and influenced by dialysis membrane exchange of toxins efficiency, it removes toxin efficiency and is not so good as blood
Slurry absorption, due to not having supplement blood plasma, cannot improve the coagulation function and Hypoproteinemia of hepatic failure patients, be unsuitable for advanced stage liver
Failure patients.And MARS treatment consumption abandons a large amount of albumin every time, is not easy to be widely used at home.But it passes through resin, work
Property charcoal absorption and synchronize carry out dialysis purification scheme be worth use for reference.As can by plasma exchange, plasma adsorption and dialysis and/or filter
It crosses and combines, can not only remove protein binding toxin and soluble toxins, supplement albumin and coagulation factor comprehensively, but also can be sufficiently
It is fed back using self again after discarded plasma purification, the dosage of clinical blood can be greatly reduced in this way, and can sufficiently meet liver failure
Exhaust the state of an illness needs of patient, the more sufferers of effective treatment.
Plasma exchange needs to draw the part blood of patient from internal, passes through centrifugal or membrane type separated plasma side
Method isolates the blood plasma containing a large amount of toxin and gives discarding, while supplementing fresh plasma.Membrane type separated plasma method is to blood sampling traffic requirement
Bigger, up to 100 ~ 120 ml/min, heparin dosage is larger in art, and the middle and advanced stage hepatic failure very poor for coagulation function is suffered from
Person has the risk for leading to bleeding and hemotoncus；Haemodialysis, blood filtering blood sampling flow be up to 200 ~ 350 ml/min, this
Three kinds of treatments are required to carry out deep venouspuncture or arteriopuncture.The art that hepatic failure patients deep venouspuncture or arteriopuncture cause
Middle postoperative complications are more, and risk is big, once bleeding or hemotoncus occurs, seriously affect successive treatment, poor prognosis.Centrifugal separation
Plasma exchange blood sampling flow only needs 30 ~ 60 ml/min, is not necessarily to deep venouspuncture, and Superficial veins puncture in periphery can meet treatment
Blood flow velocity need, and heparin dosage is relatively small, causes the risk of bleeding small；Protein binding toxin can be removed and mended
The bioactive substances such as coagulation factor and albumin are filled, patient's treatment of coagulation function difference is suitable for.But simple plasma exchange
Each toxoid cannot be removed comprehensively, it is especially limited to soluble toxins Scavenging activity, liver is also induced to serious hepatic failure patients
The risk of stupor, and clinical use is limited by blood plasma insufficient supply, therefore serious hepatic failure patients need to be filtered with plasma dialysis
And plasma adsorption combination therapy, protein binding toxin and soluble toxins can be removed to the maximum extent.In order to improve blood plasma filter
The blood plasma that centrifugal plasma displacement instrument separates need to be raised speed from 25 ~ 30 ml/min, make it with 150 by the efficiency crossed and adsorbed
The flow velocity high speed of ~ 180 ml/min passes through blood filter and two plasorbers (adsorbing different classes of toxin respectively), then
Patient's body is fed back with the speed of 25 ~ 30 ml/min again.
Document number is that the Chinese patent literature of CN203280813U discloses a kind of plasma exchange absorption for being equipped with slurry storing bag
Purification system is filtered, which combines plasma exchange, plasma adsorption with plasma dialysis, 1 hour plasma exchange is first carried out,
Blood plasma high-speed circulating absorption in 5 hours and plasma dialysis are carried out followed by by specially designed slurry storing bag, but it constitutes complexity, and
It can only be run on the basis of membranous type blood plasma separates, need deep venouspuncture, Operative risk is big, is unsuitable for coagulation function very poor evening
Phase hepatic failure patients.
Document number is that the Chinese patent literature of CN205073379U discloses one kind by using specially designed blood plasma point
Stream and replacement piping, displacement and adsorbed plasma converge pipeline, and the normal blood purification instrument for possessing 4 pumps using only one can be same
Step completes the purification system and its application method of slow type plasma exchange, plasma adsorption and filtration.But it also can only be in membranous type blood plasma
It is run on the basis of separation, is unsuitable for the very poor advanced stage hepatic failure patients of coagulation function.And blood plasma speed when plasma adsorption and filtration
Degree is 25 ~ 30ml/min, insufficient to the Scavenging activity of soluble toxins.
Utility model content
The technical problems to be solved in the utility model is to overcome the deficiencies of the prior art and provide a kind of use to be centrifugated blood
Slurry displacement, in combination with the plasma purification system of plasma dialysis accepted filtered absorption, which can be sufficiently in an artificial liver in treatment
Play centrifugal plasma displacement, plasma dialysis filtration, the dual adsorbing therapy of blood plasma advantage, and meet centrifugal plasma displacement,
Plasma dialysis filtration and plasma adsorption to the different demands of plasma flow rate, function more comprehensively, the scope of application it is wider.
In order to solve the above technical problems, the utility model uses following technical scheme:
A kind of Almightiness type plasma purification system based on centrifugal separation plasma method, including plasmapheresis device and plasma dialysis
Accepted filtered absorption device, the plasmapheresis device include centrifugal plasma separator, and the plasma purification system further includes being used for
The blood plasma transfer device collected the blood plasma after separating or recycle purified blood plasma, the blood plasma transfer device includes blood
Transfering bag and waste pulp bag are starched, blood plasma is equipped between the blood plasma output end of the plasmapheresis device and the blood plasma transfering bag and is shifted
Pipeline is equipped with blood plasma discharge line, the plasma dialysis accepted filtered absorption device between the blood plasma transfering bag and the waste pulp bag
Output end and the blood plasma discharge line between be equipped with plasma circulation pipeline.
As a further improvement of the above technical scheme:
The height of the blood plasma transfering bag and the connector of the blood plasma transfer conduit will lower than blood plasma transfering bag with it is described
The height of the connector of blood plasma discharge line.
The input terminal of the centrifugal plasma separator is connected with the blood sampling pipe for acquiring blood samples of patients, the centrifugation
The output end of formula plasma separator is connected with haemocyte output pipe and plasma outlet tube road, the plasma outlet tube road with it is described
Blood plasma transfer conduit is connected, the input terminal phase of the output end on the plasma outlet tube road and the plasma dialysis accepted filtered absorption device
Company, the plasmapheresis device further include that treated blood defeated time suffers from for the blood plasma recirculation line of autoplamotherapy and for inciting somebody to action
The output end of the intracorporal blood back pipeline of person, the haemocyte output pipe and the blood plasma recirculation line with the blood back pipeline
Input terminal be connected, the input terminal of the blood plasma recirculation line is connected with the output end of the plasma dialysis accepted filtered absorption device,
The input terminal of the blood plasma recirculation line is connected with the fresh plasma pipeline for supplementing fresh plasma.
The plasma dialysis accepted filtered absorption device includes filtered solution intake line, for carrying out dialysis filtration absorption to blood plasma
Plasma dialysis accepted filtered absorption pipeline and for by the plasma circulation recirculation line of purified plasma circulation or feedback, the blood
The input terminal of slurry dialysis filtration absorption pipeline is connected with the output end on the plasma outlet tube road, the plasma dialysis accepted filtered absorption
The output end of pipeline and the filtered solution intake line is connected with the input terminal of the plasma circulation recirculation line, the blood plasma
The output end of circulation recirculation line is connected with the input terminal of the blood plasma recirculation line and the plasma circulation pipeline respectively.
Blood filter, the first plasorber and the second plasma adsorption are successively arranged on the plasma dialysis accepted filtered absorption pipeline
Device, the lower part side opening of the blood filter are connected with dialyzate intake line, and the top side opening of the blood filter is connected with dialyzate
Discharge line.
The plasma circulation pipeline is equipped with the first connectivity port that can be connected to or disconnect, the plasma outlet tube road
The second connection end mouth that can be connected to or disconnect, the plasma circulation are equipped between the plasma dialysis accepted filtered absorption pipeline
The third connectivity port that can be connected to or disconnect, first connection are equipped between recirculation line and the blood plasma recirculation line
The two sides of port, second connection end mouth and third connectivity port are equipped with pipe clamp.
The blood sampling pipe is equipped with blood sampling pump, and the speed of the blood sampling pump is 50~60ml/min, the blood plasma output
Pipeline is equipped with blood plasma separation pump, and the speed of the blood plasma separation pump is 25~30ml/min, sets on the blood plasma recirculation line
There is blood plasma front pump, the speed of the blood plasma front pump is 25~30ml/min, is set on the plasma dialysis accepted filtered absorption pipeline
There is plasma circulation transfer tube, the speed of the plasma circulation transfer tube is 150~180ml/min, the dialyzate intake line
It is equipped with dialysis liquid pump, the speed of the dialysis liquid pump is 50~60 ml/min, and the dialyzate discharge line is equipped with waste liquid
Pump, the speed of the waste drains pump are 100~120 ml/min, and the filtered solution intake line is equipped with filtrate pump, the filtrate
The speed of pump is 50~60 ml/min.
The blood sampling pipe is equipped with the first liquid pot and the first liquid level inspection for detecting the first liquid pot liquid level
Sensor is surveyed, the plasma dialysis accepted filtered absorption pipeline is equipped with the second liquid pot and for detecting the second liquid pot liquid level
The second level detection sensors device, blood return tube road is equipped with third liquid pot and for detecting the third liquid pot liquid level
Third level detection sensors device, the filtered solution intake line is equipped with the 4th liquid pot and for detecting the 4th liquid pot liquid
4th level detection sensors device of face height, the blood plasma recirculation line are equipped with the 5th liquid pot and for detecting the 5th liquid
5th level detection sensors device of pot liquid level.
Pressure detecting connecting tube is equipped on the first liquid pot, the second liquid pot and third liquid pot.
Heparin pump is respectively connected on the first liquid pot and the second liquid pot.
The blood plasma recirculation line is equipped with the first heating component, and the plasma circulation recirculation line and the blood plasma are fed back
One end of piping connection is equipped with the second heating component.
The input terminal of the fresh plasma pipeline is equipped with fresh plasma bag, and the input terminal of the dialyzate intake line is equipped with
The output end of dialyzate bag, the dialyzate discharge line is equipped with waste fluid bag, and the input terminal of the filtered solution intake line is equipped with
Filtrate bag is equipped with extension scale for monitoring weight on the dialyzate bag, waste fluid bag and filtrate bag.
The plasmapheresis device is connected with the computer control system of plasmapheresis device described in independent control, the blood
Slurry dialysis filtration adsorbent equipment is connected with the computer control system of plasma dialysis accepted filtered absorption device described in independent control.
Compared with the prior art, the advantages of the utility model are:
The Almightiness type plasma purification system based on centrifugal separation plasma method of the utility model, including plasmapheresis device,
Plasma dialysis accepted filtered absorption device and blood plasma transfer device, plasmapheresis device is using centrifugal plasma separator, this reality
Successfully centrifugal plasma isolation technics and membrane type blood purification technology (dialysis filtration absorption) are combined with novel, combined
The advantages of above two technology, overcomes the deficiency of above two technology, by centrifugal process separated plasma, wants to blood sampling flow
It asks small, does not need just to be able to satisfy Treatment need using deep venouspuncture, the safety for the treatment of is improved, so that artificial liver in treatment can
To be extended to the very poor middle and advanced stage hepatic failure patients of coagulation function；Partial cleansing rear blood plasma is followed by blood plasma transfer device
Ring, solve centrifugal plasma separator low speed separated plasma and plasma dialysis accepted filtered absorption device needed for high plasma flow rate it
Between contradiction, enable the discarded blood plasma isolated carry out high speed dialysis, filtration and absorption circulating purification, give full play to various
The treatment advantage of purification means.Plasma circulation after blood plasma transfering bag can play temporary discarded blood plasma, will be Partial cleansing shifts
With the effect of compensator or trimmer pressure.The connection of centrifugal plasma displacement with plasma dialysis filtration, plasma adsorption may be implemented in the utility model
Treatment is closed, when lacking blood plasma or not needing to carry out plasma exchange, plasma dialysis filter is carried out to separated plasma using this system
Cross and adsorbing therapy, expanded the artificial liver in treatment mode of centrifugal plasma partition method, realize to protein binding toxin with it is water-soluble
Comprehensive removing of property toxin expands out more fully plasma purification function on the basis of its existing safety.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the Almightiness type plasma purification system of the present embodiment.
Fig. 2 is that the Almightiness type plasma purification system of the present embodiment carries out the schematic diagram of plasma exchange.
Fig. 3 is that the Almightiness type plasma purification system of the present embodiment carries out the schematic diagram of plasma dialysis accepted filtered absorption.
Marginal data:
1, plasmapheresis device；11, centrifugal plasma separator；12, blood sampling pipe；121, blood sampling pump；122, the first liquid
Pot；123, the first level detection sensors device；13, haemocyte output pipe；14, plasma outlet tube road；141, blood plasma separation pump；
142, second connection end mouth；15, blood plasma recirculation line；151, blood plasma front pump；152, the 5th liquid pot；153, the 5th level detection
Sensor；154, the first heating component；16, blood back pipeline；161, third liquid pot；162, third level detection sensors device；17, new
Fresh plasma tube；171, fresh plasma bag；2, plasma dialysis accepted filtered absorption device；21, filtered solution intake line；211, filtrate
Pump；212, the 4th liquid pot；213, the 4th level detection sensors device；214, filtrate bag；22, plasma dialysis accepted filtered absorption pipeline；
221, plasma circulation transfer tube；222, the second liquid pot；223, the second level detection sensors device；224, dialyzate intake line；
2241, dialysis liquid pump；2242, dialyzate bag；225, dialyzate discharge line；2251, waste drains pump；2252, waste fluid bag；226, blood
Filter；227, the first plasorber；228, the second plasorber；23, plasma circulation recirculation line；231, third connecting pin
Mouthful；232, the second heating component；3, blood plasma transfer device；31, blood plasma transfering bag；32, waste pulp bag；33, blood plasma transfer conduit；
34, blood plasma discharge line；35, plasma circulation pipeline；351, the first connectivity port；4, pipe clamp；5, pressure detecting connecting tube；6, liver
Element pump.
Specific embodiment
The utility model is described in further details below with reference to Figure of description and specific embodiment.
As shown in Figure 1, the Almightiness type plasma purification system based on centrifugal separation plasma method of the present embodiment, including blood plasma are set
Changing device 1 and plasma dialysis accepted filtered absorption device 2, plasmapheresis device 1 include centrifugal plasma separator 11, plasma purification system
System further includes the blood plasma transfer device 3 for collecting the blood plasma after separating or recycling purified blood plasma, blood plasma transfer
Device 3 includes blood plasma transfering bag 31 and waste pulp bag 32, is set between the blood plasma output end and blood plasma transfering bag 31 of plasmapheresis device 1
There is blood plasma transfer conduit 33, blood plasma discharge line 34 is equipped between blood plasma transfering bag 31 and waste pulp bag 32, plasma dialysis filtration is inhaled
It is equipped with plasma circulation pipeline 35 between the output end and blood plasma discharge line 34 of adsorption device 2, is equipped in the inlet of waste pulp bag 32
Pipe clamp 4.The plasma purification system includes three parts: centrifugal plasmapheresis device 1, plasma dialysis accepted filtered absorption device 2
With the blood plasma transfer device 3 for playing the role of connecting the device of front two, centrifugal plasma exchange blood sampling flow is small, treatment safety
Property it is high, be suitable for middle and advanced stage hepatic failure patients, plasma dialysis accepted filtered absorption can remove to the maximum extent protein binding toxin and
Soluble toxins, but need higher plasma flow rate, blood plasma transfer device 3 pass through the plasma circulation after will be Partial cleansing to blood plasma
Dialysis filtration adsorbent equipment 2 is to meet the needs of its high plasmaflux, while repeatedly circulating plasma purifies more thorough, therefore
Success combines centrifugation plasma exchange and plasma dialysis accepted filtered absorption, gives full play to respective treatment advantage, therapeutic effect
More preferably.
In the present embodiment, the height of the connector of blood plasma transfering bag 31 and blood plasma transfer conduit 33 will be lower than blood plasma transfering bag
31 with the height of the connector of blood plasma discharge line 34, setting in this way is in only progress plasma exchange, the toxin first separated
The higher blood plasma of concentration it is subsequent enter bag blood plasma promotion under constantly drain into waste pulp bag 32, stay in blood plasma after the completion of plasma exchange
It is the lower blood plasma containing toxin concentration finally entered in bag in transfering bag 31, it is relatively easy to purify；Furthermore it is being replaced
, can be by part plasma circulation when adsorbing combination therapy with dialysis filtration, the connector of blood plasma transfer conduit 33 is lower can be to avoid
Air enters plasma dialysis accepted filtered absorption device 2 in blood plasma transfering bag 31 when circulation, while can also make in blood plasma transfering bag 31
Remaining discarded blood plasma is introduced into plasma dialysis accepted filtered absorption device 2 and is purified, and reenters blood plasma transfering bag after purifying
31 blood plasma also enters plasma dialysis accepted filtered absorption device 2 therewith and carries out circulating purification.Blood plasma transfering bag 31 is in addition to that can shift
Blood plasma, since its volume can also play a part of pressure release bag and avoid according to change in pressure in plasma circulation pipeline 35
Pressure is excessive in plasma circulation pipeline 35, and the liquid level of observation blood plasma transfering bag 31 can also be used to understand liquid flow in disengaging bag
The dynamic equilibrium of amount.
In the present embodiment, the input terminal of centrifugal plasma separator 11 is connected with the blood sampling pipe for acquiring blood samples of patients
12, the output end of centrifugal plasma separator 11 is connected with haemocyte output pipe 13 and plasma outlet tube road 14, blood plasma output
Pipeline 14 is connected with blood plasma transfer conduit 33, and the output end on plasma outlet tube road 14 is defeated with plasma dialysis accepted filtered absorption device 2
Enter end to be connected, plasmapheresis device 1 further includes for the blood plasma recirculation line 15 of autoplamotherapy and for will treated blood
The output end of the blood back pipeline 16 of defeated time patient's body, haemocyte output pipe 13 and blood plasma recirculation line 15 with blood back pipeline
16 input terminal is connected, and the input terminal of blood plasma recirculation line 15 is connected with the output end of plasma dialysis accepted filtered absorption device 2, blood plasma
The input terminal of recirculation line 15 is connected with the fresh plasma pipeline 17 for supplementing fresh plasma.Blood sampling pipe 12 take a blood sample after send to
Centrifugal plasma separator 11, the haemocyte after separation, which is sent by haemocyte output pipe 13 to blood back pipeline 16, to be finally transmitted back to
Human body, the blood plasma after separation are flowed out from plasma outlet tube road 14, and waste pulp bag 32 can be entered by blood plasma transfer conduit 33, also optional
It selects and is sent into the progress purified treatment of plasma dialysis accepted filtered absorption device 2, purified blood plasma is entered back by blood plasma recirculation line 15
Blood vessel road 16 is finally transmitted back to human body, when only carrying out plasma exchange, can supplement fresh plasma by fresh plasma pipeline 17.
In the present embodiment, plasma dialysis accepted filtered absorption device 2 includes filtered solution intake line 21, for carrying out thoroughly to blood plasma
Analyse the plasma dialysis accepted filtered absorption pipeline 22 of accepted filtered absorption and for returning the plasma circulation of purified plasma circulation or feedback
The input terminal of defeated pipeline 23, plasma dialysis accepted filtered absorption pipeline 22 is connected with the output end on plasma outlet tube road 14, plasma dialysis
The output end of accepted filtered absorption pipeline 22 and filtered solution intake line 21 is connected with the input terminal of plasma circulation recirculation line 23, blood
The output end of slurry circulation recirculation line 23 is connected with the input terminal of blood plasma recirculation line 15 and plasma circulation pipeline 35 respectively.Blood plasma
Dialysis filtration absorption pipeline 22 receives the blood plasma from plasma outlet tube road 14 and the purified treatments such as is dialysed, filtered and adsorbed,
Treated, and blood plasma is flowed out from plasma circulation recirculation line 23, and a part enters blood plasma recirculation line 15, and another part enters blood
Slurry recirculation line 15 is recycled, to meet the needs of dialysis filtration adsorption process high flow capacity.
In the present embodiment, blood filter 226, the first plasorber are successively arranged on plasma dialysis accepted filtered absorption pipeline 22
227 and second plasorber 228, the lower part side opening of blood filter 226 be connected with dialyzate intake line 224, blood filter 226
Top side opening is connected with dialyzate discharge line 225.Specifically, the first plasorber 227 is bilirubin adsorption device, the second blood
Slurry absorber 228 is resin activity charcoal absorber.Blood filter 226, bilirubin adsorption device and resin activity charcoal absorber can be right
Blood plasma carries out effective dialysis filtration suction-operated, removes the toxin in blood plasma, and dialyzate intake line 224 mentions for dialysis procedure
For dialyzate, dialyzate discharge line 225 can recycle used dialyzate.
In the present embodiment, plasma circulation pipeline 35 is equipped with the first connectivity port 351 that can be connected to or disconnect, blood plasma
The second connection end mouth 142 that can be connected to or disconnect is equipped between output pipe 14 and plasma dialysis accepted filtered absorption pipeline 22,
The third connectivity port 231 that can be connected to or disconnect is equipped between plasma circulation recirculation line 23 and blood plasma recirculation line 15,
The two sides of first connectivity port 351, second connection end mouth 142 and third connectivity port 231 are equipped with pipe clamp 4.Three connecting pins
Mouth can these three parts be connected into one with blood plasma transfer device 3 by plasmapheresis device 1, plasma dialysis accepted filtered absorption device 2
A complete Almightiness type plasma purification system is operated, while they can also be disconnected to exclusive use, is such as divided into centrifugal
Plasma exchange and membrane type blood purification (including a variety of therapeutic modalities such as plasma exchange, plasma adsorption, hemodiafiltration)
Two relatively independent systems, while being the artificial liver in treatment of different patient's progress different modes, there is flexibility and more function
It can property.
In the present embodiment, blood sampling pipe 12 is equipped with blood sampling pump 121, and the speed of blood sampling pump 121 is 50~60ml/min, blood
It starches output pipe 14 and is equipped with blood plasma separation pump 141, the speed of blood plasma separation pump 141 is 25~30ml/min, and blood plasma feeds back pipe
Road 15 is equipped with blood plasma front pump 151, and the speed of blood plasma front pump 151 is 25~30ml/min, plasma dialysis accepted filtered absorption pipe
Road 22 is equipped with plasma circulation transfer tube 221, and the speed of plasma circulation transfer tube 221 is 150~180ml/min, and dialyzate is defeated
Enter pipeline 224 and be equipped with dialysis liquid pump 2241, the speed of dialysis liquid pump 2241 is 50~60 ml/min, dialyzate discharge line
225 are equipped with waste drains pump 2251, and the speed of waste drains pump 2251 is 100~120 ml/min, and filtered solution intake line 21 is equipped with
Filtrate pump 211, the speed of filtrate pump 211 are 50~60 ml/min.Blood plasma separation pump 141, blood plasma front pump are adjusted by linkage
151, the speed of filtrate pump 211 and waste drains pump 2251 can carry out fluid balance regulation, and then realize ultrafiltration.Specifically, setting
The speed of blood sampling pump 121 is 60ml/min, and the speed of blood plasma separation pump 141 is 30ml/min, and the speed of blood plasma front pump 151 is
25ml/min, the speed of plasma circulation transfer tube 221 are 180ml/min, and the speed of dialysis liquid pump 2241 is 50ml/min, waste liquid
The speed of pump 2251 is 115 ml/min, and the speed of filtrate pump 211 is 60ml/min, and it is 5ml/min that speed may be implemented at this time
The ultrafiltration of (300ml/h).
In the present embodiment, blood sampling pipe 12 is equipped with the first liquid pot 122 and for detecting 122 liquid level of the first liquid pot
First level detection sensors device 123, plasma dialysis accepted filtered absorption pipeline 22 are equipped with the second liquid pot 222 and for detecting the second liquid
Second level detection sensors device 223 of 222 liquid level of pot, blood back pipeline 16 are equipped with third liquid pot 161 and for detecting the
The third level detection sensors device 162 of three liquid pots, 161 liquid level, filtered solution intake line 21 are equipped with 212 He of the 4th liquid pot
For detecting the 4th level detection sensors device 213 of 212 liquid level of the 4th liquid pot, blood plasma recirculation line 15 is equipped with the 5th liquid
Pot 152 and the 5th level detection sensors device 153 for detecting 152 liquid level of the 5th liquid pot, liquid pot can keep in liquid, liquid
Face detection sensor can detecte the height of liquid level in liquid pot, guarantee the normal operation of system.
In the present embodiment, pressure detecting connecting tube is equipped on the first liquid pot 122, the second liquid pot 222 and third liquid pot 161
5, pressure detecting connecting tube 5 is conducive to system normal operation convenient for the pressure condition in signal piping.
In the present embodiment, heparin pump 6 is respectively connected on the first liquid pot 122 and the second liquid pot 222.
In the present embodiment, blood plasma recirculation line 15 is equipped with the first heating component 154, plasma circulation recirculation line 23 and blood
It starches one end that recirculation line 15 connects and is equipped with the second heating component 232.Liquid in pipeline can be heated to normally by heating component
Physiological temp guarantees the balance and stability of patient temperature in therapeutic process.
In the present embodiment, the input terminal of fresh plasma pipeline 17 is equipped with fresh plasma bag 171, dialyzate intake line 224
Input terminal be equipped with dialyzate bag 2242, the output end of dialyzate discharge line 225 is equipped with waste fluid bag 2252, filtered solution input pipe
The input terminal on road 21 is equipped with filtrate bag 214, is equipped on dialyzate bag 2242, waste fluid bag 2252 and filtrate bag 214 for monitoring
The extension scale of weight, to filtrate bag 214, the weight of dialyzate bag 2242, waste fluid bag 2252 and filtrate bag 214 is monitored, so as to
It is replaced in time when surplus deficiency in bag, in order to avoid influence treatment.
In the present embodiment, plasmapheresis device 1 is connected with the computer control system of independent control plasmapheresis device 1,
Plasma dialysis accepted filtered absorption device 2 is connected with the computer control system of independent control plasma dialysis accepted filtered absorption device 2.Specifically
, computer control system can be independently controlled from each other simultaneously in a computer, can also distinguish in 2 computers
Independently controlled.When carrying out the treatment of Almightiness type plasma purification, two computer control systems can also connect collaboration work each other
Make, by the connection of the utility model pipeline combine to an example patient carry out centrifugation plasma exchange and plasma dialysis accepted filtered absorption control
It treats.Computer control system is separately provided facilitating respectively individually makes plasmapheresis device 1 and plasma dialysis accepted filtered absorption device 2
With separately becoming 2 independent treatment systems, carry out centrifugal separated plasma displacement and membrane type to 2 different patients respectively
Plasma purification treatment, a machine double-purpose, two sets of independent computer control systems according to the actual situation can independent monitoring work, mutually not
It influences, the flexibility and versatility that the system of improving uses.
The application method of the Almightiness type plasma purification system based on centrifugal separation plasma method of the present embodiment is as follows:
(1) centrifugal separated plasma displacement and the Almightiness type plasma purification treatment of plasma dialysis accepted filtered absorption:
As shown in Fig. 2, the first connectivity port 351, second connection end mouth 142 and third connectivity port 231 are broken before treatment
Connection is opened, using heparin-saline respectively to plasmapheresis device 1 and plasma dialysis accepted filtered absorption under computer program control
Device 2 carries out pipeline preliminary filling.
Centrifugal plasma displacement is carried out by centrifugal plasma separator 11 first, and is connected to fresh plasma pipeline 17, newly
Blood slurry passes through blood plasma recirculation line 15 under the driving of blood plasma front pump 151, and thin with the blood in haemocyte output pipe 13
Born of the same parents through blood back pipeline 16 are fed back to patient's body after converging, and the blood plasma isolated is flowed out from plasma outlet tube road 14, by blood plasma
Transfer conduit 33 enters blood plasma transfering bag 31, then enters waste pulp bag 32 by blood plasma discharge line 34.
As shown in figure 3, the pipe clamp 4 and blood plasma discharge line 34 for closing fresh plasma pipeline 17 lean on after the completion of plasma exchange
Pipe clamp 4 at nearly waste pulp bag 32, the first connectivity port 351, second connection end mouth 142 are connected to third connectivity port 231, opened
Begin to carry out the treatment of plasma dialysis accepted filtered absorption: the blood plasma of 11 low speed of centrifugal plasma separator separation is flowed from plasma outlet tube road 14
Enter plasma dialysis accepted filtered absorption pipeline 22 out, while the blood plasma retained in blood plasma transfering bag 31 passes through blood plasma transfer conduit 33
Into plasma dialysis accepted filtered absorption pipeline 22, these blood plasma are defeated under the action of the plasma circulation transfer tube 221 to run at high speed
It is sent in blood filter 226, bilirubin adsorption device and resin activity charcoal absorber and carries out plasma dialysis filtration and absorption, it is purified
A part of blood plasma feeds back patient's body after converging by blood plasma front pump 151 and haemocyte, and another part blood plasma is followed by blood plasma
Endless tube road 35 enters blood plasma transfering bag 31, and the blood plasma separated with 11 low speed of centrifugal plasma separator converges, by plasma circulation
Transfer tube 221 is transported in plasma dialysis accepted filtered absorption pipeline 22 and carries out circulating purification, is realized in this way by blood plasma transfer device 3
To the circulating purification of blood plasma, it is able to satisfy differentiation requirement of the blood plasma separation with plasma dialysis filtration, plasma adsorption to plasma flow rate,
Solve centrifugal plasma separator 11 low speed separated plasma and plasma dialysis accepted filtered absorption device 2 needed for high plasma flow rate it
Between contradiction, be able to carry out the discarded blood plasma of separation dialysis filtration, the adsorption cleaning of circulation high speed, give full play to various purifications
The treatment advantage of means.
(2) centrifugal separated plasma displacement is treated respectively with membrane type blood purification:
Since plasmapheresis device 1 and plasma dialysis accepted filtered absorption device 2 are independent from each other, the first connectivity port is disconnected
351, available centrifugal separated plasma exchange system and membrane type blood behind second connection end mouth 142 and third connectivity port 231
Two independent systems of liquid purification system, wherein centrifugal separated plasma exchange system uses three pumps, membrane type blood purification system
System is not interfere with each other independently of each other, is controlled respectively by respective computer control system, can be simultaneously two patients using four pumps
The displacement of centrifugal separated plasma and membrane type blood purification (including plasma exchange, plasma adsorption, haemodialysis filter are carried out respectively
A variety of therapeutic modalities such as cross), with having flexibility and multi-functional.
Although the utility model has been disclosed with preferred embodiment as above, it is not intended to limit the utility model.It is any
Those skilled in the art, in the case where not departing from technical solutions of the utility model range, all using the disclosure above
Technology contents many possible changes and modifications are made to technical solutions of the utility model, or be revised as the equivalent of equivalent variations
Embodiment.Therefore, all contents without departing from technical solutions of the utility model, according to the utility model technical spirit to the above reality
Any simple modifications, equivalents, and modifications that example is done are applied, should all be fallen in the range of technical solutions of the utility model protection.
Claims (10)
1. a kind of Almightiness type plasma purification system based on centrifugal separation plasma method, including plasmapheresis device (1) and blood plasma it is saturating
It analyses accepted filtered absorption device (2), it is characterised in that: the plasmapheresis device (1) includes centrifugal plasma separator (11), described
Plasma purification system further includes the blood plasma transfer device for collecting the blood plasma after separating or recycling purified blood plasma
(3), the blood plasma transfer device (3) includes blood plasma transfering bag (31) and waste pulp bag (32), the blood of the plasmapheresis device (1)
It starches between output end and the blood plasma transfering bag (31) equipped with blood plasma transfer conduit (33), the blood plasma transfering bag (31) and described
Between waste pulp bag (32) be equipped with blood plasma discharge line (34), the output end of the plasma dialysis accepted filtered absorption device (2) with it is described
Plasma circulation pipeline (35) are equipped between blood plasma discharge line (34).
2. the Almightiness type plasma purification system according to claim 1 based on centrifugal separation plasma method, it is characterised in that: institute
The height for stating the connector of blood plasma transfering bag (31) and the blood plasma transfer conduit (33) will be lower than blood plasma transfering bag (31) and institute
State the height of the connector of blood plasma discharge line (34).
3. the Almightiness type plasma purification system according to claim 1 based on centrifugal separation plasma method, it is characterised in that: institute
The input terminal for stating centrifugal plasma separator (11) is connected with blood sampling pipe (12) for acquiring blood samples of patients, described centrifugal
The output end of plasma separator (11) is connected with haemocyte output pipe (13) and plasma outlet tube road (14), the blood plasma output
Pipeline (14) is connected with the blood plasma transfer conduit (33), the output end and the plasma dialysis of the plasma outlet tube road (14)
The input terminal of accepted filtered absorption device (2) is connected, and the plasmapheresis device (1) further includes the blood plasma feedback pipe for autoplamotherapy
Road (15) and for by the blood back pipeline (16) of treated defeated time patient's body of blood, the haemocyte output pipe (13) and
The output end of the blood plasma recirculation line (15) is connected with the input terminal of the blood back pipeline (16), the blood plasma recirculation line
(15) input terminal is connected with the output end of the plasma dialysis accepted filtered absorption device (2), the blood plasma recirculation line (15)
Input terminal is connected with the fresh plasma pipeline (17) for supplementing fresh plasma.
4. the Almightiness type plasma purification system according to claim 3 based on centrifugal separation plasma method, it is characterised in that: institute
Stating plasma dialysis accepted filtered absorption device (2) includes filtered solution intake line (21), for carrying out dialysis filtration absorption to blood plasma
Plasma dialysis accepted filtered absorption pipeline (22) and for by the plasma circulation recirculation line (23) of purified plasma circulation or feedback,
The input terminal of the plasma dialysis accepted filtered absorption pipeline (22) is connected with the output end of the plasma outlet tube road (14), the blood
The output end for starching dialysis filtration absorption pipeline (22) and the filtered solution intake line (21) feeds back pipe with the plasma circulation
The input terminal on road (23) is connected, the output end of the plasma circulation recirculation line (23) respectively with the blood plasma recirculation line (15)
It is connected with the input terminal of the plasma circulation pipeline (35).
5. the Almightiness type plasma purification system according to claim 4 based on centrifugal separation plasma method, it is characterised in that: institute
It states and is successively arranged blood filter (226), the first plasorber (227) and the second blood plasma on plasma dialysis accepted filtered absorption pipeline (22)
The lower part side opening of absorber (228), the blood filter (226) is connected with dialyzate intake line (224), the blood filter
(226) top side opening is connected with dialyzate discharge line (225).
6. the Almightiness type plasma purification system according to claim 4 or 5 based on centrifugal separation plasma method, feature exist
In: the plasma circulation pipeline (35) is equipped with the first connectivity port (351) that can be connected to or disconnect, the blood plasma output
The second connection end mouth that can be connected to or disconnect is equipped between pipeline (14) and the plasma dialysis accepted filtered absorption pipeline (22)
(142), being equipped between the plasma circulation recirculation line (23) and the blood plasma recirculation line (15) can be connected to or disconnect
Third connectivity port (231), first connectivity port (351), second connection end mouth (142) and third connectivity port
(231) two sides are equipped with pipe clamp (4).
7. the Almightiness type plasma purification system according to claim 5 based on centrifugal separation plasma method, it is characterised in that:
The blood sampling pipe (12) is equipped with blood sampling pump (121), and the speed of the blood sampling pump (121) is 50 ~ 60ml/min, the blood plasma
Output pipe (14) is equipped with blood plasma separation pump (141), and the speed of the blood plasma separation pump (141) is 25 ~ 30ml/min, described
Blood plasma recirculation line (15) is equipped with blood plasma front pump (151), and the speed of the blood plasma front pump (151) is 25 ~ 30ml/min,
The plasma dialysis accepted filtered absorption pipeline (22) is equipped with plasma circulation transfer tube (221), the plasma circulation transfer tube (221)
Speed be 150 ~ 180ml/min, the dialyzate intake line (224) be equipped with dialysis liquid pump (2241), the dialyzate
The speed for pumping (2241) is 50 ~ 60 ml/min, and the dialyzate discharge line (225) is equipped with waste drains pump (2251), described useless
The speed of liquid pump (2251) is 100 ~ 120 ml/min, and the filtered solution intake line (21) is equipped with filtrate pump (211), described
The speed of filtrate pump (211) is 50 ~ 60 ml/min.
8. the Almightiness type plasma purification system according to claim 4 or 5 based on centrifugal separation plasma method, feature exist
The first liquid pot (122) is equipped in: the blood sampling pipe (12) and for detecting the first liquid pot (122) liquid level
One level detection sensors device (123), the plasma dialysis accepted filtered absorption pipeline (22) are equipped with the second liquid pot (222) and for examining
Survey the second level detection sensors device (223) of the second liquid pot (222) liquid level, the blood back pipeline (16) is equipped with the
Three liquid pots (161) and third level detection sensors device (162) for detecting third liquid pot (161) liquid level, it is described
Filtered solution intake line (21) be equipped with the 4th liquid pot (212) and for detecting the 4th liquid pot (212) liquid level the
Four level detection sensors devices (213), the blood plasma recirculation line (15) are equipped with the 5th liquid pot (152) and for detecting described the
The 5th level detection sensors device (153) of five liquid pot (152) liquid levels, the first liquid pot (122), the second liquid pot (222)
With pressure detecting connecting tube (5) are equipped on third liquid pot (161), on the first liquid pot (122) and the second liquid pot (222)
It is connected with heparin pump (6).
9. the Almightiness type plasma purification system according to claim 5 based on centrifugal separation plasma method, it is characterised in that: institute
Blood plasma recirculation line (15) are stated equipped with the first heating component (154), the plasma circulation recirculation line (23) and the blood plasma
One end of recirculation line (15) connection is equipped with the second heating component (232), and the input terminal of the fresh plasma pipeline (17) is equipped with
The input terminal of fresh plasma bag (171), the dialyzate intake line (224) is equipped with dialyzate bag (2242), the dialyzate
The output end of discharge line (225) is equipped with waste fluid bag (2252), and the input terminal of the filtered solution intake line (21) is equipped with filtrate
Bag (214) is equipped with the extension for monitoring weight on the dialyzate bag (2242), waste fluid bag (2252) and filtrate bag (214)
Scale.
10. the Almightiness type plasma purification system according to any one of claims 1 to 5 based on centrifugal separation plasma method,
Be characterized in that: the plasmapheresis device (1) is connected with the computer control system of plasmapheresis device described in independent control (1)
System, the plasma dialysis accepted filtered absorption device (2) are connected with the calculating of plasma dialysis accepted filtered absorption device (2) described in independent control
Machine control system.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820226033.1U CN208552669U (en) | 2018-02-08 | 2018-02-08 | A kind of Almightiness type plasma purification system based on centrifugal separation plasma method |
| PCT/CN2018/117822 WO2019153848A1 (en) | 2018-02-08 | 2018-11-28 | Versatile plasma purification system based on centrifugal plasma separation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820226033.1U CN208552669U (en) | 2018-02-08 | 2018-02-08 | A kind of Almightiness type plasma purification system based on centrifugal separation plasma method |
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| CN208552669U true CN208552669U (en) | 2019-03-01 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108310503A (en) * | 2018-02-08 | 2018-07-24 | 中南大学湘雅二医院 | A kind of Almightiness type plasma purification system based on centrifugal separation plasma method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108310503A (en) * | 2018-02-08 | 2018-07-24 | 中南大学湘雅二医院 | A kind of Almightiness type plasma purification system based on centrifugal separation plasma method |
| CN108310503B (en) * | 2018-02-08 | 2024-11-05 | 中南大学湘雅二医院 | An all-purpose plasma purification system based on centrifugal plasma separation method |
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