Band coating screw thread catheter
Technical field
The utility model relates to the field of medical instrument technology, specifically, being a kind of band coating screw thread catheter.
Background technique
Catheter is the nursing and interfering of postoperative patient routine, and per urethra is inserted into bladder drainage urine, quilt under aseptic condition
It is widely used in postoperative, anesthesia and dysuriac.
Currently, well known Medical urethral catheter be made of with materials such as natural rubber, silicon rubber or polyvinyl chloride (PVC), can
To be inserted into bladder per urethram so that drainage of urine comes out, after catheter is inserted into bladder, there is a water at catheter head end
Capsule, the water pocket can expand after water filling, and fixed catheter stays in bladder and is not easy, and drainage tube connection urinal collects urine
Liquid.
Patient cannot restore normal voiding function quickly after prostate, it is therefore desirable to when plugging in catheter and retaining one section
Between, the length of indwelling time is determined according to the state of an illness.Many scholars have developed different types of coating catheter thus, pass through drug
Lasting slow releasing function achieve the purpose that promote prostate postoperative wound quickly heal, reduce bleeding.But due to common three chamber
Coating limited area coated by Foley catheter, therefore it is unable to reach good expected efficiency.
In addition, clinically the postoperative surface of a wound of prostate excision can generate excessive active oxygen and degradation production during healing
Object, so that the biological marker of various oxidative stress be caused to increase, the enzymatic oxidation ability of wound tissue increases, after leading to wound
There is oxidative stress.In the inflammation phase of wound healing, homeostasis of the oxidative stress as prooxidant and antioxidant
Imbalance, causes histologic lesion.Therefore, long-term oxidative stress is unfavorable for the reparation of the surface of a wound, it may be possible to which postoperative wound is difficult
More one of the reason of, carrys out certain difficulty to treatment zone.
The oxidative stress of the surface of a wound can be effectively suppressed as a kind of reducing substances in Se, so as to which Se is used for prostate
Agglutination afterwards, and then promote the reparation of the prostate surface of a wound, but therapeutic dose and toxicity dose window very little due to Se, it controls
It is easy to happen poisoning during treating, therefore limits its clinical application.
Further, since Se or a kind of indispensable microelement of body vital movement, close with a variety of diseases of human body
Cut phase is closed, and from and study found that taking in Se in right amount, is had enhancing immunity of organism, is delayed biological decay and other effects, but Se is most
Margin of safety between good concentration and intoxicating concentration is very narrow, and dosage is unable to accurately control.Since nanometer selenium is with low
Toxic action, prior art has proposed a kind of Se-SiO2 particles, are formed by porous sio2 material package Se particle, wherein more
The porous structure of hole SiO2 material can effectively control the rate of release and dosage of Se.The Se-SiO2 particle is generally made at this stage
At drug, anticancer, the immunity for enhancing human body cell etc. are carried out.
Chinese patent literature CN201621112707.2, the applying date 20161011, patent name are as follows: a kind of UV solidification coating
Catheter, the packaging bag including urethral catheterization tube body and housing outside urethral catheterization tube body;The urethral catheterization tube body, which is equipped with, gos deep into human body
The hollow conduit of bladder, the head end of hollow conduit are set as closed end, and the tail end of hollow conduit is equipped with connector, in hollow conduit
Front is equipped with urine inlet near head end, is equipped on the front outer wall of hollow conduit and reduces patient's pain in catheterization procedure
UV solidification coating;The sealing lubrication chamber for being internally provided with wet UV solidification coating of the packaging bag and the connector for placing connector are put
Chamber is set, it is intracavitary filled with the sterile water for being always ensured that UV solidification coating lubrication in sealing lubrication.
The UV solidification coating catheter of above patent document, design is rationally, structure is simple, intubation is easy, ingredient safety, energy
It enough effectively prevent that mucous membrane of urethra is caused to damage, but about a kind of band coating screw thread catheter, increases catheter external coating
Surface area, so that coating material is obtained longer action time, to reach the technical solution of stronger effect then without phase
The disclosure answered.
In conclusion needing a kind of band coating screw thread catheter, increases the surface area of catheter external coating, make coating material
Material can obtain longer action time, to reach stronger effect.And it is current about this band coating screw thread catheter
It has not been reported.
Summary of the invention
The purpose of this utility model is aiming at the shortcomings in the prior art, to provide a kind of band coating screw thread catheter, increase
The surface area for adding catheter external coating allows coating material to obtain longer action time, to reach stronger effect.
A further object of the utility model is to provide a kind of preparation method of band coating screw thread catheter.
To achieve the above object, the technical scheme adopted by the utility model is that:
A kind of band coating screw thread catheter, including a catheter tube body, close to catheter pipe on the catheter tube body
A sacculus is equipped at the position of body head end, it is characterised in that: the catheter outer surface of tube body, at the position of the sacculus
Equipped with thread protrusion, and a thread segment is formed, the thread segment periphery of the catheter tube body is coated with coating.
The improvement of the band coating screw thread catheter of the utility model is that the thread segment is equipped with groove.
The improvement of the band coating screw thread catheter of the utility model is, length of the groove along the catheter tube body
Spend direction setting.
The improvement of the band coating screw thread catheter of the utility model is that the number of recesses is set as 4.
The improvement of the band coating screw thread catheter of the utility model is that the groove is along the periphery etc. of the thread segment
Spacing setting.
The improvement of the band coating screw thread catheter of the utility model is that the length of the thread segment is 3cm.
The improvement of the band coating screw thread catheter of the utility model is that the thread segment is arranged on catheter tube body
At position corresponding with patient's prostatic, and catheter is during factory manufacturing i.e. according to the design position of thread segment to leading
Urinary catheter carries out production and forms thread segment.
The improvement of the band coating screw thread catheter of the utility model is that the coating is Se-SiO2 coating.
To realize above-mentioned second purpose, the technical scheme adopted by the utility model is that:
A kind of preparation method of band coating screw thread catheter, comprising the following steps:
Step S1 disperses Cu 2-xSe nanoparticle in n-hexane, obtains Cu 2-xSe n-hexane dispersion liquid;
Deionized water, n-hexyl alcohol, Triton X-100 are added into Cu 2-xSe n-hexane dispersion liquid by step S2
And n-hexane, stirring are added dropwise tetraethyl orthosilicate, are sufficiently mixed, ammonium hydroxide is added dropwise after 1~60min again, be stirred to react, and are added third
Ketone is simultaneously centrifugated, and is scattered in deionized water after separation product washing, 2 dispersion liquid of nanometer Se-SiO is made;
Polyvinylpyrrolidone is added in 2 dispersion liquid of nanometer Se-SiO step S3, after being stirred, stops stirring simultaneously
Heating carries out hydrothermal processes, then cools to room temperature, centrifuge washing, obtains porous 2 nanoparticle of Se-SiO;
Porous 2 nanoparticle of Se-SiO is added in chitosan liquid, is sufficiently mixed by step S4;
The thread segment of catheter tube body is immersed in alcoholic solution by step S5, general to impregnate 5-20 minutes, by thread segment
The removal such as the grease on surface is played the role of cleaning catheter surface;
Step S6 takes out the thread segment of catheter tube body from alcoholic solution, is cleaned with purified water, then impregnate chitosan
And in the mixed solution of 2 nanoparticle of Se-SiO;
Step S7 takes the thread segment of catheter tube body from the mixed solution of 2 nanoparticle of chitosan and Se-SiO
Out, it then cleaned, dried, packed and is sterilized, as needed, repeatedly the step of step S6-S7, is met the requirements with acquisition
2 coating of Se-SiO.
The utility model advantage is:
1, screw thread is arranged at the position of the applying coating needed for catheter for the band coating screw thread catheter of the utility model
Protrusion, and a thread segment is formed, to increase the coated area of coating, coating is made to reach better curative effect, promotes forefront
The postoperative fast quick-recovery of gland.
2, it is non-uniform existing to avoid the occurrence of coating for the setting of thread protrusion and groove while increasing coating coated area
As guaranteeing the reparation of patient's prostate surface of a wound quickly, healthy;
3, the catheter outer surface of tube body, at the position of the sacculus be equipped with thread protrusion, and formed a spiral shell
Line section, the thread segment are located at prostatic in a state of use.The effect of the design scheme is: thread segment can directly and hand
The art surface of a wound directly contacts, cooperate coating on drug can to the surface of a wound realize specific aim local treatment, can local hemostasis, promote the surface of a wound
Healing;
4, Se particle slow release is made by the porous structure of porous sio2, to inhibit prostate surface of a wound oxidative stress
Meanwhile the release of Se particle being avoided comparatively fast to reach toxic dose, cause Se to be poisoned, to promote the reparation of the prostate surface of a wound;
5, on the one hand chitosan makes nanometer Se-SiO2 material become the liquid coating that can be coated on catheter tube body, separately
On the one hand the sustained release agent that can also act as the release of Se particle further functions as the effect for avoiding Se from being poisoned;
6, it while effectively oxidative stress being inhibited to promote wound repair, and avoids causing serious adverse reaction, have good
Good controllability;And it is low in cost, synthesis cycle is short (1 month);Medicine-carried has biggish application prospect;Preservation condition is not severe
It carves, can be saved at 4 DEG C.
Detailed description of the invention
Attached drawing 1 is the structural schematic diagram of the band coating screw thread catheter of the utility model.
Attached drawing 2 is the structural schematic diagram of the head end of catheter tube body in the utility model.
Attached drawing 3 is the structural schematic diagram of the sacculus of catheter tube body in the utility model.
Attached drawing 4 is the structural schematic diagram of the thread segment of catheter tube body in the utility model.
Attached drawing 5 is the partial enlargement diagram of the thread segment of catheter tube body in the utility model.
Attached drawing 6 is the schematic top plan view of the thread segment of catheter tube body in the utility model.
Specific embodiment
It elaborates with reference to the accompanying drawing to specific embodiment provided by the utility model.
Appended drawing reference involved in attached drawing and component part are as follows:
1 thread segment of embodiment+coating type catheter
It please refers to shown in Fig. 1, three-cavity air bag urethral catheter includes a catheter tube body 10, the both ends of the catheter tube body 10
Respectively head end 19 and tail end 11.Cavity there are three being set at the tail end 11 of the three-cavity air bag urethral catheter, respectively water-injecting cavity 12, note
Medicine cavity 13 and exhaust chamber 14, and also there is the check valve 15 of a control water-injecting cavity 12 at the tail end 11.
Shown in referring to figure 2., side is respectively equipped at the head end 19 of the three-cavity air bag urethral catheter and opens medicine-pouring hole 16 and side
The fluid apertures that begins to rehearse 17.
Shown in referring to figure 3., a sacculus 18, the sacculus 18 warp are equipped on catheter tube body 10 at the position of near head end 19
It is expanded after being filled the water by water-injecting cavity 12, so that catheter is fixed in bladder, avoids.Above-mentioned three-cavity air bag urethral catheter is existing
There is technology, details are not described herein.
Shown in referring to figure 4., the screw thread catheter of the utility model band coating 30, in 10 appearance of catheter tube body
Face is equipped with thread protrusion 21 at the position of the sacculus 18, and forms a thread segment 20, and the thread segment 20 is in use state
It is located at prostatic down, that is, when catheter tube body 10 is inserted into patient's bladder, one section at prostatic urethra position
Catheter tube body 10 is set as thread segment 20, and in the present embodiment, the length of thread segment 20 is 3cm;In the catheter tube body 10
The periphery of thread segment 20 is also coated with coating 30.Whereby, coated area of the thread protrusion 21 to increase coating 30 improves coating
30 therapeutic effect.
The embodiment it should be understood that in 10 outer surface of catheter tube body, at the position of the sacculus 18
Equipped with thread protrusion 21, and a thread segment 20 is formed, which is located at prostatic in a state of use.The design
The effect of scheme is: 1. because surgical wound surface is located in urethra and at neck of urinary bladder, and the thread segment 20 of the present embodiment can directly and hand
The art surface of a wound directly contacts, cooperate coating 30 on drug can to the surface of a wound realize specific aim local treatment, can local hemostasis, promote wound
Face healing.And in the prior art because of the particularity of surgical wound surface position, local hemostasis and medicinal application are inconvenient.Also the biography having
System method is continuous bladder rinse joint systemic drug treatment, and draws method pain caused by patient of balloon tamponade hemostasis
Greatly, the easy ischemic in part and it is downright bad, complicate the state of an illness, prognosis is not good enough;2. carrier of the thread segment 20 as coating 30, thread segment
20 be the structure type of thread protrusion 21, and corresponding coating 30 is consistent with the shape and structure of thread segment 20, increases the painting of coating 30
Clad can product improves the therapeutic effect of coating 30 so that the local concentration of drug therapy is high.
In the embodiment, the length of thread segment 20 is 3cm, which designed according to clinical experience, is promoted
It quickly heals into prostate postoperative wound, to reduce Bleeding good.
Embodiment 2 is with reeded thread segment+coating type catheter
The present embodiment is substantially the same manner as Example 1, the difference is that: referring to figure 5. and Fig. 6, the thread segment 20
On along the catheter tube body 10 length direction be arranged fluted 22, coating 30 be coated in thread segment 20 on when, the groove 22
The channel that about 30 coating is spread is formed, certain patient's urethras and catheter tube body 10 are also prevented from while increasing coated area
On thread protrusion 21 be tightly bonded, cause coating 30 to be unevenly distributed, using incomplete.In the present embodiment, the number of groove 22
Amount is 4, and along the periphery spaced set of the thread segment 20.
Embodiment 3 is with reeded thread segment+Se-SiO2 coating type catheter
The present embodiment is substantially the same manner as Example 2, the difference is that: the present embodiment is right using Se-SiO2 coating 30
The oxidative stress of the prostate surface of a wound is effectively inhibited, and the Se-SiO2 coating 30 includes nanometer Se-SiO2 material, the nanometer
Se-SiO2 material is formed by porous sio2 material package Se particle, and the porous structure of porous sio2 material can effectively control Se
Rate of release and dosage, thus avoid occur intoxicating phenomenon, but the nanometer Se-SiO2 material be it is powdered, can not apply
It overlays on catheter tube body 10.Since chitosan can generate natural metabolin by the intracorporal lysozyme degradation of biology, there is nothing
Poison, the characteristics of capable of being fully absorbed by organism, therefore make medicinal slow release agent with biggish superiority with it, and the shell is poly-
Sugar can be coated on catheter tube body 10 in liquid.Therefore in the present invention, by the powdered nanometer Se-SiO2
Material is dissolved in chitosan, and Se-SiO2 coating 30 is formed after full and uniform mixing, and the Se-SiO2 coating 30 is coated in
On the thread segment 20 of catheter tube body 10, accelerate the reparation of the prostate surface of a wound.
In conjunction with Fig. 1 to Fig. 6, completing, prostate excision is postoperative, and patient is by the screw thread urethral catheterization of the utility model band coating 30
Pipe is inserted into patient's urethra, and 30cc sterile saline is injected into sacculus 18 by water-injecting cavity 12, fills up sacculus 18, and
And check valve 15 guarantees that the water in sacculus 18 will not be flow backwards, so that water-filled sacculus 18 is stuck in patient's bladder neck, avoids leading
Urinary catheter tube body 10 is deviate from.At this point, thread segment 20 is placed exactly at patient's prostatic, and thread segment 20 and patient's prostate are created
Face is parallel, so that the coating 30 for being coated in 20 periphery of thread segment is also parallel with the prostate surface of a wound, due to the setting of thread protrusion 21
Increase the coated area of coating 30, and then increase the drugloading rate of thread segment 20, accelerates reparation of the coating 30 to the prostate surface of a wound.
In addition, the setting of 20 upper groove 22 of thread segment, forms the channel that threadingly section 20 is spread of coating 30, therefore, increases coating 30 and apply
It prevents certain patient's urethras to be tightly bonded with thread protrusion 21 while clad can product, leads to 30 release profile of coating unevenness, utilizes
Not exclusively, and 2240 spaced set of groove, it is further ensured that the coating 30 of 20 periphery of thread segment coats uniformly.In this implementation
In example, when Se-SiO2 coating 30 is located at patient's prostatic, its chitosan in aqueous environment of Se-SiO2 coating 30
Slowly degradation, during chitosan is slowly degraded, drug Se particle can be by the porous structure of SiO2 slowly and steadily
Release, not only increases the contact area of drug and the surface of a wound, but also the rate of release and agent of Se can be effectively controlled by porous sio2
Amount is reinforced avoiding reaching again while patient's prostate wound repair effect to inhibit the oxidation of the prostate surface of a wound too drastic
The toxicity dose of Se.Later by the saline injection into patient's bladder of medicine-injecting cavity 13, guarantee that catheter will not be by blood clot
Blocking, Urine in Patients are slowly flowed out from exhaust chamber 14.
The screw thread catheter of the utility model band coating 30, thread segment 20 are arranged on catheter tube body 10 and before patient
At the corresponding position in column gland position, and catheter during factory manufacturing i.e. according to thread segment 20 design position to catheter into
Row production forms thread segment 20.
The preparation method of 4 Se-SiO2 coating 30 of embodiment
A kind of preparation method of Se-SiO2 coating 30, which comprises the following steps:
Step S1 disperses Cu 2-xSe nanoparticle in n-hexane, obtains Cu 2-xSe n-hexane dispersion liquid;
Deionized water, n-hexyl alcohol, Triton X-100 are added into Cu 2-xSe n-hexane dispersion liquid by step S2
And n-hexane, stirring are added dropwise tetraethyl orthosilicate, are sufficiently mixed, ammonium hydroxide is added dropwise after 1~60min again, be stirred to react, and are added third
Ketone is simultaneously centrifugated, and is scattered in deionized water after separation product washing, 2 dispersion liquid of nanometer Se-SiO is made;
Polyvinylpyrrolidone is added in 2 dispersion liquid of nanometer Se-SiO step S3, after being stirred, stops stirring simultaneously
Heating carries out hydrothermal processes, then cools to room temperature, centrifuge washing, obtains porous 2 nanoparticle of Se-SiO.
Porous 2 nanoparticle of Se-SiO is added in chitosan liquid, is sufficiently mixed by step S4;
The thread segment 20 of catheter tube body 10 is immersed in alcoholic solution by step S5, general to impregnate 5-20 minutes, by spiral shell
The removal such as the grease on 20 surface of line section is played the role of cleaning catheter surface.The alcoholic solution is preferably ethanol solution, isopropanol
Solution, butanol solution or methyl butanol solution;
Step S6 takes out the thread segment 20 of catheter tube body 10 from alcoholic solution, is cleaned with purified water, then impregnate shell
In the mixed solution of 2 nanoparticle of glycan and Se-SiO;
Step S7, by the thread segment 20 of catheter tube body 10 from the mixed solution of 2 nanoparticle of chitosan and Se-SiO
Then middle taking-up is cleaned, is dried, packed and is sterilized, as needed, repeatedly the step of step S6-S7, is wanted with obtaining to meet
2 coating 30 of Se-SiO asked.
Embodiment method Se-SiO2 coating 30 obtained, during chitosan is slowly degraded, drug Se particle
It can be discharged slowly and steadily by the porous structure of SiO2, not only increase the contact area of drug and the surface of a wound, but also can pass through
Porous sio2 effectively controls the rate of release and dosage of Se, to inhibit the oxidation of the prostate surface of a wound too drastic, i.e., before reinforcement patient
Avoid reaching the toxicity dose of Se while column gland wound repair effect again.
The screw thread catheter of the utility model band coating 30 has the advantages that
1) it is uneven to avoid the occurrence of coating for the setting of thread protrusion 21 and groove 22 while increasing by 30 coated area of coating
Even phenomenon guarantees the reparation of patient's prostate surface of a wound quickly, healthy;
2) in 10 outer surface of catheter tube body, thread protrusion 21, and shape are equipped at the position of the sacculus 18
At a thread segment 20, which is located at prostatic in a state of use.The effect of the design scheme is: thread segment
20 directly can directly contact with surgical wound surface, cooperate the drug on coating 30 that can realize specific aim local treatment to the surface of a wound, can office
Portion's hemostasis, wound healing;
3) Se particle slow release is made by the porous structure of porous sio2, to inhibit prostate surface of a wound oxidative stress
Meanwhile the release of Se particle being avoided comparatively fast to reach toxic dose, cause Se to be poisoned, to promote the reparation of the prostate surface of a wound;
4) on the one hand chitosan makes nanometer Se-SiO2 material become the liquid coating that can be coated on catheter tube body 10
30, it on the other hand can also act as the sustained release agent of Se particle release, further function as the effect for avoiding Se from being poisoned;
5) it while effectively oxidative stress being inhibited to promote wound repair, and avoids causing serious adverse reaction, have good
Good controllability;And it is low in cost, synthesis cycle is short (1 month);Medicine-carried has biggish application prospect;Preservation condition is not severe
It carves, can be saved at 4 DEG C.
The above is only the preferred embodiment of the utility model, it is noted that for the common skill of the art
Art personnel can also make several improvement and supplement under the premise of not departing from the utility model method, these are improved and supplement
Also it should be regarded as the protection scope of the utility model.