CN208355600U - The big animal organism aerosol mouth and nose exposure system of biological safe type primate - Google Patents

Abstract

The utility model discloses a kind of big animal organism aerosol mouth and nose exposure systems of biological safe type primate, solves the poisonous and harmful aerosol mouth and nose sucking exposure experiment problem that the big animal of primate how is effectively carried out in safely controllable environment, its technical solution be include aerosol generating device, mouth and nose exposure unit, automatic control device, detection device and waste gas recovery processing unit, it further include Biohazard Safety Equipment, the Biohazard Safety Equipment is provided with exposed chamber and the chamber wall for closing exposed chamber, the exposed chamber is disposed for placing aerosol generating device and/or mouth and nose exposure unit, the interface for being connected with vacuum tiny structure processing unit is provided on the chamber wall.The design of the technical essential, having reached prevents situations such as aerosol is leaked to the pollution caused in atmosphere to experimenter and environment in experimentation generation, securely and reliably.

Description

The big animal organism aerosol mouth and nose exposure system of biological safe type primate

Technical field

The utility model relates to animals to suck toxicological experiment field, dynamic greatly more particularly to a kind of biological safe type primate Object bioaerosol mouth and nose exposure system.

Background technique

In general, sucking toxicological experiment is the approach for simulating worker and resident's contact noxious material, to production operation ring Industrial chemistry substance in border, the poisonous substance in the atmosphere of resident living area based on environmental contaminants carry out quiet formula or dynamic inhalation contamination, Obtain the data of inhalation toxicology, including toxicity on inhalation (such as half lethal concentration, harmless activity) mechanism of action and examination Test treatment as a result, be formulate in workshop air and in the atmosphere of residential block harmful substance important evidence.Currently, being to suck poison It manages in relevant various scientific researches, more especially pair human health nuisance Quality Research, such as PM2.5, due to cannot Directly or the mankind cannot be tested first, so often to use experimental animal to carry out sucking Exposure Assessment.Therefore, animal Exposing device has a wide range of applications in industry, agricultural, medicine, environmental pollution and military science research.However, existing sudden and violent Dew experiment in some exposure tests, since mouse etc. and people's difference are too big, cannot effectively be reacted primarily directed to mouse etc. Influence of the harmful substance to people, therefore, some scientific research personnel are proposed using the big animal such as primate such as monkey as exposure Object is tested with making full use of primate with characteristic similar in people.And it is sudden and violent in existing some big animal mouth and nose In dew system, due to not having biological safety protection device, system is easy to happen the leakage of the pernicious gases such as aerosol, causes to ring Border and the pollution of experimenter etc., therefore, how to make primate can be carried out effectively mouth and nose exposure test with And the security performance of big animal mouth and nose exposure system is improved, avoid the leakage of its pernicious gas such as aerosol during the experiment from being This field urgent problem to be solved.

Utility model content

In view of the deficienciess of the prior art, the purpose of this utility model is to provide a kind of biological safe type primate is big Animal organism aerosol mouth and nose exposure system.

To achieve the above object, the utility model provides following technical solution: a kind of biological safe type primate is dynamic greatly Object bioaerosol mouth and nose exposure system, including aerosol generating device, mouth and nose exposure unit, automatic control device, detection dress Set with waste gas recovery processing unit, further include Biohazard Safety Equipment, the Biohazard Safety Equipment has exposure chamber and sudden and violent for closing Reveal the chamber wall of chamber, the exposed chamber is disposed for placing aerosol generating device and/or mouth and nose exposure unit, the chamber The interface for being connected with vacuum tiny structure processing unit is provided on wall.

By using above-mentioned technical proposal, in carrying out animal mouth and nose exposure experimentation, Biohazard Safety Equipment can will be let out The substances such as the aerosol of leakage are accommodated in exposed chamber, and the aerosol of leakage is avoided to be directly entered in atmosphere to experimenter and environment Bring pollution；

Vacuum tiny structure processing unit is connected on chamber wall, can be further improved the intracavitary experiment safety performance of exposure, The intracavitary gas of exposure will not be leaked in atmosphere.

The utility model is further arranged to: the chamber wall includes operation panel, and behaviour is provided on the operation panel Make hole, operating gloves is sealedly connected at the handle hole, the operating gloves are configured for experimenter's wearing, so that described The hand of experimenter can extend into the exposed chamber and carry out experimental implementation.

By using above-mentioned technical proposal, under the premise of guaranteeing that exposure chamber is closed, experimenter can be intracavitary to exposure Aerosol generating device or mouth and nose exposure unit carry out operation adjustment, the airtight performance for further ensuring exposed chamber is good, Avoid that outside air enters exposed chamber or the aerosol of the intracavitary leakage of exposure enters in atmosphere, structure is simple, safety It is high.

The utility model is further arranged to: the Biohazard Safety Equipment further includes transferring cabin, and the transferring cabin is configured to pass Pass object used in experimentation；And the transferring cabin is communicated with air cleaning device, the air cleaning device is configured to pair Aerosol generating device or mouth and nose exposure unit in transferring cabin carry out pure air cleaning.

By using above-mentioned technical proposal, when transmitting the object needed in experimentation, do not need to open exposed chamber progress Transmitting, directly by transferring cabin be transmitted to expose it is intracavitary, avoid aerosol generating device and mouth and nose exposure unit directly with sky Gas contact；Meanwhile the transferring cabin is communicated with air cleaning device, the air cleaning device is configured to in transferring cabin Test with object carry out pure air clean.

The utility model is further arranged to: the transferring cabin includes entrance hatch, be connected at the entrance hatch into Hatch door；

The transferring cabin and exposure chamber junction are the egress hatch of transferring cabin, are connected with out cabin at the egress hatch Door.

By using above-mentioned technical proposal, in the object transmit process needed for experimentation, hatch door can be with into hatch door and out The object is enclosed in transferring cabin, air cleaning device can clean it, guarantee to enter the intracavitary test of exposure It is sterile with object.

The utility model is further arranged to: the Biohazard Safety Equipment is multiple, including the first Biohazard Safety Equipment and second Biohazard Safety Equipment, the exposure chamber of first Biohazard Safety Equipment are configured to place aerosol generating device, the second biology peace The exposure chamber of full cabinet is configured to place mouth and nose exposure unit.

By using above-mentioned technical proposal, aerosol generating device and mouth and nose exposure unit are individually placed to different biology peaces In full cabinet, when aerosol generating device is dismounted or safeguarded, mouth and nose exposure unit not will receive impurity in outside air Pollution, conversely, aerosol generating device will not be contaminated when mouth and nose exposure unit is dismounted or safeguarded, the two phase It is mutually independent, it maintains easily.

The utility model is further arranged to: first Biohazard Safety Equipment is set as one, second bio-safety Cabinet is set as multiple, and the mouth and nose exposure unit in multiple second Biohazard Safety Equipments with first Biohazard Safety Equipment Aerosol generating device connection.

By using above-mentioned technical proposal, an aerosol generating device can connect multiple mouth and nose exposures in experimentation Unit can carry out the mouth and nose exposure experiment of same concentration to multiple animals, and structure is simple, easy to operate.

The utility model is further arranged to: the intracavitary aerosol generating device of first Biohazard Safety Equipment exposure and more The intracavitary mouth and nose exposure unit of a second Biohazard Safety Equipment exposure is connected by snorkel, and the snorkel is identical.

By using above-mentioned technical proposal, it is ensured that aerosol generating device is conveyed to the gas of multiple mouth and nose exposure units Collosol concentration is uniform, improves experiment accuracy.

The utility model is further arranged to: the mouth and nose exposure unit includes animal seat, the animal seat The exposure for being removably mounted at the second Biohazard Safety Equipment is intracavitary；

Animal seat includes vehicle frame, the vehicle frame, head fixing device, upper limb fixing device, buttocks seat plate and Lower limb fixing device, and the fixed dress of the head fixing device, the upper limb fixing device, the buttocks seat plate and the lower limb Set that position is adjustably mounted in the vehicle frame in the vertical direction.

By using above-mentioned technical proposal, it can be used for fixed primate such as monkey etc. to carry out mouth and nose sucking exposure Experiment can guarantee that the primates such as monkey have phase to obtain better experiment effect and closer experimental data The comfort level etc. answered, structure is simple, easy to operate.

The utility model is further arranged to: the mouth and nose exposure unit includes animal mouth and nose exposure component, the mouth Nose exposure component includes shield, breathing mask, suction line and discharge line；

The shield includes housing and sealing structure, and the housing has head insert port, so that the head of animal passes through It is protruded into the shield by the head insert port；The sealing structure is installed on the head insert port, to seal animal Neck and the head insert port between region；

The breathing mask is set in the shield, is configured to be installed on the face of animal；

The suction line and the discharge line are connected to the breathing mask, and are provided with negative pressure on the housing Mouthful, the negative pressure mouth is configured to connecting power device, so as to keep negative pressure state in the shield.

By using above-mentioned technical proposal, it is real can to carry out mouth and nose exposure to primate for the setting of mouth and nose exposure component It tests, tests substance, the settings of shield such as the effective Inhaled Aerosol of primate is enable to can effectively prevent gas The leakage of the substances such as colloidal sol, the further safety for guaranteeing experimenter and equipment.

The utility model is further arranged to: the mouth and nose exposure component is in removable backwards to upper limb fixing device side It is installed on the head fixing device with unloading.

By using above-mentioned technical proposal, first mouth and nose exposure component can be fixedly mounted on head fixing device, then The exposure that mouth and nose exposure component and animal seat are installed along with Biohazard Safety Equipment is intracavitary, and structure is simple, easy to operate；Setting It is kept away at the mounting means being detachably connected for the ease of mouth and nose exposure component and animal seat are safeguarded and adjusted respectively Both exempt from integrated setting both cause to influence each other, the influence for safeguard inconvenience etc..

According to the accompanying drawings to the detailed description of the utility model specific embodiment, those skilled in the art will be more Add the above-mentioned and other purposes, advantages and features of clear the use of the new type.

Detailed description of the invention

Hereinafter with reference to the accompanying drawings and some specific of the utility model is described in detail in embodiment mode and not restrictive Embodiment.Identical appended drawing reference denotes same or similar part or part in attached drawing.Those skilled in the art should manage Solution, these attached drawings are not necessarily to scale drafting.Meanwhile some pipelines in figure do not represent all, those skilled in the art Member is it should be understood that embodiments thereof.In attached drawing:

Fig. 1 is the whole of the big animal organism aerosol mouth and nose exposure system embodiment of the utility model biological safe type primate Body structural schematic diagram；

Fig. 2 is bio-safety in the big animal organism aerosol mouth and nose exposure system of the utility model biological safe type primate The structural schematic diagram of cabinet；

Fig. 3 is animal seat in the big animal organism aerosol mouth and nose exposure system of the utility model biological safe type primate The explosive schematic diagram of chair；

Fig. 4 is mouth and nose exposure in the big animal organism aerosol mouth and nose exposure system of the utility model biological safe type primate The explosive schematic diagram of component.

In attached drawing: 1. air compressor machines；2. vacuum pump；3. aerosol generating device；4. mouth and nose exposure unit；41. mouth and nose exposure Component；411. shield；The head 411a. insert port；412. breathing mask；413. negative pressure mouths；414；Discharge pipe crossing；415；It inhales Enter line portals；416. cover；417. flexible sheets；End is inserted on 418. heads；419. fixed ring；42. animal seat；421. chair Frame；421a. frame cavity；421b. guide channel；421c. adjusts guide groove；422. upper limb fixing device；422a. first is fixed Half-turn；422b. second fixes half-turn；423. buttocks seat plates；424. lower limb fixing device；424a. third fixes half-turn；424b. 4th fixed half-turn；425. chassis base；426. head fixing device；4261. movable plate；4262. support column；4263. guide rail Item；427. are screwed handle；5. Biohazard Safety Equipment；51. the first Biohazard Safety Equipment；52. the second Biohazard Safety Equipment；511. exposure Chamber；512. chamber wall；512a. interface；513. transferring cabin；514. operation panel；514a. handle hole.

Specific embodiment

To keep the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, below with reference to Fig. 1 to Fig. 4 The embodiment of the big animal organism aerosol mouth and nose exposure system of the utility model biological safe type primate is described further.

Fig. 1 is the overall structure of the big animal organism aerosol mouth and nose exposure system of the utility model biological safe type primate Schematic diagram.As shown in Figure 1, a kind of big animal organism aerosol mouth and nose exposure system of biological safe type primate, including pump head are empty Press 1, blower 2, aerosol generating device 3, mouth and nose exposure unit 4, automatic control device, detection device and waste gas recovery processing Device.The big animal organism aerosol mouth and nose exposure system of biological safe type primate further includes Biohazard Safety Equipment 5, and aerosol occurs Device 3 and mouth and nose exposure unit 4 are arranged in the Biohazard Safety Equipment 5, and specific embodiment is as follows:

As shown in Fig. 2, Biohazard Safety Equipment 5 includes support portion and work department, support portion and work department are hollow setting, branch Support part can be simply provided to be used to support work department, may be set to be including object placing cavity, work department is provided with exposed chamber 511, exposure chamber 511 includes top plate and bottom plate and surrounding chamber wall 512, and surrounding chamber wall 512 includes fixed panel and operation panel 514, operation panel 514, using fixation is threadedly coupled, is provided with behaviour with the side of fixed panel and top plate on operation panel 514 Make hole 514a, be sealedly connected at handle hole 514a operating gloves (not represented in figure), specific connection type is handle hole Connection ring (not representing in figure) is connected at 514a, connection ring is set as step-like, including mounting portion and sticking part, mounting portion Diameter be less than sticking part diameter and mounting portion and operation panel and be located at sticking part two sides, sticking part and operation panel 514 Screw is fixedly connected, and groove is provided on mounting portion, and fastening elastic ring is provided in groove, and operating gloves are first covered in mounting portion On, elastic snare then will be fastened in operating gloves and will place fastening elastic ring matching in the trench, be completed to manipulator The installation of set is fixed.Preferably, the operation panel 514 is set as being oppositely arranged before and after two and two operation panels 514.

In the further embodiment of the utility model, Biohazard Safety Equipment 5 further includes transferring cabin 513, the transferring cabin 513 are arranged on chamber wall 512, and the utility model is preferably the setting of transferring cabin 513 on fixed panel.Transferring cabin 513 includes Entrance hatch and egress hatch (being to represent in figure) are provided with for transferring cabin 513 is closed at entrance hatch and egress hatch Into hatch door and out hatch door, entrance hatch are in the outside of Biohazard Safety Equipment 5, egress hatch be located at the inside of Biohazard Safety Equipment 5 and with it is sudden and violent Dew chamber 511 communicates.For the ease of the closure of hatch door, it is provided with sliding slot on fixed panel, hatch door includes matching with sliding slot out Sliding part, the folding that hatch door is slided on fixed panel to realize egress hatch out.Transferring cabin 513 is connected with air cleaning device (not representing in figure), air cleaning device include blower, gas supply pipeline and exhaust pipe, and specific embodiment is transferring cabin 513 two sides up and down are provided with pipe interface, and downside pipe interface is connected with gas supply pipeline, and gas supply pipeline is connected with blower, For conveying air into transferring cabin 513, gas supply pipeline is also connected with air filter, for entering transferring cabin 513 Cleaning is filtered with air, guarantees the degree of purity of cleaning air, more thorough to the object cleaning being located in transferring cabin 513； Upside pipe interface connects exhaust pipe, for that will clean used air extraction transferring cabin 513.

The course of work, if desired to exposure chamber 511 in transmit experiment object when, can first close out hatch door, open into Required object is transported in transferring cabin 513 by hatch door, is then shut off into hatch door, is opened air cleaning device, at this time air-blower control It supplies gas into transferring cabin 513, air filter enters in transferring cabin 513 after first carrying out filtration, purification to gas to required object It is cleaned, is then extracted out by exhaust pipe, at this point, operator, which puts on operating gloves, extend into exposure in handle hole 514a Hatch door will be gone out in chamber 511 to open, and the experiment is moved to the appropriate location in exposed chamber 511 with object, be then shut off out cabin Door.During whole operation, the exposure discord contacting external air of chamber 511 ensure that sterile free from admixture in exposed chamber 511, whole Operating gloves are put in operation, and hand is not direct with experiment isoelectric membrane, and the accuracy of experiment can be improved.Before operation panel 514 After be oppositely arranged by two and be made of transparent material, convenient for in exposure chamber 511 aerosol generating device 3 or mouth and nose it is sudden and violent Dew unit 4 is moved or is safeguarded.

In the utility model further embodiment, multiple interfaces are provided on the chamber wall 512 of Biohazard Safety Equipment 5 512a, one of interface 512a are connected with vacuum tiny structure processing unit, an interface 512a connection waste gas recovery processing dress It sets, remaining interface includes check valve, pressure for being connected to aerosol generating device 3 and mouth and nose exposure unit 4, vacuum tiny structure device Poor table and vacuum pump, the aerosol in exposure chamber 5a for guaranteeing Biohazard Safety Equipment 5 will not leak into atmosphere.Waste gas recovery Processing unit is connected with power device, generates during the aerosol and zoopery for having leakage in exposure chamber 511 useless When gas, waste gas recovering device can draw it out exposed chamber 511.

By setting Biohazard Safety Equipment 5, waste gas recovery processing component and vacuum tiny structure processing unit, aerosol can be prevented Leakage, eliminates the pollution to operator, improves the precision of safety and contamination.

In the utility model further embodiment, Biohazard Safety Equipment 5 is set as multiple, is divided into one first biology peace Full cabinet 51 and multiple second Biohazard Safety Equipments 52, aerosol generating device 3 are removably fixedly mounted on the first Biohazard Safety Equipment In 51, in the exposure chamber 5a in the first Biohazard Safety Equipment 51, mouth and nose exposure unit 4, which is detachably fixed, is mounted on described second In the exposure chamber 5a of Biohazard Safety Equipment 52, aerosol generating device 4 and mouth and nose exposure unit 5 pass through pipeline (not representing in figure) Connection, and the interface 512a on pipeline and chamber wall 512 is tightly connected.

Preferably, the second Biohazard Safety Equipment 52 is set as 5, is fixedly installed with one in each second Biohazard Safety Equipment 52 Group mouth and nose exposure unit 4, and the mouth and nose exposure unit 52 in each second Biohazard Safety Equipment 52 is pacified with same first biology Aerosol generating device 3 in full cabinet 51 connects, and the aerosol that aerosol generating device 3 generates enters the confession of five road pipelines simultaneously The experimental animal of five groups of mouth and nose exposure units 4 is tested, and can observe different animals simultaneously under the aerosol of same concentrations Toxicological experiment differential responses etc..

Preferably, five the second Biohazard Safety Equipments 52 are communicated with the connecting pipe length between the first Biohazard Safety Equipment 51, institute It is consistent with connecting tube, so that the aerosol that same aerosol generating device 3 occurs is by identical pipeline in same work Make to be divided into five groups in environment, guarantees the even concentration of five groups of aerosols, improve the accuracy of experiment.

In the utility model further embodiment, mouth and nose exposure unit 4 includes animal seat 42 and mouth and nose exposure Component 41.The schematic explosive view of animal seat shown in Fig. 3.Animal seat may include chair frame 421, buttocks seat board 423, Lower limb fixing device 424 and head fixing device 426 and upper limb fixing device 422.There is frame cavity in chair frame 421 421a.Buttocks seat board 423 may be disposed in frame cavity 421a, and position is adjustably mounted in chair frame in the vertical direction 421.Lower limb fixing device 424 is set in frame cavity 421a, and position is adjustably mounted in chair frame in the vertical direction 421.Head fixing device 426 is set to the upside of chair frame 421, and upper limb fixing device 422 is set to head fixing device 426 Position is adjustable in the vertical direction is installed on chair frame 421 for downside, head fixing device 426 and upper limb fixing device 422. The animal when in use, can first be adjusted the height of buttocks seat board 423, be sitting in animal on buttocks seat board 423, so with seat The height of lower limb fixing device 424 is adjusted afterwards, and the lower limb of animal are fixed, and adjusts head fixing device 426 and upper limb The height of fixed device 422, and head and upper limb are fixed.Structure is simple, easy to use, animal can be made to have very high Comfort level.

In some embodiments of the utility model, the two sides of chair frame 421 all have multiple tune extended along the vertical direction Whole guide groove 421c；The both ends of buttocks seat board 423 and lower limb fixing device 424 are threadably secured handle 427 and are installed on Different adjustment guide groove 421c.In some embodiments, animal seat further includes support column 4262 and the first positioning column.Branch Dagger 4262 extends along the vertical direction, and multiple horizontally extending first positioning holes are provided on support column 4262, multiple First positioning hole is spaced setting along the vertical direction.Head fixing device 426 is arranged in towards buttocks seat plate 423 in support column 4262 Side.The rear side of chair frame 421 is provided with the guide channel 421b extended along the vertical direction.Support column 4262 is installed on guide channel 421b, and the first positioning column is installed on chair frame 421, and is inserted into a first positioning hole, so that support column 4262 is installed on chair frame 421。

In some embodiments of the utility model, head fixing device 426 may include fixed plate, movable plate 4261, frame Frame and two guide rail bars 4263.Frame is set to the upper end of support column 4262.Fixed plate is installed on frame, and has opening advanced Notch.Movable plate 4261 has the notch of opening backwards, and is slidably mounted on fixed plate along the longitudinal direction.For example, solid The two opposite sliding slots that are open are provided on the downside of fixed board, the two sides of movable plate 4261 are respectively arranged at two sliding slots.Each lead Rail bar 4263 is installed on frame, each sliding slot can be formed in 4263 upside of a guide rail bar 4263 and guide rail bar fixed plate it Between.Preferably, for the ease of the fixation on head, two rows of the second positioning arranged along the longitudinal direction are provided on movable plate 4261 Hole.There are two third location holes for setting in fixed plate；Animal seat further includes two the second positioning columns, each second positioning column It is sequentially inserted into a third location hole and a second location hole, can conveniently and efficiently adjust the size of animal neck.

In some embodiments of the utility model, for the ease of the fixation of lower limb, lower limb fixing device 424 includes two Lower limb fixed part, each lower limb fixed part have the fixed half-turn 424b of the fixed half-turn 424a and the 4th of third.Third fixes half-turn Position is adjustably mounted in chair frame 421 424a in the vertical direction.One end of 4th fixed half-turn 424b is rotatably mounted In the fixed half-turn 424a of third, the other end is adjustably installed on the fixed half-turn of third relative to the fixed position half-turn 424a of third 424a, to limit the lower limb fixation hole of adjusting, the axis edge of lower limb fixation hole jointly with the fixed half-turn 424a of third Vertical direction extends.

Similar with above-described embodiment, for the ease of the fixation of upper limb, upper limb fixing device 422 includes that two upper limbs are fixed Portion；Each upper limb fixed part has the first fixed fixed half-turn 422b of half-turn 422a and second.First fixed half-turn 422a is fixed In or be rotatably installed on head fixing device 426.Preferably first fixed half-turn 422a is rotatable around a vertical axis Setting, in order to the activity of upper limb.One end of second fixed half-turn 422b is rotatably installed on the first fixed half-turn 422a, separately One end is adjustably installed on the first fixed half-turn 422a relative to the first fixed position half-turn 422a, to fix half-turn with first 422a limits the upper limb fixation hole of adjusting jointly, and the axis of upper limb fixation hole is horizontally extending.

In the further embodiment of the utility model, the explosive schematic diagram of mouth and nose exposure component as shown in Figure 4, mouth Nose exposure component 41 may include shield 411, breathing mask 412, suction line crossing 415 and discharge pipe crossing 414.Shield 411 may include housing and sealing structure.Housing has head insert port 411a, so that the head of animal is via head insert port 411a is protruded into shield 411；Sealing structure is installed on head insert port 411a, to seal the neck and head insert port of animal Region between 411a.Shield 411 is set to the upside of head fixing device 416；For example, the upper of fixed plate can be placed in Side.Breathing mask 412 is set in shield 411, is configured to be installed on the face of primate.Breathing mask 412 is preferred To be adapted with the face of primate such as monkey.Suction line crossing 415 and discharge pipe crossing 414 with breathing mask 412 Connection, the aerosol that aerosol generating device is generated are entered by suction line crossing 415 in the mouth and nose of primate, are led to The gas etc. that discharge pipe crossing 414 breathes out primate is crossed to be discharged to outside shield 411.Negative pressure mouth is additionally provided on housing 413, negative pressure mouth 413 is configured to connecting power device, so as to keep negative pressure state in shield 411, can prevent leakage in this way Aerosol or other gases are spread in air, are threatened to experimenter or equipment.Power device can be vacuum pump.Mouthful Nose exposure component 41 can enable the tests substances such as primate effectively Inhaled Aerosol；Shield can be effectively prevented The safety of the leakage such as aerosol, guarantee test personnel and equipment etc..

In some embodiments of the utility model, housing may include tubular peripheral wall portion, head insertion end 418 and cover 416.The axis of tubular peripheral wall portion is arranged along the vertical direction.Head insertion end 418 may be disposed at the lower end of tubular peripheral wall portion, and The middle part is provided with head insert port 411a.Cover 416 may be disposed at the upper end of tubular peripheral wall portion.Suction line crossing 415, discharge Line portals 414 and negative pressure mouth 413 are mountable to tubular peripheral wall portion.Preferably, housing is fixed at suction line crossing 415, and is exhaled Inhale the inner end that mask 412 is set to suction line crossing 415.It the outer end at suction line crossing 415 can be defeated with aerosol generating device Outlet pipe connection.Discharge pipe crossing 414 is connect with the pipe fitting for being installed on tubular peripheral wall portion, and connection pipe fitting and breathing mask 412 hose or stereoplasm tube (not shown).Settable negative pressure pipe fitting in negative pressure mouth 413.

In some embodiments of the utility model, cover 416 is removably installed in the upper end of tubular peripheral wall portion.Specifically The upper surface on ground, cover 416 is provided with annular groove.Shield 411 further includes multiple rapid latchs, along the circumferential direction of tubular peripheral wall portion Direction is distributed in the upper end of tubular peripheral wall portion；And each rapid latch includes rotational handle and buckle；Rotational handle is rotationally It is installed on tubular peripheral wall portion；Buckle is rotatably installed on rotational handle, and matches with annular groove.

In some embodiments of the utility model, sealing structure is the flexible sheets 417 with central opening；Flexible sheets 417 are installed on head insertion end 418.Head insert port 411a is stepped hole, and flexible sheets 417 are installed on stepped hole.Shield 411 further include fixed ring 419, is fixed on stepped hole by screw, and be folded in flexible sheets 417 with the step surface of stepped hole Therebetween.Preferably, flexible sheets 417 are silica gel piece.Tubular peripheral wall portion and head insertion end 418 are made of clear material, so as to In preferably being observed.

Mouth and nose exposure component 41 when in use, can be then sharp by 411 sets of shield on the head of the primates such as monkey With breathing mask 412, shield 411 tubular peripheral wall portion and and/or the auxiliary cushions such as sponge shield is fixed on head In 411.Then the cover 416 of shield 411 is covered.

The utility model is primarily adapted for use in the toxicological experiment of primate, can first fill aerosol generating device 3, detection It sets and is fixed on automatic control device in the exposure chamber 511 of the first Biohazard Safety Equipment 51, aerosol generating device 3 includes aerosol Generator, plunger pump, filter, diluter, detection device include mass concentration detector, and automatic control device includes that quality is dense Spend sensor, pressure sensor.Aerosol generator generates aerosol, is transmitted at detection device by filter filtering, matter It measures concentration detector and Concentration Testing is carried out to the aerosol of transmission, when concentration deviation is larger, adjustable diluter is molten to gas Glue is diluted or aerosol generator generates aerosol, and plunger pump is used to carry out fluid infusion to aerosol generator.Detection dress Setting can be set with automatic control device in the outside of the first Biohazard Safety Equipment 51, also can be arranged directly on the first bio-safety In the exposure chamber 511 of cabinet 51.

When the big animal organism aerosol mouth and nose exposure system work of the utility model biological safe type primate, outside first Primate such as monkey are fixed on animal on seat 42 by side, then enter on its head by head insert port 411a In the shield 411 of mouth and nose exposure component 41, breathing mask 412 is put on for monkey, then by the fixed peace of mouth and nose exposure component 41 On the head fixing device 426 of animal seat 42, mounting means be preferably screwed handle connection；When monkey wears mouth Nose exposure component 41 is simultaneously fixed on animal with after on seat 42, and then opening operation panel 514, fixed by mouth and nose exposure unit 4 In exposure chamber 511, then then closed procedure panel 514 is opened empty first to pure air cleaning is carried out in exposure chamber 511 Press 1, vacuum pump 2 are started to work, and pump head air compressor machine 1 drives the work of aerosol generating device 3 to generate aerosol and conveys at this time To mouth and nose exposure unit 5, in the whole process, the waste gas recovery processing unit on Biohazard Safety Equipment 5 can be in exposure chamber 511 Aerosol and exhaust gas extraction, negative pressure of vacuum processing unit can guarantee expose chamber 511 in aerosol will not leak into atmosphere In pollute.When need to exposure chamber 511 in transmit experiment object when, open transferring cabin 513 into hatch door, by the object It is sent in transferring cabin 513, opens air cleaning device, fan aspirate, pneumatic filter is to gas filtration then via snorkel Road enters in transferring cabin 513 and cleans to the object, and then gas is extracted via exhaust pipe, is then shut off into cabin Door, operator, which puts on operating gloves and extend into exposed chamber 511, to be moved to suitable position for object and operates star, then Close out hatch door.

The above is only the preferred embodiment of the utility model, it is noted that for the common skill of the art For art personnel, without departing from the principle of this utility model, made any improvements and modifications also should be regarded as this reality With novel protection scope.

Claims (10)

1. a kind of big animal organism aerosol mouth and nose exposure system of biological safe type primate, including aerosol generating device, mouth Nose exposure unit, automatic control device, detection device and waste gas recovery processing unit, it is characterised in that: further include bio-safety There is exposure chamber and the chamber wall for closing exposed chamber, the exposed chamber to be disposed for putting for cabinet, the Biohazard Safety Equipment Aerosol generating device and/or mouth and nose exposure unit are set, is provided on the chamber wall for being connected with the processing of vacuum tiny structure The interface of device.

2. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 1, feature Be: the chamber wall includes operation panel, and handle hole is provided on the operation panel, is sealedly connected at the handle hole Operating gloves, the operating gloves are configured for experimenter's wearing so that the hand of the experimenter can extend into it is described sudden and violent Experimental implementation is carried out in dew chamber.

3. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 1, feature Be: the Biohazard Safety Equipment further includes transferring cabin, and the transferring cabin is configured to object used in transmitting experimentation；

The transferring cabin is communicated with air cleaning device, and the air cleaning device is configured to that the aerosol in transferring cabin occurs Device or mouth and nose exposure unit carry out pure air cleaning.

4. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 3, feature Be: the transferring cabin includes entrance hatch, is connected at the entrance hatch into hatch door；

The transferring cabin and exposure chamber junction are the egress hatch of transferring cabin, are connected with out hatch door at the egress hatch.

5. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 1, feature Be: the Biohazard Safety Equipment is multiple, including the first Biohazard Safety Equipment and the second Biohazard Safety Equipment, first bio-safety The exposure chamber of cabinet is configured to place aerosol generating device, and it is sudden and violent that the exposure chamber of second Biohazard Safety Equipment is configured to placement mouth and nose Reveal unit.

6. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 5, feature Be: first Biohazard Safety Equipment is set as one, and second Biohazard Safety Equipment is set as multiple, and multiple described second Mouth and nose exposure unit in Biohazard Safety Equipment is connect with the aerosol generating device of first Biohazard Safety Equipment.

7. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 6, feature It is: the intracavitary aerosol generating device of the first Biohazard Safety Equipment exposure and multiple second Biohazard Safety Equipment exposure chambers Interior mouth and nose exposure unit is connected by snorkel, and the snorkel is identical.

8. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 1, feature It is:

The mouth and nose exposure unit includes animal seat, and the animal is removably mounted at the second Biohazard Safety Equipment with seat Exposure is intracavitary；

Animal seat includes vehicle frame, head fixing device, upper limb fixing device, buttocks seat plate and lower limb fixing device, And the head fixing device, the upper limb fixing device, the buttocks seat plate and the lower limb fixing device are in vertical side Upward position is adjustably mounted in the vehicle frame.

9. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 8, feature Be: the mouth and nose exposure unit includes animal mouth and nose exposure component, and the mouth and nose exposure component includes shield, respiratory surface Cover, suction line and discharge line；

The shield includes housing and sealing structure, and the housing has head insert port, so that the head of animal is via institute Head insert port is stated to protrude into the shield；The sealing structure is installed on the head insert port, to seal the neck of animal Region between portion and the head insert port；

The breathing mask is set in the shield, is configured to be installed on the face of animal；

The suction line and the discharge line are connected to the breathing mask, and negative pressure mouth is provided on the housing, The negative pressure mouth is configured to connecting power device, so as to keep negative pressure state in the shield.

10. the big animal organism aerosol mouth and nose exposure system of biological safe type primate according to claim 9, feature Be: in being removably installed in backwards to upper limb fixing device side, the head is fixed to be filled the mouth and nose exposure component It sets.