CN208319207U - Blood fluorescence substance non-invasive detection system based on fluorescence pulse wave - Google Patents
Blood fluorescence substance non-invasive detection system based on fluorescence pulse wave Download PDFInfo
- Publication number
- CN208319207U CN208319207U CN201721138749.8U CN201721138749U CN208319207U CN 208319207 U CN208319207 U CN 208319207U CN 201721138749 U CN201721138749 U CN 201721138749U CN 208319207 U CN208319207 U CN 208319207U
- Authority
- CN
- China
- Prior art keywords
- fluorescent
- pulse wave
- blood
- detection system
- pass filter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
本实用新型公开一种基于荧光脉搏波的血液荧光物质无创检测系统。该系统包括：荧光激发光源可激发毛细血管中荧光物质发光；长波通滤光片滤除激发光；光电传感器检测发射荧光信号并产生荧光脉搏波模拟信号；放大器对荧光脉搏波信号进行放大；低通、高通滤波器分别滤除环境中超过脉搏频率成分的干扰信号，及滤除组织或环境中恒定的不随血液流动变化的荧光信号；控制器储存A/D转换器传输的脉搏波数字信号；显示器显示被放大后的脉搏波的信息。本申请基于荧光脉搏波，实时连续地检测血管中荧光物质的含量，从而获得血液中荧光物质的浓度和被机体代谢状况等信息，或监测到器官移植过程中组织器官的血液灌注情况，以评价器官存活状况。
The utility model discloses a non-invasive detection system for blood fluorescent substances based on fluorescent pulse waves. The system includes: a fluorescent excitation light source can excite fluorescent substances in capillaries to emit light; a long-wave-pass filter filters out the excitation light; a photoelectric sensor detects the emitted fluorescent signal and generates a fluorescent pulse wave analog signal; an amplifier amplifies the fluorescent pulse wave signal; The pass-through and high-pass filters filter out the interference signal exceeding the pulse frequency component in the environment, and filter out the constant fluorescent signal in the tissue or environment that does not change with the blood flow; the controller stores the pulse wave digital signal transmitted by the A/D converter; The display shows the information of the enlarged pulse wave. Based on the fluorescent pulse wave, this application continuously detects the content of fluorescent substances in blood vessels in real time, so as to obtain information such as the concentration of fluorescent substances in the blood and the metabolic status of the body, or monitor the blood perfusion of tissues and organs in the process of organ transplantation to evaluate Organ survival.
Description
Technical field
The utility model belongs to field of medical equipment, is related to a kind of applied to the base for realizing aid imaging in surgical operation
In the Blood fluorescence substance non-invasive detection system of fluorescence pulse wave.
Background technique
A kind of existing noninvasive pulse blood oxygen detection method is to be detected using photoelectric sphyg technology by langbobier law
The absorption light situation of hemoglobin, to obtain the physical signs such as heart rate, pulse, while realizing the Non-invasive detection of the oxygen content of blood.
This method selects the light measurement absorbance of different wave length based on langbobier law, is obtained in blood by simultaneous equations
The concentration blood oxygen levels of each ingredient.When light is incident on tissue, a part is absorbed by the blood, and a part is inhaled by non-blood ingredient
It receives.Due to the constant thickness of non-blood ingredient, the uptake of light is remained unchanged, blood is dynamic with arteriogram to the uptake of light to be in
Cyclically-varying, therefore, transmission (diffusing reflection) luminous intensity are also in cyclically-varying with the artery period.Because transmission (diffusing reflection) light is taken
Therefore information with blood constituent passes through the variation to diffuse caused by detection blood volume fluctuation, so that it may eliminate non-
The influence of blood constituent acquires blood oxygen saturation SaO2.But there are certain calculating mistakes for this blood blood oxygen detection method
The blood sample saturation data accuracy of difference, acquisition is poor.
A kind of method of existing sense organ transplanting hemoperfusion situation is that local group is obtained by photoacoustic imaging system
Knit blood supply situation.It is this detection site to be limited using photoacoustic imaging system detection method, there is very big operation
Limitation, testing cost is high, and is difficult to promote in clinic.
Fluorescence detection is a kind of very sensitive and effective technology, it can be widely applied to structure of matter detection and surface is existing
As observation.Fluorescence labeling material has unique application advantage in terms of the monitoring of long-time vital movement and vivo tracking, therefore,
Imaging-PAM is also applied in medical domain more and more widely.
Based on the shortcomings of the prior art, need to propose a kind of fluorescent material to contain in real-time continuous detection blood
Amount, at low cost, the Blood fluorescence substance non-invasive detection system based on fluorescence pulse wave of high sensitivity, to obtain fluorescence in blood
Material concentration and by information such as organism metabolism situations, or monitor the hemoperfusion situation of histoorgan during organ transplant.
Utility model content
(1) technical problems to be solved
In order to solve the above problem of the prior art, the utility model provides a kind of low cost, highly sensitive, can be real-time
The Blood fluorescence substance non-invasive detection system based on fluorescence pulse wave of the content of fluorescent material in continuous detection blood, by this
Fluorescent material content is to obtain in blood fluorescent material concentration and by organism metabolism situation etc. in the blood that detection system detects
Information, or monitor the hemoperfusion situation of histoorgan during organ transplant.
(2) technical solution
In order to achieve the above object, the main technical schemes that the utility model uses are as follows:
A kind of Blood fluorescence substance non-invasive detection system based on fluorescence pulse wave, the detection system include:
Fluorescence excitation light source can excite fluorescent material in capillary to shine；
Long wave pass filter, for filtering out exciting light；
Photoelectric sensor, for detecting transmitting fluorescence signal and generating fluorescence pulse wave analogue signal；
The output end of amplifier, input terminal and photoelectric sensor connects, for the fluorescence pulse wave analogue signal
It amplifies；
The output end of high-pass filter, input terminal and amplifier connects, for filter out in tissue or environment it is constant not
The fluorescence signal changed with blood flow；
The output end of low-pass filter, input terminal and high-pass filter connects, for being more than pulse frequency in filtering environmental
The interference signal of rate ingredient；
The output end of A/D converter, input terminal and low-pass filter connects, for turning fluorescence pulse wave analogue signal
Change pulse wave digital signal into；
Controller is connect with A/D converter, for receiving and storing the pulse wave digital signal of A/D converter transmission；
Display is connect with controller, the information for display pulse wave.
Preferably, the fluorescence excitation light source is encapsulated in photoelectric sensor refers to folder, ear clip, for tight with patient skin
Inside any device in the plane device of closely connected conjunction.
Preferably, the surface of the photoelectric sensor is fixed with long wave pass filter.
Preferably, the fluorescence excitation light source is excitation optical diode, and the excitation optical diode passes through opaque silica gel
It is encapsulated in and refers to folder, ear clip, the same side position inside any device in plane device.
Preferably, including detection device ontology, the amplifier, high-pass filter, low-pass filter, A/D converter and
Controller is integrated in the inside of the detection device ontology.
Preferably, the display is mounted on the surface of the detection device ontology, or, the display passes through no line number
It is connect according to transmission mode with the detection device ontology.
It further, further include the wireless data transfer module for connecting display and controller, the wireless data transmission
Module is any one of bluetooth module, WiFi module, infrared remote control module, 4G/3G module.
Preferably, the display is the display for being mounted on physiological monitoring system.
Preferably, the controller includes single-chip microcontroller, and the single-chip microcontroller is connect by data line with A/D converter, is used for
Receive and store the pulse wave digital signal of A/D converter transmission.
(3) beneficial effect
The beneficial effects of the utility model are:
The utility model excludes fluorescence present in tissue other than external environmental light or blood in the form that pulse wave detects
Interference detects the content of fluorescent material in blood vessel only real-time continuously and there are situation, passes through the content and presence of fluorescent material
Situation obtains in blood the concentration of fluorescent material and by information such as organism metabolism situations, or monitors to organize during organ transplant
The hemoperfusion situation of organ, to evaluate organ survival condition.The Blood fluorescence object based on fluorescence pulse wave of the utility model
The features such as matter non-invasive detection system has structure simple, at low cost, high sensitivity, non-invasive.
Detailed description of the invention
Fig. 1 is the Blood fluorescence substance Non-invasive detection based on fluorescence pulse wave that the preferred embodiments of the present invention provide
The structure composition figure of system；
Fig. 2 is the Blood fluorescence substance Non-invasive detection based on fluorescence pulse wave that the preferred embodiments of the present invention provide
The schematic diagram of system.
In attached drawing:
1, fluorescence excitation light source；2, long wave pass filter；3, photoelectric sensor；4, amplifier；5, low-pass filter；6, high
Bandpass filter；7, A/D converter；8, controller；9, display；10, refer to folder；11, detection device ontology.
Specific embodiment
It is with reference to the accompanying drawing, right by specific embodiment in order to understand in order to preferably explain the utility model
The utility model is described in detail.
Preferred embodiment
The Blood fluorescence substance non-invasive detection system based on fluorescence pulse wave that present embodiments provide for a kind of, such as Fig. 1 and
Shown in Fig. 2, which includes fluorescence excitation light source 1, long wave pass filter 2, photoelectric sensor 3, amplifier 4, low pass filtered
The component parts such as wave device 5, high-pass filter 6, A/D converter 7, controller 8 and display 9.
After patient is injected fluorescent material, fluorescence excitation light source 1 can excite fluorescent material in capillary to shine.Long wave is logical
Optical filter 2 can filter out exciting light, and transmitting fluorescence is only allowed to be transmitted in photoelectric sensor 3.Since the blood Unlimited period fills group
It knits, lead to the detectable transmitting fluorescence signal of photoelectric sensor 3 and generates fluorescence pulse wave analogue signal.The input terminal of amplifier 4
It connect, fluorescence pulse wave analogue signal can be amplified with the output end of photoelectric sensor 3.The input terminal of high-pass filter 6
It is connect with the output end of amplifier 4, high-pass filter 6 can filter out that may be present constant not with blood stream in tissue or environment
The fluorescence signal (constant light emitting background) of dynamic variation.The input terminal of low-pass filter 5 is connect with the output end of high-pass filter 6,
Low-pass filter 5 can be more than the dry of pulse frequency ingredient (for example, being more than the 50Hz or more of blood pulses signal) in filtering environmental
Signal is disturbed, interference signal here includes main power frequency interference signals and vibration, noise interferences etc.).A/D conversion
The input terminal of device 7 is connect with the output end of low-pass filter 5, and fluorescence pulse wave analogue signal can be converted into arteries and veins by A/D converter 7
It fights wave digital signal.8 packet single-chip microcontroller of controller, single-chip microcontroller are connect by data line with A/D converter 7, be can receive and are stored A/D
The pulse wave digital signal that converter 7 transmits.Display 9 is connect with controller 7, for showing the letter of the pulse wave after being amplified
Breath, can be seen that the characteristic informations such as waveform, amplitude and the pulse frequency of pulse wave from display 9, wherein the amplitude of pulse wave reflects
The concentration information of fluorescent material.
In order to make photoelectric sensor 3 only detect transmitting fluorescence signal, avoid detecting optical excitation signal, by the logical filter of long wave
Mating plate 2 is mounted on the surface of photoelectric sensor 3, and to separate photoelectric sensor 3 and fluorescence excitation light source 1, conveniently filtering out is needed
Background luminescences, noise and the interference such as the fluorescence spectrum and the unwanted exciting light of exclusion wanted.Long wave pass filter 2 may be selected to penetrate
Rate is high (transmitance is 95% or more), ends, resists strong light, not the glass filter of demoulding.
Fluorescence excitation light source 1 and the above-mentioned photoelectric sensor 3 for being fixed with long wave pass filter 2 are encapsulated in finger folder 10
It, certainly can be with inside any device in (referring to Fig. 1), ear clip, the plane device for being fitted closely with patient skin
It is encapsulated in the inside for detecting its hetero-organization and the device with both ends.Refer to that folder 10 can be sandwiched in measured's finger tips and refer to
Section, ear clip can be sandwiched in the two sides of ear-lobe, and plane device can be the test device of patch or other flat fitting skins.
Specifically, fluorescence excitation light source 1 can be encapsulated in photoelectric sensor 3 refers to the ipsilateral of folder 10 for referring to folder 10
Inside intermediate plate, alternatively, the two is encapsulated in inside the heteropleural intermediate plate for referring to folder 10.By taking ear clip as an example, fluorescence excitation light source 1 and photoelectricity
Sensor 3 can be encapsulated in inside the ipsilateral intermediate plate of ear clip, alternatively, the two is encapsulated in inside the heteropleural intermediate plate of ear clip.With flat
For the device of face, fluorescence excitation light source 1 and photoelectric sensor 3 are encapsulated in plane device (that is, fluorescence excitation light source 1 and photoelectricity
Sensor 3 is located at ipsilateral) in.
In the present embodiment, 1 selective exitation optical diode of fluorescence excitation light source, excitation optical diode can be by opaque
Same lateral position of the silica gel packaging inside any device in finger folder 10, ear clip, plane device, can also pass through opaque silica gel
It is encapsulated in and refers to folder 10, ear clip, the heteropleural position for detecting its hetero-organization and the device with both ends.
The detection system of the utility model includes detection device ontology 11, amplifier 4, high-pass filter 6, low-pass filter
5, A/D converter 7 and controller 8 are integrated in the inside of detection device ontology 11.Display 9 passes through cable data connection type
Or wireless data connection mode is connect with detection device ontology 11.Wherein, display 9 passes through wireless data transfer module and control
The single-chip microcontroller of device 9 connects, and wireless data transfer module is bluetooth module, in WiFi module, infrared remote control module, 4G/3G module
It is any.
Display 9 can directly be fixedly mounted on the surface of detection device ontology 11, and operator is facilitated directly to monitor arteries and veins
It fights wave；Alternatively, display 9 is mounted on the device outside detection device ontology 11, operator can monitor arteries and veins in distant location
It fights wave.When display 9 is mounted on the outside of detection device ontology 11, display 9 can be mounted on physiological monitoring system (can
Monitor the physical signs such as blood pressure, heart rate, the body temperature of human body) on, the physical signs of monitoring is increased, use scope is expanded；Into
One step, display 9 is the display of physiological monitoring system, it is not necessary that another display is individually arranged again on physiological monitoring system
Device not only increases the physical signs of monitoring, expands use scope, and save space, has saved cost, while conveniently
It carries.
The finger folder 10, the devices such as ear clip of the utility model are used to monitor perform the operation in be injected to the fluorescent material of patient's body and exist
Concentration situation of change in blood samples of patients provides reference for fluorescence imaging effect, and for evaluating patient for fluorescent material
Metabolism status.The plane device of the utility model can be used for that organ hemoperfusion feelings are contacted and indicated with transplant organ (such as skin)
Condition, for evaluating organ survival condition.
The utility model excludes fluorescence present in tissue other than external environmental light or blood in the form that pulse wave detects
Interference detects the content of fluorescent material in blood vessel only real-time continuously and there are situation, passes through the content and presence of fluorescent material
Situation obtains in blood the concentration of fluorescent material and by information such as organism metabolism situations, or monitors to organize during organ transplant
The hemoperfusion situation of organ, to evaluate organ survival condition.The Blood fluorescence object based on fluorescence pulse wave of the utility model
The features such as matter non-invasive detection system has structure simple, at low cost, high sensitivity, non-invasive.
It is to be appreciated that the description to specific embodiment of the utility model progress is simply to illustrate that this is practical above
Novel technology path and feature, its object is to allow those skilled in the art that can understand the content of the utility model simultaneously
Implement accordingly, but the utility model is not limited to above-mentioned particular implementation.All ranges in the utility model claims
The various change or modification inside made should all cover within the protection scope of the present utility model.
Claims (9)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721138749.8U CN208319207U (en) | 2017-09-06 | 2017-09-06 | Blood fluorescence substance non-invasive detection system based on fluorescence pulse wave |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721138749.8U CN208319207U (en) | 2017-09-06 | 2017-09-06 | Blood fluorescence substance non-invasive detection system based on fluorescence pulse wave |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208319207U true CN208319207U (en) | 2019-01-04 |
Family
ID=64787586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721138749.8U Active CN208319207U (en) | 2017-09-06 | 2017-09-06 | Blood fluorescence substance non-invasive detection system based on fluorescence pulse wave |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208319207U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115251844A (en) * | 2022-07-28 | 2022-11-01 | 中国科学院深圳理工大学(筹) | Non-invasive subcranial fluorescence imaging monitoring method and device for freely moving small animals |
-
2017
- 2017-09-06 CN CN201721138749.8U patent/CN208319207U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115251844A (en) * | 2022-07-28 | 2022-11-01 | 中国科学院深圳理工大学(筹) | Non-invasive subcranial fluorescence imaging monitoring method and device for freely moving small animals |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN203861234U (en) | Near-infrared dual-wavelength noninvasive blood glucose gauge | |
| US10194809B2 (en) | Integrated electronics for photoplethysmography and electrocardiography | |
| US5833602A (en) | Process of continuous noninvasive hemometry | |
| US20080183059A1 (en) | System and method for assessing capillary vitality | |
| US20160022223A1 (en) | Multi-modal depth-resolved tissue status monitor | |
| JP7650347B2 (en) | Systems and methods for monitoring an analyte or parameter - Patents.com | |
| US9320441B1 (en) | Medical glove for obtaining a patient's blood pressure, pulse and oxygen saturation | |
| WO2006079862A2 (en) | Pulse oximeter and casing for anchoring a sensor | |
| JP2004248820A (en) | Blood analyzer | |
| CN208319207U (en) | Blood fluorescence substance non-invasive detection system based on fluorescence pulse wave | |
| Ghamari et al. | Rapid prototyping of a smart device-based wireless reflectance photoplethysmograph | |
| CN106264555A (en) | blood glucose monitor | |
| Zneid et al. | Non-invasive blood pressure remote monitoring instrument based microcontroller | |
| Yao et al. | A portable multi-channel wireless NIRS device for muscle activity real-time monitoring | |
| CN109452944B (en) | Blood fluorescent substance noninvasive detection system based on fluorescent pulse wave | |
| CN205658894U (en) | Infrared sphygmometer based on singlechip | |
| Maguire et al. | The design and clinical use of a reflective brachial photoplethysmograph | |
| Mykhailova et al. | Application of the photoplethysmography technique to complex wireless diagnostic the functional state of the human body | |
| JP2023069972A (en) | Non-invasive blood sugar measurement device | |
| CN209252854U (en) | Heart rate blood oxygen probe and heart rate blood oxygen monitor | |
| Cysewska-Sobusiak et al. | Examples of the application of light-tissue interaction to biomedical engineering | |
| CN107280684A (en) | Order Scattering focuses on regulation and control blood parameters monitoring device | |
| AU2023342910A1 (en) | Real time opto-physiological monitoring method and system | |
| CN209048148U (en) | Wirelessly refer to last blood oxygen saturation detector device | |
| CA2926096A1 (en) | Medical glove for obtaining a patient's blood pressure, pulse and oxygen saturation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20241016 Address after: No. 84A, Union Road, Dadong District, Shenyang City, Liaoning Province 110000 Patentee after: Shenyang Yikewei Trading Co.,Ltd. Country or region after: China Address before: No. 195, Chuangxin Road, Hunnan District, Shenyang City, Liaoning Province Patentee before: Northeastern University Country or region before: China |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20241202 Address after: Room 202-3, No. 175-3 Chuangxin Road, Hunnan District, Shenyang City, Liaoning Province, China 110000 Patentee after: Keli (Liaoning) Medical Technology Co.,Ltd. Country or region after: China Address before: No. 84A, Union Road, Dadong District, Shenyang City, Liaoning Province 110000 Patentee before: Shenyang Yikewei Trading Co.,Ltd. Country or region before: China |
|
| TR01 | Transfer of patent right |