CN207520722U - A kind of blood plasma extraction element - Google Patents
A kind of blood plasma extraction element Download PDFInfo
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- CN207520722U CN207520722U CN201721550713.0U CN201721550713U CN207520722U CN 207520722 U CN207520722 U CN 207520722U CN 201721550713 U CN201721550713 U CN 201721550713U CN 207520722 U CN207520722 U CN 207520722U
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- blood plasma
- whole blood
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- 210000002381 plasma Anatomy 0.000 title claims abstract description 110
- 238000000605 extraction Methods 0.000 title claims abstract description 54
- 210000004369 blood Anatomy 0.000 claims abstract description 95
- 239000008280 blood Substances 0.000 claims abstract description 95
- 238000001914 filtration Methods 0.000 claims abstract description 16
- 238000010241 blood sampling Methods 0.000 claims abstract description 12
- 238000003825 pressing Methods 0.000 claims abstract description 8
- 230000003014 reinforcing effect Effects 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 2
- 239000000284 extract Substances 0.000 abstract description 2
- 238000012123 point-of-care testing Methods 0.000 description 11
- 238000001514 detection method Methods 0.000 description 9
- 239000007788 liquid Substances 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000002615 hemofiltration Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
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- 238000003745 diagnosis Methods 0.000 description 2
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- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000003918 blood extract Substances 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
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- 150000003431 steroids Chemical class 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model is suitable for medical instruments field, provides a kind of blood plasma extraction element, including：The cavity of negative pressure can be formed, one end of the cavity is mutually isolated whole blood extraction conduit and plasma outlet tube road；It is connected respectively by the first check valve and the second check valve between cavity and the whole blood extraction conduit and plasma outlet tube road；The end of whole blood extraction conduit is blood sampling end；The end in plasma outlet tube road is blood plasma output terminal, and being provided in plasma outlet tube road can be by filter device of the Whole Blood Filtration for blood plasma；When cavity forms negative pressure, whole blood can be collected through the blood sampling end in the cavity；It, can be by the Whole Blood Filtration in the cavity to be discharged after blood plasma through the blood plasma output terminal when pressing to cavity.The blood plasma extraction element can disposably complete acquisition whole blood and export blood plasma, and do not need to can obtain plasma sample by other haemocyte separate apparatus, and simple operation can accurately and quantitatively extract blood plasma, and of low cost, safe and reliable.
Description
Technical field
The utility model belongs to medical instruments field more particularly to a kind of blood plasma extraction element.
Background technology
In clinical examination, it is a common disorder in screening method to carry out screening to disease by blood biochemistry detection.Blood
Liquid is by blood plasma and is suspended in haemocyte therein and forms, and haemocyte includes red blood cell, leucocyte and blood platelet.Blood plasma is blood
Liquid component, contain moisture, plasma protein, electrolyte, nutrient, enzyme, steroids, cholesterol and other important compositions
Part.The sample of blood biochemistry detection is usually blood plasma and/or serum, that is, the blood that will be drawn into is needed to detach, obtains blood
The blood plasma and/or serum sample of biochemistry detection.
In the prior art, the blood of patient is usually extracted by medical staff and seals packing or refrigeration, then send blood back to
Liquid control laboratory is detected, therefore the period tested is longer, is unfavorable for timely diagnosis direction of medication usage of disease etc..And POCT
(point-of-care testing, real-time test) refers to carry out clinical detection (bedside detection, bedside beside patient
Testing), clinical examination teacher is usually not necessarily to carry out.Existing POCT is that the blood being drawn into directly is added to POCT
Be detected on chip, but due to everyone blood plasma and/or serum ratio it is different, so it is same amount of to extract different people
Blood, the blood plasma and/or the ratio of serum obtained after centrifugation is also different, therefore directly adds toward on POCT chips
Blood is detected will be there are sample-adding amount be inaccurate, and then the problem of influence the accuracy of testing result, this is equally unfavorable for
Accurate Diagnosis direction of medication usage to disease etc..
However, in order to improve the accuracy of POCT sample-addings, it can be isolated by the blood being drawn into progress by centrifuge
Serum and/or blood plasma are then added on POCT chips, but centrifuge is generally placed upon in laboratory the use that is exclusively managed by a specially-assigned person, and
And volume is larger, it has not been convenient to move away to bedside and detect；Or by blood cell separation device, electricity drives washed corpuscles, obtains blood
Clear and/or blood plasma, but this separation is of high cost, and the time detached is long.
Utility model content
The utility model embodiment provides a kind of blood plasma extraction element, it is intended to solve in the prior art, in POCT chips
On directly heal liquid be detected and there are sample-adding amount it is inaccurate and using other haemocyte separate apparatus washed corpuscles not
Convenient for placement, and it is of high cost, the time is long the problem of.
The utility model embodiment is achieved in that a kind of blood plasma extraction element, including：
The cavity of negative pressure can be formed, one end of the cavity is mutually isolated whole blood extraction conduit and plasma outlet tube
Road；
Pass through the first check valve and second respectively between the cavity and the whole blood extraction conduit and plasma outlet tube road
Check valve connects；
The end of the whole blood extraction conduit is blood sampling end；
The end in the plasma outlet tube road is blood plasma output terminal, and being provided in the plasma outlet tube road can be by whole blood mistake
Filter the filter device for blood plasma；
When the cavity forms negative pressure, whole blood can be collected through the blood sampling end in the cavity；
It, can be by the Whole Blood Filtration in the cavity to be arranged after blood plasma through the blood plasma output terminal when pressing to the cavity
Go out.
Further, it is equipped with to seal with the cavity inner wall in the cavity and coordinate, the plunger of movement can be pushed and pulled；
The plunger is pulled, so that the cavity forms negative pressure, whole blood can be collected the cavity through the blood sampling end
It is interior；
The plunger is pushed to press to the cavity so that the Whole Blood Filtration in the cavity for after blood plasma through the blood plasma
Output terminal is discharged.
Further, the blood plasma extraction element includes a negative pressure generating device；
The negative pressure generating device is the flexible suction ball device for the other end for being installed on the cavity.
Further, the negative pressure generating device is the bellows of the lateral wall set on the cavity.
Optionally, the filter device is set to before or after second check valve.
Preferably, the graduated scale for showing acquired botal blood volume is provided on the cavity.
Preferably, the blood plasma extraction element is a pen type structure.
Preferably, the cavity is equipped with to limit the position limiting structure that the push-and-pull of the plunger moves.
Preferably, the whole blood extraction conduit and plasma outlet tube road and the junction of the cavity are equipped with reinforcing rib.
The blood plasma extraction element that the utility model embodiment provides can be when its cavity forms negative pressure, and by taking a blood sample, end acquires
Whole blood, and when pressing to its cavity, it can be by the Whole Blood Filtration of acquisition to be exported after blood plasma, operation is very convenient, does not need to borrow
Help other haemocyte separate apparatus, it is possible to plasma sample is directly obtained, it is of low cost, that is, it solves and exists in the prior art
Directly healed on POCT chips liquid be detected and there are sample-adding amount it is inaccurate and using other haemocyte separate apparatus detach
The problem of haemocyte is not easy to dispose, and of high cost, the time is long.
Description of the drawings
Fig. 1 is the structure diagram for the blood plasma extraction element that the utility model first embodiment provides；
Fig. 2 is the structure diagram for the blood plasma extraction element that the utility model second embodiment provides；
Fig. 3 is the structure diagram for the blood plasma extraction element that the utility model 3rd embodiment provides.
Specific embodiment
In order to make the purpose of the utility model, technical solutions and advantages more clearly understood, below in conjunction with attached drawing and implementation
Example, the present invention is further described in detail.It should be appreciated that specific embodiment described herein is only used to explain
The utility model is not used to limit the utility model.
The blood plasma extraction element that the utility model embodiment provides can be when its cavity forms negative pressure, and by taking a blood sample, end acquires
Whole blood, and when pressing to its cavity, it can be by the Whole Blood Filtration of acquisition to be exported after blood plasma, operation is very convenient, does not need to borrow
Help other haemocyte separate apparatus, it is possible to plasma sample is directly obtained, it is of low cost.
Referring to Fig. 1~3, the blood plasma extraction element that the utility model embodiment provides includes：The cavity 1 of negative pressure can be formed,
One end of cavity 1 is mutually isolated whole blood extraction conduit 2 and plasma outlet tube road 3；Cavity 1 and whole blood extraction conduit 2 and blood
It is connected respectively by the first check valve 4 with the second check valve 5 between slurry output channel 3；Wherein, the end of whole blood extraction conduit 2
For end 21 of taking a blood sample；The end in plasma outlet tube road 3 is blood plasma output terminal 31, and being provided in plasma outlet tube road 3 can be by whole blood mistake
Filter the filter device 6 for blood plasma；When cavity 1 forms negative pressure, whole blood can be collected through end 21 of taking a blood sample in cavity 1；When to chamber
It, can be by the Whole Blood Filtration in cavity 1 to be discharged after blood plasma through blood plasma output terminal 31 when body 1 presses.
The blood plasma extraction element that the utility model embodiment provides can be when its cavity forms negative pressure, and by taking a blood sample, end acquires
Whole blood, and when pressing to its cavity, it can be by the Whole Blood Filtration of acquisition to be exported after blood plasma, operation is very convenient, does not need to borrow
Help other haemocyte separate apparatus, it is possible to plasma sample is directly obtained, it is of low cost, that is, it solves and exists in the prior art
Directly healed on POCT chips liquid be detected and there are sample-adding amount it is inaccurate and using other haemocyte separate apparatus detach
The problem of haemocyte is not easy to dispose, and of high cost, the time is long.
As the first embodiment of the utility model, referring to Fig. 1, it is equipped in the cavity 1 of the blood plasma extraction element and chamber
1 inner wall sealing of body coordinates, and can push and pull the plunger 7 of movement.Plunger 7 is pulled, so that cavity 1 forms negative pressure, it can be by whole blood through blood sampling
End 21 is collected in cavity 1；Plunger 7 is pushed to press to cavity 1, so that the Whole Blood Filtration in cavity 1 is defeated through blood plasma after blood plasma
Outlet 31 is discharged.
It, can be first by whole blood extraction conduit 2 and/or blood during detection of drawing blood in the embodiment of the utility model
Slurry output channel 3 is penetrated in the skin histology of patient, and the end of hand-held plunger 7, pulls out plunger 7, at this point, whole blood extracts
Air in pipeline 2 is extracted, and forms negative pressure, and whole blood is under conditions of pressure difference, as blood sampling end 21 enters whole blood extraction conduit
2, and open-top first check valve 4, the opening via the first check valve 4 enter in cavity 1；After the whole blood for being drawn into sufficient amount,
By the way that plunger 7 is pushed to apply pressure to cavity 1, being now in the whole blood in cavity 1 can be open-top under the action of the pressure of application
Second check valve 5, and entered in filter device 6 via the opening of the second check valve 5, it is filtered into blood plasma by filter device 6
Afterwards, then via blood plasma output terminal 31 it discharges.
In a preferred embodiment of the utility model, cavity 1 is equipped with to limit the limit that the push-and-pull of plunger 7 moves
Bit architecture (not shown).Specifically, can position limiting structure be set at handle 71 of the other end close to plunger 7 of cavity 1,
Plunger 7 to be prevented to be completely pulled out of in cavity 1 during pulling.Certainly, which can also be arranged on plunger 7 and connect
One end of nearly handle 71, when plunger 7 is drawn to the position limiting structure, you can plunger 7 is prevented to continue to move out.
As the second embodiment of the utility model, referring to Fig. 2, which includes a negative pressure generating device,
Wherein, which can be the flexible suction ball 8 for the other end for being installed on cavity 1.
In the embodiment of the utility model, draw blood detect during, can first squeeze flexible suction ball 8 discharge cavity 1,
Part or all of air in plasma outlet tube road 3 and flexible suction ball 8 forms negative pressure, then extracts whole blood at this time in cavity 1
Pipeline 2 and/or plasma outlet tube road 3 are penetrated in the skin histology of patient, and unclamp flexible suction ball 8, at this point, whole blood is in pressure difference
Can whole blood extraction conduit 2, and open-top first check valve 4 be entered by end 21 of taking a blood sample under effect, via opening for the first check valve 4
Mouth enters in cavity 1；After the whole blood for being drawn into sufficient amount, flexible suction ball 8 is squeezed again, is pressed to cavity 1 so that into chamber
Open-top second check valve 5 of whole blood in body 1, and enter in filter device 6 via the opening of the second check valve 5, it is filled by filtering
Put 6 be filtered into blood plasma after, discharged from blood plasma output terminal 31.
In the embodiment of the utility model, flexible suction ball 8 can be made of rubber material, rubber high resilience, very
Small external force effect is lower to be generated compared with large deformation, remove resilient after external force.
As the 3rd embodiment of the utility model, referring to Fig. 3, which can be set on the outside of cavity 1
The bellows 9 of wall.Bellows 9 can be the sensitive member of tubular elastomeric connected into foldable wrinkle piece along folding retractable direction
Part.
It is during detection of drawing blood, whole blood extraction conduit 2 and/or blood plasma is defeated in the embodiment of the utility model
Go out pipeline 3 to penetrate in the skin histology of patient, compress bellows 9 fold up its wrinkle piece, can be with piston 10 to outward transport
It is dynamic, at this point, the air in cavity 1 is extracted, negative pressure is formed, whole blood enters whole blood under the action of pressure differential, from blood sampling end 21
Extraction conduit 2, and open-top first check valve 4, are entered by the opening of the first check valve 4 inside cavity 1；When being drawn into sufficient amount
Whole blood after, unclamp bellows 9 extend its wrinkle piece, at this time piston 10 under the drive of the stretching routine of bellows 9,
Press into cavity 1 so that the whole blood in cavity 1 can open-top second check valve 5, and opening via the second check valve 5
Mouth enters in filter device 6, after filter device 6 is filtered into blood plasma, is discharged from blood plasma output terminal 31.
The blood plasma extraction element that above-mentioned first, second, third embodiment provides can lead to when its cavity forms negative pressure
Blood sampling end acquisition whole blood is crossed, and when pressing to its cavity, can be by the Whole Blood Filtration of acquisition to be exported after blood plasma, operation is very just
Victory is not needed to by other haemocyte separate apparatus, it is possible to plasma sample is directly obtained, it is of low cost, and improve POCT
It is loaded accuracy.
In the embodiment of the utility model, above-mentioned filter device 6 is hemofiltration film, can farthest inhibit haemolysis,
Separating and filtering red blood cell is quickly realized in short time, and stability and homogeneity are good, can rapidly be realized point by hemofiltration film
Blood plasma and haemocyte are separated out, blood plasma can be discharged by hemofiltration film, and haemocyte is then trapped on hemofiltration film, the cost of separation
It is low, and operate simple.
In the embodiment of the utility model, filter device 6 can be set to before or after the second check valve 5.Tool
Body, before filter device 6 is set to the second check valve 5, then the whole blood in cavity 1 is filtered by filter device 6
After blood plasma, discharged using the second check valve 5, blood plasma output terminal 31.After filter device 6 is set to the second check valve 5,
Then the whole blood in the cavity 1, which is flowed into via the second check valve 5 in filter device 6, is filtered, and blood plasma is from blood plasma output terminal
31 discharges.
In a preferred embodiment of the utility model, it can be set on cavity 1 for the acquired botal blood volume of display
Graduated scale 11.By the scale of graduated scale 11, medical staff can clearly, be visually observed that the blood volume of current extraction, with
Just the blood volume of extraction is controlled at any time, so that the plasma volume of discharge can not only meet the usage amount of blood biochemistry detection, but also rapidly complete
It is extracted into blood plasma, reduces the blood drawing feeling of pain and psychological pressure of patient.But also conducive to accurately quantifying, improve the accurate of detection
Degree.
In a preferred embodiment of the utility model, the blood plasma extraction element be a pen type structure, compact,
It is light, it carries, use convenient for medical staff.
In a preferred embodiment of the utility model, whole blood extraction conduit 2 and plasma outlet tube road 3 and cavity 1
Junction is equipped with reinforcing rib (not shown), to improve connecing for whole blood extraction conduit 2 and plasma outlet tube road 3 and cavity 1
Intensity is closed, needle tubing is reduced and occurs the risk being broken in use.
In the embodiment of the utility model, which may be used Shooting Technique one-pass molding, be primary
The product that property uses, avoids the cross contamination of blood, high safety and reliability.
The blood plasma extraction element that the utility model embodiment provides can be when its cavity forms negative pressure, and by taking a blood sample, end acquires
Whole blood, and when pressing to its cavity, it can be by the Whole Blood Filtration of acquisition to be exported after blood plasma, operation is very convenient, does not need to borrow
Help other haemocyte separate apparatus, it is possible to plasma sample is directly obtained, it is of low cost.It is whole device compact, light,
It can be carried around, facilitate the use of personnel, mitigate the workload of medical staff, and use one-time formed technique, be simple to manufacture；
It is disposable more safe and reliable.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
All any modification, equivalent and improvement made within the spirit and principle of utility model etc., should be included in the utility model
Protection domain within.
Claims (9)
1. a kind of blood plasma extraction element, which is characterized in that including：
The cavity of negative pressure can be formed, one end of the cavity is mutually isolated whole blood extraction conduit and plasma outlet tube road；
It is unidirectional by the first check valve and second respectively between the cavity and the whole blood extraction conduit and plasma outlet tube road
Valve connects；
The end of the whole blood extraction conduit is blood sampling end；
The end in the plasma outlet tube road is blood plasma output terminal, and being provided in the plasma outlet tube road can be by Whole Blood Filtration
The filter device of blood plasma；
When the cavity forms negative pressure, whole blood can be collected through the blood sampling end in the cavity；
It, can be by the Whole Blood Filtration in the cavity to be discharged after blood plasma through the blood plasma output terminal when pressing to the cavity.
2. blood plasma extraction element as described in claim 1, which is characterized in that be equipped in the cavity and the cavity inner wall
Sealing cooperation can push and pull the plunger of movement；
The plunger is pulled, so that the cavity forms negative pressure, whole blood can be collected through the blood sampling end in the cavity；
The plunger is pushed to press to the cavity, so that the Whole Blood Filtration in the cavity is exports through the blood plasma after blood plasma
End discharge.
3. blood plasma extraction element as described in claim 1, which is characterized in that the blood plasma extraction element is generated including a negative pressure
Device；
The negative pressure generating device is the flexible suction ball device for the other end for being installed on the cavity.
4. blood plasma extraction element as described in claim 1, which is characterized in that the negative pressure generating device is set on the cavity
Lateral wall bellows.
5. the blood plasma extraction element as described in claim 1,2,3 or 4, which is characterized in that the filter device is set to described
Before or after second check valve.
6. blood plasma extraction element as described in claim 1, which is characterized in that be provided on the cavity and acquired for showing
Botal blood volume graduated scale.
7. blood plasma extraction element as described in claim 1, which is characterized in that the blood plasma extraction element is a pen type structure.
8. blood plasma extraction element as claimed in claim 2, which is characterized in that the cavity is equipped with to limit the plunger
Push-and-pull movement position limiting structure.
9. blood plasma extraction element as described in claim 1, which is characterized in that the whole blood extraction conduit and plasma outlet tube road
Reinforcing rib is equipped with the junction of the cavity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721550713.0U CN207520722U (en) | 2017-11-20 | 2017-11-20 | A kind of blood plasma extraction element |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721550713.0U CN207520722U (en) | 2017-11-20 | 2017-11-20 | A kind of blood plasma extraction element |
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| Publication Number | Publication Date |
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| CN207520722U true CN207520722U (en) | 2018-06-22 |
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ID=62582810
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| CN201721550713.0U Active CN207520722U (en) | 2017-11-20 | 2017-11-20 | A kind of blood plasma extraction element |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019096259A1 (en) * | 2017-11-20 | 2019-05-23 | 李泉 | Blood plasma extraction device |
| CN111789601A (en) * | 2019-04-09 | 2020-10-20 | 李泉 | Blood filter and blood filtering apparatus |
| CN111999488A (en) * | 2019-05-11 | 2020-11-27 | 南京岚煜生物科技有限公司 | Quantitative method convenient for whole blood detection |
| CN115128294A (en) * | 2021-03-25 | 2022-09-30 | 深圳市活水床旁诊断仪器有限公司 | Method and device for rapidly and automatically extracting blood plasma from whole blood |
-
2017
- 2017-11-20 CN CN201721550713.0U patent/CN207520722U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019096259A1 (en) * | 2017-11-20 | 2019-05-23 | 李泉 | Blood plasma extraction device |
| CN109806657A (en) * | 2017-11-20 | 2019-05-28 | 李泉 | A plasma extraction device |
| CN111789601A (en) * | 2019-04-09 | 2020-10-20 | 李泉 | Blood filter and blood filtering apparatus |
| CN111999488A (en) * | 2019-05-11 | 2020-11-27 | 南京岚煜生物科技有限公司 | Quantitative method convenient for whole blood detection |
| CN115128294A (en) * | 2021-03-25 | 2022-09-30 | 深圳市活水床旁诊断仪器有限公司 | Method and device for rapidly and automatically extracting blood plasma from whole blood |
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