CN207384906U - A chromatography device for extracting cannabidiol from industrial hemp - Google Patents

Abstract

The utility model discloses a chromatography device for extracting cannabidiol in industrial hemp, the chromatography device including joining in marriage liquid device, chromatography column and controller, join in marriage liquid device and include mobile phase A storage tank, mobile phase B storage tank, blending tank, add the fluid reservoir, mobile phase A storage tank, mobile phase B storage tank all be connected with the blending tank, mobile phase A storage tank and blending tank between be provided with flow control valve A, mobile phase B storage tank and blending tank between be provided with flow control valve B, the blending tank in be provided with agitating unit, add the fluid reservoir setting in the below of blending tank, add the fluid reservoir in be provided with liquid concentration sensor, controller electricity connect liquid concentration sensor, flow control valve A and flow control valve B; the liquid adding device is characterized in that liquid is added between the liquid adding tank and the chromatographic column through a conveying pump, the chromatographic column comprises a liquid inlet, a column body and a liquid outlet, and a liquid flow distributor is arranged below the liquid inlet.

Description

A chromatography device for extracting cannabidiol from industrial hemp

technical field

The utility model belongs to the technical field of separation and purification equipment, in particular to a chromatographic device for extracting cannabidiol from industrial hemp.

Background technique

Cannabidiol (CBD) is a non-toxic, edible and high-value-added phenolic substance extracted from industrial hemp. Systemic effects, and has pharmacological activities such as anti-spasmodic, anti-rheumatoid arthritis, and anti-anxiety. Chromatography technology is currently one of the most efficient separation methods in the fields of pharmacy and chemical industry, and it is also one of the important means for the separation of natural products and the preparation and separation of other high-purity substances.

The crudely extracted cannabidiol extract contains a variety of chemical components, many of which are unknown, so the use is subject to many restrictions. Purification by chromatographic technology is the first choice to obtain high-purity CBD, but there are still many problems in the existing chromatographic equipment. The analysis period is long, and most of them need to contact the eluent for a long time, which will damage the health of the body. Some of them use the pre-prepared eluent to add liquid, but due to the existence of factors such as liquid volatilization, it is difficult to keep the eluent ratio constant, and A large number of eluents are configured, and it is difficult to adjust the ratio of eluents at any time during the chromatography process according to the actual situation. Once the ratio is adjusted, a large amount of pre-prepared eluents will be discarded and need to be recycled before they can be reused, which is time-consuming and laborious. . At the same time, during the chromatographic process, it is easy to cause dry column phenomenon due to the failure of liquid preparation equipment, which directly leads to chromatographic failure. Moreover, there is no mixing device between the existing mobile phases, so that the mixing between the mobile phases is uneven, and when elution is performed, the eluent ratio is inconsistent, and it is easy to cause chromatography failure.

Therefore, it is necessary to develop a chromatography device for extracting cannabidiol from industrial hemp.

Utility model content

The purpose of the utility model is to provide a chromatography device for extracting cannabidiol from industrial hemp.

The purpose of the utility model is achieved in that the chromatographic device includes a liquid distribution device, a chromatography column and a controller, and the liquid distribution device includes a mobile phase A storage tank, a mobile phase B storage tank, a mixing tank, Liquid addition tank, the mobile phase A storage tank and the mobile phase B storage tank are connected to the mixing tank, a flow control valve A is arranged between the mobile phase A storage tank and the mixing tank, and the mobile phase B A flow control valve B is arranged between the storage tank and the mixing tank, the mixing tank is provided with a stirring device, the liquid adding tank is arranged under the mixing tank, and a liquid concentration sensor is arranged in the liquid adding tank , the controller is electrically connected to the liquid concentration sensor, the flow control valve A and the flow control valve B; the liquid addition tank and the chromatographic column are filled by a delivery pump, and the chromatographic column includes a liquid inlet , a column and a liquid outlet, and a liquid flow distributor is arranged below the liquid inlet.

Compared with the prior art, the utility model has the following technical effects:

1. The utility model fully mixes the mobile phase in the mixing tank through the stirring device, and real-time control makes the ratio of the eluent in the liquid addition tank stable, improving the stability of the chromatography process; at the same time, the utility model can also The ratio of the eluent is adjusted at any time according to the chromatographic process, which avoids various disadvantages of pre-preparation in the prior art, and has high separation efficiency and saves time and effort.

2. The utility model arranges a liquid flow distributor under the liquid inlet of the chromatographic column, so that the eluent is evenly distributed, the operation is stable, and the separation efficiency is effectively improved; The dry column phenomenon caused by equipment failure can effectively improve the success rate of passing through the column and facilitate the separation of products.

3. The utility model adopts a plurality of liquid-receiving tanks to circulate the liquid, which greatly reduces the possibility of compounding the separated high-purity cannabidiol and impurities, effectively improves the separation efficiency, and facilitates the direct obtaining of high-purity products. At the same time, it is convenient for single The recovery of the mobile phase during column flushing simplifies the process and reduces the cost.

4. The utility model makes the mobile phases mix evenly through the setting of the mixing tank, which greatly improves the success rate of chromatography.

5. The stainless steel cylinder of the utility model can meet the needs of industrial production. At the same time, the existence of the visible window is convenient for real-time observation of the column of the chromatography column. When bubbles and faults appear in the filler in the column, it can be found and adjusted in time, which is convenient Control of the chromatographic process.

6. The utility model has a simple structure, and the obtained product has high purity and good quality, and realizes automation to a certain extent, greatly reduces labor costs, is environmentally friendly and energy-saving, and is convenient for expanded use.

Description of drawings

Fig. 1 is the structural representation of the utility model;

Fig. 2 is the schematic diagram of the principle of the utility model;

In the figure: 1-mobile phase A storage tank, 2-mobile phase B storage tank, 3-mixing tank, 4-liquid addition tank, 5-chromatographic column, 6-flow control valve A, 7-flow control valve B, 8-stirring device, 9-liquid concentration sensor, 10-liquid flow distributor, 11-liquid level sensor.

Detailed ways

The utility model will be further described below in conjunction with the accompanying drawings, but the utility model is not limited in any way. Any transformation or replacement based on the teaching of the utility model belongs to the protection scope of the utility model.

The chromatographic device as shown in accompanying drawings 1 to 2 includes a liquid distribution device, a chromatography column 5 and a controller, and the liquid distribution device includes a mobile phase A storage tank 1, a mobile phase B storage tank 2, and a mixing tank 3 , liquid addition tank 4, the mobile phase A storage tank 1 and the mobile phase B storage tank 2 are all connected to the mixing tank 3, and a flow control valve A6 is arranged between the mobile phase A storage tank 1 and the mixing tank 3 , a flow control valve B7 is arranged between the mobile phase B storage tank 2 and the mixing tank 3, a stirring device 8 is arranged in the mixing tank 3, and the liquid addition tank 4 is arranged below the mixing tank 3 , the liquid addition tank 4 is provided with a liquid concentration sensor 9, and the controller is electrically connected to the liquid concentration sensor 9, the flow control valve A6 and the flow control valve B7; the liquid addition tank 4 and the chromatographic column 5 Liquid is added through a delivery pump, and the chromatography column 5 includes a liquid inlet, a column body and a liquid outlet, and a liquid flow distributor 10 is arranged below the liquid inlet.

The described filling tank 4 is provided with an alarm device, and the described warning device comprises a liquid level sensor 11 arranged in the liquid adding tank 4 and an alarm device arranged outside the liquid adding tank 4, and the described liquid level sensor 11 And the alarm is also electrically connected with the controller.

Described controller is PLC controller.

The liquid flow distributor 10 is a spray type liquid flow distributor.

The packing of the column body of the chromatography column 5 is silica gel or macroporous adsorption resin.

The column body of the chromatography column 5 is a stainless steel column body, and the column body is provided with a viewing window.

A temperature control jacket is arranged outside the column of the chromatography column 5 .

The liquid outlet of the chromatography column 5 is connected with 2 to 8 liquid receiving tanks.

The liquid receiving tanks are all connected to the centrifugal scraper film concentrator.

The delivery pump is an industrial peristaltic pump.

The working principle and working process of the utility model: after the column adsorption of the cannabidiol crude extract sample is completed, the flow control valve A6 and the flow control valve B7 are first adjusted by the controller, and the mobile phase A (in the chromatography of the cannabidiol Purified water (purified water) is used in the process to wash the chromatography column 5 for a period of time, and then the elution starts. First, the flow control valve A6 and the flow control valve B7 are adjusted by the controller, and the mobile phase A storage tank 1 and the mobile phase B storage tank 2 The mobile phase is added into the mixing tank 3, and the mobile phase A (purified water in the chromatography process of cannabidiol) and mobile phase B (ethanol in the chromatography process of cannabidiol) are fully mixed by the stirring device 8 Mix to obtain an eluent with uniform concentration, and the fully mixed eluent enters the liquid addition tank 4, detects the liquid concentration through the liquid concentration sensor 9, and feeds back to the controller to control the flow control valve A6 and flow control valve B7 in real time to make the addition The ratio of the eluent in the liquid tank 4 is stable; moreover, the utility model can also adjust the ratio of the eluent at any time according to the chromatography process; by setting the liquid flow distributor 10 under the liquid inlet of the chromatography column 5, The eluent is evenly distributed, the operation is stable, and the separation efficiency is effectively improved.

Further, when the signal of the liquid level sensor 11 is lower than the preset value during the chromatography process, the controller controls the alarm to give an alarm, so as to avoid the dry column phenomenon, effectively improve the success rate of passing through the column, and facilitate the separation of products.

Further, the utility model can choose a PLC controller.

Further, the utility model adopts a plurality of liquid receiving tanks to receive liquid in a cycle. When a single mobile phase (such as purified water) is used to flush the column, no further treatment will be performed after directly contacting the liquid, which simplifies the process and reduces the cost; and multiple receiving tanks The liquid tank is separated from the liquid, which greatly reduces the possibility of the separated high-purity cannabidiol being mixed with impurities, effectively improves the separation efficiency, and facilitates the direct obtaining of high-purity products.

Further, the column body of the chromatography column 5 is a stainless steel column body, and the column body is provided with a visual window; the stainless steel column body can meet the needs of industrial production, and the presence of the visual window facilitates real-time observation of the column body, avoiding Bubbles, faults, etc. in the filler cannot be detected and adjusted in time.

The utility model has simple operation, realizes automation, and greatly reduces labor costs.

Claims (10)

1. a kind of chromatographic apparatus for extraction cannabidiol in industrial hemp, it is characterised in that the chromatographic apparatus includes matching somebody with somebody Liquid device, chromatographic column（5）And controller, the liquid dispensing device include mobile phase A storage tank（1）, Mobile phase B storage tank（2）, mixing Tank（3）, liquid feeding tank（4）, the mobile phase A storage tank（1）, Mobile phase B storage tank（2）And blending tank（3）Connection, the stream Dynamic phase A storage tanks（1）With blending tank（3）Between be provided with flow control valve A（6）, the Mobile phase B storage tank（2）With blending tank （3）Between be provided with flow control valve B（7）, the blending tank（3）In be provided with agitating device（8）, the liquid feeding tank （4）It is arranged on blending tank（3）Lower section, the liquid feeding tank（4）In be provided with strength of fluid sensor（9）, the control Device is electrically connected strength of fluid sensor（9）, flow control valve A（6）With flow control valve B（7）；The liquid feeding tank（4）With layer Analyse column（5）Between pass through delivery pump liquid feeding, the chromatographic column（5）Including inlet, cylinder and liquid outlet, the inlet Lower section is provided with liquid stream distributor（10）.

2. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described Liquid feeding tank（4）In be provided with warning device, the warning device includes being arranged on liquid feeding tank（4）Interior liquid level sensor （11）Be arranged on liquid feeding tank（4）Outer alarm, the liquid level sensor（11）With alarm also with the controller Electrical connection.

3. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described Controller be PLC controller.

4. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described Liquid stream distributor（10）For atomizing liquid stream distributor.

5. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described Chromatographic column（5）Cylinder filler be silica gel or macroporous absorbent resin.

6. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described Chromatographic column（5）Cylinder for stainless steel cylinder, and be provided with visual window on the cylinder.

7. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described Chromatographic column（5）Cylinder be provided outside temperature control chuck.

8. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described Chromatographic column（5）Liquid outlet be connected with 2 ~ 8 and connect flow container.

9. the chromatographic apparatus according to claim 8 for extraction cannabidiol in industrial hemp, it is characterised in that described The flow container that connects be connected to centrifugal scraper plate thin film concentrator.

10. the chromatographic apparatus according to claim 1 for extraction cannabidiol in industrial hemp, it is characterised in that described Delivery pump be industrial peristaltic pump.