CN207148122U - A kind of fluorescence excitation and transmitting optical module and immunofluorescence analysis instrument - Google Patents

Abstract

The utility model provides a kind of fluorescence excitation and transmitting optical module and immunofluorescence analysis instrument, including optics fixed support and it is arranged at a pair of fluorescence excitation light sources and exciting light filter disc on the optics fixed support top, the exciting light filter disc is located at fluorescence excitation light source top, and two groups of fluorescence excitation light sources and exciting light filter disc middle part are provided with transmitting light filter disc, the optics fixed support opens up through hole at transmitting light filter disc position, and transmitting light filter disc is arranged in the through hole；Optics fixed support top, which is integrally formed, to be provided with for placing fluorescence excitation light source, exciting light filter disc and the boss for launching light filter disc, in actual use, the exciting light of fluorescence excitation light source with high brightness is filtered by exciting light filter disc, fluorescent dye in the exciting light irradiating and detecting card excites fluorescence, fluorescence launches light filter disc along straight-line pass, in the sensor for the camera for being collected into smart mobile phone, so as to produce real-time fluoroscopic image, reasonable in design, detection accuracy is high.

Description

A kind of fluorescence excitation and transmitting optical module and immunofluorescence analysis instrument

[technical field]

Immunofluorescence analysis instrument equipment technical field is the utility model is related to, more particularly to a kind of reasonable in design, behaviour Facilitate, fluorescence excitation and transmitting optical module and the immunofluorescence analysis instrument of low manufacture cost.

[background technology]

Real-time test is a segmented industry of in-vitro diagnosis work, and it relies on convenient, quick advantage, may be implemented in patient Diagnostic result is quickly obtained at one's side, turns into a fast-developing in recent years emerging field, its skill of the foundation currently developed Art characteristic is mainly divided into the first generation of the three generations based on quick diagnosis test paper such as blood sugar test paper bar, early pregnancy test strips, with The second generation based on cartridge type nucleic acid amplification, the third generation based on the application of smart mobile phone, compared to preceding two generation, the 3rd In generation, possesses the quantitative detectability of the special multi-parameter of highly sensitive height due to it and more integrates portable, easy to operate, Yong Huyou Many potential advantages such as good, it has also become the forefront technology of external detection field immediately.

Immunofluorescence analysis technology is the accurate immune labeled detection technique that new development is got up, with traditional enzyme linked immunological Method and Gold standard are compared, and immunofluorescence analysis sensitivity is high, and high specificity is easy to operate, without radioactive substance conduct Label, thus with "dead", label it is stable, be easy to long-term preservation, test repeatability is good, analyze speed is fast, sample Dosage is few and the advantages that standard curve broad quantum, after the XRF light of certain frequency that has been measure material absorbing, material , there is proportional relation in the intensity of light itself launched, can be by determining the light of fluorescence between the intensity and amount of material of fluorescence Spectrum and fluorescence intensity, qualitative or quantitative analysis is carried out to material, and immunofluorescence analysis technology is in current biomedical inspection Conventional quick analytical technology, microorganism, viral antigen or antibody test, hormone test, tumor-marker analyte detection, cell because The fields such as son detection have broad application prospects.

The diagnostic biomarkers clinically commonly used at present, detection method such as chemiluminescence, El isa quantitative determination process, no The determination methods such as the quick and convenient use of energy, the collaurum of fast diagnosis reagent are not easily achieved quantitative determination, and these detection reagents are being cured Operated with institute by professional, in the prior art without easy, quick, be suitable for detection reagent that household person uses and Instrument, it can be seen that, the Immunofluorescence test instrument of Quantitative detection a kind of can be invented, make its can each hospital emergency treatment and Applied in the intracardiac professional section office of grade, facilitate patient and the household person of friend's person in middle and old age health prevention to use again, while can pass through Testing result is transferred to the family doctor or specialist of user by client, so that medical professional is possible to for those The patient that acute disease occurs provides prevention, health care, urgent see a doctor guidance and Treatment monitoring, turns into those skilled in the art's letter and waits to solve Technical barrier certainly.

[utility model content]

To overcome the problems of prior art, the utility model provides a kind of reasonable in design, operation facility, system Make the low fluorescence excitation of cost and transmitting optical module and immunofluorescence analysis instrument.

The scheme that the utility model solves technical problem is to provide a kind of fluorescence excitation with launching optical module and being immunized glimmering Light analyzer, including optics fixed support and be arranged at a pair of fluorescence excitation light sources on the optics fixed support top and excite Light filter disc, the exciting light filter disc are located at fluorescence excitation light source top, and among two groups of fluorescence excitation light sources and exciting light filter disc Position is provided with transmitting light filter disc, and the optics fixed support opens up through hole at transmitting light filter disc position, and transmitting light filter disc is arranged at In the through hole；The optics fixed support top be integrally formed be provided with for place fluorescence excitation light source, exciting light filter disc with And the boss of transmitting light filter disc；Transmitting light filter disc is located at the centre of boss；And extended upward simultaneously at the boss both ends Shape identical fluorescence excitation erecting bed, fluorescence excitation light source, exciting light filter disc are all arranged on the fluorescence excitation erecting bed； The light source slot for placing fluorescence excitation light source is offered on each fluorescence excitation erecting bed respectively and is excited for placing The filter disc groove of light filter disc.

Preferably, the fluorescence excitation erecting bed is in 120-160 degree relative to the surface and boss plane of transmitting light filter disc Angle.

Preferably, the fluorescence excitation light source is light emitting diode.

Preferably, the exciting light filter disc is square structure, launches the rounded structure of light filter disc.

A kind of immunofluorescence analysis instrument, including lucifuge cavity and fluorescence excitation as described above and transmitting optics group Part；The fluorescence excitation is arranged at lucifuge inside cavity with transmitting optical module；In the lucifuge cavity close to fluorescence excitation and hair Penetrate optical module one end and offer the detection card patchhole that card is detected for inserting；And lucifuge cavity front is provided with use In the stable mobile phone stopper slot for placing external smart mobile phone, on the mobile phone stopper slot, with fluorescence excitation and transmitting optical module Corresponding position offers light hole.

Preferably, the lucifuge cavity includes lower chamber and the upper cavity being flexibly connected with lower chamber；The lower chamber is in L Type moulding；And several threaded connection holes are offered in upper cavity.

Preferably, the optics fixed support of the fluorescence excitation and transmitting optical module is correspondingly arranged with upper cavity, and light Learn through hole and the positive light hole position correspondence of lucifuge cavity that fixed support opens up at transmitting light filter disc position.

Preferably, the lower chamber is internally provided with threaded post corresponding with each threaded connection hole.

Preferably, the fluorescence excitation and transmitting optical module engaging are arranged at lucifuge inside cavity.

Compared with prior art, a kind of fluorescence excitation of the utility model leads to transmitting optical module and immunofluorescence analysis instrument Cross while optics fixed support 171 is set and is arranged at a pair of fluorescence excitation light sources on the top of optics fixed support 171 (176,177) and exciting light filter disc (174,175), exciting light filter disc (174,175) are located on fluorescence excitation light source (176,177) Portion, and transmitting light filter disc is set in two groups of fluorescence excitation light sources (176,177) and exciting light filter disc (174,175) middle part 1731, in actual use, the exciting light with the fluorescence excitation light source (176,177) of high brightness passes through exciting light filter disc (174,175) filter, the fluorescent dye in the exciting light irradiating and detecting card excites fluorescence, and fluorescence is filtered along straight-line pass transmitting light Piece 1731, it is reasonable in design so as to produce real-time fluoroscopic image in the sensor for the camera for being collected into smart mobile phone, It is high to detect accuracy.

[brief description of the drawings]

Fig. 1 is the stereoscopic-state structural representation of a kind of fluorescence excitation of the utility model and transmitting optical module.

Fig. 2 is a kind of fluorescence excitation of the utility model and the stereoscopic-state structural representation at another visual angle of transmitting optical module Figure.

Fig. 3 is a kind of stereoscopic-state structural representation of immunofluorescence analysis instrument of the utility model.

Fig. 4 is a kind of explosive state structural representation of immunofluorescence analysis instrument of the utility model.

[embodiment]

To make the purpose of this utility model, technical scheme and advantage are more clearly understood, below in conjunction with drawings and Examples, The utility model is further elaborated.It should be appreciated that specific embodiment described herein is used only for explaining this Utility model, it is not used to limit this utility model.

Fig. 1 to Fig. 4 is referred to, a kind of fluorescence excitation of the utility model includes optics fixed support with transmitting optical module 17 171 and it is arranged at a pair of fluorescence excitation light sources (176,177) and exciting light filter disc on the top of optics fixed support 171 (174,175), the exciting light filter disc (174,175) are located at fluorescence excitation light source (176,177) top, and in two groups of fluorescence excitations Light source (176,177) and exciting light filter disc (174,175) middle part are provided with transmitting light filter disc 1731, the optics fixed support 171 open up through hole at transmitting light filter disc 1731 position, and transmitting light filter disc 1731 is arranged in the through hole；The optics fixed support 171 tops, which are integrally formed, to be provided with for placing fluorescence excitation light source (176,177), exciting light filter disc (174,175) and hair Penetrate the boss 173 of light filter disc 1731；Launch the centre that light filter disc 1731 is located at boss 173；It is and same at the both ends of boss 173 When extend upward shape identical fluorescence excitation erecting bed 1733, fluorescence excitation light source (176,177), exciting light filter disc (174,175) are all arranged on the fluorescence excitation erecting bed 1733；Opened up respectively on each fluorescence excitation erecting bed 1733 There are the light source slot for placing fluorescence excitation light source (176,177) and the filter disc for placing exciting light filter disc (174,175) Groove.

By setting optics fixed support 171 simultaneously and being arranged at a pair of fluorescence on the top of optics fixed support 171 Excitation source (176,177) and exciting light filter disc (174,175), exciting light filter disc (174,175) are located at fluorescence excitation light source (176,177) top, and set in two groups of fluorescence excitation light sources (176,177) and exciting light filter disc (174,175) middle part Launch light filter disc 1731, in actual use, there is the exciting light of fluorescence excitation light source (176,177) of high brightness by swashing Luminous filter disc (174,175) filtering, the fluorescent dye in the exciting light irradiating and detecting card excite fluorescence, and fluorescence is along straight-line pass Launch light filter disc 1731, in the sensor for the camera for being collected into smart mobile phone, so as to produce real-time fluoroscopic image, structure is set Meter is reasonable, and detection accuracy is high.

Preferably, surface and boss 173 plane of the fluorescence excitation erecting bed 1733 relative to transmitting light filter disc 1731 In the angle of 120-160 degree.It is reasonable in design.

Preferably, the fluorescence excitation light source (176,177) is light emitting diode.

Preferably, be square the exciting light filter disc (174,175) structure, 1731 rounded structure of transmitting light filter disc.

A kind of immunofluorescence analysis instrument 1, including lucifuge cavity 15 and fluorescence excitation as described above and transmitting optics Component 17；The fluorescence excitation is arranged inside lucifuge cavity 15 with transmitting optical module 17；In the lucifuge cavity 15 close to glimmering Light excites and launched the one end of optical module 17 to offer the detection card patchhole for inserting detection card 13；And in lucifuge chamber The front of body 15 is provided with for the stable mobile phone stopper slot 111 for placing external smart mobile phone, on the mobile phone stopper slot 111, with Fluorescence excitation and the transmitting corresponding position of optical module 17 offer light hole 113.

In actual use, smart mobile phone is positioned in mobile phone stopper slot 111, smart mobile phone can be by means of the instrument Device detect the fluoroscopic image collection of card, and then the albumen detected to Immunofluorescence test paper strip in sample quantifies, and And detection process is simple and quick, detection sensitivity is high, the degree of accuracy is high.

Preferably, the lucifuge cavity 15 includes lower chamber and the upper cavity 11 being flexibly connected with lower chamber；The cavity of resorption The L-shaped moulding of body；And several threaded connection holes are offered in upper cavity 11.It is reasonable in design.

Preferably, the optics fixed support 171 of the fluorescence excitation and transmitting optical module 17 is corresponding with upper cavity 11 sets Put, and the through hole and the positive light hole 113 of lucifuge cavity 15 that optics fixed support 171 opens up at transmitting light filter disc 1731 position Position correspondence.

Preferably, the lower chamber is internally provided with threaded post corresponding with each threaded connection hole.Stable connection is reliable.

Preferably, the fluorescence excitation and the transmitting engaging of optical module 17 are arranged inside lucifuge cavity 15.

Compared with prior art, a kind of fluorescence excitation of the utility model is with launching optical module 17 by setting optics simultaneously Fixed support 171 and a pair of the fluorescence excitation light sources (176,177) and exciting light for being arranged at the top of optics fixed support 171 Filter disc (174,175), exciting light filter disc (174,175) is located at fluorescence excitation light source (176,177) top, and swashs in two groups of fluorescence Light emitting source (176,177) and exciting light filter disc (174,175) middle part set transmitting light filter disc 1731, actually use process In, the exciting light with the fluorescence excitation light source (176,177) of high brightness is filtered by exciting light filter disc (174,175), and this swashs Fluorescent dye in luminous irradiating and detecting card excites fluorescence, and fluorescence launches light filter disc 1731 along straight-line pass, is collected into intelligence Reasonable in design so as to produce real-time fluoroscopic image in the sensor of the camera of mobile phone, detection accuracy is high.

Above-described the utility model embodiment, does not form the restriction to scope of protection of the utility model.It is any Made within spirit of the present utility model and principle modifications, equivalent substitutions and improvements etc., should be included in the utility model Claims within.

Claims (9)

1. a kind of fluorescence excitation and transmitting optical module, it is characterised in that：Including optics fixed support and it is arranged at the optics A pair of fluorescence excitation light sources and exciting light filter disc on fixed support top, the exciting light filter disc are located at fluorescence excitation light source top, And two groups of fluorescence excitation light sources and exciting light filter disc middle part are provided with transmitting light filter disc, the optics fixed support is being launched Light filter disc position opens up through hole, and transmitting light filter disc is arranged in the through hole；The optics fixed support top is integrally formed setting Have for placing fluorescence excitation light source, exciting light filter disc and the boss for launching light filter disc；Transmitting light filter disc is located in boss Center portion position；And shape identical fluorescence excitation erecting bed is extended upward simultaneously at the boss both ends, fluorescence excitation light source, excite Light filter disc is all arranged on the fluorescence excitation erecting bed；Offered respectively on each fluorescence excitation erecting bed glimmering for placing The light source slot in phot-luminescence source and the filter disc groove for placing exciting light filter disc.

2. a kind of fluorescence excitation as claimed in claim 1 and transmitting optical module, it is characterised in that：The fluorescence excitation installation Angle of the platform relative to the surface of transmitting light filter disc with boss plane in 120-160 degree.

3. a kind of fluorescence excitation as claimed in claim 1 or 2 and transmitting optical module, it is characterised in that：The fluorescence excitation Light source is light emitting diode.

4. a kind of fluorescence excitation as claimed in claim 1 and transmitting optical module, it is characterised in that：The exciting light filter disc is in Square structure, launch the rounded structure of light filter disc.

A kind of 5. immunofluorescence analysis instrument, it is characterised in that：Including lucifuge cavity and such as above-mentioned any one claim institute The fluorescence excitation stated and transmitting optical module；The fluorescence excitation is arranged at lucifuge inside cavity with transmitting optical module；Described Lucifuge cavity offers the detection card patchhole for inserting detection card close to fluorescence excitation and transmitting optical module one end； And the mobile phone stopper slot for stable placement external smart mobile phone is provided with lucifuge cavity front, on the mobile phone stopper slot, Light hole is offered with fluorescence excitation and transmitting optical module corresponding position.

A kind of 6. immunofluorescence analysis instrument as claimed in claim 5, it is characterised in that：The lucifuge cavity include lower chamber with And the upper cavity being flexibly connected with lower chamber；The L-shaped moulding of the lower chamber；And several threaded connections are offered in upper cavity Hole.

A kind of 7. immunofluorescence analysis instrument as claimed in claim 6, it is characterised in that：The fluorescence excitation and transmitting optics group Optics fixed support and the upper cavity of part are correspondingly arranged, and the through hole that optics fixed support opens up at transmitting light filter disc position is with keeping away The positive light hole position correspondence of optical cavity body.

A kind of 8. immunofluorescence analysis instrument as claimed in claim 6, it is characterised in that：The lower chamber be internally provided with respectively Threaded post corresponding to threaded connection hole.

A kind of 9. immunofluorescence analysis instrument as claimed in claim 5, it is characterised in that：The fluorescence excitation and transmitting optics group Part engaging is arranged at lucifuge inside cavity.