CN206992048U - A kind of paper spraying ionization and mass spectrographic combined apparatus - Google Patents

Abstract

The utility model discloses a combined device of paper spray ionization and mass spectrometry, which comprises: an object stage with a liquid holding chamber; chromatographic paper connected with the liquid holding chamber; samples placed on the chromatographic paper; A dielectric barrier discharge ion source erected on the stage for spraying plasma to the chromatographic paper; receiving a mass spectrum of sample ionization after plasma spraying. The utility model sprays the plasma generated by the dielectric barrier discharge ion source directly on the chromatographic paper, so that the sample on it reacts with the plasma and ionizes, and then enters the mass spectrometer together under the movement of the plasma, realizing Ionization under normal temperature and pressure without high voltage.

Description

A Combined Device of Paper Spray Ionization and Mass Spectrometry

technical field

The utility model relates to the technical field of sample ionization detection, in particular to a combined device for paper spray ionization and mass spectrometry.

Background technique

Mass spectrometer is a scientific analytical instrument with fast analysis speed, high sensitivity and molecular specificity. It is widely used in many fields such as chemistry, biology, environmental monitoring, medical and health.

Paper spray ionization technology is a new type of atmospheric pressure ion source developed in 2010. The technology first loads solid or liquid samples on the surface of paper matrix composed of cellulose and hemifibers, and then uses high-voltage electric drive to make the solvent dissolve, migrate and ionize the compounds in complex samples, and then occurs at the tip of the paper. Electrospray, and finally real-time online detection by mass spectrometry. Due to the fast, low-cost and high-efficiency characteristics of this ionization technology, it has been used in the analysis and detection of compounds in blood samples, urine samples, food, biological tissue samples, algae and other samples, and also played an important role in the study of chemical reaction processes. .

The dielectric barrier discharge ion source is also an ion source developed in recent years. Dielectric barrier discharge is a non-equilibrium gas discharge in which an insulating medium is inserted into the discharge space. The most notable feature is the ability to generate stable low-temperature plasma at atmospheric pressure. The plasma hits the sample surface, reacts with the sample and ionizes it, which is then detected in real time by mass spectrometry.

Utility model content

The utility model provides a combination device of paper spray ionization and mass spectrometry. The plasma generated by the dielectric barrier discharge ion source is directly sprayed on the chromatographic paper, so that the sample on it reacts with the plasma and is ionized. Under the motion of the plasma, it enters the mass spectrometer together, realizing ionization at normal temperature and pressure without high voltage.

A combined device for paper spray ionization and mass spectrometry, comprising:

Stage with liquid chamber;

Chromatographic paper connected with the liquid chamber;

a sample placed on said chromatographic paper;

a dielectric barrier discharge ion source installed on the stage for injecting plasma to the chromatographic paper;

Receive a mass spectrum of sample ionization after plasma spray.

In the utility model, the sample is placed on the chromatographic paper, the end of the chromatographic paper is immersed in the solution in the liquid chamber, the solution is absorbed by the capillary phenomenon to separate the sample dropped on the chromatographic paper, and the dielectric barrier discharge ion source sprays The resulting plasma ionizes the sample and sends it to the mass spectrometer. The utility model uses plasma to ionize the sample loaded on the chromatographic paper, realizes ionization at normal temperature and pressure without high voltage, and uses capillary phenomenon to avoid solution dripping in the measurement process, thereby realizing automation and array type Determination.

Following is preferred as the utility model:

The carrier table is recessed to form a liquid holding chamber, which is used to hold a solution that is convenient for dissolving, migrating and ionizing the sample.

The liquid holding chamber of the carrier table is covered with a dust shield.

The dust shield plate is provided with erection slots for erecting dielectric barrier discharge ion sources.

Compared with the prior art, the beneficial effects of the utility model are:

In the utility model, the sample is placed on the chromatographic paper, and the end of the chromatographic paper is immersed in the solution in the liquid chamber for the sample, and the solution is absorbed by the capillary phenomenon to separate the sample dropped on the chromatographic paper, and the dielectric barrier discharge ion source The ejected plasma ionizes the sample and sends it to the mass spectrometer. The utility model uses plasma to ionize the sample loaded on the chromatographic paper, realizes ionization at normal temperature and pressure without high voltage, and uses capillary phenomenon to avoid solution dripping in the measurement process, thereby realizing automation and array type Determination.

Description of drawings

Fig. 1 is a schematic structural view of a stage with a liquid holding chamber in the utility model;

Fig. 2 is a schematic structural view of the mid-range dust plate of the present invention;

Fig. 3 is a structural schematic diagram of the combined device for paper spray ionization and mass spectrometry of the present invention.

detailed description

Below in conjunction with accompanying drawing, the utility model is described in further detail.

As shown in Fig. 1, Fig. 2 and Fig. 3, a combined device for paper spray ionization and mass spectrometry includes: a stage 1 with a liquid holding chamber 2; a chromatographic paper 3 connected to the liquid containing chamber 2; The sample 4 on the chromatographic paper 3; the dielectric barrier discharge ion source 7 mounted on the stage 1 for spraying plasma 9 to the chromatographic paper 3; receiving the mass spectrometer 11 of the sample ionization 10 after plasma spraying.

The stage 1 is recessed to form a liquid holding chamber 2 for holding a solution so as to dissolve, migrate and ionize the sample 4 .

The liquid holding chamber of the stage 1 is covered with a dust-shielding plate 5 .

The dust plate 5 is provided with an erection groove 6 for erecting a dielectric barrier discharge ion source 7 .

In the utility model, the sample 4 is placed on the chromatographic paper 3, the end of the chromatographic paper 3 is immersed in the solution in the liquid chamber 2, and the sample 4 dropped on the chromatographic paper 3 is separated by absorbing the solution by capillary phenomenon, The plasma 9 ejected from the dielectric barrier discharge ion source 7 ionizes 10 the sample and sends it into the mass spectrometer 11 . The utility model uses plasma to ionize the sample 4 loaded on the chromatographic paper, realizes ionization under normal temperature and pressure without high voltage, and uses capillary phenomenon to avoid solution dripping in the measurement process, thereby realizing automation and array type determination.

The above are only preferred embodiments of the present utility model, and are not intended to limit the scope of patent protection of the present utility model. All equivalent structural transformations made by using the description of the utility model and the contents of the accompanying drawings are directly or indirectly used in other related technical fields. , are all included in the protection scope of the present utility model in the same way.

Claims (4)

1. A combined device for paper spray ionization and mass spectrometry, characterized in that it comprises: Stage with liquid chamber; Chromatographic paper connected with the liquid chamber; a sample placed on said chromatographic paper; a dielectric barrier discharge ion source installed on the stage for injecting plasma to the chromatographic paper; Receive a mass spectrum of sample ionization after plasma spray. 2 . The combined device for paper spray ionization and mass spectrometry according to claim 1 , wherein the stage is concaved to form a liquid chamber. 3 . 3. The combined device of paper spray ionization and mass spectrometry according to claim 1, characterized in that the liquid chamber of the stage is covered with a dust shield. 4. The combined device of paper spray ionization and mass spectrometry according to claim 3, characterized in that, the dust shield plate is provided with an erection groove for erecting a dielectric barrier discharge ion source.