CN206818653U - A kind of gas chromatography combined with mass spectrometry interface, system - Google Patents
A kind of gas chromatography combined with mass spectrometry interface, system Download PDFInfo
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- CN206818653U CN206818653U CN201720335398.3U CN201720335398U CN206818653U CN 206818653 U CN206818653 U CN 206818653U CN 201720335398 U CN201720335398 U CN 201720335398U CN 206818653 U CN206818653 U CN 206818653U
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Abstract
It the utility model is related to a kind of gas chromatography combined with mass spectrometry interface, system.The connecting interface includes sheath flow device, the sheath flow device is provided with the internal chromatogram connector that can be interconnected, mass spectrum connector, carrier gas interface, the chromatogram connector is used to be passed through gas with the carrier gas interface, and the mass spectrum connector is used for output gas.The technical solution of the utility model is introduced except interference gas is used as carrier gas by the use of sheath flow device, to balance the difference of mass spectrum injection port flow and column outlet flow, solve mass spectrometer and the unmatched problem of chromatographic isolation instrument flow, improve the inaccurate effect of the spectrogram for causing analysis to draw because mass spectral analysis is limited by chromatography throughput.
Description
Technical field
The utility model generally relates to vapor detection field, and in particular to a kind of gas chromatography combined with mass spectrometry interface, system.
Background technology
With the rapid development of World Economics, it is also very important that mankind's activity destroys to caused by the earth.In the world
Developed country during industrial accelerated development, all once lived through the stage that haze is wreaked havoc, nowadays as maximum development
Also can often there be haze appearance middle country, Chinese Heavy industrial city.The generation of haze is not result overnight, but industrial
Waste gas is continuously increased more than caused by environment self detergent power.Therefore, occur to prevent heavily contaminated weather, it should closely
The change of constituent of atomsphere concentration is paid close attention to, rationally controls the discharge of harmful substance, formulates targetedly environmental emission reduction measure, this is just
Need precision instrument more accurately to carry out qualitative and quantitative analysis to gas component, the detections of gas component concentrations thus turn into
The focus of current research.
In numerous gas on-line analysis equipment, mass spectrograph is good with its distinctive high sensitivity, high specificity, the degree of accuracy
The advantages that enjoy favor, at the scene in application process, analyze speed is fast, and result reliability is high.Due to surrounding air component more
Complexity, single on-line mass spectroscopy analysis constituent of atomsphere can not meet the needs of practical application, and existing gas chromatography-mass spectrum
It is mostly lab analysis to be combined instrument, and existing weather feelings can not be reacted in real time by relying solely on spot sampling lab analysis
Condition, while can also introduce very big error in sampling process and sampling apparatus also has certain suction-operated to gas component.
In the extremely complex gas of analysis component, the spectrogram that various ingredients obtain is extremely complex, can usually give spectrum unscrambling work
Author brings very big difficulty.In order to realize fast qualitative and quantitative purpose, lab analysis using gas-chromatography-
Mass spectrometry means, the pre-separation function of multicomponent gas is realized by chromatographic column.Because on-line mass spectroscopy instrument is different from fact
Room analysis is tested, majority uses continuous sample introduction, and inlet flow rate is big, and the mismatch problem that can cause flow velocity is directly connected with chromatogram,
Chromatographic column post effect due to back pressure can not only declined, and mass spectrum can be made quantitative inaccurate due to sample size deficiency.
Therefore, research and develop a kind of connecting interface applied to online gas chromatography-mass spectrometry analysis equipment to design, divide online for mass spectrum
Analysis has great importance.
Existing chromatography-mass spectroscopy connector is only applicable to laboratory gas chromatography-mass spectrometry analysis equipment, and laboratory is set
Back-up, which analyses live constituent of atomsphere, can bring many inconvenience and component damages.
In existing chromatography-mass spectroscopy connector access on-line mass spectroscopy, the inappropriate problem of flow matches, mass spectrum can be introduced
Analysis is limited by chromatogram throughput, and test concentrations are relatively low, and chromatogram is influenceed by mass spectrum cavity back pressure, retention time and post effect hair
It is raw to change.
Chromatographic column saturation can be then set to be unable to reach expected separation effect to adjust chromatographic flow rates by on-line mass spectroscopy sample introduction flow
Fruit.
If on-line analysis need not be utilized when chromatographic isolation, it is necessary to connecting interface be dismounted again, during use
Due to repeatedly switching interface can be caused to loosen, sealing declines.
On-line continuous sample introduction equipment may be influenceed by surrounding air during constituent of atomsphere is analyzed, gas occur
The unstable situation of body sample size, if only by gas-chromatography and the mass spectrographic tune for being directly connected to, throughput can not being realized
Section, analyzing the spectrogram drawn may be fluctuated due to the change of throughput.
After the gas isolated from chromatographic column enters mass spectrum injection port, because gas flow is less, sample introduction pipeline can not be full of,
Therefore when gaseous sample is also introduced into mass spectrum, chromatographic separation process is over, so the gas after chromatographic isolation
Component can mix again at mass spectrum injection port, lose the due meaning of chromatographic isolation.
So the technological development of on-line chromatograph-mass spectrometry has been imperative, and the company of chromatographic isolation and mass spectral analysis
Connection interface design is the critical stage of this technological development, and the design of this interfacing scheme should meet on-line mass spectroscopy height simultaneously
The characteristics of requirement of flux and chromatographic isolation low sample introduction volume.
Utility model content
The purpose of this utility model is to provide a kind of gas chromatography combined with mass spectrometry interface, system, to balance mass spectrum sample introduction
The difference of mouth flow and column outlet flow, solve mass spectrometer and the unmatched problem of chromatographic isolation instrument flow, improve
Cause to analyze the inaccurate effect of the spectrogram drawn because mass spectral analysis is limited by chromatography throughput.
The utility model aims to provide a kind of gas chromatography combined with mass spectrometry interface, and the connecting interface includes sheath flow device,
The sheath flow device is provided with the internal chromatogram connector that can be interconnected, mass spectrum connector, carrier gas interface, and the chromatogram connects
Interface is used to be passed through gas of carrier gas with the carrier gas interface, and the mass spectrum connector is used for output gas.
Connecting interface as described above, the connecting interface also include air-path adapter, and it connects the sheath flow device
Chromatogram connector or the mass spectrum connector.
Connecting interface as described above, the connecting interface also include seal, and its sealed set connects in the chromatogram
At mouth, mass spectrum connector or carrier gas interface.
Connecting interface as described above, valve is respectively equipped with the mass spectrum connector and the carrier gas interface.
Connecting interface as described above, the sheath flow device are threeway or multiple-pass joint.
Preferably, connecting interface as described above, the sheath flow device are equal tee.
The utility model also provides a kind of gas chromatography combined with mass spectrometry system, and the system includes chromatographic isolation instrument, mass spectrum
Analyzer and connecting interface as described above, the chromatogram connector of the connecting interface connects the chromatographic isolation instrument, described
The mass spectrometer is connected with the mass spectrum connector of interface.
The technical solution of the utility model is one sheath flow device of addition, the tow channel gas of the device at mass spectrographic injection port
Stream connects chromatographic column and mass spectrum entrance respectively, and remaining air-flow all the way is connect except the gas of carrier gas such as hydrocarbon air are to balanced flow, avoids color
Spectrum separation and mass spectral analysis are affected.The utility model is introduced except interference gas is as carrier gas, to balance by the use of sheath flow device
The difference of mass spectrum injection port flow and column outlet flow, solves mass spectrometer and chromatographic isolation instrument flow is unmatched
Problem, improve the inaccurate effect of the spectrogram for causing analysis to draw because mass spectral analysis is limited by chromatographic isolation throughput.
Brief description of the drawings
Fig. 1 is the utility model gas chromatography combined with mass spectrometry workflow schematic diagram；
Fig. 2 is the utility model gas chromatography combined with mass spectrometry structural representation.
Embodiment
Below in conjunction with drawings and examples, specific embodiment of the present utility model is described in more details, with
Just the advantages of better understood when scheme of the present utility model and its various aspects.However, specific implementations described below
Mode and embodiment are for illustrative purposes only, rather than to limitation of the present utility model.
The design of online gas chromatography-mass spectrography interface be in order to meet on-line mass spectroscopy with during gas chromatography combined use
Flow velocity matching problem and design.
Chromatographic isolation is that mixed gas flows through chromatographic column, retention time of the different materials in chromatographic column under pressure-driven
Difference, so as to reach the purpose of separation mixed gas.Online gas chromatography-mass spectrography equipment can utilize chromatogram to mix
It is incorporated into mass spectrum and is analyzed after gas separation, chromatogram is as mass spectrographic preprocessing means, after mass spectrum is as chromatographic isolation
Detection method.Mass spectral analysis is after gaseous sample is ionized, and enters analysis cavity by ion transport device, in mass analyzer
Electric field or magnetic fields under realize the centrifugation of different quality material, the material of the different quality after being separated reaches detection
The time of device is different, and then to accurate qualitative substance classes, sample concentration is then by getting to ion populations on tally
It is how many to calculate.
Online gas chromatography-mass spectrometry analysis device is a kind of live real-time gas analytical equipment, can be in a period of time
The change in concentration of every kind of gas component does continuous monitoring, and wherein gas-chromatography is to separate mixed gas, and mass spectrum is identifying gas
Body title and calculating gas content.
In chromatograph-mass spectrometer coupling equipment, enter mass spectrographic throughput needs and the gas consumption of mass spectral analysis from chromatographic column
It is consistent, the influence of back pressure or malleation to analytical equipment performance is avoided with this.
As shown in figure 1, gas chromatography combined with mass spectrometry interface of the present utility model, agent structure is sheath flow device 10, thereon
Provided with inside can be interconnected chromatogram connector 101, mass spectrum connector 102, carrier gas interface 103, chromatogram connector 101 with
The carrier gas interface 103 is used to be passed through gas of carrier gas, and the mass spectrum connector 102 is used for output gas.Chromatogram connector 101 is used
It is connected in chromatographic isolation instrument, mass spectrum connector 102 is used to be connected with mass spectrometer 20.And carrier gas interface 103 is used to input
Gas of carrier gas, the separation gas entered from chromatogram connector 101 is introduced mass spectrometer 20 by it.
For connecting interface and chromatographic isolation instrument and mass spectrometer 20 is connected or convenient disassembly, connecting interface may also include
Air-path adapter 30, an air-path adapter is connected respectively at the chromatogram connector 101 or mass spectrum connector 102 of sheath flow device 10
30, or chromatogram connector 101 with setting air-path adapter 30 simultaneously at mass spectrum connector 102.
Above-mentioned connecting interface, in order to which hermetic seal is intact, single seal is may also include in junction, its sealed set
Between chromatogram connector 101 and chromatographic isolation instrument, between mass spectrum connector 102 and mass spectrometer 20 or carrier gas interface 103
Between carrier gas input channel 40.Certain seal can also become one with pipe joint, for example be used at several connectors
Ferrule fitting 50.
In order to freely control the gas flow of each passage, can distinguish at mass spectrum connector 102 and the carrier gas interface 103
Valve 60 is set, to adjust the matching of flow and switch at any time.
Preferably, for convenient processing and manufacture, sheath flow device 10 can be threeway or multiple-pass joint.Certainly, sheath flow device
The airtight container with gas mixing function can be processed as, mixed gas is passed through mass spectrum injection port, such as：Ratio
Diluter etc..
Preferably, sheath flow device 10 is equal tee, is so easy to interchangeability of parts.
The utility model also provides a kind of gas chromatography combined with mass spectrometry system, and the system includes chromatographic isolation instrument, mass spectrum
Analyzer 20 and connecting interface as described above, the chromatogram connector 101 of the connecting interface connects chromatographic isolation instrument, described
The mass spectrometer 20 is connected with the mass spectrum connector 102 of interface.
The utility model also provides a kind of flow matches method using above-mentioned gas chromatography combined with mass spectrometry system, mainly
It is by being passed through carrier gas by described in the separation gas inputted from chromatogram connector 101 introducing to the carrier gas interface 103 of connecting interface
Mass spectrometer 20.Such gas of carrier gas is added with the two-part gas flow of chromatographic isolation gas can be to meet the big stream of mass spectrum
Measure the demand of gas.
The appropriateness of specific flow matches, it can design the several logical of sheath flow device 10 depending on different detection objects
Road internal diameter causes flow matches, also can be steady by the flow of carrier gas being adjusted throughput required for making mass spectrometer
It is fixed.
The carrier gas is anti-interference gas.It is specific visual tested for example carrier gas can be selected except hydrocarbon air, nitrogen, hydrogen etc.
Survey depending on gas.
The utility model can be connected on-line mass spectroscopy analyzer and gas-chromatography separator using connecting interface, with one
Gas to be analyzed after chromatographic isolation is brought into mass spectral analysis cavity by road-load gas, goes for on-line analysis equipment, effectively
The absorption error that ground avoids the deficiency of laboratory equipment and sampling analysis introduces；Chromatogram is reasonably balanced by introducing carrier gas
The mismatch of flow and mass spectrum flow so that keep one into the flow needed for the gas flow of mass spectrometer and mass spectral analysis
Cause, while also prevent the generation of chromatogram port of export back pressure, be unlikely to influence the normal operation of chromatographic column.
Device of the present utility model changes sample size without chromatogram, while and can meets the air-flow required for mass spectral analysis
Amount, thus be also not in the phenomenon of the pillar saturation caused by chromatography column feed materials amount is big；If during field assay not
Chromatographic isolation is needed, chromatographic valve can be closed, directly introduces sample from carrier gas inlet end, it is not necessary to excessive disassembly process.
In addition, occur the fluctuation of sample introduction gas flow amount unavoidably during the real-time continuous analysis in scene, it is of the present utility model
Device can automatically adjusting to meet the stability of the throughput required for mass spectral analysis by carrier gas flux；By chromatogram point
From sample in the presence of carrier gas, be brought into mass spectral analysis cavity quickly, will not in mass spectrum injection port substantial dwell time,
Thus it is also impossible to the phenomenon that the component after separating mixes again when being not introduced into mass spectrum occur.
Embodiment
The workflows of technical solutions of the utility model is led to as shown in Fig. 2 sheath flow device 10 is a threeway gas path joint
Crossing addition, sample is brought into spectrometer analysis cavity by carrier gas all the way, as can be carried in above-mentioned embodiment using valve to realize
The break-make of gas and chromatographic column stream, it can open or close in use any air-flow all the way.
The locking nut of existing gas chromatography-mass spectrum connector is applied to 1/16, and " pipe joint, chromatographic column pass through gas circuit
Adapter 30 is connected with as the isodiametric three-way connector of sheath flow device 10, and carrier gas accesses three-way connection by valve 60, and by sample
Product gas is brought into mass spectral analysis cavity.Gas of carrier gas is except hydrocarbon air.
Sample is ionized after entering mass spectrometer, enters analysis cavity by ion transport device, in quality point
The centrifugation of different quality material is realized under the electric field or magnetic fields of parser, the material of the different quality after being separated is carried out
Ion detection, the material of different quality reach the time difference of detector, and then to accurate qualitative substance classes, sample concentration
Be then by get to ion populations on tally number calculate, wherein molecular pump and mechanical pump are used for providing ion analysis
With the vacuum environment of detection.
Finally it should be noted that：Obviously, above-described embodiment is only intended to clearly illustrate the utility model example,
And the restriction not to embodiment.For those of ordinary skill in the field, may be used also on the basis of the above description
To make other changes in different forms.There is no necessity and possibility to exhaust all the enbodiments.And thus
Among the obvious changes or variations amplified out is still in the scope of protection of the utility model.
Claims (7)
1. a kind of gas chromatography combined with mass spectrometry interface, it is characterised in that the connecting interface includes sheath flow device, the sheath stream dress
Put provided with the internal chromatogram connector that can be interconnected, mass spectrum connector, carrier gas interface, the chromatogram connector with it is described
Carrier gas interface is used to be passed through gas of carrier gas, and the mass spectrum connector is used for output gas.
2. connecting interface as claimed in claim 1, it is characterised in that the connecting interface also includes air-path adapter, and it connects
Connect the chromatogram connector of the sheath flow device or the mass spectrum connector.
3. connecting interface as claimed in claim 2, it is characterised in that the connecting interface also includes seal, and its sealing is set
It is placed at the chromatogram connector, mass spectrum connector or carrier gas interface.
4. connecting interface as claimed in claim 1, it is characterised in that punished in the mass spectrum connector and the carrier gas interface
She You not valve.
5. connecting interface as claimed in claim 1 or 2 or 3 or 4, it is characterised in that the sheath flow device is threeway or led to more
Joint.
6. connecting interface as claimed in claim 5, it is characterised in that the sheath flow device is equal tee.
A kind of 7. gas chromatography combined with mass spectrometry system, it is characterised in that the system include chromatographic isolation instrument, mass spectrometer and
Any described connecting interface of claim 1 to 6, the chromatogram connector of the connecting interface connect the chromatographic isolation instrument, institute
The mass spectrum connector for stating connecting interface connects the mass spectrometer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720335398.3U CN206818653U (en) | 2017-03-31 | 2017-03-31 | A kind of gas chromatography combined with mass spectrometry interface, system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720335398.3U CN206818653U (en) | 2017-03-31 | 2017-03-31 | A kind of gas chromatography combined with mass spectrometry interface, system |
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| CN206818653U true CN206818653U (en) | 2017-12-29 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106841459A (en) * | 2017-03-31 | 2017-06-13 | 北京雪迪龙科技股份有限公司 | A kind of gas chromatography combined with mass spectrometry interface, system and flow matches method |
| CN109557217A (en) * | 2019-01-27 | 2019-04-02 | 广西科技大学鹿山学院 | A kind of gas-chromatography --- mass spectrometer interface seal joint pressing device |
-
2017
- 2017-03-31 CN CN201720335398.3U patent/CN206818653U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106841459A (en) * | 2017-03-31 | 2017-06-13 | 北京雪迪龙科技股份有限公司 | A kind of gas chromatography combined with mass spectrometry interface, system and flow matches method |
| CN109557217A (en) * | 2019-01-27 | 2019-04-02 | 广西科技大学鹿山学院 | A kind of gas-chromatography --- mass spectrometer interface seal joint pressing device |
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