CN206508943U - Porous light particle preparation facilities - Google Patents

Abstract

The utility model provides a preparation device for porous lightweight particles, which includes an atomization unit 10 configured to atomize a liquid sample 123 into a plurality of mist droplets; a freezing unit 20 configured to cool the plurality of mist droplets into several ice particles and a drying unit 30 configured to dry a number of ice particles into a plurality of porous particles, so as to obtain a solid powder formed by a collection of a plurality of porous particles. The porous lightweight particle preparation device relies on the atomizing part 10 to uniformly atomize the liquid sample 123 into countless micron-sized droplets with the same particle size, relies on the freezing part 20 to freeze the droplets into several ice particles, and relies on the drying part 30 to freeze the droplets into several ice particles. The granules are dried at low temperature into porous and light particles, so that liquid samples 123 with heat sensitivity, consistency, active materials and high sugar content can be directly prepared into powders composed of porous and light particles, which can not only make the original biological and The chemical properties remain unchanged, and the specific surface area of the particles is large, the fluidity is good, and the aerosol dynamic properties are good. It is suitable for inhalation preparations and can also be used in other fields.

Description

Porous lightweight particle preparation device

technical field

The utility model relates to the technical field of particle preparation, in particular to a porous light particle preparation device.

Background technique

Vaccines and drugs are effective means to deal with emerging and severe infectious diseases. The current research direction is to prepare liquid samples of vaccines or drugs into solid powders. Powdered vaccines can be used for direct nasal mucosal immunity or lung inhalation immunity. Powdered drugs can be directly inhaled for treatment, or can be injected after dissolving, getting rid of the links of cold chain transportation and low temperature storage. The existing particle preparation methods mainly include spray drying method and vacuum freeze drying method, both of which have certain defects. The temperature or pressure in the spray-drying process may affect the biological activity of the vaccine. Although vacuum freeze-drying can protect the original activity of the sample to the greatest extent, the product is usually cake or block after drying, which needs to be crushed and ground again to obtain Powdered product.

Utility model content

The utility model aims at overcoming at least one defect in the preparation of existing powdered vaccines or medicines, and provides a preparation device for porous light particles, which can directly prepare heat-sensitive, thick, active materials and liquid samples with high sugar content. The powder composed of porous light particles not only keeps the original biological and chemical properties of the sample unchanged, but also has a large specific surface area, good fluidity, and good aerosol dynamic properties, making it suitable for inhalation preparations.

For this reason, the utility model provides a kind of porous lightweight particle preparation device, it comprises:

an atomization unit configured to atomize the liquid sample into a plurality of droplets;

a freezing section configured to cool a plurality of said mist droplets into a plurality of ice particles; and

The drying part is configured to dry several of the ice particles into a plurality of porous particles, so as to obtain a solid powder formed by a collection of the plurality of porous particles.

Further, the freezing part has a cooling space for receiving a plurality of the mist droplets;

The drying part has a drying space for receiving the plurality of ice particles.

Further, the atomization part is a vibrating mesh atomizer, which has a diaphragm arranged horizontally and a vibrating device that drives the diaphragm to vibrate; and

The membrane is provided with a plurality of holes, and the upper side of the membrane is configured to contain the liquid sample;

The vibrating device drives the diaphragm and the liquid sample on the upper side of the diaphragm to vibrate, so that the liquid sample on the upper side of the diaphragm passes through a plurality of holes on the lower side of the diaphragm. A plurality of the droplets are formed on the side.

Further, the diameter of each hole is in the range of 1 to 100 microns.

Further, the cooling space is also configured to receive liquid nitrogen for freezing a plurality of the mist droplets; and

The freezing part further includes a stirring device configured to stir the mist and the liquid nitrogen in the cooling space so as to fully mix them.

Further, the freezing part further includes a cooling tank, and the cooling space is defined inside the cooling tank;

The stirring device is a magnetic stirrer, which includes a stirring rotor located in the cooling space and a guiding device located below the freezing tank.

Further, the drying part is a freeze dryer.

Further, the atomizing part has a droplet outlet for the plurality of droplets to flow out, and communicates with the cooling space.

The porous light particle preparation device of the utility model relies on the atomizing part to uniformly atomize the liquid sample into countless micron-sized mist droplets with equal particle diameters, relies on the freezing part to freeze the mist droplets into several ice particles, and relies on the drying part to freeze the ice particles Dry at low temperature into porous and light particles, so that heat-sensitive, thick, active materials and liquid samples with high sugar content can be directly prepared into powders composed of porous and light particles, which can not only make the original biological and chemical properties of the samples It remains unchanged, and the specific surface area of the particles is large, the fluidity is good, and it has good aerosol dynamic characteristics. It is suitable for inhalation preparations and can also be used in other fields.

Description of drawings

Hereinafter, some specific embodiments of the present utility model will be described in detail in an exemplary rather than restrictive manner with reference to the accompanying drawings. The same reference numerals in the drawings designate the same or similar parts or parts. Those skilled in the art will appreciate that the drawings are not necessarily drawn to scale. In the attached picture:

Fig. 1 is a schematic structural diagram of a porous lightweight particle preparation device according to an embodiment of the present invention.

Fig. 2 is the powder prepared by the porous lightweight particle preparation device of the present invention.

Figure 3 is a scanning electron micrograph of the obtained powder.

detailed description

In order to make the purpose, technical solutions and advantages of the embodiments of the present invention more clear, specific embodiments will be described in detail below in conjunction with the accompanying drawings.

Fig. 1 is a schematic structural diagram of a porous lightweight particle preparation device according to an embodiment of the present invention. As shown in Figure 1, the embodiment of the present invention provides a device for preparing porous lightweight particles. The device for preparing porous lightweight particles may include an atomization unit 10 , a freezing unit 20 and a drying unit 30 . The atomizing unit 10 is configured to atomize liquid samples such as vaccines, medicines, and proteins into a plurality of fine mist droplets, the freezing unit 20 is configured to cool the plurality of mist droplets into several ice particles, and the drying unit 30 is configured to dry some ice particles. into a plurality of porous particles to obtain a solid powder formed by the collection of a plurality of porous particles. In this way, heat-sensitive, viscous, active materials and liquid samples with high sugar content can be directly prepared into powders composed of porous light particles, which not only keep the original biological and chemical characteristics of the samples unchanged, but also have large specific surface areas. , good fluidity, good aerosol dynamics, suitable for inhalation preparations.

Further, in some embodiments of the present invention, the freezing part 20 has a cooling space 210 for receiving a plurality of fine mist droplets, and the drying part 30 has a drying space for receiving several ice particles. In some embodiments of the present invention, the atomizing part 10 also has a droplet outlet for a plurality of droplets to flow out, and communicates with the cooling space 210 . When the porous lightweight particle preparation device of the present invention is in use, the atomizing part 10 uniformly atomizes the liquid sample into countless fine mist droplets, and the small mist droplets enter the freezing part 20 and are cooled into ice particles, and the formed ice particles enter The drying part 30 is finally dried into a solid powder composed of porous particles.

In some embodiments of the present utility model, the atomizing part 10 is a vibrating mesh atomizer 12 , which has a diaphragm 121 arranged horizontally and a vibrating device 122 that drives the diaphragm 121 to vibrate. The diaphragm 121 is provided with a plurality of holes of equal size, and the diameter of each hole ranges from 1 to 100 microns. The upper side of the diaphragm 121 is configured to contain a liquid sample 123 . The vibrating device 122 drives the membrane 121 and the liquid sample 123 on the upper side of the membrane 121 to vibrate, so that the liquid sample 123 on the upper side of the membrane 121 passes through multiple holes to form a plurality of droplets on the lower side of the membrane 121 . The vibrating device 122 is driven by piezoelectricity, which drives the diaphragm 121 to vibrate, and can generate millions of micron-sized mist droplets per second.

In some embodiments of the present invention, the freezing unit 20 further includes a cooling tank 220 , and a cooling space 210 is defined in the cooling tank 220 , and the cooling space 210 can receive liquid nitrogen for freezing a plurality of mist droplets. For example, the cooling tank 220 may be provided with a plurality of openings 230, the liquid nitrogen stored in the liquid nitrogen tank enters the cooling tank 220 through one or more openings, and the volatilized nitrogen gas exits the cooling tank 220 through the remaining openings.

In order to ensure that the mist droplets are sufficiently cooled, in some embodiments of the present invention, the freezing unit 20 further includes a stirring device 240 configured to stir the mist droplets and liquid nitrogen in the cooling space 210 to fully mix them. The stirring device 240 can be a magnetic stirrer, which includes a stirring rotor 241 located in the cooling space 210 and a guiding device 242 located below the freezing tank.

In some embodiments of the present invention, the drying unit 30 is a freeze dryer, which can dry the ice particles under low temperature and vacuum environment, and can retain the original biological activity of the vaccine or medicine. Specifically, the freeze dryer has a drying space, and a sample tray is arranged in the drying space, and the ice particles to be dried are placed in the sample tray. The freeze dryer can maintain a low-temperature environment (that is, a temperature environment of -10°C to -60°C) and a vacuum environment in the drying space. The ice particles are dried and become loose and porous particles, many of which make up a pile of powder. These powders are the drug powders or vaccine powders obtained for inhalation preparations, etc. The final obtained powders are shown in Figure 2, and the scanning electron micrographs of the powders are shown in Figure 3, which shows that the obtained powders are composed of porous and light micron-sized particles composition.

The above is only a preferred embodiment of the utility model, and it should be pointed out that for those of ordinary skill in the art, without departing from the principle of the utility model, any improvements and modifications made should also be regarded as Protection scope of the present utility model.

Claims (8)

1. a kind of porous light particle preparation facilities, it is characterised in that including：

Atomization portion, is configured to fluid sample being atomized into multiple droplets；

Frozen part, if being configured to multiple droplets being cooled to dry ice pellet；With

Drying section, is configured to some ice pellets being dried to multiple porous granules, to obtain by the multiple porous granule collection Close the solid powder formed.

2. porous light particle preparation facilities according to claim 1, it is characterised in that

The frozen part has the cooling space for being used for receiving multiple droplets；

If the drying section has the dry place for receiving the dry ice pellet.

3. porous light particle preparation facilities according to claim 1 or 2, it is characterised in that

The atomization portion is vibration hole sizer atomizer, the vibration dress with horizontally disposed diaphragm and the drive diaphragm vibration Put；And

It is provided with the diaphragm on the upside of multiple holes, and the diaphragm and is configured to hold the fluid sample；

The vibrating device drives the fluid sample vibration on the upside of the diaphragm and the diaphragm, so that on the diaphragm The fluid sample of side forms multiple droplets in the downside of the diaphragm through multiple described holes.

4. porous light particle preparation facilities according to claim 3, it is characterised in that

The diameter (span) of each described hole is 1 to 100 microns.

5. porous light particle preparation facilities according to claim 2, it is characterised in that

The cooling space is configured to receive the liquid nitrogen for being used for freezing multiple droplets；And

The frozen part also includes agitating device, and the agitating device is configured to the mist that stirring is located in the cooling space Drop and the liquid nitrogen, so that the two is sufficiently mixed.

6. porous light particle preparation facilities according to claim 5, it is characterised in that

The frozen part also includes limiting the cooling space in cooling tank, the cooling tank；

The agitating device is magnetic stirring apparatus, and it includes the stirring rotator being located in the cooling space and positioned at the freezing Guide device below tank.

7. porous light particle preparation facilities according to claim 2, it is characterised in that

The drying section is freeze drier.

8. porous light particle preparation facilities according to claim 2, it is characterised in that

The atomization portion, which has, to be used to the droplet outlet that the multiple droplet flows out, connect with the cooling space.