CN206434624U - A kind of hydrophilic lubrication implant electrode wire - Google Patents
A kind of hydrophilic lubrication implant electrode wire Download PDFInfo
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- CN206434624U CN206434624U CN201621112177.1U CN201621112177U CN206434624U CN 206434624 U CN206434624 U CN 206434624U CN 201621112177 U CN201621112177 U CN 201621112177U CN 206434624 U CN206434624 U CN 206434624U
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- 238000009422 external insulation Methods 0.000 claims abstract description 36
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- Materials For Medical Uses (AREA)
- Electrotherapy Devices (AREA)
Abstract
The utility model discloses a kind of hydrophilic lubrication implant electrode wire, electrode cable includes conductive layer and external insulation layer, lubricating layer is provided with outside the external insulation layer, the lubricating layer is the functional layer containing the copolymer with hydrophilic molecule segment and hydrophobic molecule segment.The implant electrode wire that the utility model is provided greatly reduces resistance during wire implantation, and lubricity is good, improves the smooth degree and security of wire implantation, protects external insulation layer, the service life of extension lead, it is ensured that wire is used safely.
Description
Technical field
The utility model belongs to medical instruments field, is related to a kind of implant electrode wire, specifically a kind of hydrophilic lubrication
Implant electrode wire.
Background technology
Pacemaker and electric cardioversion defibrillator be for heart can not one kind of patient of normal work long-term plant
Entering property medicine equipment, pacemaker is to be directed to Symptomatic bradycardia and the invalid patient of drug therapy；Electric cardioversion
Defibrillator is the patient for having ventricular fibrillation, ventricular flutter and other tachy-arrhythmias for another major class patient.Either
The pacemaker being chronically implanted, or electric cardioversion defibrillator, are required for intracardiac electrode wire electric pulse stimulation signal
Or shock energy reaches heart from pace-making generator or electrical conversion defibrillator.Intracardiac electrode wire sends into the chambers of the heart by vein, separately
One end is connected with pace-making generator or electrical conversion defibrillator, regular electric pulse or energy is reached heart, too slow or mistake
Fast heartbeat is adjusted to required frequency, so as to ensure normal heart action.
Brain pacemaker, also known as Deep brain stimulation (Deep brain stimulation (DBS)), it is specific in intracerebral
Nerve nucleus implant electrode, discharge high-frequency electrical stimulation, for treating various out of control nervous disorders, particularly for
Mitigate Parkinsonian symptoms.Three cardinal symptoms of Parkinson's are alleviated in treatment:Tremble, stiff and bradykinesia etc..Brain is paced
Device includes impulse generator, an electrode cable, and these parts implant.
Neuromodulation（Neuromodulation）It can be used to treat dyskinesia, spasm, epilepsy and Pain Syndrome,
Most common product is the spinal cord stimulation trial for treating back and lower limb pain, and the medical treatment device includes the nerve being chronically implanted
Stimulation instrument and electrode cable.
Although the illness of three major types product treatment above is different, the electrode cable of implantation is required for.
At present, the electrically insulating material of the implant electrode wire used is all relative hydrophobic, when implanted electrode cable meeting
Friction blood vessel or other tissues cause to cause the implantation of electrode cable difficult than larger frictional resistance, while to patient
Unnecessary pain is caused, or even infection can be brought to injure.
Patent No. CN103893833A Chinese invention patent discloses a kind of catheter in blood vessel for improving surface lubrication,
Using polyurethane material as the catheter in blood vessel of matrix, outermost layer scribbles one layer of parylene film.Because dimethylbenzene film is met
One layer of lubricating film is quickly formed after water, with extremely excellent lubrication, lubricity is 10~100 times of common conduit, therefore is subtracted
Lack the damage to vascular tissue when being intubated, it is therefore prevented that the generation of complication, substantially reduced platelet adhesion reaction, reduce thrombus shape
Into.But lubricating film easily comes off, the persistence of lubricant effect and lubrication can not be ensured.
Surface has the medical instruments of lubricity when and for example being moistened disclosed in Publication No. US20110274918, by metal
The substrate layer 1 of material formation, and cover the compound at least one of, that there are multiple mercaptos by intramolecular of substrate layer 1
The intermediate layer 2 of formation, and the covering surface of intermediate layer 2, the surface that is formed by the hydrophilic macromolecule with reactive functional groups
Lubricating layer 3, wherein, by making the compound with mercapto be reacted with hydrophilic macromolecule, surface lubrication layer 3 is via intermediate layer
2 combine on substrate layer 1.But be isolation material for substrate layer, it is impossible to realize.
Currently for the hydrophilic lubrication problem of implantation, occur in that and many improved guide pipe lubricating using hydrophilic coating
Method.But, the problem of having certain among these, such as patent CN101455861A, CN102166377A, CN1442458A
And CN1537643A, organic solvent system is all employ, the volatilization of these organic solvents not only brings production hidden danger, and pollution
Environment, potential threat is all had to sufferer or the healthy of the workman for producing conduit.
The content of the invention
In order to solve the above mentioned problem that existing implant electrode wire is present, the utility model provides a kind of hydrophilic lubrication and planted
Enter electrode cable, by setting hydrophilic lubrication layer with the extexine of human contact, improve lubricity, reduction wire implantation resistance
Power, wire implantation is more smooth, safer.
In order to achieve the above object, the utility model is adopted the following technical scheme that：A kind of hydrophilic lubrication implant electrode is led
Line, including inner conducting layer and external insulation layer, are provided with lubricating layer outside the external insulation layer, and the lubricating layer is containing with parent
The functional layer of the copolymer of aqueous molecule segment and hydrophobic molecule segment.
In electrode cable implantation process, in order to reduce conduit implantation resistance, the diameter except limiting electrode cable, application
People is had found, hydrophilic lubricant coating is coated outside electrode cable, the lubricity of implantation can be substantially improved.Using copolymer come
Lubricating layer is formed, the density of hydrophilic segment is higher, more preferably, biocompatibility is also more preferable, between external insulation layer for lubricant effect
Fitness is higher, it is ensured that the biological safety that electrode cable is used, and is also beneficial to the processing of electrode cable lubricating layer.
The hydrophilic molecule segment, including polyethylene glycol（Polyethylene glycol, abbreviation PEG）And polyethylene
Pyrrolidones（Polyvinylpyrrolidone, abbreviation PVP）One or both of mixture.
Applicant selects from numerous hydrophilic materials, but no matter is single use or by these hydrophily high scores
Sub- material is used in mixed way, but lubricant effect is unsatisfactory, and main cause is that these hydrophilic high molecular materials are easy to from coating
Middle precipitation is migrated into blood, does not reach the lubrication of long period.Also some lubricant coatings prepare complexity, and cost is held high
It is expensive.
Applicant further investigation revealed that, hydrophilic material is polymerize what is formed with hydrophobic molecule segment
Copolymer can improve lubricant effect well as the principal component of lubricating layer, and relative cost is relatively low.Selected in the application
PEG, PVP polymerize the copolymer to be formed with hydrophobic molecule segment, as the principal component of lubricating layer, and its lubricant effect shows the most
Write, not only high lubricating effect, lasting greasy property can also reach the requirement of needs.
Preferably, the hydrophobic molecule segment is polyurethane（Polyurethane, abbreviation PU）, PPOX
（Polypropylene oxide, abbreviation PPO）, one or more in silicon rubber (silicone rubber), this is several
After molecule segment polymerize with PEG, PVP, more preferably, more stable in intracardiac electrode conductive line surfaces, security is more preferable for lubricant effect.
For example, the copolymer containing PEG chain segment（copolymer, PEG-CP）：CP segments in PEG-CP be it is hydrophobic,
CP hydrophobic performance can be fixed on PEG-CP with hydrophobic substrate molecule formation molecule winding, also mutual Van der Waals force
Electrode cable surface.
If PEG is blended into polyurethane or silicon rubber electrically insulating material, pure PEG is easy to separate out simultaneously from material
It is dissolved into blood, so that the smooth effect in the surface needed for not reaching electrode cable.The long-chain-segment of copolymer containing PEG and height
Molecule insulated electric conductors substrate molecule mutually tangles and makes PEG-CP stable there is provided longer in electrode catheter polymer insulation layer surface
The hydrophilic lubrication effect of phase.
Typical example is PEG-PPO-PEG copolymers, and hydrophilic PEG is stretched in blood, while hydrophobic PPO and dredging
The polyurethane or silicon rubber of water play fixed effect by Van der Waals force and molecule winding.
Further preferably, it is to form PEG-PU on the electrode cable surface that external insulation layer is polyurethane（Polyurethane segment）Apply
Layer, PEG provides hydrophilicity, PU（Polyurethane segment）It is compatible to the polyurethane insulating material with similar structure to be formed well
Molecule is wound and Van der Waals force is so as to provide excellent fixation.Other similar copolymers include PEG-PU-PEG, PEG-
PU-PEG-PU, PEG-PU-PEG-PU-PEG etc..
The copolymer (PVP-CP) of other hydrophilic segments is PVP-PU, PVP-PU-PVP, PVP-PU-PVP-PU, PVP-PU-
PVP-PU-PVP etc..
It is silicon rubber for external insulation layer, available hydrophilic coating copolymer is PEG-Silicone, PEG-Silicone-
PEG、PEG-Silicone-PEG-Silicone 、PEG-Silicone-PEG-Silicone-PEG、PVP-Silicone、
PVP-Silicone-PVP, PVP-Silicone-PVP-Silicone, PVP-Silicone-PVP-Silicone-PVP etc..
Further preferably, when external insulation layer is silicon rubber, the first segment is used as using PVP.
Further preferably, when external insulation layer is polyurethane, the first segment is used as using PEG.
Preferably, the first chain segment molecular weight is 100 to 30000.
Preferably, second of chain segment molecular weight is 100 to 30000.
Further preferably, the first segment and second of chain segment molecular weight are 100 to 10000.
100-10000 models in the molecular size range influence polymerization effect of the first segment and second of segment, this programme
In enclosing, polymerization effect is good, and obtained performance of copolymer is stable, can meet hydrophilic and hydrophobic balance.
Preferably, the molecular weight of the copolymer is 200 to 100000.
Further preferably, the molecular weight of the copolymer is 300 to 50000, further preferred 500 to 20000.
The molecular weight of copolymer is too small, and lubrication is not obvious, and the effective time of lubrication is limited, in the scope of the program
Interior, the bigger effect of molecular weight is better, but when more than 100000, lubricant effect is no longer lifted, and cost also increases.
Preferably, the lubricating layer also includes base-material, the base-material is polyurethane or silicones, and the base-material adds
Dosage is the 50%W to 99.5%W of the lubricating layer, and lubricating layer can also be but single completely by principal component copolymer component
Copolymer component, not only cost is high, and poor with the associativity of external insulation layer, and the requirement to technique is harsher, and difficulty of processing is big,
A certain amount of base-material is added in lubricating layer, difficulty of processing can be reduced.
Further preferably, the base-material accounts for the 50%W to 90%W of the lubricating layer.
Preferably, the thickness of the lubricating layer is 0.005mm to 1mm.
Further preferably, the thickness of the lubricating layer is 0.05mm to 1mm.
Still more preferably, the thickness of the lubricating layer is 0.10mm to 0.50mm.
Preferably, the thickness difference of the lubricating layer of electrode cable is no more than 0.6mm.
By implementing above-mentioned technical proposal, when the implant electrode wire that the utility model is provided greatly reduces wire implantation
Resistance, lubricity is good, improves the smooth degree and security of wire implantation, protects external insulation layer, the service life of extension lead,
Ensure wire safe handling.
Brief description of the drawings
Accompanying drawing 1 is the cross section view of the embodiment of the utility model one；
Accompanying drawing 2 is the cross section view of another embodiment of the utility model；
Accompanying drawing 3 is the cross section view of the utility model embodiment 5.
Embodiment
Below by specific embodiment, the utility model is described in further detail.
Embodiment 1：
A kind of hydrophilic lubrication implant electrode wire, as shown in Figure 1, including conductive layer 1 and external insulation layer 2, external insulation layer 2
Using polyurethane insulating material, the lubricating layer 3 that thickness is 0.05mm is provided with outside the external insulation layer 2, for containing with PEG
The functional layer of segment and the copolymer of PU segments formation, PEG provides hydrophilicity, PU（Polyurethane segment）To with similar structure
Polyurethane insulating material compatible form good molecule winding and Van der Waals force to provide excellent fixation.
Embodiment 2：
A kind of hydrophilic lubrication implant electrode wire, including conductive layer 1 and external insulation layer 2, external insulation layer 2 are exhausted using polyurethane
Edge material, is provided with the lubricating layer 3 that thickness is 0.1mm, for containing with PEG chain segment and polycyclic oxygen outside the external insulation layer 2
The copolymer of propane PPO segments formation and the functional layer of polyurethane base-material, polyurethane base-material is the 70% of the weight of lubricating layer 3,
PEG chain segment provides hydrophilicity, hydrophobic PPO segments and external insulation layer 2 formed good molecule winding and Van der Waals force from
And excellent fixation is provided.
Embodiment 3：
A kind of hydrophilic lubrication implant electrode wire, including conductive layer 1 and external insulation layer 2, external insulation layer 2 are exhausted using polyurethane
Edge material, is provided with the lubricating layer 3 that thickness is 0.1mm, for containing with PEG chain segment and PU segments outside the external insulation layer 2
The copolymer of formation and the functional layer of polyurethane base-material, the addition of polyurethane base-material are 95%, PEG of the weight of lubricating layer 3
Segment provides hydrophilicity, and hydrophobic polyurethane segment is compatible to the polyurethane base material with similar structure to form good point
Son winding and Van der Waals force are so as to provide excellent fixation.
Embodiment 4：
A kind of hydrophilic lubrication implant electrode wire, including conductive layer 1 and external insulation layer 2, external insulation layer 2 are exhausted using silicon rubber
Edge material, is provided with the lubricating layer 3 that thickness is 0.1mm outside the external insulation layer 2, and the lubricating layer 3 is containing with PVP chains
Section provides hydrophilicity, hydrophobic silicon with the copolymer of silicon rubber segment formation and the functional layer of silicon rubber base-material, PVP segments
The good molecule winding of rubber segment formation compatible to the external insulation layer 2 with similar structure and Van der Waals force are so as to provide excellent
Fixation.
Embodiment 5：
A kind of hydrophilic lubrication implant electrode wire, the present embodiment is by taking ICD electrode cables as an example, as shown in Figure 2, including electricity
Cable 4 and external insulation layer 2, external insulation layer 2 use polyurethane insulating material, and external insulation layer 2 contains 4 function passages 21, Mei Gegong
Cable 4 can be set in passage 21, the lubricating layer 3 that thickness is 0.2mm is provided with outside the external insulation layer 2, the lubricating layer 3
Principal component is the copolymer of PEG chain segment and PPOX PPO segments formation, and adds and account for the 80% of the weight of lubricating layer 3
Polyurethane, the molecular weight of copolymer is in 500-10000.
Embodiment 6：
A kind of hydrophilic lubrication implant electrode wire, as shown in Figure 3, including the first conductive layer 101, is arranged on described first
The first insulating barrier 102 outside conductive layer 101, the second conductive layer 103 being arranged on outside first insulating barrier 102 and it is arranged on institute
The external insulation layer 104 outside the second conductive layer 103 is stated, external insulation layer 104 uses polyurethane insulating material, in the external insulation layer
The lubricating layer 105 that thickness is 0.5mm is provided with outside 104, the principal component of the lubricating layer 105 is PEG and PPOX PPO chains
The copolymer that section is formed, and 65% silicones for accounting for the weight of lubricating layer 105 is added, the molecular weight of copolymer is in 30000-
40000。
Claims (9)
1. a kind of hydrophilic lubrication implant electrode wire, including inner conducting layer and external insulation layer, it is characterised in that in the external insulation
Layer is outer to be provided with lubricating layer, and the lubricating layer is to contain the copolymer with hydrophilic molecule segment and hydrophobic molecule segment
Functional layer.
2. a kind of hydrophilic lubrication implant electrode wire according to claim 1, it is characterised in that the lubricating layer is containing
State the functional layer of copolymer and base-material.
3. a kind of hydrophilic lubrication implant electrode wire according to claim 2, it is characterised in that the base-material containing polyurethane or
Person's silicon rubber.
4. a kind of hydrophilic lubrication implant electrode wire according to claim 1, it is characterised in that the thickness of the lubricating layer is
0.005mm to 1mm.
5. a kind of hydrophilic lubrication implant electrode wire according to claim 1 or claim 2, it is characterised in that the external insulation layer is
Layer of polyurethane or silastic-layer.
6. a kind of hydrophilic lubrication implant electrode wire according to claim 1, it is characterised in that the copolymer by PEG with
Polyurethane segment and/or polypropylene oxide segments and/or silicon rubber segment copolymerization are formed.
7. a kind of hydrophilic lubrication implant electrode wire according to claim 2, it is characterised in that the copolymer by PEG with
Polyurethane segment and/or polypropylene oxide segments and/or silicon rubber segment copolymerization are formed.
8. a kind of hydrophilic lubrication implant electrode wire according to claim 1, it is characterised in that the copolymer by PVP with
Polyurethane segment and/or polypropylene oxide segments and/or silicon rubber segment copolymerization are formed.
9. a kind of hydrophilic lubrication implant electrode wire according to claim 2, it is characterised in that the copolymer by PVP with
Polyurethane segment and/or polypropylene oxide segments and/or silicon rubber segment copolymerization are formed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621112177.1U CN206434624U (en) | 2016-10-11 | 2016-10-11 | A kind of hydrophilic lubrication implant electrode wire |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621112177.1U CN206434624U (en) | 2016-10-11 | 2016-10-11 | A kind of hydrophilic lubrication implant electrode wire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206434624U true CN206434624U (en) | 2017-08-25 |
Family
ID=59644525
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621112177.1U Expired - Fee Related CN206434624U (en) | 2016-10-11 | 2016-10-11 | A kind of hydrophilic lubrication implant electrode wire |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206434624U (en) |
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2016
- 2016-10-11 CN CN201621112177.1U patent/CN206434624U/en not_active Expired - Fee Related
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Granted publication date: 20170825 Termination date: 20181011 |