CN206411073U - A chromatographic switcher for a liquid chromatograph with cleaning and detection functions - Google Patents

Abstract

The utility model discloses a chromatographic switcher of a liquid chromatograph with cleaning and detecting functions, which comprises at least two liquid phase columns; the input ends of the liquid phase columns are respectively provided with a first three-way valve; the input ends of the liquid phase columns are respectively provided with a second three-way valve; the other two ends of the first three-way valve are respectively connected to the liquid supply pipe and the cleaning pump; the other two ends of the second three-way valve are respectively connected to the other ends of the at least one detector and the cleaning pump; one end of the cleaning pump is connected with a liquid mixing cavity in series; the liquid mixing cavity is arranged below the bottom of the liquid phase column; the first three-way valve, the second three-way valve and the cleaning pump are respectively connected to the controller through a driving circuit; the controller is electrically connected with a plurality of feeding channel switching keys; the utility model discloses a liquid chromatograph's chromatogram switch with wash and detect function can realize the flow path automatic switch-over between the many detectors of liquid phase, and carries out online cleaning, labour saving and time saving when can realizing detecting.

Description

A chromatographic switcher for a liquid chromatograph with cleaning and detection functions

technical field

The utility model relates to a liquid chromatograph assembly, in particular to a chromatogram switcher of a liquid chromatograph with cleaning and detection functions, and belongs to the technical field of liquid chromatographs.

Background technique

Liquid chromatography is an instrument that uses the difference in the distribution ratio of the mixture between liquid-solid or two immiscible liquids to separate the mixture first and then analyze and identify it; the system consists of a liquid reservoir, a pump, a sampler, a chromatographic Column, detector, recorder and other parts; the mobile phase of the liquid chromatograph in the liquid reservoir is pumped into the system by a high-pressure pump, the sample solution enters the mobile phase through the sample injector, and is loaded into the chromatogram by the mobile phase In the column (stationary phase), since each component in the sample solution has different distribution coefficients in the two phases, when the two phases are in relative motion, after repeated adsorption-desorption distribution processes, each component in the There is a big difference in the moving speed, which is separated into individual components and flows out of the column in turn. When passing through the detector, the sample concentration is converted into an electrical signal and sent to the recorder, and the data is printed out in the form of a graph. The high performance liquid chromatography is mainly There are sampling system, infusion system, separation system, detection system and data processing system. The existing liquid chromatograph can only perform one-way detection, and it needs to be shut down for cleaning after the liquid phase detection. Check and clean column functionality.

Utility model content

In order to solve the above problems, the utility model proposes a chromatographic switcher for a liquid chromatograph with cleaning and detection functions, which can realize automatic switching of flow paths between liquid phase multi-detectors, and can realize online cleaning during detection .

The chromatographic switcher of the liquid chromatograph with cleaning and detection functions of the utility model comprises at least two liquid phase columns; the input ends of the liquid phase columns are respectively equipped with first three-way valves; the input ends of the liquid phase columns A second three-way valve is respectively installed; the other two ends of the first three-way valve are respectively connected to the liquid supply pipe and the cleaning pump; the other two ends of the second three-way valve are respectively connected to at least one detector and the other two ends of the cleaning pump One end; one end of the cleaning pump is connected in series with a mixed liquid cavity; the mixed liquid cavity is installed under the bottom of the liquid phase column; the first three-way valve, the second three-way valve and the cleaning pump are respectively connected to the control circuit through the drive circuit device; the controller is electrically connected with a plurality of feeding channel switching buttons; the upper part of the feeding channel switching button is provided with a cleaning detection switching button electrically connected to the controller; select the corresponding channel through the feeding channel switching button, and pass The cleaning and detection switching button selects the cleaning or detection mode, and the controller controls the first three-way valve and the second three-way valve to form corresponding passages.

As a preferred embodiment, the detector is composed of multiple detection modules of different types; the input end of each detection module is connected with the second three-way valve through a solenoid valve; the output of each detection module is The terminal is connected to the back pressure regulator; the solenoid valve is electrically connected to the controller; the controller is also electrically connected to a detection channel selection button; the corresponding channel is selected by the detection channel selection button, and the controller opens the corresponding solenoid valve; the channel detection The module sends the data to the computer for display; the utility model can be directly assembled with various detection modules, and here, the specific circuit and working process of a single detector are not described in detail.

As a preferred embodiment, the input end of the liquid supply pipe is provided with a sub-pipe; the sub-pipe is provided with a solenoid valve; each of the solenoid valve input ends is connected to the feed interface; Enter detection.

As a preferred embodiment, the liquid mixing chamber is provided with an inlet valve and an outlet valve.

As a preferred embodiment, a vacuum device is also provided on the side of the liquid mixing chamber.

Compared with the prior art, the utility model has the chromatographic switcher of the liquid chromatograph with cleaning and detection functions, which can realize the automatic switching of the flow path between the liquid phase multi-detectors, and can realize the detection Online cleaning, saving time and effort.

Description of drawings

Fig. 1 is a schematic structural view of Embodiment 1 of the present utility model.

Fig. 2 is a structural schematic diagram of Embodiment 2 of the present utility model.

detailed description

Example 1:

As shown in Figure 1, the chromatographic switcher of the liquid chromatograph with cleaning and detection functions of the present invention includes at least two liquid phase columns 1; the input ends of the liquid phase columns are respectively equipped with a first three-way valve 2 The input end of the liquid phase column 1 is respectively equipped with a second three-way valve 3; the other two ends of the first three-way valve 2 are respectively connected to the liquid supply pipe 4 and the cleaning pump 5; the second three-way valve 3 The other two ends are respectively connected to at least one detector 6 and the other end of the cleaning pump 5; one end of the cleaning pump 5 is connected in series with a mixed liquid cavity 7; the mixed liquid cavity 7 is installed below the bottom of the liquid phase column 1; A three-way valve 2, a second three-way valve 3 and a cleaning pump 5 are respectively connected to a controller (not shown) through a drive circuit; the controller is electrically connected to a plurality of feeding channel switching buttons 8; the feeding There is a cleaning detection switching button 9 electrically connected to the controller above the channel switching button 8; the corresponding channel is selected through the feeding channel switching button 8, and the cleaning or detection mode is selected through the cleaning detection switching button, and the controller controls the first three-way valve. 2 and the second three-way valve 3 form corresponding passages.

Example 2:

As shown in Figure 2, the present embodiment is basically consistent with Embodiment 1, wherein the detector 6 is composed of a plurality of detection modules 9 of various types; the input end of each detection module 9 passes through a solenoid valve 10 Connected to the second three-way valve 3; the output end of each detection module 9 is connected to the back pressure regulator 11; the solenoid valve 10 is electrically connected to the controller; the controller is also electrically connected to a detection channel selection button; Other structures are consistent with Embodiment 1; the corresponding channel is selected by the detection channel selection button, and the controller opens the corresponding solenoid valve; the channel detection module sends the data to the computer for display; the utility model can be directly assembled by using various detection modules. Therefore, the specific circuit and working process of the single detector will not be described in detail.

Example 3:

This embodiment is basically the same as Embodiment 1, wherein, the input end of the liquid supply pipe 4 is provided with branch pipes (not shown); the branch pipes are provided with solenoid valves; the input ends of each solenoid valve are connected to feed Interface; through the feed interface, the entry detection of different detection liquids can be realized.

Wherein, the liquid mixing chamber 7 is provided with an inlet valve 12 and an outlet valve 13 . A vacuum device 14 is also provided on the side of the liquid mixing chamber 7 .

Compared with the prior art, the utility model has the chromatographic switcher of the liquid chromatograph with cleaning and detection functions, which can realize the automatic switching of the flow path between the liquid phase multi-detectors, and can realize the detection Online cleaning, saving time and effort.

Inspired by the above ideal embodiment according to the utility model, through the above description content, relevant staff can completely make various changes and modifications within the scope of not deviating from the technical idea of the utility model. The technical scope of this utility model is not limited to the content in the description, but must be determined according to the scope of the claims.

Claims (5)

1. A chromatographic switcher of a liquid chromatograph with cleaning and detection functions, characterized in that: comprise at least two liquid phase columns; said liquid phase column input ends are respectively equipped with a first three-way valve; said liquid phase column A second three-way valve is respectively installed at the input end of the phase column; the other two ends of the first three-way valve are respectively connected to the liquid supply pipe and the cleaning pump; the other two ends of the second three-way valve are respectively connected to at least one detector and the other end of the cleaning pump; one end of the cleaning pump is connected in series with a mixed liquid cavity; the mixed liquid cavity is installed below the bottom of the liquid phase column; the first three-way valve, the second three-way valve and the cleaning pump are respectively driven The circuit is connected to the controller; the controller is electrically connected to a plurality of feeding channel switching buttons; a cleaning detection switching button electrically connected to the controller is arranged above the feeding channel switching buttons. 2. the chromatogram switcher of the liquid chromatograph with cleaning and detection function according to claim 1, is characterized in that: described detector is made of a plurality of detection modules of multiple different types; Each described detection module Its input end is connected to the second three-way valve through the solenoid valve; the output end of each detection module is connected to the back pressure regulator; the solenoid valve is electrically connected to the controller; the controller is also electrically connected to the detection channel selection button. 3. The chromatographic switcher of the liquid chromatograph with cleaning and detection functions according to claim 1, characterized in that: the input end of the liquid supply pipe is provided with a branch pipe; the branch pipe is provided with a solenoid valve; each The input end of the solenoid valve is connected to the feed port. 4 . The chromatographic switcher of a liquid chromatograph with cleaning and detection functions according to claim 1 , wherein an inlet valve and an outlet valve are arranged on the liquid mixing chamber. 5 . The chromatographic switcher of a liquid chromatograph with cleaning and detection functions according to claim 1 , wherein a vacuum device is provided on the side of the mixed liquid cavity. 6 .