CN206183436U - Artificial cornea - Google Patents
Artificial cornea Download PDFInfo
- Publication number
- CN206183436U CN206183436U CN201620206083.4U CN201620206083U CN206183436U CN 206183436 U CN206183436 U CN 206183436U CN 201620206083 U CN201620206083 U CN 201620206083U CN 206183436 U CN206183436 U CN 206183436U
- Authority
- CN
- China
- Prior art keywords
- artificial cornea
- cornea
- fixed part
- artificial
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000004087 cornea Anatomy 0.000 title claims abstract description 36
- 230000003287 optical effect Effects 0.000 claims abstract description 20
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 14
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 6
- 239000002105 nanoparticle Substances 0.000 claims abstract description 4
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 2
- 239000010936 titanium Substances 0.000 claims description 2
- 229910052719 titanium Inorganic materials 0.000 claims description 2
- 239000011247 coating layer Substances 0.000 claims 3
- 239000011248 coating agent Substances 0.000 abstract description 9
- 238000000576 coating method Methods 0.000 abstract description 9
- 244000005700 microbiome Species 0.000 abstract description 3
- 241000894006 Bacteria Species 0.000 abstract description 2
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 230000000474 nursing effect Effects 0.000 abstract description 2
- 239000002245 particle Substances 0.000 abstract description 2
- 210000001742 aqueous humor Anatomy 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 4
- 239000004926 polymethyl methacrylate Substances 0.000 description 4
- 230000002093 peripheral effect Effects 0.000 description 3
- 230000010354 integration Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 208000005422 Foreign-Body reaction Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 206010014801 endophthalmitis Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
Landscapes
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
本实用新型公开了一种人工角膜，它包括中央光学部分和设在周边的固定部分，其特征在于：在所述人工角膜中央光学部分的圆柱侧外表面和固定部分(2)的内表面涂覆有羟基磷灰石涂层(3)。所述的涂层的纳米粒的平均粒径为20nm。本实用新型的优点在于利用涂层的隔离性和羟基磷灰石具有的抗菌特性，将其涂覆在人工角膜光学部分圆柱形外表面及周边固定物内表面后，对与患者角膜、房水接触的细菌等微生物产生杀灭作用；由于羟基磷灰石可长久性地涂覆在人工角膜光学部分周围，不改变人工角膜材料本身的特征，人工角膜所具有的固有特性仍被保持，使治疗、护理达到最好的效果。
The utility model discloses an artificial cornea, which comprises a central optical part and a fixed part arranged around the periphery, and is characterized in that: the outer surface of the cylindrical side of the central optical part of the artificial cornea and the inner surface of the fixed part (2) are coated with Covered with a hydroxyapatite coating (3). The average particle diameter of the nanoparticles of the coating is 20nm. The utility model has the advantage of using the isolation of the coating and the antibacterial properties of hydroxyapatite, after coating it on the cylindrical outer surface of the optical part of the artificial cornea and the inner surface of the surrounding fixtures, it is effective against the patient's cornea, aqueous humor Microorganisms such as bacteria that come into contact with it can kill them; because hydroxyapatite can be permanently coated around the optical part of the artificial cornea without changing the characteristics of the artificial cornea material itself, the inherent characteristics of the artificial cornea are still maintained, making the treatment , Nursing to achieve the best results.
Description
技术领域technical field
本实用新型涉及医药技术领域，具体是涉及一种带有增加生物整合性的涂层医用人工角膜。The utility model relates to the technical field of medicine, in particular to a coated medical artificial cornea with increased biological integration.
背景技术Background technique
人工角膜是无法用角膜手术复明的角膜混浊病人的最终复明手段。为达到理想的光学效果，人工角膜目前多采用贯通式，即人工角膜光学部分贯通角膜全层，通过支架将光学部分固定在角膜中央，因此人工角膜光学部分与周边支架及组织结构间有一定缝隙。在临床上，正因为这些潜在腔隙，增加了微生物进入眼内的机会，可能导致人工角膜术后最严重的并发症-眼内炎的发生，给疾病的治疗、护理工作带来极大不便，给患者带来痛苦和危险。Artificial corneas are the ultimate means of vision recovery for patients with corneal cloudiness who cannot recover their vision with corneal surgery. In order to achieve the ideal optical effect, the artificial cornea mostly adopts the penetrating type at present, that is, the optical part of the artificial cornea penetrates the whole layer of the cornea, and the optical part is fixed in the center of the cornea through the bracket, so there is a certain gap between the optical part of the artificial cornea and the surrounding bracket and tissue structure . Clinically, because of these potential cavities, the chance of microorganisms entering the eye is increased, which may lead to the occurrence of endophthalmitis, the most serious complication after artificial cornea surgery, and bring great inconvenience to the treatment and nursing work of the disease. , causing pain and danger to the patient.
实用新型内容Utility model content
本实用新型的目的在于提供一种具有抗菌功能的医用人工角膜，用以减少人工角膜的使用过程中的感染发生率。The purpose of the utility model is to provide a medical artificial cornea with antibacterial function to reduce the incidence of infection during the use of the artificial cornea.
为实现上述目的，本实用新型可采取下述技术方案：In order to achieve the above object, the utility model can take the following technical solutions:
本实用新型提供了一种人工角膜，它包括中央光学部分和设在周边的固定部分，其特征在于：在所述人工角膜中央光学部分的圆柱侧外表面和固定部分(2)的内表面涂覆有羟基磷灰石涂层(3)。The utility model provides an artificial cornea, which includes a central optical part and a fixed part arranged on the periphery, and is characterized in that: the outer surface of the cylindrical side of the central optical part of the artificial cornea and the inner surface of the fixed part (2) are coated with Covered with a hydroxyapatite coating (3).
优选地，所述的中央光学部分为中央光学镜柱(1)，所述的固定部分(2)为角膜板层间固定物或角膜后表面固定物。Preferably, the central optical part is a central optical lens column (1), and the fixed part (2) is an interlamellar fixation of the cornea or a fixation on the posterior surface of the cornea.
优选地，所述的中央光学镜柱(1)的材质为医用级聚甲基丙烯酸甲酯和/或甲基丙烯酸羟乙酯。Preferably, the material of the central optical mirror column (1) is medical grade polymethyl methacrylate and/or hydroxyethyl methacrylate.
优选地，所述的角膜板层间固定物或角膜后表面固定物材料选自医用级聚甲基丙烯酸甲酯或医用级别钛金属。Preferably, the material of the interlayer corneal plate fixation or corneal posterior surface fixation is selected from medical grade polymethyl methacrylate or medical grade titanium metal.
所述的羟基磷灰石涂层(3)的纳米粒的平均粒径为5～50nm，优选10～30nm，更优选20nm。The average particle size of the nanoparticles of the hydroxyapatite coating (3) is 5-50 nm, preferably 10-30 nm, more preferably 20 nm.
本实用新型的优点在于将羟基磷灰石涂覆在人工角膜光学部分圆柱形外表面和周边固定部分内表面后，羟基磷灰石吸引生物分子电荷而炎症反应轻微，减少PMMA引起的异物反应，使涂层后的镜柱和周围组织达到生物整合的目的，从而减少PMMA镜柱和周围组织的间隙，进一步减少细菌等微生物进入眼内的机会。羟基磷灰石涂层具有较好的生物功能性，同时不改变人工角膜材料本身的特征，人工角膜所具有的固有特性仍被保持，使治疗、护理达到最好的效果。The utility model has the advantage that after the hydroxyapatite is coated on the cylindrical outer surface of the optical part of the artificial cornea and the inner surface of the peripheral fixed part, the hydroxyapatite attracts biomolecular charges and the inflammatory reaction is slight, reducing the foreign body reaction caused by PMMA, The coated lens column and the surrounding tissue achieve the purpose of biological integration, thereby reducing the gap between the PMMA lens column and the surrounding tissue, and further reducing the chance of bacteria and other microorganisms entering the eye. The hydroxyapatite coating has good biological functionality, and at the same time does not change the characteristics of the artificial cornea material itself, and the inherent characteristics of the artificial cornea are still maintained, so that the treatment and care can achieve the best results.
附图说明Description of drawings
下面结合附图对本实用新型作进一步说明。Below in conjunction with accompanying drawing, the utility model is further described.
图1是本实用新型人工角膜的中央光学镜柱(1)、周边固定部分(2)及其表面羟基磷石灰涂层(3)的结构示意图。Fig. 1 is a schematic structural view of the central optical lens column (1), the peripheral fixed part (2) and the hydroxyapatite coating (3) on the surface of the artificial cornea of the present invention.
具体实施方式detailed description
以下通过具体实施方式对本实用新型的技术方案进行进一步的说明和描述。本领域技术人员可以理解的是，以下的具体实施方式仅仅是为了进一步阐述本实用新型的目的，而非以任何方式限制本实用新型的保护范围。The technical solutions of the present utility model are further illustrated and described below through specific embodiments. Those skilled in the art can understand that the following specific embodiments are only for the purpose of further elaborating the utility model, rather than limiting the protection scope of the utility model in any way.
如图1所示，本实用新型描述的羟基磷灰石医用人工角膜包括中央光学镜柱(1)、设在周边的固定部分(2)以及在所述人工角膜中央光学镜柱(1)的圆柱侧外表面和周边固定部分(2)的内表面涂覆有羟基磷灰石涂层(3)。As shown in Figure 1, the hydroxyapatite medical artificial cornea described in the utility model comprises a central optical mirror column (1), a fixed part (2) located at the periphery and a central optical mirror column (1) of the artificial cornea. The outer surface of the cylindrical side and the inner surface of the peripheral fixing part (2) are coated with a hydroxyapatite coating (3).
Claims (6)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620206083.4U CN206183436U (en) | 2016-03-17 | 2016-03-17 | Artificial cornea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620206083.4U CN206183436U (en) | 2016-03-17 | 2016-03-17 | Artificial cornea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206183436U true CN206183436U (en) | 2017-05-24 |
Family
ID=58735593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620206083.4U Expired - Fee Related CN206183436U (en) | 2016-03-17 | 2016-03-17 | Artificial cornea |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206183436U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491242A (en) * | 2016-03-17 | 2017-03-15 | 黄飞 | Artificial cornea |
-
2016
- 2016-03-17 CN CN201620206083.4U patent/CN206183436U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491242A (en) * | 2016-03-17 | 2017-03-15 | 黄飞 | Artificial cornea |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN202472154U (en) | Improved corneal contact lens for treatment | |
| US20190101669A1 (en) | Novel anti-microbial bandage contact lens with ocular drug delivery | |
| CN107811751A (en) | A kind of contact lenses for being used to treat xerophthalmia | |
| CN206597081U (en) | Dispoable medical Blepharostat for use in ophthalmologic operation | |
| Wang et al. | Lollipop‐inspired multilayered drug delivery hydrogel for dual effective, long‐term, and NIR‐defined glaucoma treatment | |
| Ying-Yan et al. | NIR-triggered drug delivery system for chemo-photothermal therapy of posterior capsule opacification | |
| CN106491242A (en) | Artificial cornea | |
| CN201029958Y (en) | Non-penetrating one-piece artificial cornea | |
| CN206183436U (en) | Artificial cornea | |
| CN206411352U (en) | A kind of contact lens | |
| CN205698126U (en) | Artificial cornea | |
| CN100500115C (en) | Porous nanocarbon-polyvinyl alcohol hydrogel artificial cornea | |
| CN210130973U (en) | an artificial cornea | |
| CN103735350B (en) | Disposable ophthalmic surgery corneal protection mirror | |
| CN113425496A (en) | Contact lens for treating fungal keratitis by administration | |
| CN208988832U (en) | Split Cystoscope with Hybrid Coating Threaded Soft Scope Sheath | |
| CN106473837A (en) | Artificial cornea | |
| CN108784888A (en) | A kind of artificial cornea | |
| TWI768176B (en) | Method for making contact lens material with high oxygen permeability, moisturizing and antibacterial | |
| CN205235152U (en) | Eye drops is with supplementary glasses | |
| KR20040089035A (en) | Nano silver perfume contain contact lens | |
| CN206934239U (en) | Ophthalmology Application of releasing aqueous humor of anterior chamber instrument | |
| CN206102827U (en) | A graded slow-release punctal plug | |
| KR100753888B1 (en) | Contact lenses containing nano platinum | |
| CN2734190Y (en) | Drug administration insulator of eyes conjunctival sac |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210426 Address after: 100039 Yongding Road, Beijing, No. 69, No. Patentee after: Third Medical Center, General Hospital of the Chinese PLA Address before: 100853 301 Hospital, Fuxing Road, Beijing, Haidian District 28, China Patentee before: Huang Yifei Patentee before: Wang Liqiang |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170524 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |