CN206080497U - Attached formula cancer cell abnormal temperature probe of skin - Google Patents

Abstract

The utility model belongs to the technical field of human parameter measures, a attached formula cancer cell abnormal temperature probe of skin is proposed, this probe contains attached formula body surface physiological parameters measuring device, and the device includes: flexible base member, temperature, measurement human parameter's sensor, and adhesion layer. The utility model discloses structure to the adhesion layer is improved, and the hydrogel layer who has the fretwork shape through the selection makes as the adhesion layer measuring device can closely combine with the measuring point to solved because sluggish the change and unsafe problem of measurement that heat capacity that the adhesion layer material has itself was brought, still improved attached formula cancer cell abnormal temperature probe of skin's lasting measurement capability. This probe can be attached on skin and last the monitor as body temperature and use by the continuation to abnormal temperature to producing because of the cancer cell abnormal metabolism surveys.

Description

Skin-attached cancer cell abnormal temperature probe

technical field

The utility model belongs to the field of human body parameter measurement, in particular to an attached human body parameter skin-attached abnormal temperature probe for cancer cells.

Background technique

With the continuous advancement and development of wearable technology, more and more wearable device products are coming. How to use wearable technology to monitor human body parameters such as temperature and humidity in order to provide data for health evaluation has become a demand.

Utility model content

For the measurement of human body parameters, the skin-attached cancer cell abnormal temperature probe to be disclosed by the utility model can be used as an electronic device, combined with common wearable products, such as earphones, socks, insoles, etc., Therefore, it can be directly attached to the surface of the human body for long-term and continuous monitoring of human body parameters such as temperature and humidity, and provide data for medical diagnosis or health evaluation.

Taking temperature measurement as an example, for an attached temperature measuring device, an important performance index is the temperature measurement accuracy, and there are many factors that affect the temperature measurement accuracy. In the research process of the applicant, an adhesive layer is provided to improve the tightness of the temperature measurement device and the temperature measurement part of the human body.

In the process of using the temperature measuring device with an adhesive layer, the applicant found that the area of the adhesive layer used is relatively large, and there are many adhesive materials, which will affect the temperature measurement. Because the adhesive layer has a large heat capacity, it will absorb a certain amount of heat from the body surface, which makes the temperature environment around the temperature sensor deviate from the real state. For example, when the temperature rises and falls suddenly, the heat absorption or release effect produced by the human body may be affected by the adhesion layer, so that the temperature change measured by the temperature sensor will lag behind the actual body temperature change.

The applicant also found that under different temperature conditions, the amount of sweat released from the body surface is different, which will lead to different humidity in the micro-atmosphere of the body surface. In other words, when the body surface temperature rises, if it is accompanied by sweating, temperature and humidity will be correlated. Using humidity sensors to monitor the humidity on the surface of the human body and establishing a separate evaluation system, or comprehensively evaluating humidity combined with temperature information on the body surface, has become an important research direction for human body parameter monitoring. In view of the relationship between body surface temperature and humidity, it is still meaningful to monitor body surface temperature or humidity separately, and it can still solve the problem of measuring and monitoring human body parameters, which will be reflected in the utility model. Of course, in the process of measuring human body parameters such as sweat, in addition to using humidity sensors, special sensing devices such as sweat sensors can also be used. , proteins, etc.

For now, how to reduce or eliminate the measurement deviation caused by the heat capacity of the adhesive material has become an urgent problem to be solved.

The utility model provides a skin-attached cancer cell abnormal temperature probe, the probe includes an attached body surface physiological parameter measuring device, and the measuring device includes: a flexible base body, which is provided with a conductive part; at least one body The surface physiological parameter sensor is fixed on the first side of the flexible substrate and is electrically connected to the conductive part; and the adhesive layer is hollowed out and distributed around the body surface physiological parameter sensor.

Preferably, the substrate is a flexible substrate, but semi-rigid or rigid materials are not excluded for the substrate.

Preferably, the body surface physiological parameter sensor is at least one of a temperature sensor, a humidity sensor, a temperature and humidity sensor, and a sweat sensor.

Preferably, the hollow shape includes a closed pattern surrounding at least one of the body surface physiological parameter sensors.

Preferably, the body surface physiological parameter sensor includes a temperature sensor, and/or a humidity sensor, and/or a sweat sensor that are respectively electrically connected to the conductive part and at least partially surrounded by the closed pattern.

Preferably, the closed pattern is in the shape of a circular ring, an elliptical ring, a square ring, a triangular ring, or an irregular ring.

Preferably, said hollow shape comprises a multi-segment discrete pattern surrounding at least one of said body surface physiological parameter sensors.

Preferably, the body surface physiological parameter sensor includes a temperature sensor, and/or a humidity sensor, and/or a sweat sensor that are respectively electrically connected to the conductive part and at least partially surrounded by the multi-segment discrete patterns.

Preferably, the multi-segment discrete patterns are circular rings, elliptical rings, square rings, triangular rings, or irregular and discontinuous ring shapes composed of arc line segments and/or line segments.

Preferably, the hollowed-out shape comprises a pattern interlaced with the sensor.

Preferably, the hollow shape divides the sensor into a plurality of regions.

Preferably, each of said plurality of regions contains at least one of said sensors.

Preferably, the carrier is a breathable material.

Preferably, the adhesive layer comprises a hydrogel.

Preferably, the area of the adhesive layer corresponding to the sensor is hollowed out.

Preferably, a heat conduction layer covers the temperature sensor, and the height of the heat conduction layer is not lower than the adhesion layer.

Preferably, the heat conduction layer is heat conduction glue.

Preferably, the thermally conductive glue is a combination of one or more of silicone thermally conductive glue, epoxy resin, polyurethane glue or thermally conductive silicone grease.

Preferably, the thermal conductive glue includes metal fillers.

Preferably, the anti-adhesive layer is arranged on the adhesive layer.

Preferably, the temperature sensor is a thermistor, and the conductive part is a printed circuit.

Preferably, the flexible substrate is provided with a through hole, and an adhesive layer and a temperature sensor are not provided at the position of the through hole.

Preferably, the flexible substrate is X-shaped, and four branches of the X-shaped flexible substrate are radially distributed relative to the through hole; the sensor is arranged on the four branches.

Preferably, the flexible base is in the shape of a cover; the sensor is arranged on the cover.

Preferably, the hydrogel is a temperature-sensitive hydrogel or a light-sensitive hydrogel or an electric-sensitive hydrogel.

Preferably, the hollow shape is an array shape.

Preferably, the units in the array shape are rectangular rings or circular rings.

Preferably, the hollow shape is an irregular shape, and the irregular shape matches the temperature measurement surface of the human body.

Preferably, the device is used to measure physiological parameters of the breast surface.

Preferably, the hollow shape is used to reduce the volume of the adhesive layer material, and/or the hollow shape is used to reduce the attachment area of the adhesive layer and the temperature measuring surface.

That is to say, the above-mentioned device can reduce the heat absorbed by the adhesive layer from the body surface by setting the hollow shape of the adhesive layer, and try to avoid the influence of the adhesive layer on the real measurement environment, which helps to weaken the heat absorption or release generated by the human body The effect may be affected by the adhesion layer, making the results measured by the relevant sensors inaccurate, which can improve the accuracy of temperature, humidity or temperature and humidity and other human body parameters.

More importantly, the skin-attached abnormal temperature probe for cancer cell can be applied to the skin-attached abnormal temperature probe for cancer cell. The skin-attached cancer cell abnormal temperature probe with this device can be continuously attached to the skin and used as a continuous body temperature monitor in the above-mentioned and other application scenarios, so as to prevent the abnormal temperature caused by the abnormal metabolism of cancer cells. detection of abnormal temperatures.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the accompanying drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description These are only some embodiments of the utility model, and those skilled in the art can also obtain other drawings based on these drawings without creative work;

Fig. 1A is a schematic cross-sectional structure diagram of an attached temperature measuring device according to an embodiment of the present invention;

Fig. 1B is a schematic cross-sectional structure diagram of an attached temperature measuring device according to another embodiment of the present invention;

Fig. 2 is a schematic cross-sectional structure diagram of an attached temperature measuring device according to another embodiment of the present invention;

Fig. 3 is a schematic structural view of an attached temperature measuring device according to another embodiment of the present invention;

Fig. 4 is a graph showing the measurement results of the temperature change hysteresis effect caused by the adhesive layer material according to the present invention;

5 is a diagram of an attached temperature measuring device with a hollowed-out adhesive layer according to an embodiment of the present invention;

Fig. 6 is a diagram of an attached temperature measuring device with a hollowed-out adhesive layer according to another embodiment of the present invention;

7 is a partial view of a hollowed-out adhesive layer with a one-piece closed shape according to an embodiment of the present invention;

8 is a partial view of a hollowed-out adhesive layer with multi-segment discrete patterns according to another embodiment of the present invention;

9 is a partial view of a hollowed-out adhesive layer with a rectangular ring array pattern according to an embodiment of the present invention;

10 is a partial view of a hollowed-out adhesive layer with an elliptical ring array pattern according to another embodiment of the present invention;

Fig. 11 is a partial view of a hollowed-out adhesive layer with an irregular pattern according to an embodiment of the present invention.

detailed description

In order to enable those skilled in the art to better understand the technical solutions in the embodiments of the utility model, the technical solutions in the embodiments of the utility model will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the utility model, obviously , the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the scope of protection of the present utility model.

As mentioned above, in view of the relationship between body surface temperature and humidity, it is still meaningful to monitor body surface temperature or humidity separately, and it can still solve the problem of measuring and monitoring human body parameters. For the convenience of description, the following embodiments mainly illustrate various technical solutions of the present invention by taking the human body parameter to be measured as temperature. Since the utility model utilizes the correlation between body surface temperature and body surface sweating, the corresponding embodiment of measuring humidity will not be described in detail.

In one embodiment, the present invention provides an attached temperature measuring device, which includes a flexible substrate 101 , a temperature sensor 102 and an adhesive layer 103 .

There can be one or more sensors, as long as the basic measurement requirements are met. The flexible base 101 can be made of materials with soft properties, but it does not exclude the use of semi-rigid or rigid materials when the base needs a specific shape. As an example, it can be realized by using a flexible circuit board. The flexible circuit board includes at least the following components :

(1) Substrate: polyimide can be selected as the substrate of the flexible circuit board. In order to ensure the comfort of the human body to the base material, a base material with a thickness of 25 μm can be selected. If the circuit board needs to be harder, the thickness of the base material can be increased, for example, a base material with a thickness of 50 μm can be selected. Conversely, if the circuit board needs to be softer, a substrate with a thickness of 13 μm can be used.

(2) Transparent glue for the base material: It is divided into two types: epoxy resin and polyethylene. The thicker the base material and the transparent glue on it, the harder the circuit board. If the circuit board has a relatively large bending area, a thinner substrate and transparent glue can be used to reduce the stress on the surface of the copper foil, so that the chance of micro-cracks in the copper foil is relatively small. For such areas, single-layer boards can be used as much as possible.

(3) Copper foil: divided into rolled copper and electrolytic copper. Rolled copper has high strength and is resistant to bending, but it is more expensive. Electrolytic copper is much cheaper, but its strength is poor and it is easy to break. It is generally used in occasions where there is little bending. The choice of copper foil thickness depends on the minimum width and minimum spacing of the leads. The thinner the copper foil, the smaller the minimum achievable width and spacing. In the embodiment of the utility model, rolled copper is selected, and the rolling direction of the copper foil is guaranteed to be consistent with the main bending direction of the circuit board.

(4) Protective film and its transparent glue: For the solution in this application, a 13 μm protective film is selected due to the circuit board with relatively large bending. The transparent glue can be made of epoxy resin or polyethylene, and the thickness of the transparent glue is set to be 13 μm.

(5) Pad coating: electroplating nickel + electroless gold plating layer, the thickness of the electroplating nickel layer is controlled at 0.5-2 μm, and the thickness of the electroless gold plating layer is controlled at 0.05-0.1 μm.

The inside of the flexible base 101 is provided with a conductive part 106 (see FIG. 3 ), the conductive part is at least one printed circuit, and the printed circuit can be made of copper foil and other metal materials with good electrical conductivity and bending resistance. It can be freely bent, wound, and folded, and can be arranged arbitrarily according to the requirements of the spatial layout, and can be moved and stretched arbitrarily in three-dimensional space, so as to achieve the integration of component (such as temperature sensor) assembly and wire connection.

In order to be able to collect temperature data from human objects, it is necessary to install temperature sensors 102 in the attached temperature measuring device. These temperature sensors 102 collect temperature data from the surface of the object to be measured at predetermined time intervals, for example, it can be set every five minutes Collect temperature data once and continue to collect for a period of time (such as 10 hours). All generated temperature data is stored on a portable storage device. The sensor 102 is fixed on one side of the flexible base and connected with the circuit in the flexible base. Continuous collection is obviously conducive to monitoring relevant data over a period of time.

The temperature sensor 102 can be realized by a multipurpose sensor. For example, the temperature sensor 102 can be realized by a thermistor. Based on the difference of the thermosensitive material, the thermistor can adopt a semiconductor thermistor, a metal thermistor as required Resistors and alloy thermistors.

In addition, the adhesive temperature measuring device also includes an adhesive layer 103. The main purpose of the adhesive layer 103 is to fix the temperature sensor on the human body. See Figure 1A and Figure 1B. The adhesive layer can be set in various ways on a flexible substrate. The existence of an adhesive layer and the skin-attached cancer cell abnormal temperature probe, especially the flexible substrate, are obviously also beneficial for monitoring relevant data over a period of time.

As shown in FIG. 1A , the adhesive layer is directly covered on the temperature sensor 102 and the flexible substrate. This method is more convenient to implement, and facilitates cutting and mass production of the adhesive layer during preparation.

In addition to the above method, referring to FIG. 1B, the adhesive layer 103 can also be arranged in other areas except the temperature sensor 102, and the adhesive layer 103 is provided with a through hole at the position where the temperature sensor is installed, so that the temperature sensor can Installed in the through hole, the adhesive layer 103 is directly connected to the flexible substrate 101 in other areas outside the through hole.

The adhesive layer can be made of various viscous materials, for example, hydrogel which has strong adhesion to the skin and can be painlessly separated can be used.

Using the hydrogel layer to replace the traditional adhesive tape and other fixing methods can make the temperature sensor of the temperature measuring device more convenient and fit the surface of the human body more closely, so that the temperature sensor and the measured area of the body surface can be thermally contacted more fully. Transfer to improve the measurement accuracy of the temperature measuring device.

The attached temperature measuring device based on the above structural design can achieve better beneficial effects. Taking the temperature measurement of the chest area as an example, the following three different types of temperature measuring devices are used respectively: (1) ordinary electronic thermometer (some The company model is the thermometer product of MC-246); (2) the temperature sensing device in the present embodiment; (3) the invasive blood temperature measuring instrument.

Through multiple measurements, the body temperature of the research subjects measured by the above three body temperature skin-attached cancer cell abnormal temperature probes are: 1) 36.77°C, 2) 36.86°C, 3) 36.90°C.

The body temperature data measured by the invasive blood temperature measuring instrument is used as the standard reference data; according to the statistics of the axillary body temperature measurement results of 100 research subjects, the data measured by the ordinary electronic thermometer are lower than the body temperature data measured by the invasive blood temperature measuring instrument. Within the error interval of [-0.97%, +0.31%], the distribution center of the measured data relative to the standard reference data is basically located at -0.57%. The data measured by the temperature sensing device in this embodiment is within the error range of [-0.19%, +0.06%] of the body temperature data measured by the invasive blood temperature measuring instrument, and the distribution center of the measured data relative to the standard reference data Basically at -0.08%, the accuracy of its measurement data is significantly better than that of ordinary electronic thermometers.

In addition to setting the adhesive layer, in order to fix the temperature measuring device conveniently, some fixing devices can be set. Referring to FIG. 3 , taking the temperature test of human breast as an example, a through hole 105 can be provided on the flexible substrate, and no adhesive layer and temperature sensor are provided at the position of the through hole 105 . The through hole 105 is used for socketing nipples or other protruding parts of the body to help fix the device on the body. The flexible base is set in an X shape, which is convenient for pasting on the breast of the human body and takes up less space. Of course, in addition to the X shape, the flexible base can also be set in other common shapes, such as a Y shape.

In order to ensure the accuracy and effectiveness of temperature measurement, referring to Fig. 2, a heat conduction part 104 is covered above the temperature sensor 102, so that the heat conduction part is higher than the adhesive layer 103, thereby ensuring that when the temperature sensing device is pasted on the body, The heat conduction part is fully attached to the skin to enhance the heat transfer effect and the accuracy of the sensor to sense body temperature. Specifically, the heat conduction part can be made of a variety of materials with heat conduction characteristics. For example, the heat conduction part can be a heat conduction glue for heat conduction. The heat conduction glue can be epoxy resin, silicone heat conduction glue, polyurethane glue, heat conduction One or more of silicone grease; more preferably, aluminum powder, copper powder, iron powder and other metal powders are mixed in the thermal conductive adhesive, which can enhance its thermal conductivity.

The temperature measurement device with the above structure is added, and the accuracy of temperature measurement is further improved. Taking the temperature measurement of the chest area as an example, the following three different types of temperature measurement devices are used respectively: (1) ordinary electronic thermometer (some The company model is the thermometer product of MC-246); (2) the temperature sensing device in the present embodiment; (3) the invasive blood temperature measuring instrument.

Through multiple measurements, the body temperature of a research subject was measured by the above three body temperature skin-attached cancer cell abnormal temperature probes in order: 1) 36.77°C, 2) 36.86°C, 3) 36.90°C.

The body temperature data measured by the invasive blood temperature measuring instrument is used as the standard reference data; according to the statistics of the axillary body temperature measurement results of 100 research subjects, the data measured by the ordinary electronic thermometer are lower than the body temperature data measured by the invasive blood temperature measuring instrument. Within the error interval of [-0.97%, +0.31%], the distribution center of the measured data relative to the standard reference data is basically located at -0.57%. The data measured by the temperature sensing device in this embodiment is within the error range of [-0.10%, +0.02%] of the body temperature data measured by the invasive blood temperature measuring instrument, and the distribution center of the measured data relative to the standard reference data Basically at -0.04%, the accuracy of its measurement data is significantly better than that of ordinary electronic thermometers.

In order to prevent the adhesive layer from being contaminated with dust and reduce the viscosity, the adhesive layer is covered with an anti-adhesive layer, and the anti-adhesive layer may specifically be a piece of plastic paper.

As a specific implementation, the adhesive layer 103 is made of hydrogel material. The hydrogel material is directly used in contact with human tissue, which can prevent the infection of microorganisms in vitro, inhibit the loss of body fluid, transmit oxygen to the wound, and generally promote wound healing.

When the hydrogel is implanted or injected into the organism, the hydrogel can maintain or control release the drug embedded in the hydrogel to the body fluid. Generally speaking, there are two types of controlled release, one is like gel Adhesive coatings release small molecules, or the polymer matrix containing the drug gradually breaks down. In this case, the drug diffuses into the surrounding environment, controlled by the biodegradation rate of the material. Sometimes hydrogels are loaded with drugs as micelles, and the drug release rate is achieved by adjusting the degree of cross-linking and the chemical composition of the hydrogel. Especially since the advent of smart hydrogels, hydrogels have been used more widely.

Specifically, the hydrogel can be a temperature-sensitive hydrogel, and common temperature-sensitive hydrogels include: ionized polyacrylamide hydrogel, poly(N,N-dihexyl)acrylamide hydrogel glue and poly(N-isopropyl)acrylamide hydrogel, etc.

In addition, the hydrogel can also use light-sensitive hydrogel and electric-sensitive hydrogel.

During the experiment, the applicant found that if the adhesive layer 103 adopts a continuous shape with uniform thickness, the adhesive layer will stick to the skin surface during use. Heat dissipation or heat absorption hinders the temperature change around the temperature sensor, which will cause the temperature change of the human body sensed by the temperature sensor to lag behind the actual change, affecting the temperature detection sensitivity. The test results show that the volume (mass) of the adhesion layer and the contact area between the adhesion layer and the temperature measuring surface are the most important factors affecting the temperature change hysteresis. As shown in the comparison between the actual temperature change and the measured temperature change curve in Figure 4, the hysteresis of the temperature change will increase as the volume (mass) of the adhesion layer increases. When the same volume of adhesive layer material is used, but different thicknesses of the adhesive layer are used, it is found that the hysteresis of temperature change increases with the increase of the contact area between the adhesive layer and the temperature measuring surface (skin).

In order to solve the above problems, since the hysteresis phenomenon of temperature change is caused by the heat capacity of the adhesion layer material itself, on the premise of not affecting the adhesion firmness, reducing the volume (mass) of the adhesion layer material can greatly reduce the temperature caused by the adhesion. The heat capacity of the layer material. In addition, the larger the contact area between the adhesive layer and the temperature measuring surface, the larger the heat transfer area. Therefore, reducing the contact area between the adhesive layer and the temperature measuring surface is also to improve the temperature change hysteresis. Use at least one of these two methods to improve the hysteresis effect of temperature.

In one embodiment, while ensuring firm adhesion, the adhesive layer is hollowed out to reduce the material of the adhesive layer and the contact area between the adhesive layer and the temperature measuring surface, and the hollowed-out adhesive layer is partially continuous One-stage closed shape, a local closed space is formed between the closed shape, the temperature measuring surface and the flexible substrate 101. Due to the small heat capacity of the closed shape and the small contact with the temperature measuring surface, a local microclimate is formed in the closed space, and the temperature The sensor can collect temperature information for this part without being affected.

In one embodiment, the device may also include a humidity sensor, and the hollowed-out adhesive layer is partially in a multi-segment discrete pattern, and the multi-segment discrete pattern is wrapped around the temperature sensor and the humidity sensor. This setting can increase the temperature and humidity sensor. The openness of the part where the array is located enables the temperature and humidity sensor array to collect the temperature and humidity parameters in the body surface microenvironment closest to the natural state.

In one embodiment, the device can also be equipped with a sweat sensor instead of a humidity sensor. The sensor can analyze the components in sweat, help collect more abundant data, and provide professional advice. By integrating the sweat sensor into a small sticker In the patch, then placed against the skin, it detects biomarkers in your sweat that indicate your body's condition, such as hydration, electrolytes, sodium, lactic acid, and protein. The collected biomarkers can be analyzed by preset algorithms. On the one hand, the biological status can be evaluated separately, and you can know when you need to add water, how much water you need to drink, whether you need to drink pure water or sports drinks. Even, it can warn of the danger of heat stroke and excessive exercise. In addition to electrolyte balance detection and moisture detection, the sensor technology can also monitor muscle fatigue, physical exertion level, breathing and skin pH, which can effectively reduce the occurrence of cramps during exercise. On the other hand, it can be combined with the body temperature obtained by the temperature sensor, and the evaluation system composed of the temperature and sweat sensor will effectively monitor the human body condition.

In some other embodiments, the hollowed-out adhesive layer may also be arranged alternately with the temperature and humidity sensors.

In the above embodiments, the temperature sensor, the humidity sensor, the sweat sensor, and the temperature and humidity sensor are respectively electrically connected to the conductive part, which ensures the independent transmission of the signals obtained by the sensors.

During the measurement process, different measurement modes can be considered. In the embodiment corresponding to Fig. 5, the flexible substrate is made into the shape of a bra to measure the temperature at the breast. The hollowed-out adhesive layer includes: One part is a continuous one-piece closed shape, and another part is a multi-segment discrete pattern. The temperature sensor array and humidity sensor are wrapped in temperature and humidity patterns of different shapes. The hollow pattern can greatly reduce the influence of the heat capacity of the adhesive layer material on the local temperature, and the local closed shape can also use the local microclimate formed in the closed space, so that the temperature sensor can collect temperature information for this part without being affected; A local multi-segment discrete pattern enables the temperature and humidity sensor array to collect the temperature and humidity parameters in the body surface microenvironment closest to the natural state. The temperature hysteresis effect caused by the adhesion layer material can be further corrected by collecting data of two local temperatures.

In the embodiment corresponding to Figure 6, the flexible substrate is made into the shape of a bra to measure the temperature at the breast, in which there are 3 sets of temperature and humidity sensor arrays, and the hollowed-out adhesive layer is discretely arranged in a closed manner Between the 3 sets of temperature and humidity sensor arrays. When in use, the adhesive parts 1-4 are attached to the skin of breasts and other parts, so that the three sets of temperature and humidity sensor arrays can respectively measure the temperature and humidity information of the corresponding parts. The flexible substrate is made of breathable material, so that it does not hinder the heat dissipation and water evaporation of the body surface in the natural state, so that the temperature and humidity sensor array can capture the temperature and humidity information in the natural state.

In the embodiment corresponding to FIGS. 5-8 , the hollowed-out adhesive layer is partially in the shape of a circular ring, an elliptical ring, a rectangular ring, a triangular ring, or an irregular ring composed of arc line segments and/or line segments. The above-mentioned adhesive layer is also configured as a one-segment closed shape or a multi-segment discrete pattern, and different hollow patterns are disposed on flexible substrates of different shapes, so as to be suitable for temperature measurement of different parts.

In the embodiment corresponding to FIGS. 9-11 , the adhesive layer can also be arranged in an array shape of a certain pattern. In Fig. 9, the adhesive layer is hollowed out into an array shape composed of rectangular rings, and each rectangular ring is surrounded by a set of temperature and humidity sensors. This type of hollowed out structure is more suitable for relatively flat temperature measurement surfaces, such as on abdominal belts, Wristband or headband to take temperature on abdomen, wrist or head.

In Figure 10, the adhesive layer is hollowed out into an array shape composed of elliptical rings, and each elliptical ring is surrounded by a set of temperature and humidity sensors. Band or headband to take temperature on abdomen, wrist or head. In addition, the ellipse or circle can engrave more material than the square shape, and the adhesion effect of the ring shape to the temperature measurement surface is also slightly better than that of the square shape.

In Figure 11, the adhesion layer is hollowed out into a semi-open irregular shape, which can better fit different temperature measurement surfaces of the human body. The temperature and humidity parameters in the environment.

In other embodiments, the adhesive layer array may be an array of hollow patterns of different shapes or discrete shapes.

In the figure, a "diamond" represents a humidity sensor, and a "square" represents a temperature sensor or a sweat sensor. As far as the sensor is surrounded, semi-surrounded, or interlaced with the hollow pattern, it can be a single temperature sensor or a single humidity sensor or an array formed by a combination of the two, or an array that integrates temperature and humidity sensors. Temperature and humidity sensor with humidity measurement function.

The temperature measuring device in some of the above-mentioned embodiments is also used as a cancer cell thermometer, which is used to detect and monitor the human body, especially the body surface, for temperature abnormalities that may occur due to the growth and canceration of cancer cells, so that it can be used as an indicator of body temperature changes. , to assist in disease (such as cancer) screening and health assessment.

In particular, the above-mentioned embodiments mostly take the measurement of temperature as an example, and some embodiments combine the measurement of humidity. As mentioned above, each of the above embodiments uses a temperature measuring device for measuring temperature to illustrate the human body parameter skin-attached cancer cell abnormal temperature probe of the present invention. Since the utility model utilizes the correlation between body surface temperature and body surface sweating, the corresponding embodiment of measuring humidity will not be described in detail, and the corresponding embodiment focusing on measuring humidity and combined with measuring temperature will not be described in detail.

More importantly, the skin-attached abnormal temperature probe for cancer cell can be applied to the skin-attached abnormal temperature probe for cancer cell. The skin-attached cancer cell abnormal temperature probe with this device can be continuously attached to the skin and used as a continuous body temperature monitor in the above-mentioned and other application scenarios, so as to prevent the abnormal temperature caused by the abnormal metabolism of cancer cells. detection of abnormal temperatures.

The above is only a specific embodiment of the utility model, but the scope of protection of the utility model is not limited thereto, and any skilled person familiar with the technical field can easily think of changes within the technical scope disclosed in the utility model Or replacement, all should be covered within the scope of protection of the present utility model. Therefore, the protection scope of the present utility model should be based on the protection scope of the claims.

Claims (25)

1. a kind of skin attachment formula cancer cell abnormal temperature probe, the probe includes sticking type body surface physiological parameter measurement dress Put, it is characterised in that the measurement apparatus include：Flexible substrate, is provided with conducting part；At least one body surface physiological parameter is sensed Device, is fixed on the first side of the flexible substrate, electrically connects with the conducting part；And adhesion layer, in hollow out shape, it is distributed in Around the body surface physiological parameter sensors.

2. skin attachment formula cancer cell abnormal temperature probe according to claim 1, it is characterised in that：The body surface physiology Parameter sensors are at least one in temperature sensor, humidity sensor, Temperature Humidity Sensor, perspiration sensor.

3. skin attachment formula cancer cell abnormal temperature probe according to claim 1, it is characterised in that：The hollow out shape Including the closed pattern around body surface physiological parameter sensors described at least one.

4. skin attachment formula cancer cell abnormal temperature probe according to claim 3, it is characterised in that：The body surface physiology Parameter sensors, including electrically connecting with the conducting part respectively, and the temperature surrounded by the closed pattern at least in part is passed Sensor, and/or humidity sensor, and/or perspiration sensor.

5. skin attachment formula cancer cell abnormal temperature probe according to claim 3, it is characterised in that：The closed pattern For annulus, elliptical ring, Fang Huan, three square rings or irregular ring-shaped.

6. skin attachment formula cancer cell abnormal temperature probe according to claim 1, it is characterised in that：The hollow out shape Including the multistage discrete pattern around body surface physiological parameter sensors described at least one.

7. skin attachment formula cancer cell abnormal temperature probe according to claim 6, it is characterised in that：The body surface physiology Parameter sensors, including the temperature for electrically connecting with the conducting part respectively and surrounded by the multistage discrete pattern at least in part Degree sensor, and/or humidity sensor, and/or perspiration sensor.

8. skin attachment formula cancer cell abnormal temperature probe according to claim 6, it is characterised in that：The multistage is discrete Pattern is annulus, elliptical ring, Fang Huan, three square rings or the irregular discontinuous ring-shaped being made up of line segment.

9. skin attachment formula cancer cell abnormal temperature probe according to claim 1, it is characterised in that：The hollow out shape Comprising the pattern interlaced with the sensor.

10. skin attachment formula cancer cell abnormal temperature probe according to claim 1, it is characterised in that：The hollow out shape The sensor is divided into multiple regions by shape.

11. skin attachment formula cancer cell abnormal temperature probes according to claim 10, it is characterised in that：The plurality of area Each in domain includes at least one of described sensor.

The 12. skin attachment formula cancer cell abnormal temperature probes according to any one of claim 1-11, it is characterised in that：Institute Flexible substrate is stated for gas permeable material.

The 13. skin attachment formula cancer cell abnormal temperature probes according to any one of claim 1-11, it is characterised in that：Institute Adhesion layer is stated including hydrogel.

14. skin attachment formula cancer cell abnormal temperature probes according to claim 1, it is characterised in that：

The adhesion layer corresponds to the region of the sensor by hollow out.

15. skin attachment formula cancer cell abnormal temperature probes according to claim 2, it is characterised in that：

Heat-conducting layer, covers the temperature sensor, and the height of the heat-conducting layer is not less than the adhesion layer.

16. skin attachment formula cancer cell abnormal temperature probes according to claim 15, it is characterised in that：

The heat-conducting layer is heat-conducting glue.

17. skin attachment formula cancer cell abnormal temperature probes according to claim 1, it is characterised in that：

Adherent layer, the adherent layer is arranged on the adhesion layer.

18. skin attachment formula cancer cell abnormal temperature probes according to claim 2, it is characterised in that：

The temperature sensor is thermistor, and the conducting part is printed circuit.

19. skin attachment formula cancer cell abnormal temperature probes according to claim 1, it is characterised in that：

The flexible substrate is provided with through hole, and flexible substrate surface arranges adhesion layer and temperature sensor.

20. skin attachment formula cancer cell abnormal temperature probes according to claim 19, it is characterised in that：

The flexible substrate is X-shaped, and four branches of the X-shaped flexible substrate are radially distributed relative to the through hole；Institute State sensor to be arranged in four branches.

21. skin attachment formula cancer cell abnormal temperature probes according to claim 1, it is characterised in that：

The flexible substrate is shaped as cover body；The sensor is arranged on the cover body.

22. skin attachment formula cancer cell abnormal temperature probes according to claim 13, it is characterised in that：

The hydrogel is temperature sensitive type water gel or photaesthesia type hydrogel or electric sensitive hydrogel.

23. skin attachment formula cancer cell abnormal temperature probes according to claim 1, it is characterised in that：The hollow out shape Shape is array configuration.

24. skin attachment formula cancer cell abnormal temperature probes according to claim 23, it is characterised in that：The array shape Unit in shape is straight-flanked ring or circular rings.

25. skin attachment formula cancer cell abnormal temperature probes according to claim 1, it is characterised in that：The hollow out shape Shape is irregularly shaped, the irregularly shaped matching human body thermometric surface.