CN204636278U - Inner peeping type OCT miniature probe and OCT imaging system - Google Patents
Inner peeping type OCT miniature probe and OCT imaging system Download PDFInfo
- Publication number
- CN204636278U CN204636278U CN201520297768.XU CN201520297768U CN204636278U CN 204636278 U CN204636278 U CN 204636278U CN 201520297768 U CN201520297768 U CN 201520297768U CN 204636278 U CN204636278 U CN 204636278U
- Authority
- CN
- China
- Prior art keywords
- oct
- module
- miniature probe
- probe
- optical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn - After Issue
Links
- 239000000523 sample Substances 0.000 title claims abstract description 115
- 238000003384 imaging method Methods 0.000 title claims abstract description 40
- 208000008918 voyeurism Diseases 0.000 title claims abstract description 12
- 244000144985 peep Species 0.000 claims abstract description 22
- 230000003287 optical effect Effects 0.000 claims description 101
- 239000000835 fiber Substances 0.000 claims description 66
- 238000012545 processing Methods 0.000 claims description 48
- 239000011521 glass Substances 0.000 claims description 30
- 238000006243 chemical reaction Methods 0.000 claims description 23
- 230000005540 biological transmission Effects 0.000 claims description 18
- 238000010408 sweeping Methods 0.000 claims description 14
- 230000010363 phase shift Effects 0.000 claims description 13
- 230000008859 change Effects 0.000 claims description 5
- 238000009423 ventilation Methods 0.000 claims description 5
- 238000010276 construction Methods 0.000 claims description 4
- 238000009877 rendering Methods 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- 210000004204 blood vessel Anatomy 0.000 abstract description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 3
- 210000002345 respiratory system Anatomy 0.000 abstract description 3
- 238000003325 tomography Methods 0.000 abstract 1
- 238000012014 optical coherence tomography Methods 0.000 description 113
- 238000000034 method Methods 0.000 description 29
- 239000013307 optical fiber Substances 0.000 description 24
- 229910001220 stainless steel Inorganic materials 0.000 description 20
- 239000010935 stainless steel Substances 0.000 description 20
- 210000003238 esophagus Anatomy 0.000 description 15
- 230000011664 signaling Effects 0.000 description 15
- 230000008569 process Effects 0.000 description 14
- 239000003292 glue Substances 0.000 description 12
- 230000010287 polarization Effects 0.000 description 12
- 238000010586 diagram Methods 0.000 description 10
- 238000012546 transfer Methods 0.000 description 10
- 238000012952 Resampling Methods 0.000 description 9
- 238000013461 design Methods 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 210000001835 viscera Anatomy 0.000 description 9
- 210000004400 mucous membrane Anatomy 0.000 description 8
- 230000006870 function Effects 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 201000009310 astigmatism Diseases 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000010606 normalization Methods 0.000 description 5
- 238000012805 post-processing Methods 0.000 description 5
- 238000013519 translation Methods 0.000 description 5
- 239000006185 dispersion Substances 0.000 description 4
- 230000003595 spectral effect Effects 0.000 description 4
- 210000004876 tela submucosa Anatomy 0.000 description 4
- 238000013480 data collection Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000003466 welding Methods 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 229920002614 Polyether block amide Polymers 0.000 description 2
- 229920000297 Rayon Polymers 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 210000005081 epithelial layer Anatomy 0.000 description 2
- RGNPBRKPHBKNKX-UHFFFAOYSA-N hexaflumuron Chemical compound C1=C(Cl)C(OC(F)(F)C(F)F)=C(Cl)C=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F RGNPBRKPHBKNKX-UHFFFAOYSA-N 0.000 description 2
- 230000004899 motility Effects 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 238000007639 printing Methods 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 230000003319 supportive effect Effects 0.000 description 2
- HPTJABJPZMULFH-UHFFFAOYSA-N 12-[(Cyclohexylcarbamoyl)amino]dodecanoic acid Chemical compound OC(=O)CCCCCCCCCCCNC(=O)NC1CCCCC1 HPTJABJPZMULFH-UHFFFAOYSA-N 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000011846 endoscopic investigation Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 238000009998 heat setting Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 238000012634 optical imaging Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Landscapes
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
This utility model relates to technical field of medical instruments, provides a kind of the OCT miniature probe and the imaging system that are applied to inner peeping type high resolution optics coherence Tomography.Described OCT miniature probe scioptics assembly changes the operating distance of OCT miniature probe, increases the clear aperature of GRIN Lens, and then improves numerical aperture and the lateral resolution of OCT miniature probe.It is low that it can solve OCT miniature probe lateral resolution in existing OCT system, and the problem that scanning image out easily deforms, therefore, peep scanning imagery in the OCT with OCT miniature probe in this utility model and can be applied to blood vessel, digestive tract and respiratory tract etc. or tissue narrow space.
Description
Technical field
This utility model relates to technical field of medical instruments, is particularly applied to body lumen OCT scanning imagery and detects, provide OCT miniature probe, OCT imaging system and the using method of peeping scanning imagery in a kind of OCT.
Background technology
Optical coherence tomography scanning imagery (Optical Coherence Tomography, be called for short OCT), be widely used in ophthalmic diagnosis field, this technology is based upon on the basis of optics, electronics and computer technology science, it is the novel imaging technique that light harvesting electricity and the multinomial front subject such as high-speed data acquisition and image procossing are integrated, OCT relies on it have the advantage such as high-resolution, high speed imaging and enjoy the concern of people, and starts to be paid attention to and apply with clinical diagnosis field biomedical.
Compared with other imaging modes such as existing CT, ultrasonic, MRI, OCT has high resolution, and compared with traditional laser confocal microscope, the imaging depth of OCT has obvious advantage.The core technology of traditional optical probe mostly adopts fibre bundle to carry out light conduction and carries out imaging, or adopt CCD technology to carry out imaging, this type of inner peeping type probe only can detect the pathological changes of tissue surface, but the symptom of early-stage cancer occurs in the degree of depth of below epidermis 1-3 millimeter, therefore in traditional optical, pry head just seems unable to do what one wishes.Also have at present and undertaken spying upon head in medical imaging by ultrasonic principle, although can obtain the darker organizational information in below biological tissue top layer, resolution is only a millimeter magnitude, easily causes fail to pinpoint a disease in diagnosis early stage cancer.
Inner peeping type OCT technology is born and a flourish OCT branch technique with OCT technology development for nearly ten years, its core objective is under the prerequisite not reducing resolution, OCT optical imaging apparatus is microminiaturized, provides the high-resolution OCT image of inside of human body internal organs tube chamber.This technology extends the application of OCT technology greatly, makes OCT check object develop into human body viscera by body surface organ or biopsy samples, as blood vessel, digestive tract and respiratory tract etc.At present at clinicing aspect, OCT endoscopic technique is in inspection atherosclerosis and check that intravascular stent is laid in situation etc. and had preliminary application.
A critical component in inner peeping type OCT system is then OCT miniature probe.It can be combined with existing endoscope or the less invasive techniques of using clinically, stretches into inside of human body internal organs, gathers and collect the back-scattering light from biological tissue; Also to meet that physical size is little, mechanical strength high simultaneously.
As the GRIN Lens of the vital part of OCT miniature probe, there is processing technique maturation, low production cost, structure simply assembles the features such as easy, also can accomplish very little size simultaneously, become the first-selection of producing OCT miniature probe, but also there are some defects in it, as: under very small size, its numerical aperture is limited, cause the lateral resolution of OCT miniature probe to reduce, especially use during the GRIN Lens of long reach and lateral resolution can be caused sharply to decline.
Simultaneously; OCT miniature probe in use; generally all can position with columniform plastic, transparent sleeve pipe and protect; when laser is through columniform plastic, transparent sleeve pipe; be equivalent to have passed through a face of cylinder minus lens, have the generation of astigmatism phenomenon, this will cause laser circular light spot to become oval hot spot; cause the image scanning out to there occurs distortion, affect diagnostic result.
In sum, need to design a kind of OCT detection system being applied to blood vessel, digestive tract and respiratory tract etc. or tissue narrow space, and there is higher lateral resolution, the high-resolution OCT miniature probe that the image scanning out deforms can be prevented.
Utility model content
The purpose of this utility model is to provide the OCT miniature probe peeping scanning imaging system in a kind of OCT, and described OCT miniature probe comprises single-mode fiber, is enclosed within bourdon tube; Lens subassembly, make to be gathered in predetermined operating distance place by the light of spread fiber, described lens subassembly comprises Glass rod and GRIN Lens, can be changed the operating distance of OCT miniature probe by the gummed distance changing Glass rod and single-mode fiber; By the gummed of GRIN Lens and Glass rod, increase the clear aperature of GRIN Lens, and then improve numerical aperture and the lateral resolution of OCT probe.Described OCT miniature probe also can comprise reflecting mirror, support stainless steel tube and fluting stainless steel tube, and these optical element end face optical glue are glued together.
Wherein, described single-mode fiber one end is with sonet standard joint; this joint can be connected with the fiber spinning end of OCT system; described single-mode fiber is enclosed within bourdon tube and (is covered with PTFE film); bourdon tube can available protecting single-mode fiber; reduce resistance when probe rotates; make described OCT miniature probe entire scan more steady and smooth; described sonet standard joint is with support stainless steel tube; this stainless steel tube plays a supportive role when OCT miniature probe scans, more steady when making whole probe rotation sweep.The other end of described single-mode fiber is inclined end face, also be that Glass rod one end end face of inclined end face glues together with same, the inclination of cemented surface effectively reduces the interference of reflected light to flashlight, can change the operating distance of OCT miniature probe to reach required expection operating distance by the gummed distance changing Glass rod and single-mode fiber.The other end of described Glass rod and described GRIN Lens are packaged in after gluing together with 0 ° of angle end face slots in stainless steel tube, the use of Glass rod not only increases the operating distance of miniature probe, and increase the numerical aperture of miniature probe, and the increase of numerical aperture also causes the raising of lateral resolution, this design simultaneously has also shortened the length of GRIN Lens greatly, ensure that the curved property of the mistake of miniature probe, make whole miniature probe can directly enter human body esophagus by endoscopic forceps channel together with conduit.
Preferably, the face that described GRIN Lens contacts with air is coated with anti-reflection film, can reduce the reflection of light between optical surface and increase light transmission, thus reducing because the reflected light of optical surface is on the impact of flashlight, improve the sensitivity of OCT miniature probe.
Preferably, the angle of the cemented surface of described Glass rod and described single-mode fiber is 4 degree-12 and spends.
Preferably, the reflecting surface of described reflecting mirror is packaged in stainless steel tube towards stainless steel tube otch, in order to reduce the astigmatism of light source by cylindrical interior pipe to the impact of imaging, reflecting mirror herein can design cylindrical mirror according to the cylindrical internal-and external diameter of interior pipe and the refractive index of inner tube material, the astigmatism impact of pipe in offsetting, correct the shape of hot spot, reach the object improving image quality.
Another object of the present utility model is to provide in a kind of OCT peeps scanning imaging system, comprise sweeping laser module, intervention module, detector module, data acquisition module, data processing module, image display, actuator, foley's tube, inflation/deflation equipment, described OCT miniature probe, wherein
Described sweeping laser module comprises high speed frequency swept laser, fibre optic isolater and fiber coupler, the optical signalling exported and subsequent optical path is isolated from frequency swept laser, and the optical signalling interference laser preventing subsequent optical path from returning normally works; Described intervention module can adopt optical fiber type Mach-Zeng Deer interferometer (MZI) or optical fiber type Michelson (Michelson) interferometer structure.Wherein Mach-Zeng Deer interferometer structure is primarily of two fiber couplers, two optical fiber circulators and two optical fiber polarization controller compositions, wherein first fiber coupler generally adopts asymmetric fiber coupler, by most of Laser output to the miniature probe of sample arm; In reference arm and sample arm, all place an optical fiber circulator reflect or back scattered optical signalling from two arms to collect; Second fiber coupler can adopt symmetrical expression 2 × 2 fiber coupler (namely splitting ratio is 50/50) to produce optical interference signal and to reduce DC common-mode signal, optical fiber polarization controller is placed symmetrically in reference arm and sample arm, for adjusting the polarization state of two arms to obtain best optical interference signal.Michelson's interferometer structure is then made up of symmetrical expression 2 × 2 fiber coupler, an optical fiber circulator and two optical Polarized Beam Controller, first sweeping laser is entering fiber coupler after optical fiber circulator, interference signal is being produced through same fiber coupler from reference arm and sample arm reflection or back scattered optical signalling, optical fiber polarization controller is placed symmetrically in reference arm and sample arm, for adjusting the polarization state of two arms to obtain best optical interference signal.The advantage of Mach-Zeng Deer interferometer (MZI) is that symmetrical configuration, dispersion management are simple, detectivity is high.The advantage of Michelson (Michelson) interferometer is that structure is simple and can not introduces polarization mode dispersion (PMD), both something in commons are that the optical path difference in the middle of two arms determines the free spectral range (FSR) that optical clock occurs, and also finally determine the maximum imaging depth of OCT image; Detector module can adopt adjustment of balance photodetector, is mainly used in converting the interferometric optical signal exported from intervention module to electrical signal; Described data acquisition module is high speed analog-digital conversion capture card, is mainly used in converting simulation electrical signal to digital electrical signal, and digital signal is supplied to data processing module and carries out Digital Signal Processing; Described data processing module is the chip (as CPU, GPGPU, DSP, FPGA etc.) with digital signal processing capability, is mainly used in processing primary signal and being converted into final picture signal; Described image display is mainly used in display image signals and is responsible for post processing and the surveying work of image; Described actuator is made up of fiber rotation connector, motor and motorized precision translation stage, electric rotating machine in actuator drives OCT miniature probe to carry out rotation sweep, motorized precision translation stage drives actuator to move toward a direction simultaneously, at this moment the rotation sweep data got and translation stage mobile data are rebuild by software, namely produce 3D rendering; Described OCT miniature probe is mainly used in entering inside of human body internal organs to transmit sweeping laser and the optical signalling of collection backscattering from biological tissue; Described foley's tube, for expanding inside of human body internal organs pipeline, is eliminated gauffer and OCT miniature probe is stable at balloon center; Described inflation/deflation equipment is mainly used in expansion of balloon catheter.
Preferably, described foley's tube comprises: handle, and an interface of described handle is HPI, and another interface is ventilation interface; Double lumen tube, described double lumen tube can allow OCT optic probe to pass through; Sacculus, the front end shutoff of described sacculus and sacculus has scale; Interior pipe, the concentricity of described interior pipe and described sacculus departs from and is no more than 200 microns under 3 atmospheric pressure; Soft head, described soft head is solid construction, and wherein, described double lumen tube one end is connected with described handle, and the other end is connected with one end of described interior pipe and described sacculus, and described sacculus is connected with described soft head with the other end of described interior pipe.
Traditional foley's tube needs seal wire to support and guiding, and seal wire diameter is generally 0.018in, 0.035in, 0.014in, 0.038in, and foley's tube of the present utility model can by the OCT optics miniature probe of 0.055in.Described sacculus there is ink printing scale, line thickness≤0.1mm, the direction of scanning probe can be distinguished, the scanning that both can not affect normal picture judges also to tell scanning position on a display screen simultaneously, described sacculus front end shutoff, prevent from body fluid from entering to impact optical scanning, adopt flexible material again simultaneously, patient's esophagus can not be scratched.The use pressure of sacculus is 3 atmospheric pressure, can not damage normal esophageal at low pressures, simultaneously the heat setting process of sacculus and welding procedure can ensure that the concentricity of pipe and sacculus under 3 atmospheric pressure in departs from and be no more than 200 microns, are convenient to optical imagery.Described soft head is solid construction, can prevent body fluid from entering.Described double lumen tube is connected with described handle by UV viscose glue, and other each parts all adopt welding procedure to connect.Described inner tube length is according to the length fixed length of described sacculus, and it is shorter in length than described sacculus, when described sacculus welds with described soft head, certain distance is pushed away by under described sacculus, make it concordant with interior pipe and fixing after weld, make sacculus when full, have one to extend surplus, thus mate the stretching of interior pipe and keep with one heart.Because interior Guan Taihou can affect the definition of scanogram, too thin, can affect rotation and the concentricity of probe, therefore described interior pipe is the design of OCT miniature probe specially, and inner tube diameter is 1.4mm, and external diameter is 1.65mm.In addition, in this utility model, handle material can adopt Merlon, and double lumen tube and soft head material can adopt block polyetheramides, and sacculus and inner tube material can adopt nylon and polymer-modified.
Preferably, inflation/deflation equipment is applied in described OCT and peeps scanning imaging system, namely comprise sweeping laser module, intervention module, detector module, data acquisition module, data processing module, image display, actuator, foley's tube, OCT miniature probe and inflation/deflation equipment, described inflation/deflation equipment is automatic inflatable/air equipment, described automatic inflatable/air equipment comprises: control and display module, air pump, inflation/deflation electromagnetic valve, pressure transducer, explosion-proof pressure sensor, mechanical pressure switches.Described automatic inflatable/air equipment achieves automatic inflating and air-breathing; and there is the function setting different pneumatic parameter; can carry out inflation/deflation to the sacculus of different size, equipment is stopping inflation after reaching the atmospheric pressure value of setting in inflated process, and has over-voltage protecting function.Its attainable effect is: first, eliminates the operation of doctor to the manual inflation/deflation of sacculus, shortens the time of doctor's inflation/deflation, and improve safety, avoids the risk that sacculus overcharges blast; Secondly, accurate air pressure controls the shape coincidence after making inflated and is guaranteed, due to the shape sensitive of the scanned object that optical imagery is propped up for sacculus, this is just carried out the repeatability of Multiple-Scan better to same by sweep object, and doctor can compare for the view data after scanning; Again, when emergency process, while can realizing automatic deflation, doctor does other operation.
Preferably, peep scanning imaging system in described OCT and comprise the optical clock module be made up of described intervention module, described detector module and optical clock conversion circuit module, wherein, intervention module can adopt all-fiber formula Mach-Zender interferometer (MZI) structure, form primarily of two fiber couplers, wherein second bonder is symmetrical expression 2 × 2 fiber coupler, first two-way light is punished at the first fiber coupler, this two-way light, respectively through the first optical fiber of two sections of fixed light path differences and the second optical fiber, interferes at the second fiber coupler place.Detector module can adopt adjustment of balance photodetector, is mainly used in converting the interferometric optical signal exported from intervention module to electrical signal.After being converted to electrical signal from the optical interference signal of MZI generation by a balance photodetector, through optical clock conversion circuit module, to be namely converted to through wideband 90-degree phase shifter, zero-crossing comparator, XOR gate or door and optical clock signal output module successively on frequency domain evenly, at the optical clock signal of time domain up-conversion rate.Wherein, wideband 90-degree phase shifter is mainly used in the phase shift 90 degree of MZI electrical signal, zero-crossing comparator is mainly used in the MZI electrical signal after to original MZI electrical signal and phase shift and carries out Zero-cross comparator to be converted to digital signal, and the zero point of MZI signal is uniformly distributed on frequency domain, rising edge or the trailing edge of the digital signal therefore produced after Zero-cross comparator are also uniformly distributed on frequency domain, XOR gate is mainly used in two dagital clock signals to merge, in a free spectral range (FSR), two clock signals are produced to obtain, add the maximum imaging depth of OCT not increasing under FSR prerequisite like this, decrease the shake (jitter) produced by optical signalling.And between two adjacent scanning, always there are some free times due to frequency swept laser, optical clock signal also needs by one or inserts the clock signal of some vacations to ensure that high speed analog-digital conversion capture card can normally work in blank space, or door achieves the function merged with false clock signal by true optical clock signal, optical clock signal output module is mainly used in the true optical clock signal after by merging and is transported to data acquisition module with false clock signal.Described optical clock module is used by peeping in OCT in scanning imaging system, the requirement to data Collection & Processing System can be reduced, and reduce the collection of redundancy, alleviate the burden of storage system, thus improve the integrated level of whole OCT system, and then reduce system cost, and the signal to noise ratio of picture signal can also be improved, reduce detectivity decay, thus improve the definition of image.
Preferably, utilize general image processor (GPGPU) in OCT, peep in scanning imaging system the method processing OCT signal, data acquisition that the method comprises (1); (2) data transmission; (3) date processing; (4) image display four, storehouse step is passed to.
Wherein, (1) data acquisition, this utility model obtains FD-OCT initial data by outside collecting device;
(2) data transmission, the FD-OCT initial data obtained in data collection steps is placed in computer system or embedded system memory, these data are deposited in Installed System Memory in units of frame, after meeting certain condition (one frames as enough in data accumulation or multiframe), these data can be passed through data/address bus (as PCIExpress) and transfer in the device memory of general image processor; Because bus transfer speed is relatively slow, while transmission data, the OCT initial data that the last time transfers in device memory by general image processor carries out parallel processing.This kind of method has efficient Parallel signal processing ability, can realize Real-time digital signal processing, greatly improve efficiency of transmission, save bus resource;
(3) date processing, the Digital Signal Processing of carrying out in general image processor is divided into three steps: a dimension word resampling, one dimension fast fourier transform (FFT) and calculate amplitude normalization.Wherein realize a quick one dimension cubic interpolation to improve the precision of resampling by two sublinear texture lookups in a dimension word resampling steps;
(4) image display storehouse is passed to, the data placement handled well is in the internal memory in image display storehouse, image display storehouse can directly be called, without the need to passing through bus transfer again, greatly improve efficiency of transmission, save bus resource, there is efficient Parallel signal processing ability, realize Real-time digital signal processing, portable high, can seamless combination owing to showing storehouse with popular image, also improve the motility (such as: post processing can also be carried out by general image processor to image) of software display, lower hardware and software development cost can be realized.
Another object of this utility model also comprises the using method providing and peep scanning imaging system in a kind of OCT, and step comprises:
The first step, imports in foley's tube in pipe by OCT miniature probe, and described OCT miniature probe comprises single-mode fiber and lens subassembly, and described lens subassembly comprises Glass rod and GRIN Lens; Second step, scioptics assembly provides light source to single-mode fiber and hot spot is assembled at predetermined operating distance place; 3rd step, collects the optical signal returned from surveyed area; 4th step, carries out process according to the optical signal returned and obtains OCT data.Due to the defect of the processing technique of GRIN Lens own, clear aperature can only reach about 80% of its diameter, therefore the spot diameter after focusing on is also smaller, it is as follows that hot spot assembles adjustment process: the first step, and facula position regulates: can change by the gummed distance changing described Glass rod and described single-mode fiber the operating distance that OCT pops one's head in; Second step, spot size regulates: by the gummed of described GRIN Lens and described Glass rod, can increase the clear aperature of described GRIN Lens, and then improves numerical aperture and lateral resolution that OCT pops one's head in.
Accompanying drawing explanation
Fig. 1 is OCT miniature probe of the present utility model component diagram in kind;
Fig. 2 is OCT miniature probe key position amplification profile of the present utility model;
Fig. 3 be the OCT of having miniature probe of the present utility model OCT in peep scanning imaging system schematic diagram;
Fig. 4 is balloon catheter structure schematic diagram of the present utility model;
Fig. 5 is inflation/deflation device structure schematic diagram of the present utility model;
Fig. 6 is inflation/deflation equipment workflow diagram of the present utility model;
Fig. 7 is optical clock module diagram of the present utility model;
Fig. 8 is optical clock signal generating process schematic diagram of the present utility model;
Fig. 9 peeps scanning imaging system schematic diagram in the OCT with optical clock module of the present utility model;
Figure 10 is FD-OCT signal processing step schematic diagram of the present utility model;
Figure 11 is that general image processor data of the present utility model transmission, with signal processing is parallel, schematic diagram occurs;
Figure 12 is whole implementation structural representation of the present utility model;
Figure 13 is OCT miniature probe operating distance of the present utility model, gummed distance and lateral resolution curve relation figure;
Figure 14 is healthy animal esophagus scintigram of the present utility model;
Figure 15 is healthy animal esophagus scintigram partial enlarged drawing of the present utility model;
Figure 16 is healthy animal esophagus 3D rendering of the present utility model.
drawing reference numeral explanation
1, single-mode fiber, 2, bourdon tube, 3, Glass rod, 4, GRIN Lens, 5, reflecting mirror, 6, fluting stainless steel tube, 7, support stainless steel tube, 8, soft head, 9, interior pipe, 10, sacculus, 11, double lumen tube, 12, handle, 13, ventilation interface, 14, HPI,
81, squamous epithelial layer (SE), 82, lamina propria (LP), 83, muscularis mucosae (MM), 84, tela submucosa (SM), 85, intrinsic basic unit (MP),
91, after wideband 90-degree phase shifter, there is the MZI electrical signal of 90 degree of phase shift, 92, there is not the MZI electrical signal of phase shift, 93, signal 91 carries out the digital signal after Zero-cross comparator, 94, signal 92 carries out the digital signal after Zero-cross comparator, 95, false clock signal, 96, the signal of digital signal 93 and 94 after XOR gate merges
101, air pump, 102, inflation electromagnetic valve, 103, pressure transducer, 104, choke valve, 105, pressure transducer, 106, explosion-proof pressure sensor, 107, suction solenoid valve, 108, mechanical pressure switches.
Detailed description of the invention
Below in conjunction with accompanying drawing, technical solutions of the utility model are described in detail.
Embodiment 1
Peep an OCT miniature probe for scanning imaging system in OCT, as depicted in figs. 1 and 2: single-mode fiber 1 is enclosed within bourdon tube 2, bourdon tube 2, while the optical fiber of available protecting fragility, reduces resistance when probe rotates; Glass rod 3 one end and GRIN Lens 4 zero degree edged surface glue together, the other end and single-mode fiber 1 tilt to glue together, the operating distance of OCT probe can be changed by the gummed distance changing Glass rod 3 and single-mode fiber 1 two end faces to reach the operating distance required by expection, and then improve numerical aperture and the lateral resolution of OCT probe; Reflecting mirror 5 is cylindrical mirror and is packaged in fluting stainless steel tube 6, and the reflecting surface of reflecting mirror 5, towards the otch of fluting stainless steel tube 6, can reduce the astigmatism of light source by cylindrical interior pipe to the impact of imaging with this.
As depicted in figs. 1 and 2, described OCT miniature probe comprises single-mode fiber 1, bourdon tube 2, Glass rod 3, GRIN Lens 4, and reflecting mirror 5, fluting stainless steel tube 6 and support stainless steel tube 7, these optical element end face optical glue are glued together.Specifically, reflecting mirror 5 is loaded in fluting stainless steel tube 6, be then placed in frock and put A/B glue, then put UV glue under the microscope, Glass rod 3 and GRIN Lens 4 are assembled; Single-mode fiber 1 is penetrated in bourdon tube 2, again the Glass rod 3 assembled and GRIN Lens 4, single-mode fiber 1 and bourdon tube 2 are used a UV glue assembling, finally put into by the bourdon tube assembly after assembling in fluting stainless steel tube 6, edge voids place uses A/B glue to fill up.
Single-mode fiber 1 outer cover has stainless steel spring pipe 2 (being covered with PTFE film), while the optical fiber of available protecting fragility, reduces resistance when probe rotates, makes miniature probe scan more steady and smooth.Supporting the Main Function of stainless steel tube 7 is play a supportive role when OCT probe scans, and more steady when making whole probe rotation sweep, the notch of fluting stainless steel tube 6 can make light beam be irradiated on sample by this notch.
Anti-reflection film can reduce the reflection of light between optical surface and increase light transmission, thus reduce because the reflected light of optical surface is on the impact of flashlight, therefore, in the present embodiment, the face that GRIN Lens 4 contacts with air is coated with anti-reflection film, simultaneously one end of Glass rod 3 and GRIN Lens 4 zero angle end face glue together, and improve sensitivity and the resolution of miniature probe.The other end of Glass rod 3 and the cemented surface of single-mode fiber 1 have certain angle of inclination, in the present embodiment, the angle of inclination of cemented surface can be 8 ° herein, the inclination of cemented surface effectively reduces the interference of reflected light to flashlight, generally, the operating distance of OCT probe can be changed by the gummed distance changing these two end faces to reach the operating distance required by expection.Because 45° angle installs reflecting mirror 5, make incident ray vertical with reflection ray thus cause light to disturb, in the present embodiment, 40 ° of corner reflectors 5 are installed in miniature probe front end, reflecting mirror 5 to be packaged in fluting stainless steel tube 6 and reflecting surface towards the otch of fluting stainless steel tube 6, simultaneously in order to reduce the astigmatism of light source by cylindrical interior pipe to the impact of imaging, in the present embodiment, reflecting mirror herein designs cylindrical mirror according to the cylindrical internal-and external diameter of interior pipe and the refractive index of inner tube material.
Embodiment 2
As shown in Figure 3, scanning imaging system is peeped in a kind of OCT, comprise sweeping laser module, intervention module, detector module, data acquisition module, data processing module, image display, actuator, foley's tube, inflation/deflation equipment and the OCT miniature probe shown in Fig. 1 and Fig. 2, wherein
Described sweeping laser module comprises high speed frequency swept laser, fibre optic isolater and fiber coupler, the optical signalling exported and subsequent optical path is isolated from frequency swept laser, and the optical signalling interference laser preventing subsequent optical path from returning normally works; Described intervention module can adopt optical fiber type Mach-Zeng Deer interferometer (MZI) or optical fiber type Michelson (Michelson) interferometer structure.Wherein Mach-Zeng Deer interferometer structure is primarily of two fiber couplers, two optical fiber circulators and two optical fiber polarization controller compositions, wherein first fiber coupler generally adopts asymmetric fiber coupler, by most of Laser output to the miniature probe of sample arm; In reference arm and sample arm, all place an optical fiber circulator reflect or back scattered optical signalling from two arms to collect; Second fiber coupler can adopt symmetrical expression 2 × 2 fiber coupler (namely splitting ratio is 50/50) to produce optical interference signal and to reduce DC common-mode signal, optical fiber polarization controller is placed symmetrically in reference arm and sample arm, for adjusting the polarization state of two arms to obtain best optical interference signal.Michelson's interferometer structure is then made up of symmetrical expression 2 × 2 fiber coupler, an optical fiber circulator and two optical Polarized Beam Controller, first sweeping laser is entering fiber coupler after optical fiber circulator, interference signal is being produced through same fiber coupler from reference arm and sample arm reflection or back scattered optical signalling, optical fiber polarization controller is placed symmetrically in reference arm and sample arm, for adjusting the polarization state of two arms to obtain best optical interference signal.The advantage of Mach-Zeng Deer interferometer (MZI) is that symmetrical configuration, dispersion management are simple, detectivity is high.The advantage of Michelson (Michelson) interferometer is that structure is simple and can not introduces polarization mode dispersion (PMD), both something in commons are that the optical path difference in the middle of two arms determines the free spectral range (FSR) that optical clock occurs, and also finally determine the maximum imaging depth of OCT image; Detector module can adopt adjustment of balance photodetector, is mainly used in converting the interferometric optical signal exported from intervention module to electrical signal; Described data acquisition module is high speed analog-digital conversion capture card, is mainly used in converting simulation electrical signal to digital electrical signal, and digital signal is supplied to data processing module and carries out Digital Signal Processing; Described data processing module is the chip (as CPU, GPGPU, DSP, FPGA etc.) with digital signal processing capability, is mainly used in processing primary signal and being converted into final picture signal; Described image display is mainly used in display image signals and is responsible for post processing and the surveying work of image; Described actuator is made up of fiber rotation connector, motor and motorized precision translation stage, is mainly used in driving the scanning of OCT miniature probe mechanical spiral to obtain OCT image; Described OCT miniature probe is mainly used in entering inside of human body internal organs to transmit sweeping laser and the optical signalling of collection backscattering from biological tissue; Described foley's tube, for expanding inside of human body internal organs pipeline, is eliminated gauffer and OCT miniature probe is stable at balloon center; Described inflation/deflation equipment is mainly used in expansion of balloon catheter.
Embodiment 3
Peep scanning imaging system in a kind of OCT, similar to embodiment 2, difference be described foley's tube as shown in Figure 4, comprising: handle 12, an interface of handle 12 is HPI 14, and another interface is ventilation interface 13; Double lumen tube 11, can allow OCT optic probe to pass through; Sacculus 10, the front end shutoff of sacculus 10 and sacculus has scale; Interior pipe 9, interior pipe 9 departs from the concentricity of sacculus 10 and is no more than 200 microns under 3 atmospheric pressure; Soft 8 is solid construction, wherein, double lumen tube 11 one end is connected with handle 12, and the other end is connected with one end of interior pipe 9 and sacculus 10, and sacculus 10 is connected with soft 8 with the other end of interior pipe 9, double lumen tube 11 is connected with handle 12 by UV viscose glue, and other each several parts are all connected by the mode of welding.
Handle 12 material is Merlon, and double lumen tube 11 and soft 8 materials are block polyetheramides, and sacculus 10 and interior pipe 9 material are nylon and polymer-modified.
Sacculus 10 has ink printing scale, line thickness≤0.1mm, can distinguish the direction of scanning probe, the scanning that both can not affect normal picture judges also to tell scanning position on a display screen simultaneously.Double lumen tube 11 is printed on scale, and therefore, doctor can judge the position scanned.
Traditional foley's tube needs seal wire to support and guiding, and seal wire diameter is generally 0.018in, 0.035in, 0.014in, 0.038in, and in the present embodiment, the double lumen tube 11 of OCT foley's tube can by 0.055inOCT optic probe.Because interior Guan Taihou can affect the definition of scanogram, too thin, can affect rotation and the concentricity of probe, in the present embodiment, pipe 9 internal diameter is 1.4mm, and external diameter is 1.65mm, is OCT probe designs specially.Described inner tube length is according to the length fixed length of described sacculus, and it is shorter in length than described sacculus, when described sacculus welds with described soft head, certain distance is pushed away by under described sacculus, make it concordant with interior pipe and fixing after weld, make sacculus when full, have one to extend surplus, thus mate the stretching of interior pipe and keep with one heart.
Embodiment 4
Scanning imaging system is peeped in a kind of OCT, similar to embodiment 2 or 3, difference is described inflation/deflation equipment is automatic inflatable/air equipment, as shown in Figure 5, described automatic inflatable/air equipment comprises: power pack, control and display section and air pump and control system part thereof, described air pump and control system part thereof comprise: air pump, inflation/deflation electromagnetic valve, choke valve, pressure transducer, explosion-proof pressure sensor, mechanical pressure switches.As shown in Figure 6, the use procedure of described automatic inflatable/air equipment comprises:
1) gas replenishment process: first user sets the parameters such as sacculus 10 air pressure, inflationtime, send inflation order, control system reads the data of pressure transducer 103,105, if be less than the air pressure of user's setting, then booster air pump 101, open inflation electromagnetic valve 102, choke valve 104, the value of feedback of pressure transducer 103,105 is read in real time in gas replenishment process, until be charged to the atmospheric pressure value of setting, close air pump 101, close choke valve 104, inflation electromagnetic valve 102;
2) deflation course: first user sets the parameters such as sacculus 10 air pressure, deflation time, control system reads the data of pressure transducer 105, if be greater than the air pressure of user's setting, then booster air pump 101, open suction solenoid valve 107, choke valve 104, read the value of feedback of pressure transducer 105 in deflation course in real time, until be drawn onto the atmospheric pressure value of setting, holding one's breath 101 pumps in pass, closes choke valve 104, suction solenoid valve 107.
In inflation/deflation process, system is monitored the value of feedback of explosion-proof pressure sensor 106 in real time, if exceed user's air pressure upper limit set value, then carries out software program protection immediately, closes air pump 101, and reports to the police; Mechanical pressure switches 108 is hardware protection, and as exceeded setting value, then switch opens, pressure release is protected.
Embodiment 5
As shown in Figure 7, a kind ofly in OCT, peep the optical clock module used in scanning imaging system, it comprises intervention module, detector module and optical clock conversion circuit module, and described optical clock conversion circuit module comprises circuit and the optical clock signal output module of wideband 90-degree phase shifter, zero-crossing comparator and XOR gate or door composition.Wherein, intervention module adopts all-fiber formula Mach-Zender interferometer (MZI) structure, form primarily of two fiber couplers, wherein second bonder is symmetrical expression 2 × 2 fiber coupler, first two-way light is punished at the first fiber coupler, this two-way light, respectively through the first optical fiber of two sections of fixed light path differences and the second optical fiber, interferes at the second fiber coupler place.Detector module is made up of adjustment of balance photodetector, is mainly used in converting the interferometric optical signal exported from intervention module to electrical signal.A MZI electrical signal part after detector module conversion is transferred to wideband 90-degree phase shifter, another part is transferred to zero-crossing comparator, the phase shift of 90 degree that the electrical signal being transferred to wideband 90-degree phase shifter occurs, zero-crossing comparator is mainly used in carrying out Zero-cross comparator to be converted to digital signal to generation phase shift and signal that phase shift do not occur.XOR gate is mainly used in two dagital clock signals to merge, in a free spectral range (FSR), two clock signals are produced to obtain, add the maximum imaging depth of OCT not increasing under FSR prerequisite like this, decrease the shake (jitter) that optical signalling produces.Because frequency swept laser always exists some free times between two adjacent scanning, optical clock signal also needs by one or inserts the clock signal of some vacations to ensure that high speed analog-digital conversion capture card can normally work in blank space, or door achieves the function merged with false clock signal by true optical clock signal.Optical clock signal output module is mainly used in the true optical clock signal after by merging and is transported to data acquisition module with false clock signal.
As shown in Figure 8, 91 is the MZI electrical signal that 90 degree of phase shift occur after wideband 90-degree phase shifter, 92 for there is not the MZI electrical signal of phase shift, 93 carry out the digital signal after Zero-cross comparator for there is the MZI signal 91 of phase shift, 94 carry out the digital signal after Zero-cross comparator for the MZI signal 92 that phase shift do not occur, because the zero point of MZI signal is uniformly distributed on frequency domain, rising edge or the trailing edge of the digital signal therefore produced after Zero-cross comparator are also uniformly distributed on frequency domain, 96 is the signal of digital signal 93 and 94 after XOR gate merges that frequency domain is evenly distributed, 95 is false clock signal, 95 and 96 form the optical clock signal after warp or door merging jointly.
As shown in Figure 9, peep scanning imaging system in a kind of OCT, similar to embodiment 2-4, difference comprises sweeping laser module, optical clock module, data acquisition module, data processing module, image display, actuator, OCT miniature probe and foley's tube and inflation/deflation equipment, wherein: described optical clock module as shown in Figure 7, comprises intervention module, detector module and optical clock conversion circuit module, described optical clock conversion circuit module comprises wideband 90-degree phase shifter, zero-crossing comparator and XOR gate, or door composition circuit and external timing signal output module, from MZI produce optical interference signal be converted to electrical signal by a balance photodetector after, through one by wideband 90-degree phase shifter, the circuit of zero-crossing comparator and XOR gate composition and to be converted on frequency domain evenly, at the optical clock signal of time domain up-conversion rate, or the true optical clock signal of goalkeeper merges the normal work with high speed analog-digital conversion capture card with false clock signal.
Described sweeping laser module includes high speed frequency swept laser, fibre optic isolater and fiber coupler, the optical signalling exported from frequency swept laser and subsequent optical path are isolated, the optical signalling interference laser preventing subsequent optical path from returning normally works, and the output of sub-fraction sweeping laser is separated to optical clock module, most of laser continues to export; Described optical clock module comprises intervention module, detector module and optical clock conversion circuit module, to be mainly used in obtaining on frequency domain evenly, at the optical clock signal of time domain up-conversion rate; Described data acquisition module can adopt high speed analog-digital conversion capture card, and the optical clock signal mainly exported with optical clock module gathers original image signal for benchmark, and is supplied to data processing module and processes; Described data processing module is the chip (as CPU, GPGPU, DSP, FPGA etc.) with digital signal processing capability, is mainly used in processing primary signal and being converted into final picture signal; Described image display is mainly used in display image signals and is responsible for post processing and the surveying work of image; Described actuator is made up of fiber rotation connector, motor and motorized precision translation stage, is mainly used in driving the scanning of OCT miniature probe mechanical spiral to obtain OCT image; Described OCT miniature probe is mainly used in entering inside of human body internal organs to transmit sweeping laser and the optical signalling of collection backscattering from biological tissue; Described foley's tube, for expanding inside of human body internal organs pipeline, is eliminated gauffer and OCT miniature probe is stable at balloon center; Described inflation/deflation equipment is mainly used in expansion of balloon catheter.
Embodiment 6
Peep scanning imaging system in a kind of OCT, similar to embodiment 2-5, difference be utilize general image processor process OCT signal scheme as shown in Figure 10, comprise (1) data acquisition be connected successively; (2) data transmission; (3) date processing and (4) are passed to these steps of image display storehouse, wherein when data are transmitted because bus transfer speed is relatively slow, while transmission data, the OCT initial data that last time transfers in device memory by general image processor carries out parallel processing, and its parallel transmission and processing procedure are as shown in figure 11; The process of date processing is divided into three steps: a dimension word resampling, one dimension fast fourier transform (FFT) and calculate amplitude normalization, wherein, a quick one dimension cubic interpolation is realized to improve the precision of resampling by two sublinear texture lookups in a dimension word resampling steps.
As shown in Figure 10, a kind of scheme of general image processor process OCT signal that utilizes comprises (1) data acquisition be connected successively; (2) data transmission; (3) date processing and (4) are passed to the several step in image display storehouse.
Wherein, (1) data acquisition, this utility model obtains FD-OCT initial data by outside collecting device;
(2) data transmission, the FD-OCT initial data obtained in data collection steps is placed in computer system or embedded system memory, these data are deposited in Installed System Memory in units of frame, after meeting certain condition (one frames as enough in data accumulation or multiframe), these data can be passed through data/address bus (as PCIExpress) and transfer in the device memory of general image processor (GPGPU); Because bus transfer speed is relatively slow, while transmission data, the OCT initial data that the last time transfers in device memory by general image processor carries out parallel processing.
Such as: as shown in Figure 11, while the initial data of the n-th frame is transferred to general image processor device internal memory, the initial data of the (n-1)th frame is carried out Digital Signal Processing simultaneously in general image processor, and frame synchronization is carried out after data transmission and process terminate, namely no matter be that data are transmitted or the reef knot Shu Houzai completed after wait is carried out the operation of next frame by the side that date processing completes, effectively can be improved the data processing speed of general image processor by this parallel signal transmission/transaction module.
(3) date processing, as shown in Figure 10, the Digital Signal Processing of carrying out in general image processor is divided into three steps: a dimension word resampling, one dimension fast fourier transform (FFT) and calculate amplitude normalization.Wherein digital resampling can pass through the built-in texture lookups functional realiey of image processor (GPU), the built-in texture lookups function of image processor can realize two-dimensional linear interpolation automatically to interpolation, and the texture lookups module of image processor has special hardware optimization to interpolation, faster relative to general general image processor interpolation speed, particularly for the non-equidistant interpolation in OCT signal processing; By accurately arranging a dimension search a little, can by the built-in texture lookups functional realiey one-dimensional linear interpolation of image processor.On this basis, a quick one dimension cubic interpolation is realized by two sublinear texture lookups, thus to improve the precision of resampling, because texture lookups module has carried out special optimization to non-equidistant interpolation, this method implements on general image processor than direct cubic interpolation that amount of calculation is less, computational efficiency is higher; FFT can be realized by the numerical computations storehouse (cuFFT storehouse or OpenCL FFT storehouse as nVidia) of common commercialization based on image processor; Calculating amplitude normalization then can realize by oneself writing image processor program, and the CUDA storehouse that nVidia such as can be used to provide realizes the quick traversal of 2-D data to write corresponding kernel function (kernelfunction) to realize amplitude and normalization calculates.
(4) image display storehouse is passed to, the data placement handled well is in the internal memory in image display storehouse, image display storehouse can directly be called, without the need to passing through bus transfer again, greatly improve efficiency of transmission, save bus resource, there is efficient Parallel signal processing ability, realize Real-time digital signal processing, portable high, can seamless combination owing to showing storehouse with popular image, also improve the motility (such as: post processing can also be carried out by general image processor to image) of software display, lower hardware and software development cost can be realized.
Embodiment 7
As shown in figure 12, a kind of miniature probe carrying out OCT image scanning for human body esophagus, miniature probe is inserted until in sacculus pipe 9 from balloon proximal handle guidewire lumen, sacculus handle ventilation interface 13 is connected to automatic inflation pump (not shown), nominal pressure is inflated to by sacculus 10, so that extended by esophagus, described sacculus 10 and interior pipe 9 are all that optically transparent material is made, and have fabulous light transmission.The effect of sacculus 10 is that expansion esophagus is to reduce esophagus wrinkle and to be fixed within its operating distance scope by OCT miniature probe.The radius that sacculus 10 is expanded is greatly between 8-10mm, and this is also the radius after esophagus launches completely, and therefore, a relatively large operating distance (greatly about 8-10mm) is the characteristic that OCT miniature probe must have.
Glass rod 3 is devised especially in the present embodiment, mention in aforementioned that the gummed distance changing Glass rod 3 and single-mode fiber 1 can change the operating distance of miniature probe, this routine miniature probe is used for human body esophagus, operating distance, greatly about 8-10mm, should be less than 0.3mm by the gummed distance on calculating and tested glass rod 3 and single-mode fiber 1 two sides.The design ap-plication of Glass rod 3 not only makes OCT miniature probe can be operated within the scope of longer operating distance, can also change numerical aperture and the lateral resolution of miniature probe.
The clear aperature relation of numerical aperture and optical element is as follows:
Wherein, D is the clear aperature of optical element, W.D is operating distance, N.A is numerical aperture, and when operating distance W.D. mono-timing, numerical aperture is directly proportional to the clear aperature (D) of optical element, due to the defect of the processing technique of GRIN Lens own, clear aperature can only reach about 80% of its diameter, and leading portion plays the effect of expanding after adding Glass rod, namely increases clear aperature.
The relation of resolution and numerical aperture is as follows:
Wherein, λ is lambda1-wavelength is definite value, and lateral resolution △ X is proportional to numerical aperture (N.A), and namely numerical aperture is larger, lateral resolution higher (numerical value is less).
In summary, the use of Glass rod 3 not only increases the operating distance of miniature probe, and increase the numerical aperture of miniature probe, and the increase of numerical aperture also causes the raising of lateral resolution, this design simultaneously, also shortened the length of GRIN Lens greatly, ensure that the curved property of the mistake of miniature probe, whole like this miniature probe still can directly enter human body esophagus by endoscopic forceps channel together with foley's tube.This design effectively, make the lateral resolution of probe be about 10-30 micron, operating distance can reach 8-10 millimeter, and the relation of the lateral resolution of operating distance and miniature probe is as Figure 13.The diameter of whole miniature probe is less than 1.5 millimeters, and as adopted diameter 1.0 millimeters of GRIN Lens, the diameter of whole miniature probe is less than 1.3 millimeters; As adopted diameter 0.7 millimeter of GRIN Lens, the diameter of whole miniature probe is less than 1.0 millimeters; As adopted diameter 0.5 millimeter of GRIN Lens, the diameter of whole miniature probe is less than 0.7 millimeter.
Figure 14 is the one section of healthy animal esophagus image obtained by peeping scanning imaging system in OCT, and picture size is 1200 transversal scanning number × 4096 longitudinal scannings, and sweep speed is 0.2cm/3s, and scale is 1mm.Figure 15 is the partial enlarged drawing of Figure 14 healthy animal esophagus image, recognizable layer comprises, and 81: squamous epithelial layer (SE), 82: lamina propria (LP), 83: muscularis mucosae (MM), 84: tela submucosa (SM) and 85: intrinsic basic unit (MP).Scan-data, for carry out luminal surface and depth scan by peeping scanning imaging system in OCT, is then carried out the healthy animal esophagus 3D rendering of software rebuild generation by Figure 16.
Be only the preferred implementation of the application described in upper, those skilled in the art understood or realizes the utility model of the application.For these embodiments multiple amendment and combination will be apparent for a person skilled in the art, General Principle as defined herein when not departing from the spirit or scope of the application, can realize in other embodiments.Therefore, the application can not be limited in these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (10)
1. be applied in OCT the OCT miniature probe peeping scanning imagery, it is characterized in that, described miniature probe comprises:
Single-mode fiber, is enclosed within available protecting single-mode fiber, reduces in the bourdon tube of resistance when probe rotates;
Make the lens subassembly being gathered in predetermined operating distance place by the light of spread fiber, described lens subassembly comprises:
Glass rod, can change by the gummed distance changing described Glass rod and described single-mode fiber the operating distance that OCT pops one's head in;
GRIN Lens, by the gummed with described Glass rod, increases the clear aperature of described GRIN Lens, and then improves numerical aperture and the lateral resolution of OCT probe.
2. peep the OCT miniature probe of scanning imagery in the OCT of being applied to according to claim 1, it is characterized in that: the face that described GRIN Lens contacts with air is coated with the anti-reflection film that can reduce the reflection of light between optical surface and increase light transmission.
3. peep the OCT miniature probe of scanning imagery in the OCT of being applied to according to claim 1, it is characterized in that: the cemented surface of described Glass rod and described single-mode fiber is inclined-plane, reduce reflected light to the interference of flashlight.
4. peep the OCT miniature probe of scanning imagery in the OCT of being applied to according to claim 3, it is characterized in that: the angle of the cemented surface of described Glass rod and described single-mode fiber is 4 °-12 °.
5. peep the OCT miniature probe of scanning imagery in the OCT of being applied to according to claim 1, it is characterized in that: also comprise reflecting mirror, and described reflecting mirror is cylindrical mirror.
6. peep a scanning imaging system in OCT, it is characterized in that: described OCT system comprises OCT miniature probe described in sweeping laser module, intervention module, detector module, data acquisition module, data processing module, image display, actuator, foley's tube, inflation/deflation equipment and claim 1-5.
7. peep scanning imaging system in OCT according to claim 6, it is characterized in that, described actuator drives described OCT miniature probe to carry out rotation sweep, can produce 3D rendering.
8. peep scanning imaging system in OCT according to claim 6, it is characterized in that, described foley's tube comprises:
Handle, an interface of described handle is HPI, and another interface is ventilation interface;
Allow the double lumen tube that OCT optic probe passes through;
Sacculus, the front end shutoff of described sacculus and sacculus has scale;
Interior pipe, the concentricity of described interior pipe and described sacculus departs from and is no more than 200 microns under 3 atmospheric pressure;
Soft head, described soft head is solid construction, wherein,
Described double lumen tube one end is connected with described handle, and the other end is connected with one end of described interior pipe and described sacculus, and described sacculus is connected with described soft head with the described interior pipe other end.
9. peep scanning imaging system in OCT according to claim 6, it is characterized in that, described inflation/deflation equipment is automatic inflatable/air equipment, and described automatic inflatable/air equipment comprises: control and display module, air pump, inflation/deflation electromagnetic valve, pressure transducer, explosion-proof pressure sensor, mechanical pressure switches.
10. peep scanning imaging system in OCT according to claim 6, it is characterized in that: described system comprises the optical clock module be made up of described intervention module, described detector module and optical clock conversion circuit module, wherein, described optical clock conversion circuit module comprises wideband 90-degree phase shifter, zero-crossing comparator, XOR gate or the door and optical clock signal output module that connect successively, electrical signal after the conversion of described detector module to be converted on frequency domain evenly, at the optical clock signal of time domain up-conversion rate, wherein
Described wideband 90-degree phase shifter makes the phase shift 90 degree of part MZI electrical signal;
Described zero-crossing comparator carries out Zero-cross comparator to original MZI electrical signal and the MZI electrical signal after there is phase shift and is converted to digital signal, and the digital signal after conversion is evenly distributed on frequency domain;
Described XOR gate is mainly used in two dagital clock signals after zero-crossing comparator conversion to merge;
Described or door is mainly used in true optical clock signal and false clock signal to merge;
Described optical clock signal output module is mainly used in the true optical clock signal after by merging and is transported to data acquisition module with false optical clock signal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520297768.XU CN204636278U (en) | 2015-05-08 | 2015-05-08 | Inner peeping type OCT miniature probe and OCT imaging system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520297768.XU CN204636278U (en) | 2015-05-08 | 2015-05-08 | Inner peeping type OCT miniature probe and OCT imaging system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204636278U true CN204636278U (en) | 2015-09-16 |
Family
ID=54089066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520297768.XU Withdrawn - After Issue CN204636278U (en) | 2015-05-08 | 2015-05-08 | Inner peeping type OCT miniature probe and OCT imaging system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204636278U (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825121A (en) * | 2015-05-08 | 2015-08-12 | 南京微创医学科技有限公司 | Endoscopic OCT (Optical Coherence Tomography) miniature probe, OCT imaging system and use method |
| WO2016180289A1 (en) * | 2015-05-08 | 2016-11-17 | 南京微创医学科技有限公司 | Application of automatic inflation/deflation device in oct endoscopic scanning and imaging system |
| WO2016180287A1 (en) * | 2015-05-08 | 2016-11-17 | 南京微创医学科技有限公司 | Method and system for processing oct signal using general-purpose graphics processing unit |
| CN106691506A (en) * | 2016-12-29 | 2017-05-24 | 天津恒宇医疗科技有限公司 | OCT imaging conduit with high imaging quality |
| CN106880339A (en) * | 2017-03-09 | 2017-06-23 | 广州永士达医疗科技有限责任公司 | A kind of respiratory tract OCT systems |
| CN110113983A (en) * | 2016-12-27 | 2019-08-09 | 德普伊新特斯产品公司 | For providing system, the method and apparatus of illumination in endoscope imaging circumstances |
| JP2023523274A (en) * | 2020-04-22 | 2023-06-02 | シンプソン インターベンションズ， インコーポレイテッド | OCT catheter with low refractive index optical material |
-
2015
- 2015-05-08 CN CN201520297768.XU patent/CN204636278U/en not_active Withdrawn - After Issue
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104825121A (en) * | 2015-05-08 | 2015-08-12 | 南京微创医学科技有限公司 | Endoscopic OCT (Optical Coherence Tomography) miniature probe, OCT imaging system and use method |
| WO2016180289A1 (en) * | 2015-05-08 | 2016-11-17 | 南京微创医学科技有限公司 | Application of automatic inflation/deflation device in oct endoscopic scanning and imaging system |
| WO2016180287A1 (en) * | 2015-05-08 | 2016-11-17 | 南京微创医学科技有限公司 | Method and system for processing oct signal using general-purpose graphics processing unit |
| WO2016180291A1 (en) * | 2015-05-08 | 2016-11-17 | 南京微创医学科技有限公司 | Endoscopic oct microprobe, oct imaging system, and use method |
| CN110113983A (en) * | 2016-12-27 | 2019-08-09 | 德普伊新特斯产品公司 | For providing system, the method and apparatus of illumination in endoscope imaging circumstances |
| CN110113983B (en) * | 2016-12-27 | 2022-05-13 | 德普伊新特斯产品公司 | Systems, methods, and apparatus for providing illumination in an endoscopic imaging environment |
| CN106691506A (en) * | 2016-12-29 | 2017-05-24 | 天津恒宇医疗科技有限公司 | OCT imaging conduit with high imaging quality |
| CN106880339A (en) * | 2017-03-09 | 2017-06-23 | 广州永士达医疗科技有限责任公司 | A kind of respiratory tract OCT systems |
| WO2018161384A1 (en) * | 2017-03-09 | 2018-09-13 | 广州永士达医疗科技有限责任公司 | Oct system for respiratory tract |
| JP2023523274A (en) * | 2020-04-22 | 2023-06-02 | シンプソン インターベンションズ， インコーポレイテッド | OCT catheter with low refractive index optical material |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104825121B (en) | Endoscopic OCT (Optical Coherence Tomography) miniature probe, OCT imaging system and use method | |
| CN104825118B (en) | Balloon catheter applied to OCT (optical coherence tomography) endoscopic scanning imaging, use method and OCT imaging system | |
| CN204636278U (en) | Inner peeping type OCT miniature probe and OCT imaging system | |
| CN104799802B (en) | Automatic inflatable/air equipment peeps the application in scanning imaging system in OCT | |
| CN104825120A (en) | Optical clock signal generation system and method used in OCT (Optical Coherence Tomography) endoscopic scanning imaging system | |
| CN104794740A (en) | Method and system for processing OCT (Optical Coherence Tomography) signal by using general purpose graphic processing unit | |
| CN100455253C (en) | Spectral domain OCT endoscopic imaging system for in vivo optical biopsy | |
| CN204698494U (en) | The optical clock module used in scanning imaging system is peeped in OCT | |
| CN201019719Y (en) | Spectral domain OCT endoscopic imaging device for in vivo optical biopsy | |
| CN104739377A (en) | Device, system and method for simultaneously carrying out OCT imaging and pressure measurement in blood vessel | |
| CN102525382B (en) | Spiral scanning common-path interference type endoscopic frequency-sweeping OCT real-time imaging method and system | |
| US20230324603A1 (en) | Multicore Fiber with Distal Motor | |
| CN204671101U (en) | Be applied in OCT the foley's tube and OCT imaging system of peeping scanning imagery | |
| CN105054901A (en) | Single-optical-fiber endoscope system integrated with optical coherence tomography and fractional flow reserve detection | |
| CN204500629U (en) | Ink vessel transfusing carries out OCT imaging and pressure gauge and system simultaneously | |
| CN204636277U (en) | Scanning imaging system is peeped in the OCT with automatic inflatable/air equipment | |
| CN204889951U (en) | Peep device in single fiber that relevant chromatography of integrated optics and blood flow deposit mark detected | |
| Xu et al. | In vivo endoscopic optical coherence elastography based on a miniature probe | |
| CN110169758A (en) | A kind of optoacoustic endoscopy imaging device and method of full light | |
| CN111436908A (en) | Optical coherence tomography endoscope probe and imaging system | |
| CN201101518Y (en) | Common channel type endoscopic optical coherent chromatography imaging system | |
| Balakrishnan | Endoscopic optical coherence tomography imaging of the airway | |
| CN221949788U (en) | Integrated ultrasonic synchronous imaging probe for intrabronchial OCT (optical coherence tomography) | |
| CN204318720U (en) | Optical coherence tomography system | |
| Chen et al. | High-speed three-dimensional endoscopic OCT using MEMS technology |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20150916 Effective date of abandoning: 20170426 |