CN204332209U - A teaching tool for polypeptide main chain conformation angle model - Google Patents

Abstract

The utility model discloses a kind of model teaching aid for displayed polypeptides Conformation of the main chain corner structure.This model teaching aid comprises the sphere structure representing atom and the club structure representing chemical bond; Described sphere structure and described club structure removably connect.Two planar unit of peptide are linked together by adjacent C α (alpha-carbon atom), form two adjacent planar unit of peptide.Connect the C α of two planar unit of peptide, its side is connected with N (nitrogen-atoms), and opposite side is connected with C (carbon atom), and these two junctions are designed to rotatable mode.Rotate the connecting key of C α and N, be angle, or the connecting key rotating C α and C, be ψ angle, just can obtain the model at different polypeptide backbone conformation angles.The model teaching aid assembling at this polypeptide backbone conformation angle and demonstration are simply, fast, flexibly, the model after dismounting is easy to carry.

Description

A teaching tool for polypeptide main chain conformation angle model

technical field

The utility model relates to the field of model teaching aids, in particular to a model teaching aid for displaying the conformation angle structure of a polypeptide main chain.

Background technique

Protein is an important functional molecule in organisms. The complex life activities of organisms are completed by proteins, such as catalyzing various metabolic reactions in organisms, immune responses against foreign bacteria and other infections, transporting oxygen and other substances etc. The function of a protein is closely related to its structure, and its function is not only related to the primary structure, but also closely related to the spatial structure. A protein is a polypeptide chain formed by connecting amino acids through peptide bonds. The polypeptide main chain forms a peptide plane, and the adjacent peptide planes exist at a certain conformational angle, which determines the spatial structure of the protein. Different proteins have different conformation angles of adjacent peptide planes in the main chain of the polypeptide due to the difference in the number and type of amino acids and the sequence of the amino acids, thus forming protein molecules with different spatial conformations.

Accurately understanding the structure of the peptide plane conformation angle of the polypeptide backbone is crucial to grasping the relationship between protein structure and function. The teaching of protein structure is mainly completed in the "Biochemistry" course in colleges and universities. This is a very important and popular basic course. Students in agronomy, medicine, life science, and even mathematics and computer related students who are engaged in bioinformatics must learn the course. In the teaching of "Biochemistry", the conformation angle of the polypeptide main chain is a teaching difficulty. .

Utility model content

The purpose of the utility model is to provide a model teaching aid for displaying the conformation angle structure of the polypeptide main chain.

In order to solve the above-mentioned technical problems, the utility model provides a model teaching aid of the conformation angle of the polypeptide main chain, which includes a sphere structure representing atoms and a stick structure representing chemical bonds; the sphere structure and the stick structure are detachably connected.

Preferably, the detachable connection is a screw connection or a buckle connection.

Preferably, the buckle connection is a hook-and-slot connection, and the ball structure and the stick structure are respectively provided with a slot and a hook that cooperate with each other.

Preferably, the sphere structure is provided with a slot, the stick structure is provided with a hook, and the slot cooperates with the hook.

Preferably, the threaded connection is provided with a threaded hole at the end of the stick structure, and the ball structure is provided with a through hole corresponding to the threaded hole, and the bolt is inserted into the through hole and can be connected with the threaded hole. The hole is screwed tight.

Preferably, the polypeptide backbone comprises at least 1 peptide plane.

Preferably, the polypeptide backbone comprises at least 2 peptide planes.

Preferably, the two adjacent peptide planes are connected by α-carbon atoms, and the two adjacent peptide planes can rotate relative to each other.

In the preferred scheme of the present utility model, according to the different sizes of atoms, design 4 kinds of plastic spheres of different sizes, representing carbon atoms, nitrogen atoms, oxygen atoms and hydrogen atoms respectively, and the angles of the chemical bonds connected by atoms on the spheres Differently, grooves are prepared. Four sticks of different lengths are designed according to the size of the chemical bonds connected between different atoms, and the two ends of the sticks have structures inserted into the grooves in the ball. Use sticks to connect these atoms together according to the composition of peptide planes, and then connect two peptide planes through adjacent Cα (alpha carbon atoms) to form two adjacent peptide planes. The Cα connecting two peptide planes is connected to N (nitrogen atom) on one side and C (carbon atom) on the other side, and the two connections are designed to be rotatable. Rotate the bond between Cα and N, that is Angle, or rotate the bond between Cα and C, that is, the ψ angle, you can obtain different models of the conformational angle of the polypeptide main chain. The assembly and demonstration of the model teaching aid for the conformation angle of the main chain of the polypeptide is simple, fast and flexible, and the disassembled model is easy to carry.

Description of drawings

Fig. 1 shows the schematic diagram of sphere structure and stick structure;

Fig. 2 shows the scale diagram of sphere structure and stick structure;

Figure 3 shows a structural diagram of a peptide plane;

Fig. 4 shows the structural diagram of the polypeptide conformation angle provided by Example 1;

Fig. 5 shows the structural diagram of the polypeptide conformation angle provided in Example 2;

Figure 6 shows the structural diagram of the polypeptide conformation angle provided in Example 3;

Fig. 7 shows the structural diagram of the polypeptide conformation angle provided in Example 4.

Detailed ways

The core of the utility model is to provide a model teaching aid for displaying the conformation angle structure of the polypeptide main chain.

In order to enable those skilled in the art to better understand the solution of the utility model, the utility model will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

The utility model provides a model teaching aid for the conformation angle of the polypeptide main chain, including a sphere structure representing an atom (see Figure 1 (A)) and a stick structure representing a chemical bond (see Figure 1 (B)); the sphere structure (A) and The stick structure (B) is detachably connected. According to the different sizes of atoms, design 4 kinds of plastic spheres of different sizes, representing carbon atoms, nitrogen atoms, oxygen atoms and hydrogen atoms respectively, and the angles of the chemical bonds connected by atoms on the spheres and at the two ends of the sticks are different. Disconnect the connection. Different sphere structures are marked with different element symbols, C stands for carbon atom, N stands for nitrogen atom, O stands for oxygen atom, H stands for hydrogen atom; 1-8 in Fig. The number of detachable connections between the sphere structure and the stick structure can be determined according to specific conditions, at least one, can be 1, 2 or 3, and any situation that meets the actual value of the bond is within the scope of protection of the present utility model As long as it meets the actual teaching needs. The detachable connections between different stick structures and different atoms may or may not be the same. The matching hooks and slots here can be provided in multiples at different positions, and the shape of the hooks and the depth of the slots can be specifically designed, and will not be repeated here.

In some embodiments of the present invention, the detachable connection is a screw connection or a snap connection.

Specifically, the buckle connection is a hook-and-slot connection, and the sphere structure (A) and the stick structure (B) are respectively provided with hooks 9 and slots 1-8 that cooperate with each other.

Specifically, the sphere structure (A) is provided with hooks 1-8, and the stick structure (B) is provided with hooks 9, and the slots 1-8 cooperate with the hooks 9.

Specifically, the threaded connection is that the end of the stick structure (B) is provided with a threaded hole, and the ball structure (A) is provided with a through hole corresponding to the threaded hole, and the bolt is inserted into the through hole and can be tightened with the threaded hole.

Specifically, please refer to Figure 1, which shows the structural diagrams of different components. Figure 1 (B) shows the stick structure representing chemical bonds; Figure 1 (A) shows the sphere structure representing atoms, which is the cross-section of the sphere (through the Center), the balls representing different atoms have different sizes, among which there are three grooves on the C atom and the N atom, and the distance between each groove is designed according to the angle of the chemical bond connecting the C atom and the N atom, and the O atom and the H atom There is only one groove in the atom.

Four sticks of different lengths are designed according to the size of the chemical bonds connecting different atoms, showing the size ratio of the chemical bonds connecting different atoms, and the size ratio of different atomic diameters. Figure 2 shows the ratio of different components.

Atoms are connected together with sticks according to the composition of peptide planes, and two peptide planes are connected together through adjacent Cα to form two adjacent peptide planes. The Cα connecting two peptide planes is connected to N (nitrogen atom) on one side and C (carbon atom) on the other side, and the two connections are designed to be rotatable. Rotate the bond between Cα and N, that is Angle, or rotate the bond between Cα and C, that is, the ψ angle, you can obtain different models of the conformational angle of the polypeptide main chain.

In some embodiments of the present invention, the polypeptide main chain includes at least 1 peptide plane; in other embodiments of the present invention, the polypeptide main chain includes at least 2 peptide planes.

The structure of a peptide plane is shown in Figure 3. Specifically, in Figure 3, N and C are first connected together to form a peptide bond, then one H and one Cα are connected on N, and one O and another Cα are connected on C, and O and H are respectively placed on the peptide On both sides of the bond, the angles between the chemical bonds of the three atoms connected by N on the peptide bond are: N-C and N-Cα are 122°, N-Cα and N-H are 118°, N-H and N-C are 120°; The angles between the chemical bonds of the three atoms connected by C are: C-Cα and C-O are 120.5°, C-O and C-N are 123.5°, and C-N and C-Cα are 116°. All 6 atoms are in one plane with chemical bonds.

Specifically, in FIG. 4 , two peptide planes A and B are connected together by Cα2 on the peptide plane. C2-Cα2-N1-C1 forms a dihedral angle, and the dihedral angle rotated around Cα2-N1 is N1-Cα2-C2--N2 forms a dihedral angle, and the dihedral angle rotated around Cα2-C2 is ψ. Depend on and ψ constitute a conformational angle, which specifies the conformation of two adjacent peptide planes. Rotate Cα2-N1 and Cα2-C2 so that O1 on the A plane is close to H2 on the B plane, and the two peptide planes A and B are on the same plane. At this time, the conformation angle ψ=0.

Specifically, in the embodiment shown in FIG. 5, on the basis of the example in FIG. 4, the Cα2-N1 and Cα2-C2 chemical bonds are rotated clockwise by 180°, and the conformational angle is now ψ = 180°.

Specifically, in the embodiment shown in Figure 6, on the basis of the example in Figure 4, the Cα2-C2 chemical bond is rotated clockwise by 180°, and the conformational angle is now ψ = 180°.

Specifically, in the embodiment shown in Figure 7, on the basis of the example in Figure 4, the Cα2-N1 chemical bond is rotated clockwise by 180°, and the conformational angle is now ψ=0°.

By rotating Cα2-N1 and Cα2-C2, structural forms with different conformational angles can be displayed.

In the preferred scheme of the present utility model, according to the different sizes of atoms, design 4 kinds of plastic spheres of different sizes, representing carbon atoms, nitrogen atoms, oxygen atoms and hydrogen atoms respectively, and the angles of the chemical bonds connected by atoms on the spheres Differently, grooves are prepared. Four sticks of different lengths are designed according to the size of the chemical bonds connected between different atoms, and the two ends of the sticks have structures inserted into the grooves in the ball. Use sticks to connect these atoms together according to the composition of peptide planes, and then connect two peptide planes through adjacent Cα (alpha carbon atoms) to form two adjacent peptide planes. The Cα connecting two peptide planes is connected to N (nitrogen atom) on one side and C (carbon atom) on the other side, and the two connections are designed to be rotatable. Rotate the bond between Cα and N, that is Angle, or rotate the bond between Cα and C, that is, the ψ angle, you can obtain different models of the conformational angle of the polypeptide main chain. The assembly and demonstration of the model teaching aid for the conformation angle of the main chain of the polypeptide is simple, fast and flexible, and the disassembled model is easy to carry.

A model teaching aid for displaying the conformational angle structure of the polypeptide main chain provided by the utility model has been introduced in detail above. In this paper, specific examples have been used to illustrate the principle and implementation of the utility model. The description of the above examples It is only used to help understand the method of the present utility model and its core idea. It should be pointed out that for those of ordinary skill in the art, without departing from the principle of the utility model, some improvements and modifications can also be made to the utility model, and these improvements and modifications also fall into the protection of the claims of the utility model. within range.

Claims (3)

1. A model teaching aid for the conformation angle of a polypeptide main chain, characterized in that it comprises a sphere structure representing an atom and a stick structure representing a chemical bond; the sphere structure is detachably connected to the stick structure; According to the different sizes of atoms, design 4 kinds of spheres of different sizes, representing carbon atoms, nitrogen atoms, oxygen atoms and hydrogen atoms respectively, and prepare grooves on the spheres according to the angles of the chemical bonds connected by atoms; The size of the chemical bonds connected between them is designed with four different lengths of sticks, The polypeptide main chain includes at least 1 peptide plane; the structure of a peptide plane is: connect N and C together to form a peptide bond, then connect an H and a Ca on the N, and connect an O and another on the C A Cα, O and H are respectively placed on both sides of the peptide bond, and the angles between the three atom chemical bonds connected by N on the peptide bond are: NC and N-Cα are 122 ⁰ , N-Cα and NH are 118 ⁰ , NH and NC are 120 ⁰ ; the angles between the chemical bonds of the three atoms connected by C on the peptide bond are: C-Cα and CO are 120.5 ⁰ , CO and CN are 123.5 ⁰ , CN and C-Cα are 116 ⁰ ; Two adjacent peptide planes are connected by α carbon atoms, and the two adjacent peptide planes can be rotated relative to each other; rotating the connecting bond between Cα and N is the φ angle, or rotating the connecting bond between Cα and C , which is the ψ angle, to obtain models of different polypeptide main chain conformation angles. 2. The model teaching aid according to claim 1, wherein the detachable connection is a buckle connection, and the buckle connection is a hook slot connection, and the sphere structure and the stick structure are respectively provided with A hook and a slot cooperating with each other; the sphere structure is provided with a slot, the stick structure is provided with a hook, and the slot and the hook cooperate with each other. 3. The model teaching aid according to claim 1, wherein the detachable connection is a threaded connection, and the threaded connection is provided with a threaded hole at the end of the stick structure, and the spherical structure is provided with a A through hole corresponding to the threaded hole, the bolt is inserted into the through hole and can be screwed tightly with the threaded hole.