CN204318763U - A kind of checkout gear based near infrared detection human body biochemical parameter - Google Patents
A kind of checkout gear based near infrared detection human body biochemical parameter Download PDFInfo
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- CN204318763U CN204318763U CN201420671683.9U CN201420671683U CN204318763U CN 204318763 U CN204318763 U CN 204318763U CN 201420671683 U CN201420671683 U CN 201420671683U CN 204318763 U CN204318763 U CN 204318763U
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- 239000000126 substance Substances 0.000 claims description 3
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 14
- 239000008280 blood Substances 0.000 description 14
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- 238000013528 artificial neural network Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000000862 absorption spectrum Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
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- 159000000007 calcium salts Chemical class 0.000 description 2
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- 240000001624 Espostoa lanata Species 0.000 description 1
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- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
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- 150000002304 glucoses Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
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- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The utility model discloses a kind of checkout gear based near infrared detection human body biochemical parameter.Utilize wave filter to realize adaptive filtering and the modulation to light intensity to optical source wavelength, it is eliminated by frequency spectrum algorithm/genetic algorithm by final signal from detection signal, obtains the detection signal that signal to noise ratio is higher; Wherein reference light pond also comprises at least one standard reference concentration, carries out real time calibration to dynamic disturbance.This checkout gear, comprises light source, wave filter, long light path reflecting mirror and detector; Detected part is arranged in the space that long light path reflecting mirror is formed, and wherein light source sends light device, long light path reflecting mirror arrival detector after filtering.This utility model is mainly used in the fields such as biomedical detection, environment measuring, food inspection, safety monitoring, medicine detection.
Description
Technical field
This utility model relates to biochemistry detection field, is specifically related to but is not limited to the functions such as light source process, light source filtering, the process of absorption light path, detection detect in the noinvasive biochemical parameter of one.
Background technology
In domestic biochemistry detection, especially blood sugar test, vitro detection is carried out in main employing blood sampling at present, is the main flow instrument analyzing blood glucose for a long time.But these samplings bring the pain of examinee, and there is the risk of cross infection, need, for consumptive material pays high expense, to become the financial resources of examinee, psychological burden simultaneously.
Current more and more urgent requirement is proposed to Non-invasive detection and accuracy thereof, owing to detecting noinvasive, fast, consumptive material is few, expense is low, sampling etc. is simple to operate, and the portable non-invasive biochemistry detection occasion that requirement of real-time is high at the scene will play an increasingly important role.But the common index that current noinvasive domestic biochemistry detection instrument can detect is only limitted to the indexs such as blood pressure/blood oxygen/heart rate, and (index such as blood pressure, heart rate is obviously beneficial to detection because of the mechanical vibration of pulse, blood oxygen mainly has remarkable absorption in HONGGUANG and near infrared light, organize body fluid at this, wave band to absorb more weak simultaneously, and easily make light pass through, seem that " transparent " also achieves Non-Destructive Testing), the detection by quantitative of the indexs such as Woundless blood sugar/blood fat can't be realized.Reason has several aspect: blood glucose/blood fat absorbs weak, and signal intensity is inadequate; Their feature light wave is also easily absorbed by water/tissue/bone bone/skin and attachment/perspiration etc. thereof and is easily interfered in addition.
Utility model content
In order to overcome the deficiencies in the prior art, the purpose of this utility model is to provide a kind of checkout gear based near infrared detection human body biochemical parameter and method.
Based on a checkout gear near infrared detection human body biochemical parameter, comprise light source, wave filter, long light path reflecting mirror and detector; Detected part is arranged in the space that long light path reflecting mirror is formed, and wherein light source sends light device, long light path reflecting mirror arrival detector after filtering.
The wavelength that described light source comprises is 600nm-2500nm.
Described light source is or array of source, lens, or array of source, lens combination.
Described wave filter comprises light filter shell, detects light pond, reference light pond, and wherein the filter center wavelength of light filter shell is the sensitive wave length of tested substance.
Described reference light pond comprises the mixture of reference measured matter and apery body body fluid components, and described detection light pond comprises the mixture of apery body body fluid components.
Described space is to hold the structure that fixing human detects position.
Described detected part comprises ear-lobe, finger, hands palm or phalanx web, arm, wrist, lip or tongue.
Described space comprises one group of reflecting mirror, and being used for increases light path.
Described detector is near infrared sensor or near-infrared photographic head.
This utility model noinvasive, quantitatively, fast, consumptive material is few, expense is low, simple to operate, be mainly used in the fields such as biomedical detection, environment measuring, food inspection, safety monitoring, medicine detection, there is market prospect.
Accompanying drawing explanation
Fig. 1 is the index path of the calibrating installation that this utility model noinvasive biochemical parameter detects;
Fig. 2 is the structure of the light filter schematic diagram of the calibrating installation that this utility model noinvasive biochemical parameter detects;
In figure, light source 1, light filter 2, light filter shell 21, detection light pond 22, reference light pond 23, long light path reflecting mirror 3, detector 4.
Detailed description of the invention
Below in conjunction with accompanying drawing, this utility model is described further.
Fig. 1 shows work model figure.Multiple wavelength light that light source 1 sends, by after material absorbing wherein in light filter 2, then through tested person soma, produce and absorb.Filter in light filter pond difference, then absorbed wavelength amplitude is different, by the signal level of detector, sets up the information between measured matter concentration, each wavelength or optical filtering pond, set up mapping matrix.By fft algorithm, method of least square and neural network algorithm compute matrix constant.Set up equation as follows:
First, optical absorption obeys Beer-Lambert formula, as formula (1):
(1)
Wherein, I
0for initial beam intensity, I is the light intensity after material absorbing, and α is the absorptance of material, and C is the concentration of material, and L is for absorbing light path.
Under human body complex material environment, and there is the overlapping material of absworption peak, objectively produce multiple absorption, then Beer-Lambert formula is just deformed into formula (2):
（2）
Available A represents absorbance, A=
.
The material concentration of different ratio is configured in optical filtering pond, then light is often just corresponding through an optical filtering pond occurs once as the absorption of formula (2), in theory, when there are several similar optical filtering ponds, then to several absorptions as (2) should be had to form equation group, by matrix notation as formula (3):
（3）
Absorbing wavelength containing measured matter in light source 1, light source 1 can be made up of the lamp source of many phase co-wavelengths, also can be the lamp source composition of multiple different wave length.The wavelength of light source 1 is the combination of one or several wavelength between 600nm ~ 2500nm.Light source 1 can be the combination of several light sources, also can increase lens or collimating mirror, improves encircled energy.Wherein the light of at least one wavelength is in measured matter absorption spectrum.Light at least containing a wavelength is not in the absorption spectrum of measured matter.Light source 1 can in the typical apply situation of each field, and brightness able to programme or switching frequency carry out light modulation.
As shown in Figure 2, light filter shell 21 is made by having high near-infrared permeable material, and material can be optical quartz, optical glass, polystyrene etc.
As shown in Figure 2, solid, liquid even gas can be loaded in described light filter 2.Light filter 2 has fixed volume, the stable components of material in it, and composition comprises the mixture of more than one compositions following: normal saline, saccharide, lipid, potassium salt, calcium salt, protein, blood lead, ferrum and stabilizing agent.Light filter 2 is made up of at least two optical filtering ponds, can make square plate or disk loose structure, every Kong Weiyi optical filtering pond.Have one in reference light pond 23 containing measured matter, its content is known; Detect in light pond 22 not containing measured matter.All the other materials configure according to the background of sample.
Detector 1 can be photodiode, imageing sensor, photographic head, photomultiplier tube.By modulating light source, through carrying out demodulation to detector signal, the impact of bias light and dark current can be eliminated by signal differential algorithm, improving to-noise ratio.After filtering behind device two kinds of optical filtering ponds, light is absorbed by measured matter in human body further, and acquired signal and concentration form mapping matrix, and obtains concentration calibration model through neural network algorithm.
embodiment 1
Below to detect blood glucose, this utility model is described.
The wavelength that in this utility model, light source 1 is launched contains at least one wavelength in 714 ± 20nm, 939 ± 20nm, 1126 ± 20nm, 1408 ± 20nm, 1536 ± 50nm, 1688 ± 50nm, 2261 ± 20nm, 2326 ± 20nm.If the energy of interference wavelength is comparatively strong, optical filter can be selected to suppress interference wavelength.
As shown in Figure 1, 2, light filter 2 has two optical filtering ponds at least, and an optical filtering pond and reference light pond 23 are containing glucose, and light pond 22 is detected not containing glucose in another optical filtering pond namely.Other composition of optical filtering pond consists of the following composition: normal saline, lipid, potassium salt, calcium salt, fibrin, collagen protein etc.
Light after light filter 2 again through tested position.Tested position can be finger, refer to the positions such as web, palm, wrist, arm, ear-lobe, lip.Adopt cotton ball soaked in alcohol cleaning-sterilizing in measuring point before measurement, after air-dry, put into measuring position.
When light is through the optical filtering pond containing glucose, gained absorbance equation is as formula (2); When light is through the optical filtering pond not containing glucose, gained absorbance equation, than the absorption of aforementioned equation one item missing glucose, can try to achieve the glucose under conditions present by difference, and then obtains the absorptance of blood glucose or glucose.
Tested position gained absorbance equation after light of blood sugar concentration the unknown, than the characteristic absorption containing more absorption glucoses in glucose, extrapolates the blood sugar concentration at tested position according to neural network algorithm and current absorptance.
If its absorptance of wavelength selected is large not, then can increases and absorb light path to increase absorbance, as shown in Figure 1.Long light path reflecting mirror 3 can use the materials such as aluminum, copper, silver, gold or platinum to make reflecting surface.The surface configuration of reflecting surface is just in time mated with the profile at tested position, excellently goodly selects condenser mirror, to converge energy.
As shown in Figure 1, the photodiode, imageing sensor, photomultiplier tube etc. of infrared-sensitive selected by detector 4.
Light source is modulated, again demodulation is carried out to detection light according to modulation signal, the signal of more high s/n ratio can be obtained.
By fft algorithm by regular signal extractions such as blood pressures out, blood pressure, heart rate information can be obtained.These signals are distinguished from blood sugar test signal, blood sugar test signal to noise ratio can be improved further.
Increase the optical filtering pond of standard glucose concentration at light filter, as shown in reference light pond 23 in Fig. 2, multiple spot calibration can be carried out to detection system and check.
In such as Fig. 2, detect substance and measured object in light pond 22 and absorbs the material had nothing to do, then can calibrate the optical absorption coefficient at the tested position of human body in real time, raising detecting reliability.
embodiment 2
Except glucose, also have the indexs such as cholesterol/triglyceride also can apply method described in this device and detect.Be that solution in reference light pond comprises the measured matter of normal concentration and light source needs to launch its characteristic light with case study on implementation 1 difference.
Claims (9)
1. based on a checkout gear near infrared detection human body biochemical parameter, it is characterized in that: comprise light source, wave filter, long light path reflecting mirror and detector; Detected part is arranged in the space that long light path reflecting mirror is formed, and wherein light source sends light device, long light path reflecting mirror arrival detector after filtering.
2. device according to claim 1, is characterized in that: the wavelength that described light source comprises is 600nm-2500nm.
3. device according to claim 1, is characterized in that: described light source is array of source, lens, or array of source, lens combination.
4. device according to claim 1, is characterized in that: described wave filter comprises light filter shell, detects light pond, reference light pond, and wherein the filter center wavelength of light filter shell is the sensitive wave length of tested substance.
5. device according to claim 4, is characterized in that: described reference light pond comprises the mixture of reference measured matter and apery body body fluid components, and described detection light pond comprises the mixture of apery body body fluid components.
6. device according to claim 1, is characterized in that: described space is to hold the structure that fixing human detects position.
7. device according to claim 1, is characterized in that: described detected part comprises ear-lobe, finger, hands palm or phalanx web, arm, wrist, lip or tongue.
8. device according to claim 6, is characterized in that: described space comprises one group of reflecting mirror, and being used for increases light path.
9. device according to claim 1, is characterized in that: described detector is near infrared sensor or near-infrared photographic head.
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| CN201420671683.9U CN204318763U (en) | 2014-11-12 | 2014-11-12 | A kind of checkout gear based near infrared detection human body biochemical parameter |
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| CN201420671683.9U CN204318763U (en) | 2014-11-12 | 2014-11-12 | A kind of checkout gear based near infrared detection human body biochemical parameter |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367327A (en) * | 2014-11-12 | 2015-02-25 | 杭州欣安医疗科技有限公司 | Detecting device and method for detecting human body biochemical parameters based on near-infrared rays |
| CN107440684A (en) * | 2016-05-09 | 2017-12-08 | 三星电子株式会社 | Method and apparatus for the concentration of forecast analysis thing |
| CN111436948A (en) * | 2019-04-28 | 2020-07-24 | 上海爱德赞医疗科技有限公司 | Non-invasive method and equipment for monitoring blood component concentration of human body |
-
2014
- 2014-11-12 CN CN201420671683.9U patent/CN204318763U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367327A (en) * | 2014-11-12 | 2015-02-25 | 杭州欣安医疗科技有限公司 | Detecting device and method for detecting human body biochemical parameters based on near-infrared rays |
| CN107440684A (en) * | 2016-05-09 | 2017-12-08 | 三星电子株式会社 | Method and apparatus for the concentration of forecast analysis thing |
| CN107440684B (en) * | 2016-05-09 | 2022-08-23 | 三星电子株式会社 | Method and apparatus for predicting the concentration of an analyte |
| CN111436948A (en) * | 2019-04-28 | 2020-07-24 | 上海爱德赞医疗科技有限公司 | Non-invasive method and equipment for monitoring blood component concentration of human body |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
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Granted publication date: 20150513 Termination date: 20161112 |