CN204116295U - A kind of chromatographic analyzer of liquid phase static mixer - Google Patents
A kind of chromatographic analyzer of liquid phase static mixer Download PDFInfo
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- CN204116295U CN204116295U CN201420622178.5U CN201420622178U CN204116295U CN 204116295 U CN204116295 U CN 204116295U CN 201420622178 U CN201420622178 U CN 201420622178U CN 204116295 U CN204116295 U CN 204116295U
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- 230000003068 static effect Effects 0.000 title claims abstract description 41
- 239000007791 liquid phase Substances 0.000 title abstract 2
- 239000002245 particle Substances 0.000 claims abstract description 26
- 238000001179 sorption measurement Methods 0.000 claims abstract description 26
- 239000000945 filler Substances 0.000 claims description 26
- 238000004811 liquid chromatography Methods 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 6
- MCMNRKCIXSYSNV-UHFFFAOYSA-N ZrO2 Inorganic materials O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 claims description 5
- 239000000741 silica gel Substances 0.000 claims description 5
- 229910002027 silica gel Inorganic materials 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 238000012856 packing Methods 0.000 claims description 4
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 239000003365 glass fiber Substances 0.000 claims description 3
- 125000005647 linker group Chemical group 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 239000003456 ion exchange resin Substances 0.000 claims description 2
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 claims 1
- 238000010828 elution Methods 0.000 abstract description 3
- 238000000746 purification Methods 0.000 abstract description 2
- 230000000903 blocking effect Effects 0.000 abstract 1
- 239000012071 phase Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 4
- 239000000243 solution Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 239000005416 organic matter Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
Description
技术领域technical field
本实用新型属于静态混合器领域，具体涉及一种液相色谱分析仪用静态混合器。The utility model belongs to the field of static mixers, in particular to a static mixer for liquid chromatography analyzers.
背景技术Background technique
色谱应用中通常需要用到两种或两种以上不同的溶液，因此在泵与色谱柱之间加入静态混合器增加流体的混匀效果。现有技术中的静态混合器如图1所示，包括外管(1)，设置在外管两端的法兰(2)和设置在外管内的多个扰流单元板(3)；或者如图2所示，包括外管(1)和设置在外管内通过连接杆(4)连接的多个扰流单元板(3)。此类静态混合器空腔体积(死体积)大，为了达到较好的分析效果，一般应尽量减少静态混合器中的死体积。Chromatographic applications usually require two or more different solutions, so a static mixer is added between the pump and the chromatographic column to increase the mixing effect of the fluid. Static mixer in the prior art as shown in Figure 1, comprises outer pipe (1), is arranged on the flange (2) of outer pipe two ends and is arranged on a plurality of turbulence unit plates (3) in outer pipe; Or as Fig. 2 As shown, it includes an outer tube (1) and a plurality of spoiler unit plates (3) arranged in the outer tube and connected by connecting rods (4). This type of static mixer has a large cavity volume (dead volume). In order to achieve better analysis results, the dead volume in the static mixer should generally be reduced as much as possible.
另外流动相或流动相的通管路中常含有不需要的有机物、离子等杂质，因此色谱应用中在泵与色谱柱之间加入净化器进行流动相预处理，所述净化器内通常填充有对有机物、离子有吸附能力的颗粒，但静态混匀器与净化器的内腔体积(死体积)均会影响色谱梯度洗脱的延迟时间，从而影响分析性能；当串联静态混匀器与净化器使用时，需要更多的接头与管线连接，因此死体积更大；并且串联使用也会增加仪器的故障率；且制造成本高。还有所述净化器由颗粒性物质填充，由于颗粒大小并不完全一致，因此使用一段时间后，小颗粒逐渐重排，把净化器里面的缝隙堵住，从而导致净化器压力过高而无法使用。In addition, the mobile phase or the pipeline of the mobile phase often contains unwanted organic substances, ions and other impurities. Therefore, in chromatographic applications, a purifier is added between the pump and the chromatographic column for pretreatment of the mobile phase. The purifier is usually filled with Particles with adsorption capacity for organic matter and ions, but the inner cavity volume (dead volume) of the static mixer and the purifier will affect the delay time of the chromatographic gradient elution, thereby affecting the analytical performance; when the static mixer and the purifier are connected in series When used, more joints are needed to be connected with pipelines, so the dead volume is larger; and the use in series will also increase the failure rate of the instrument; and the manufacturing cost is high. In addition, the purifier is filled with granular substances. Since the particle sizes are not exactly the same, after a period of use, the small particles will gradually rearrange and block the gaps in the purifier, resulting in excessive pressure in the purifier. use.
实用新型内容Utility model content
针对现有技术中的不足，本实用新型旨在提供一种液相色谱分析仪用静态混合器，填充物占据混合器的部分空间，从而减少死体积，提高梯度洗脱的性能，同时可以在线净化流动相，预防色谱柱的堵塞与污染。Aiming at the deficiencies in the prior art, the utility model aims to provide a static mixer for a liquid chromatography analyzer. The filler occupies part of the space of the mixer, thereby reducing the dead volume and improving the performance of gradient elution. Purify the mobile phase to prevent clogging and contamination of the chromatographic column.
为实现上述目的，本实用新型的技术方案是：In order to achieve the above object, the technical solution of the utility model is:
一种液相色谱分析仪用静态混合器，包括外管和置于外管内的多个扰流单元板，在扰流单元板的两侧设置有筛板，并在扰流单元板和外管管壁之间的空腔内填充有吸附填料，且所述吸附填料的粒径大于所述筛板的孔径。A static mixer for a liquid chromatography analyzer, comprising an outer tube and a plurality of turbulence unit plates placed in the outer tube, sieve plates are arranged on both sides of the turbulence unit plate, and the turbulence unit plate and the outer tube The cavities between the pipe walls are filled with adsorption fillers, and the particle size of the adsorption fillers is larger than the pore diameter of the sieve plate.
所述吸附填料的平均粒径为1μm-500μm，更优选3微米-300微米。The average particle diameter of the adsorption filler is 1 μm-500 μm, more preferably 3 μm-300 μm.
所述吸附填料优选选自硅胶及硅胶键合基团颗粒、二氧化锆颗粒、高分子聚合物颗粒、石墨化碳颗粒及二氧化锆键合基团颗粒、离子交换树脂颗粒中的一种或几种。The adsorption filler is preferably selected from one or more of silica gel and silica gel bonding group particles, zirconia particles, polymer particles, graphitized carbon particles, zirconia bonding group particles, and ion exchange resin particles. Several kinds.
筛板的材料优选选自烧结不锈钢、玻纤滤纸、大分子多孔材料中的任意一种。The material of the sieve plate is preferably selected from any one of sintered stainless steel, glass fiber filter paper, and macromolecular porous materials.
所述多个扰流单元板之间优选设有用于连接扰流单元板的连接杆。A connecting rod for connecting the turbulence unit plates is preferably provided between the plurality of turbulence unit plates.
所述筛板的厚度小于5mm。The thickness of the sieve plate is less than 5mm.
下面对本实用新型做进一步的解释和说明：The utility model is further explained and illustrated below:
本实用新型用吸附填料紧密填充扰流器与管壁之间的缝隙，因为内充的填料占据管内空间，从而使混匀器内部体积比常规的混匀器更小；在扰流单元板间加入筛板，使吸附填料也被分成数层，不同层间的吸附填料颗粒不能发生重排与堆积，避免填料间的缝隙被堵塞，从而使内充填料保持畅通，防止管道堵塞；流体流过扰流器时，发生剪切、涡流、回旋等效应，实现混匀目的；致密的吸附填料可以阻挡流体中的不溶性颗粒，同时吸附填料可以根据填料吸附性能吸附流体中的有机物、离子等杂质，因此形成净化效果。The utility model tightly fills the gap between the spoiler and the pipe wall with the adsorption filler, because the filled filler occupies the space in the pipe, so that the internal volume of the mixer is smaller than that of the conventional mixer; between the spoiler unit plates The sieve plate is added to divide the adsorption filler into several layers. The adsorption filler particles between different layers cannot be rearranged and accumulated, so as to avoid the gap between the fillers from being blocked, so as to keep the inner filling smooth and prevent the pipeline from clogging; the fluid flows through When using a spoiler, effects such as shearing, vortex, and gyration occur to achieve the purpose of mixing; the dense adsorption filler can block insoluble particles in the fluid, and at the same time, the adsorption filler can absorb organic matter, ions and other impurities in the fluid according to the adsorption performance of the filler. Thus a purifying effect is formed.
扰流单元板的结构可以多种多样，圆形，半圆形，螺旋状或者其它不规则形状均可，如图4-5所示。The structure of the turbulence unit plate can be various, such as circular, semicircular, spiral or other irregular shapes, as shown in Fig. 4-5.
外管的截面形状可以使圆形、方形、或者其它不规则形状。The cross-sectional shape of the outer tube can be circular, square, or other irregular shapes.
吸附填料的颗粒可以为球形或者其它形状。The particles of the adsorptive filler can be spherical or other shapes.
与现有技术相比，本实用新型的优势是：Compared with the prior art, the utility model has the advantages of:
1、本实用新型的静态混合器在同一装置同时具备混匀与净化功能，减少安装复杂程度及安装材料。1. The static mixer of the present invention has both mixing and purification functions in the same device, which reduces the complexity of installation and installation materials.
2、本实用新型的静态混合器中吸附填料占据扰流器与管壁的空间，有效减少空腔死体积，提高色谱系统性能，以岛津公司的混匀器空腔体积为2.7mL的静态混合器为例，若填充吸附填料后，死体积可以降到0.6mL以下。2. In the static mixer of the present utility model, the adsorption filler occupies the space between the spoiler and the tube wall, effectively reduces the dead volume of the cavity, and improves the performance of the chromatographic system. The static mixer with a cavity volume of 2.7mL of Shimadzu Corporation Take the mixer as an example, if it is filled with adsorption filler, the dead volume can be reduced to below 0.6mL.
3、本实用新型的静态混合器具有多层结构，可以防止内充吸附填料的重排与堆积，从而使内充填料保持畅通，防止管道堵塞。3. The static mixer of the utility model has a multi-layer structure, which can prevent the rearrangement and accumulation of the inner filling material, so as to keep the inner filling material unimpeded and prevent pipeline blockage.
4、本实用新型的静态混合器中细径吸附填料可以增加流体的接触表面积，有助于提高混匀效果。4. The fine-diameter adsorption filler in the static mixer of the present invention can increase the contact surface area of the fluid and help to improve the mixing effect.
附图说明Description of drawings
图1是现有技术中一种静态混合器的结构示意图；Fig. 1 is the structural representation of a kind of static mixer in the prior art;
图2是现有技术中另一种静态混合器的内部结构示意图；Fig. 2 is the internal structural representation of another kind of static mixer in the prior art;
图3是本实用新型的一种液相色谱分析仪用静态混合器的内部结构示意图；Fig. 3 is a schematic diagram of the internal structure of a static mixer for a liquid chromatography analyzer of the present invention;
图4是扰流单元板的一种结构示意图；Fig. 4 is a kind of structural representation of spoiler unit plate;
图5是扰流单元板的另一种结构示意图；Fig. 5 is another structural schematic view of the spoiler unit plate;
其中，1是外管，2是法兰，3是扰流单元板，4是连接杆，5是筛板，6是吸附填料。Among them, 1 is the outer pipe, 2 is the flange, 3 is the spoiler unit plate, 4 is the connecting rod, 5 is the sieve plate, and 6 is the adsorption packing.
具体实施方式Detailed ways
下面结合附图和实施例对本实用新型做进一步的说明。Below in conjunction with accompanying drawing and embodiment the utility model is described further.
如图3所示，一种液相色谱分析仪用静态混合器，包括外管1和置于外管内的可通过连接杆4连接的多个扰流单元板3，在相邻两扰流单元板3之间或者在扰流单元板3的两侧设置有筛板5，并使用平均粒度10μm的阳离子交换树脂吸附填料6填充外管1内的空腔。所述吸附填料的粒径大于所述筛板的孔径。As shown in Figure 3, a static mixer for a liquid chromatography analyzer includes an outer tube 1 and a plurality of turbulence unit plates 3 that can be connected by connecting rods 4 placed in the outer tube, and two adjacent turbulence units A sieve plate 5 is arranged between the plates 3 or on both sides of the turbulence unit plate 3, and the cavity in the outer tube 1 is filled with cation exchange resin adsorption packing 6 with an average particle size of 10 μm. The particle size of the adsorption filler is larger than the pore size of the sieve plate.
所述吸附填料6也可以为硅胶、离子树脂、石墨化碳、高分子聚合物材料中的一种或几种。The adsorption filler 6 can also be one or more of silica gel, ion resin, graphitized carbon, and high molecular polymer materials.
所述筛板5的材料选自烧结不锈钢、玻纤滤纸、大分子多孔材料中的任意一种。The material of the sieve plate 5 is selected from any one of sintered stainless steel, glass fiber filter paper, and macromolecular porous materials.
效果数据：Effect data:
选取3种不同内体积的常规静态混合器，用氮气排空内部溶液，称重得重量W1，往内部注入蒸馏水溶液后，待充满后称重得重量W2，静态混合器内部体积可通过V＝(W2-W1)/ρ(ρ为蒸馏水的密度)计算得到。Choose 3 kinds of conventional static mixers with different internal volumes, empty the internal solution with nitrogen, weigh to get the weight W1, inject the distilled aqueous solution into the inside, and weigh it to get the weight W2 after being filled, the internal volume of the static mixer can be obtained by V= (W2-W1)/ρ (ρ is the density of distilled water) is calculated.
采用本实用新型原理，在上述静态混合器中内充ODP‐4H吸附填料，同理测定内部体积，结果见表1，说明本实用新型可以有效减少静态混合器内部死体积。Using the principle of the utility model, the above-mentioned static mixer is filled with ODP-4H adsorption filler, and the internal volume is measured in the same way. The results are shown in Table 1, which shows that the utility model can effectively reduce the internal dead volume of the static mixer.
Claims (7)
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104280488A (en) * | 2014-10-24 | 2015-01-14 | 王峰 | Static mixer for liquid chromatographic analyzer |
| US11185830B2 (en) | 2017-09-06 | 2021-11-30 | Waters Technologies Corporation | Fluid mixer |
| US11555805B2 (en) | 2019-08-12 | 2023-01-17 | Waters Technologies Corporation | Mixer for chromatography system |
| US11821882B2 (en) | 2020-09-22 | 2023-11-21 | Waters Technologies Corporation | Continuous flow mixer |
| US11898999B2 (en) | 2020-07-07 | 2024-02-13 | Waters Technologies Corporation | Mixer for liquid chromatography |
| US11988647B2 (en) | 2020-07-07 | 2024-05-21 | Waters Technologies Corporation | Combination mixer arrangement for noise reduction in liquid chromatography |
-
2014
- 2014-10-24 CN CN201420622178.5U patent/CN204116295U/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104280488A (en) * | 2014-10-24 | 2015-01-14 | 王峰 | Static mixer for liquid chromatographic analyzer |
| US11185830B2 (en) | 2017-09-06 | 2021-11-30 | Waters Technologies Corporation | Fluid mixer |
| US11555805B2 (en) | 2019-08-12 | 2023-01-17 | Waters Technologies Corporation | Mixer for chromatography system |
| US12352733B2 (en) | 2019-08-12 | 2025-07-08 | Waters Technologies Corporation | Mixer for chromatography system |
| US11898999B2 (en) | 2020-07-07 | 2024-02-13 | Waters Technologies Corporation | Mixer for liquid chromatography |
| US11988647B2 (en) | 2020-07-07 | 2024-05-21 | Waters Technologies Corporation | Combination mixer arrangement for noise reduction in liquid chromatography |
| US11821882B2 (en) | 2020-09-22 | 2023-11-21 | Waters Technologies Corporation | Continuous flow mixer |
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