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CN203838156U - Quick diagnosis test system integrated with image sensing system and embedded system - Google Patents

Quick diagnosis test system integrated with image sensing system and embedded system Download PDF

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Publication number
CN203838156U
CN203838156U CN201320815438.6U CN201320815438U CN203838156U CN 203838156 U CN203838156 U CN 203838156U CN 201320815438 U CN201320815438 U CN 201320815438U CN 203838156 U CN203838156 U CN 203838156U
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unit
embedded
image sensing
embedded system
gold
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CN201320815438.6U
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Inventor
李建国
李�浩
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Shanghai Jie Hao Scientific Instrument Co Ltd
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Shanghai Jie Hao Scientific Instrument Co Ltd
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Abstract

The utility model provides a quick diagnosis test system integrated with an image sensing system and an embedded system. The quick diagnosis test system comprises a gold-labeled numerical reading instrument module and the embedded system, wherein the gold-labeled numerical reading instrument module at least comprises a clamping slot part and an image picking unit; the clamping slot part is fixed in a shell and used for locating immune paper strips to be detected; the image picking unit is arranged relative to the clamping slot part and equipped with a wide-angle macro lens, a light filter, a light source part arranged relative to the clamping slot part and a display unit; the embedded system comprises an embedded processing unit, a storage unit, an interface unit and a power supply unit; the embedded processing unit is connected to the light source part, the image picking unit and the display unit and fixed in the shell; the storage unit is connected to the embedded processing unit; the interface unit is connected to the embedded processing unit; the power supply unit is connected to the embedded processing unit. The quick diagnosis test system is complete in functions, small in volume and light in weight and can be intuitively and conveniently used in laboratories or detection fields.

Description

Quick diagnosis detection system combining image sensing and embedded system
Technical Field
The utility model relates to a quick-diagnosis detection area especially relates to a quick-diagnosis detecting system that image sensing and embedded system combined together.
Background
The whole immunoassay technology is developed in two directions: one is full-automatic immunoassay; the other is POCT fast immunochromatography technology taking a nitrocellulose membrane as a carrier. The Immunochromatography (IC) technology is a rapid immunoassay method combining an immunological technology and a chromatographic technology, which has been developed in the 80's of the 20 th century after undergoing stages of radioimmunoassay, enzyme immunoassay, chemiluminescence assay, and the like. The principle of the rapid immunochromatography technology is that a strip-shaped fiber chromatographic material is used as a solid phase, a sample solution is electrophoresed on a chromatographic strip by virtue of capillary action, meanwhile, an object to be detected in a sample and a receptor (such as an antibody or an antigen) of the object to be detected on the chromatographic material are subjected to high-specificity and high-affinity immunoreaction, an immune complex is enriched or trapped in a certain area (detection zone) of the chromatographic material in the chromatography process, and an intuitive experimental result can be obtained within a short biological reaction time (5-10 min) by virtue of enzymatic chromogenic reaction or direct use of a visual colored marker (such as colloidal gold). The analysis technology does not need to separate the combined marker from the free marker, thereby omitting the fussy steps of sample adding and washing, having simple and quick operation and clear analysis result. However, the current common judgment means is visual inspection, and only qualitative and semi-quantitative tests can be satisfied. With the development of bedside diagnosis and rapid diagnosis concepts, the current rapid diagnosis technology represented by colloidal gold is widely applied in China with the advantages of low cost, simple preparation, mature process and the like, and is the most important rapid diagnosis technology in China at present.
Bedside in vitro diagnosis (POCT) is a test mode that obtains test results within minutes using portable equipment and reagents, and is widely used in the fields of hospitals, nursing wards, rescue units, insurance companies, home health care networks, and the like, and its emergence has given more work traditionally done by specialized test personnel to non-test personnel. The method is a rapid inspection mode, can meet the time requirement of people, and is suitable for the development requirement of the modern society.
POCT not only has the characteristics of rapid result obtaining, simple operation, easy use, miniaturization and the like, but also does not need the traditional hospital experiment field and equipment. This enables a private clinic or an unconditional social medical machine to be diagnosed quickly and accurately. Most attractive is that with the continuous emergence of many home disease self-checking (Homelab) products developed based on POCT, patients can independently complete some disease detection operations at their own home, and the home self-checking products of this type will become a development trend in the field of future immediate inspection.
The current gold-labeled reading instrument or gold-labeled detection system in China has the following two types: 1, scan type, 2, imaging method type.
For example, in chinese patent No. 201120449209.8, 11/2011, the "gold-labeled reader" of the utility model applied by the new biotechnology limited company of south-developing japan and the scientific instruments limited company of shanghai, the applicant describes a scanning-type gold-labeled reader for qualitative and quantitative detection of a colloidal gold immunochromatographic reagent plate. The gold mark reading instrument is provided with a case, and a light source system, a scanning device, a signal acquisition system and a signal processing system are arranged in the case; the case is provided with a data display output system, a colloidal gold immunochromatography reagent plate tray, a power switch, an adapter socket and a dry battery placing port. The gold-labeled reading instrument can not only perform qualitative judgment, but also give specific concentration values of the drugs contained in the tested sample, thereby avoiding human errors; in addition, the method can also be used for instantly storing, copying and outputting the measurement result, is convenient to carry, and is suitable for different detection environments.
However, the gold-labeled reading instrument has the following disadvantages: because the scanning reading device is adopted, the time consumption for completing the whole test process is excessive, the structure is complex, the assembly and adjustment processes are complex, the mechanical noise is large, and the cost is high; in addition, the method is only suitable for the application of a certain specific gold-labeled test paper box, and only can be applied to the optical energy scanning processing of colloidal gold, and the image processing of common fluorescence and time-resolved fluorescence is not included, so that the function is single.
For another example, the invention of the chinese patent application No. 201310025671.9, filed by the chinese inspection and quarantine science research institute on 21/1/2013, "a colloidal gold-labeled detector", provides a camera-type gold-labeled reading instrument. The colloidal gold mark detector comprises an image acquisition system for acquiring images of the test strip, a central control system for analyzing and processing the acquired images and a printing device for printing the analysis and processing results. Although the colloidal gold label detector can qualitatively and quantitatively detect test strip information and record analysis data results, the central processing unit with the X86 architecture is adopted and works under a windows operating system, so that the cost of a hardware system is high, the cost of a software operating system version is also high, and the power consumption of the whole system is large; and the method can only be applied to the optical energy scanning processing of the colloidal gold, and does not comprise the image processing of common fluorescence and time-resolved fluorescence.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a quick diagnosis detecting system that multi-functional image sensing and embedded system combined together.
In order to achieve the above and other objects, the present invention provides a quick diagnosis detection system combining image sensing and embedded system, which comprises a gold-labeled reading instrument module and an embedded system connected to the gold-labeled reading instrument module; wherein, the gold mark reading instrument module at least comprises:
the clamping groove component is fixed in the shell and used for positioning the immune paper slip to be detected;
an image pickup unit disposed opposite to the card slot member and fixed in the housing, and configured with a wide-angle macro lens and an optical filter;
a light source unit disposed opposite to the card slot unit and fixed in the housing;
the display unit is partially exposed out of the surface of the shell;
the embedded system includes:
the embedded processing unit is connected with the light source component, the image shooting unit and the display unit and is fixed in the shell;
the storage unit is connected with the embedded processing unit and is fixed in the shell;
the interface unit is connected with the embedded processing unit and fixed in the shell;
and the power supply unit is connected with the embedded processing unit and is fixed in the shell.
Preferably, the gold-label reading instrument module is further configured with at least one of a single-item test paper box sample slot, a single-item test paper strip sample slot, a multi-item test paper box sample slot, a multi-item test paper strip sample slot, a dot-matrix multi-item test paper strip, or a dot-matrix multi-item test paper box. Preferably, the test strip sample cell can be 2-4 single item test strip sample cells or more than one single item test strip sample cell and more than one multi-item test strip box sample cell.
Preferably, the light source part includes an LED light source and a pulse/brightness adjusting unit.
Preferably, the display screen of the display unit includes a touch screen.
Preferably, the storage unit includes an SD card.
Preferably, the interface unit includes a unit providing a plurality of USB interfaces. Preferably, the number of the USB interfaces is two, three or four.
Preferably, the interface unit includes a communication unit providing an ethernet interface.
Preferably, the interface unit includes a wireless communication unit.
Preferably, the interface unit includes a unit providing a connection interface with an upper computer.
Preferably, the power supply unit is provided with a portable power supply.
As described above, the utility model discloses a quick diagnosis detecting system that image sensing and embedded system combined together has following advantage: the multifunctional portable detector has the advantages of complete functions, small volume, light weight, intuition and convenience for use in a laboratory or a detection field.
Other aspects of the invention will be apparent to those skilled in the art in view of the disclosure herein.
The present invention will be described in detail with reference to the accompanying drawings.
Drawings
Fig. 1 is a schematic structural diagram of a rapid diagnosis detection system combining image sensing and an embedded system according to the present invention;
fig. 2a to 2c are schematic diagrams of a housing of a rapid diagnosis detection system combining image sensing and an embedded system according to the present invention, wherein 2a is a top view, fig. 2b is a left side view, and fig. 2c is a rear view;
fig. 3 is a preferred schematic diagram of the rapid diagnosis detection system combining image sensing and embedded system according to the present invention.
Detailed Description
As shown in fig. 1, the present invention provides a quick diagnosis detection system combining image sensing and embedded system. The quick diagnosis detection system 1 includes: a gold mark reading instrument module 11 and an embedded system 12 connected with the gold mark reading instrument module.
The gold mark reading instrument module 11 includes: a card slot section 111, an image pickup unit 112, a light source section 113, and a display unit 114; the embedded system 12 includes: an embedded processing unit 121, a storage unit 122, an interface unit 123, and a power supply unit 124.
The slot part 111 is fixed in the shell and used for positioning the immune test strip to be tested. The housing is small and beautiful, and is convenient to carry, and may be made of metal or plastic, and the shape thereof is preferably "bread board", and the upper surface thereof is exposed with a display screen, as shown in fig. 2a to 2c, wherein fig. 2a is a top view, fig. 2b is a left view, and fig. 2c is a rear view.
The image capturing unit 112 is disposed opposite to the card slot component 111, fixed in the housing, configured with a wide-angle macro lens and an optical filter, and further includes an image sensor formed by a CMOS camera chip, as shown in fig. 3, and configured to capture an image of the immune test strip to be tested located by the card slot component 111.
The light source part 113 is disposed opposite to the card slot part 111 and fixed in the housing for providing a required illumination for image capturing, and preferably includes an LED light source and a pulse/brightness adjusting unit for adjusting the LED light source so as to provide a uniform light source required for image capturing, as shown in fig. 3.
The display unit 114 is used for displaying the test result, and includes a display screen exposed on the surface of the housing, as shown in fig. 2 a.
Preferably, the display screen comprises a touch screen.
Preferably, the gold-label reader module 11 is further configured with a test paper box sample slot 115 and a test paper strip sample slot 116, as shown in fig. 3; of course, a test paper box sample groove or a test paper strip sample groove can be configured according to the requirement.
The embedded processing unit 121 is connected to the light source unit 113, the image capturing unit 112, and the display unit 114, and fixed in the housing, and configured to complete control and data processing, and includes: setting respective negative/positive and weak positive of test strips of different projects, establishing and correcting a concentration direct-reading mathematical model and the like; especially, different test paper boxes or test strips, different gold-labeled reaction strip positions, different reaction mechanisms (sandwich method or competition method), different judgment thresholds, direct reading of concentration and the like can be preset according to the requirements of items to be detected (at most 99 items can be preset); moreover, the result and condition of each reading can be automatically stored in the SD card or an externally inserted usb disk or transmitted to the upper-level data station through an ethernet port or a wireless communication unit by the embedded processing unit 121; the embedded processing unit 121 may also control image pickup or transfer of data based on instructions of an upper computer.
The storage unit 122 is connected to the embedded processing unit 121 and fixed in the housing for storing data, and is preferably an SD card.
The interface unit 123 is connected to the embedded processing unit 121, and is fixed in the housing for communicating with other components or devices.
Preferably, the interface unit 123 may include: a unit providing a plurality of USB interfaces (for example, a unit of 4 USB interfaces), a communication unit providing an ethernet interface, a wireless communication unit, a unit interfacing with an upper computer, etc., whereby a keyboard, a mouse, a USB disk, a barcode scanner, etc. can be connected through the USB interfaces; connection to a Local Area Network (LAN) is made through an ethernet interface; the link with the 3G network, the WiFi network, etc. may be implemented through the wireless communication unit, as shown in fig. 3.
As shown in fig. 2c, 4 USB interfaces and one ethernet interface are exposed on the rear surface of the housing.
The power supply unit 124 is connected to the embedded processing unit 121 and fixed in the housing for supplying electric power, and preferably includes a mobile power supply, i.e., a unit powered by a rechargeable battery, e.g., a lithium battery, and may also include a unit powered by commercial power. By adopting the mobile power supply, the quick diagnosis detection system 1 can be used for detection in different environments, such as a test site, a laboratory, a detection vehicle and the like.
The working process of the quick diagnosis detection system 1 is as follows:
during testing, when an object to be tested in a sample and a receptor (such as an antibody or an antigen) of the object to be tested on a chromatographic material generate high-specificity and high-affinity immunoreaction, after a short-time biological reaction (within 5-10 min), common fluorescence, time-resolved fluorescence or color reaction generated by a coloring marker (such as fluorescent latex particles or colloidal gold) can be obtained, so that the image of the immune test strip is captured by the image capturing unit 112 through the color filter under the irradiation of the light source part 113 through the clamping groove part 111, then the captured image is processed and judged by the embedded processing unit 121, and finally the result is displayed on the touch screen; meanwhile, the embedded processing unit 121 may link to the internet through an ethernet port or a wireless communication unit, respectively, or connect to an upper computer according to a predetermined protocol to complete the following operations: a) controlling the image taking, b) acquiring real-time data, and c) storing the data in an upper computer memory; in addition, the embedded processing unit 121 may also store data and corresponding control instructions and the like into the connected usb disk or SD card according to a predetermined convention; furthermore, the whole system can be operated by the connected mouse, and the corresponding information of the immune test paper can be provided after being collected by the connected bar code scanner according to the requirement.
To sum up, the utility model discloses a quick-diagnosis detection system that image sensing and embedded system combined together adopts the CMOS camera that is furnished with wide angle macro lens, and the illuminance regulation of light filter and LED adds, except can accomplish the ordinary colloidal gold color development optical image photography that the reaction of immunity test paper strip produced, can also accomplish at the light filter or the LED light source that suit with colored latex fluorescent particle/time resolution nanometer particle, through pulse/illuminance regulation control accomplish ordinary fluorescence or time resolution fluorescence's marker image processing; the kit can complete the test of a plurality of items of test paper boxes/strip groove modules on a plurality of test paper strips at one time besides the test paper boxes/strip groove modules of a common single item (single T), is suitable for different test paper boxes and bare strips, is also suitable for different test paper with single detection, double detection and triple detection, has wide application range, is suitable for the requirements of different inspection institutions, and can be used for the detection of cardiovascular diseases (myocardial infarction and heart failure), infectious diseases (HBV, HIV, H1N 1), tumor markers, drugs, pesticide residues, food safety (melamine, clenbuterol, trace antibiotic residues) and the like; the utility model has powerful functions, low power consumption and great competitiveness; in addition, the appearance is flat and beautiful, and the hand-held operation and carrying are convenient.
All documents mentioned in this application are incorporated by reference into this application as if each were individually incorporated by reference. Furthermore, it should be understood that various changes and modifications of the present invention may be made by those skilled in the art after reading the above teachings of the present invention, and these equivalents also fall within the scope of the appended claims.

Claims (10)

1. A quick diagnosis detection system combining image sensing and an embedded system is characterized by comprising a gold-labeled reading instrument module and the embedded system connected with the gold-labeled reading instrument module; wherein,
the gold mark reading instrument module at least comprises:
the clamping groove component is fixed in the shell and used for positioning the immune paper slip to be detected;
an image pickup unit disposed opposite to the card slot member and fixed in the housing, and configured with a wide-angle macro lens and an optical filter;
a light source unit disposed opposite to the card slot unit and fixed in the housing;
the display unit is partially exposed out of the surface of the shell;
the embedded system includes:
the embedded processing unit is connected with the light source component, the image shooting unit and the display unit and is fixed in the shell;
the storage unit is connected with the embedded processing unit and is fixed in the shell;
the interface unit is connected with the embedded processing unit and fixed in the shell;
and the power supply unit is connected with the embedded processing unit and is fixed in the shell.
2. The image sensing and embedded system combined rapid diagnosis detection system according to claim 1, wherein the gold-label reading instrument module is further configured with: at least one of a single item test paper box sample groove or a single item test paper strip sample groove, or a multi-item test paper box sample groove or a multi-item test paper strip sample groove, or a dot-matrix multi-item test paper strip or a dot-matrix multi-item test paper box.
3. The rapid diagnosis detection system combining image sensing and embedded system according to claim 1, wherein the light source component comprises an LED light source and a pulse/brightness adjustment unit.
4. The system of claim 1, wherein the display screen of the display unit comprises a touch screen.
5. The rapid diagnosis detection system combining image sensing and embedded system according to claim 1, wherein the storage unit comprises an SD card.
6. The system for rapid diagnosis detection combined with image sensing and embedded system according to any of claims 1-5, wherein the interface unit comprises a unit providing a plurality of USB interfaces.
7. The system for rapid diagnosis detection combined with image sensing and embedded system according to any of claims 1-5, wherein the interface unit comprises a communication unit providing Ethernet interface.
8. The system for rapid diagnosis detection combined with image sensing and embedded system according to any one of claims 1-5, wherein the interface unit comprises a wireless communication unit.
9. The embedded system-based portable multifunctional gold-labeled quick diagnosis detector image sensing combined quick diagnosis detection system based on the embedded system as claimed in any one of claims 1 to 5, wherein the interface unit comprises a unit for providing an interface for connecting with an upper computer.
10. The system for rapid diagnosis detection combined with image sensing and embedded system according to any one of claims 1-5, wherein the power supply unit is configured with a mobile power supply.
CN201320815438.6U 2013-12-10 2013-12-10 Quick diagnosis test system integrated with image sensing system and embedded system Expired - Fee Related CN203838156U (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104914239A (en) * 2015-06-29 2015-09-16 上海交通大学 Immunochromatographic test strip detection equipment
CN104954639A (en) * 2014-09-23 2015-09-30 天津起跑线生物信息技术有限公司 Digital-imaging-technology-based distributed medical detection system
CN105259148A (en) * 2015-11-02 2016-01-20 深圳市锦瑞电子有限公司 Fluorescence immunoassay quantitative analyzer
CN106680439A (en) * 2015-11-09 2017-05-17 北京艾旗斯德科技有限公司 Miniature food safety and in-vitro diagnosis analyzer
CN109738622A (en) * 2018-12-29 2019-05-10 北京化工大学 Rapid detection device for lateral flow paper strips based on microfluidic chip
CN111337683A (en) * 2020-03-24 2020-06-26 北京万泰生物药业股份有限公司 Portable HIV Testing Device
CN114678093A (en) * 2022-03-25 2022-06-28 深圳傲威网络有限公司 Detection information processing method and system

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104954639A (en) * 2014-09-23 2015-09-30 天津起跑线生物信息技术有限公司 Digital-imaging-technology-based distributed medical detection system
CN104914239A (en) * 2015-06-29 2015-09-16 上海交通大学 Immunochromatographic test strip detection equipment
CN105259148A (en) * 2015-11-02 2016-01-20 深圳市锦瑞电子有限公司 Fluorescence immunoassay quantitative analyzer
CN106680439A (en) * 2015-11-09 2017-05-17 北京艾旗斯德科技有限公司 Miniature food safety and in-vitro diagnosis analyzer
CN109738622A (en) * 2018-12-29 2019-05-10 北京化工大学 Rapid detection device for lateral flow paper strips based on microfluidic chip
CN109738622B (en) * 2018-12-29 2020-12-11 北京化工大学 Rapid detection device for lateral flow paper strips based on microfluidic chip
CN111337683A (en) * 2020-03-24 2020-06-26 北京万泰生物药业股份有限公司 Portable HIV Testing Device
CN111337683B (en) * 2020-03-24 2024-02-09 北京万泰生物药业股份有限公司 Portable HIV detection device
CN114678093A (en) * 2022-03-25 2022-06-28 深圳傲威网络有限公司 Detection information processing method and system

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Granted publication date: 20140917

Termination date: 20191210