CN203763292U - Device for intravenous infusion of mouse - Google Patents
Device for intravenous infusion of mouse Download PDFInfo
- Publication number
- CN203763292U CN203763292U CN201420047073.1U CN201420047073U CN203763292U CN 203763292 U CN203763292 U CN 203763292U CN 201420047073 U CN201420047073 U CN 201420047073U CN 203763292 U CN203763292 U CN 203763292U
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- CN
- China
- Prior art keywords
- mouse
- transfusion
- infusion
- control valve
- utility
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000001802 infusion Methods 0.000 title claims abstract description 25
- 238000001990 intravenous administration Methods 0.000 title abstract description 5
- 238000002347 injection Methods 0.000 claims abstract description 15
- 239000007924 injection Substances 0.000 claims abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 8
- 210000003462 vein Anatomy 0.000 claims description 17
- 241000699666 Mus <mouse, genus> Species 0.000 claims description 14
- 238000005070 sampling Methods 0.000 claims description 14
- 241000699670 Mus sp. Species 0.000 claims description 13
- 241000581650 Ivesia Species 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 9
- 239000004033 plastic Substances 0.000 claims description 9
- 229920003023 plastic Polymers 0.000 claims description 9
- 239000000853 adhesive Substances 0.000 claims description 7
- 230000001070 adhesive effect Effects 0.000 claims description 7
- 238000009423 ventilation Methods 0.000 claims description 7
- 229920005479 Lucite® Polymers 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 13
- 229940079593 drug Drugs 0.000 abstract description 8
- 231100000419 toxicity Toxicity 0.000 abstract description 7
- 230000001988 toxicity Effects 0.000 abstract description 7
- 238000000034 method Methods 0.000 abstract description 5
- 230000002618 waking effect Effects 0.000 abstract description 2
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 238000009434 installation Methods 0.000 abstract 1
- 210000003128 head Anatomy 0.000 description 17
- 238000002474 experimental method Methods 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 238000010253 intravenous injection Methods 0.000 description 5
- 239000011505 plaster Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000006184 cosolvent Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 229910001651 emery Inorganic materials 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000005224 forefinger Anatomy 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
Landscapes
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The utility model discloses a device for intravenous infusion of a mouse. The device comprises a control pipe, an installation plate, a fixing plate and an infusion device. The control pipe comprises a cylinder body with one end closed and a cover plate. The cover plate is arranged at the open end of the cylinder body, closes the cylinder body and is connected with the cylinder body in a threaded or buckled mode. Meanwhile, the cover plate is provided with a through hole. In the injection state, the tail of the mouse placed in the control pipe extends out from the through hole and is placed on the fixing plate to be fixed, and then intravenous infusion is carried out on the tail of the mouse through the infusion device. According to the device for intravenous infusion of the mouse, catheter burying before an operation is avoided, in a non-anesthetic and waking state, the mouse is limited in the control pipe by fixing the tail of the mouse, and then infusion can be carried out on the mouse. The mouse can move the body slightly in the infusion process, liquid is infused smoothly and does not overflow or leak, infusion can be timed and quantitative, and toxicity and drug efficacy research of multiple drugs can be carried out through infusion. In addition, the device is simple in structure and convenient to operate.
Description
Technical field
This utility model relates to medical experiment equipment technical field, relates in particular to a kind of device for mouse vein transfusion.
Background technology
Mice is the most frequently used laboratory animal, is usually used in toxicity test, evaluating drug effect, Surgical experiment etc., and common medication is intravenous injection, intraperitoneal administration, subcutaneous injection, oral administration gavage etc.But under a lot of feelings, adopt the medications such as intravenous injection can not complete experiment, science and the verity of impact experiment.For example: antitumor drug methotrexate, intravenous anti-tumor effect is only 30% of venous transfusion 3 hours.Cisplatin emulsion does not have toxicity in 8 hours at venous transfusion, and intravenous injection same dose causes 50% animal dead.In addition, a lot of insoluble drugs need cosolvent and with organic solvent preparation, these auxiliary elements have very large toxicity, and intravenous injection can cause that one crosses property high concentration, and causes the death of animal, even if well medicine is also because of problem the failure of an experiment of medication.For example paclitaxel is effective antitumour medicine at present, due to the toxicity of cosolvent, can cause that the death of mice and toxicity increase after intravenous injection.Therefore, when carrying out medical experiment, need to infuse to mouse vein, with this, improve the science of experiment.
Utility model content
In view of this, a technical problem to be solved in the utility model is to provide a kind of device for mouse vein transfusion, and avoiding performs the operation in advance buries conduit, under non-narcotic waking state, can complete the venous transfusion to mice.
A device for mouse vein transfusion, comprising: control valve, installing plate, fixing head and infusion set; Described control valve and described fixing head are arranged on described installing plate, and are fixedly connected with described installing plate respectively; Described control valve comprises cylindrical shell and the cover plate of one end sealing, and described cover plate is arranged on the open end of described cylindrical shell and seals described cylindrical shell, and described cover plate is connected with described cylinder screw or buckle connects, and on described cover plate, through hole is set; Wherein, the tail that is placed on the mice in described control valve can stretch out and be placed on described fixing head from described through hole to be fixed, the venous transfusion by described infusion set to mouse tail.
According to an embodiment of the present utility model, further, on the blind end of described cylindrical shell, vent is set.
According to an embodiment of the present utility model, further, a plurality of ventilation slots are set on the barrel of described cylindrical shell.
According to an embodiment of the present utility model, further, the quantity of described a plurality of ventilation slots is 6-8.
According to an embodiment of the present utility model, further, described control valve and described fixing head are bonded on described installing plate by adhesive.
According to an embodiment of the present utility model, further, the material of described control valve is plastics; The material of described installing plate is lucite or plastics, and described fixing head is plank.
According to an embodiment of the present utility model, further, described infusion set comprises: tube for transfusion, injection needle, connecting needle, syringe and micro-sampling pump; The two ends of described tube for transfusion are connected with described connecting needle with described injection needle respectively, and the injection outlet of described syringe is connected with described connecting needle, and described micro-sampling pump is controlled time and the flow of described syringe output medicinal liquid.
According to an embodiment of the present utility model, further, material silica gel or the plastics of described tube for transfusion.
Device for mouse vein transfusion of the present utility model, by fixing mousetail and mice is limited in pipe mice is infused, mice can light activity body during infusing, liquid infusion is unobstructed, does not overflow no leakage, and transfusion can be regularly, quantitatively, multi-medicament can carry out toxicity and drug efficacy study by transfusion, and simple structure is easy to operate.
Accompanying drawing explanation
In order to be illustrated more clearly in this utility model embodiment or technical scheme of the prior art, to the accompanying drawing of required use in embodiment or description of the Prior Art be briefly described below, apparently, accompanying drawing in the following describes is only embodiment more of the present utility model, for those of ordinary skills, do not paying under the prerequisite of creative work, can also obtain according to these accompanying drawings other accompanying drawing.
Figure 1A is according to the schematic diagram of an embodiment of the device for mouse vein transfusion of the present utility model; Figure 1B is the schematic diagram for the cover plate of the device of mouse vein transfusion;
Fig. 2 is tube for transfusion, the injection needle of an embodiment of the device for mouse vein transfusion of the present utility model, the connection diagram of connecting needle;
Fig. 3 is the schematic diagram that mousetail is fixed on fixing head;
Fig. 4 is according to the schematic diagram of the micro-rear pump of an embodiment of the device for mouse vein transfusion of the present utility model.
The specific embodiment
With reference to the accompanying drawings this utility model is described more fully, exemplary embodiment of the present utility model is wherein described.Below in conjunction with the accompanying drawing in this utility model embodiment, the technical scheme in this utility model embodiment is clearly and completely described, obviously, described embodiment is only this utility model part embodiment, rather than whole embodiment.Embodiment based in this utility model, those of ordinary skills are not making the every other embodiment obtaining under creative work prerequisite, all belong to the scope of this utility model protection.Below in conjunction with figure and embodiment, the technical solution of the utility model is carried out to many-sided description.
As shown in Figure 1A and 1B, the device for mouse vein transfusion comprises: control valve, installing plate 4, fixing head 3 and infusion set (not shown in FIG.).Control valve and fixing head 3 are arranged on installing plate 4, and be fixedly connected with installing plate 4 respectively, the relative position of control valve and fixing head 3 can arrange according to actual needs, the modes such as control valve and fixing head 3 can adopt and be threaded, buckle connection, control valve and fixing head 3 also can be bonded on installing plate 4 by adhesive, such as using 502 glue etc.
Control valve comprises the cylindrical shell 1 of one end sealing and for the cover plate 2 of closed cylinder, cover plate 2 is threaded with cylindrical shell 1 or buckle is connected, and on cover plate 2, through hole is set, and the shape of through hole can be semicircle or circular etc.
According to an embodiment of the present utility model, under the state of injecting, be placed on the tail of mice in control valve and stretch out from through hole, and be placed on fixing head 3 fixingly, for example fixing mode is for can adopt adhesive plaster to be fixed.Venous transfusion by infusion set to mouse tail, infusion set can be existing multiple infusion set, for example, comprises the infusion set of syringe needle, tube for transfusion and transfusion bottle.
According to an embodiment of the present utility model, vent 7 is set on the blind end of cylindrical shell 1.A plurality of ventilation slots 5, air vent 6 are set on the barrel of cylindrical shell.The quantity of ventilation slot 5, air vent 6 can design according to specific circumstances, and for example, the quantity of a plurality of ventilation slots is 6-8.According to an embodiment of the present utility model, control pipe range 100mm, external diameter 30mm, internal diameter 28mm.The long 250mm of installing plate, wide 30mm, high 3mm.The long 140mm of fixing head, wide 30mm, high 3mm.
According to an embodiment of the present utility model, according to an embodiment of the present utility model, the material of control valve can be plastics, metal etc.The material of installing plate can be lucite, plastics, metal etc.Fixing head can be plank, rubber slab.
According to an embodiment of the present utility model, as shown in Figures 2 and 4, infusion set comprises: tube for transfusion 9, injection needle 8, connecting needle 10, syringe 18 and micro-sampling pump 15.The two ends of tube for transfusion 9 are connected with connecting needle 10 with injection needle 8 respectively.Injection needle 8 can adopt the fixed needle of 1mm syringe, and connecting needle 10 can adopt the removable syringe needle of 1mm syringe, with emery wheel, needle point is polished, and injection needle 8 is inserted in tube for transfusion 9, then tube for transfusion 9 is connected with connecting needle 10.The injection outlet of syringe 18 is connected with connecting needle, and micro-sampling pump is controlled output medicinal liquid time and the flow of syringe 15.
According to an embodiment of the present utility model, the material of tube for transfusion can be silica gel or plastics etc.The internal diameter of tube for transfusion 9 is 0.3mm, long 350mm; The external diameter of injection needle is 0.35mm, long 18mm, and the external diameter of connecting needle is 0.35mm.
According to an embodiment of the present utility model, the form that syringe 18 is arranged on micro-sampling pump 15 can be for multiple, for example, micro-sampling pump comprises syringe clamping device 16, syringe 18 is arranged in clamp structure 16, advance baffle plate 19 to connect stepper motor, by operation stepper motor, drive the piston that advances baffle plate 19 to advance syringe 18.Micro-sampling pump 15 can be for the multichannel of market sale controlled micro-sampling pump, use the syringe of 1～5mm, the speed of transfusion can be set by time, speed controlling panel 17.
According to an embodiment of the present utility model, as shown in Figure 3, fixing head 3, is fixed on mousetail on fixing head 3 by adhesive plaster 12 at a distance of 10～15mm with cover plate 2.To mousetail push up and down, both sides are unsettled fixing, and mousetail two lateral veins are fully expanded, and guarantee that liquid and blood backflow are unimpeded.Micro-sampling pump can be set as transfusion time 1 minute-12 hours, amount of infusion 0.1-4ml.
According to experiment needs, pre-set transfusion time and the flow of micro-sampling pump, again the syringe that medicinal liquid is housed is fixed in the syringe fixation clamp of the controlled micro-sampling pump of multichannel, then with the syringe that normal saline is housed by connecting needle, tube for transfusion, injection needle one by one order aerofluxus inject saline.Mice is packed in control valve and buckle cover plate, right hand forefinger and thumb are held 13 punctures of entry needle scalp acupuncture end of line bar lateral vein, after seeing blood back, with adhesive plaster 12, tail is posted on tail fixing head 3 by pressure viscosity up and down, then with adhesive plaster 12, tube for transfusion and tail end is simultaneously fixing.Successively that 10 mouse tail vein punctures are fixing complete.Start micro-sampling pump, medicine is input in animal body by predetermined time and dosage.Device for mouse vein transfusion of the present utility model also can be infused to laboratory animals such as rats.
Device for mouse vein transfusion of the present utility model, by fixing mousetail and mice is limited in pipe mice is infused, mice can light activity body during infusing, liquid infusion is unobstructed, does not overflow no leakage, and transfusion can be regularly, quantitatively, multi-medicament can carry out toxicity and drug efficacy study by transfusion, and simple structure is easy to operate.
Above-mentioned arbitrary technical scheme disclosed in the utility model unless otherwise stated, if it discloses numerical range, so disclosed numerical range is preferred numerical range, any it should be appreciated by those skilled in the art: preferred numerical range is only the obvious or representative numerical value of technique effect in many enforceable numerical value.Because numerical value is more, cannot be exhaustive, so this utility model just discloses part numerical value to illustrate the technical solution of the utility model, and the above-mentioned numerical value of enumerating should not form the restriction of this utility model being created to protection domain.
Simultaneously, if above-mentioned this utility model discloses or has related to parts or the structural member of connection fastened to each other, so, unless otherwise stated, be fixedly connected with and can be understood as: can dismantle and be fixedly connected with (for example using bolt or screw to connect), also can be understood as: non-removable being fixedly connected with (for example rivet, weld), certainly, connection fastened to each other also can for example, be replaced (obviously cannot adopt except integrally formed technique) by integral type structure (use casting technique is integrally formed to be created).
In addition, in the disclosed arbitrary technical scheme of above-mentioned this utility model applied for the term that represents position relationship or shape unless otherwise stated its implication comprise and its approximate, similar or approaching state or shape.Arbitrary parts that this utility model provides can be both to be assembled by a plurality of independent ingredients, the produced separate part of the technique that also can be one of the forming.
Finally should be noted that: above embodiment is only in order to illustrate that the technical solution of the utility model is not intended to limit; Although this utility model is had been described in detail with reference to preferred embodiment, those of ordinary skill in the field are to be understood that: still can modify or part technical characterictic is equal to replacement the specific embodiment of the present utility model; And not departing from the spirit of technical solutions of the utility model, it all should be encompassed in the middle of the technical scheme scope that this utility model asks for protection.
Claims (8)
1. for a device for mouse vein transfusion, it is characterized in that, comprising:
Control valve, installing plate, fixing head and infusion set;
Described control valve and described fixing head are arranged on described installing plate, and are fixedly connected with described installing plate respectively; Described control valve comprises cylindrical shell and the cover plate of one end sealing, and described cover plate is arranged on the open end of described cylindrical shell and seals described cylindrical shell, and described cover plate is connected with described cylinder screw or buckle connects, and on described cover plate, through hole is set; Wherein, the tail that is placed on the mice in described control valve can stretch out and be placed on described fixing head from described through hole to be fixed, the venous transfusion by described infusion set to mouse tail.
2. device as claimed in claim 1, is characterized in that:
On the blind end of described cylindrical shell, vent is set.
3. device as claimed in claim 2, is characterized in that:
A plurality of ventilation slots are set on the barrel of described cylindrical shell.
4. device as claimed in claim 3, is characterized in that:
The quantity of described a plurality of ventilation slots is 6-8.
5. device as claimed in claim 4, is characterized in that:
Described control valve and described fixing head are bonded on described installing plate by adhesive.
6. device as claimed in claim 1, is characterized in that:
The material of described control valve is plastics; The material of described installing plate is lucite or plastics, and described fixing head is plank.
7. device as claimed in claim 1, is characterized in that:
Described infusion set comprises: tube for transfusion, injection needle, connecting needle, syringe and micro-sampling pump;
The two ends of described tube for transfusion are connected with described connecting needle with described injection needle respectively, and the injection outlet of described syringe is connected with described connecting needle, and described micro-sampling pump is controlled time and the flow of described syringe output medicinal liquid.
8. device as claimed in claim 7, is characterized in that:
The material of described tube for transfusion is silica gel or plastics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420047073.1U CN203763292U (en) | 2014-01-24 | 2014-01-24 | Device for intravenous infusion of mouse |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420047073.1U CN203763292U (en) | 2014-01-24 | 2014-01-24 | Device for intravenous infusion of mouse |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203763292U true CN203763292U (en) | 2014-08-13 |
Family
ID=51280549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420047073.1U Expired - Fee Related CN203763292U (en) | 2014-01-24 | 2014-01-24 | Device for intravenous infusion of mouse |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203763292U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748073A (en) * | 2014-12-15 | 2016-07-13 | 中国科学院大连化学物理研究所 | Cage for mouse in waking state and application of cage |
| CN106386538A (en) * | 2016-08-31 | 2017-02-15 | 中国人民解放军南京军区南京总医院 | Mouse cage of parenteral nutrition feeding type |
| CN106420101A (en) * | 2016-09-22 | 2017-02-22 | 西安医学院 | Injecting and fixing device for mouse |
| CN108836554A (en) * | 2018-05-09 | 2018-11-20 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | Fixed device is injected intraperitoneally in caudal vein joint |
-
2014
- 2014-01-24 CN CN201420047073.1U patent/CN203763292U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748073A (en) * | 2014-12-15 | 2016-07-13 | 中国科学院大连化学物理研究所 | Cage for mouse in waking state and application of cage |
| CN106386538A (en) * | 2016-08-31 | 2017-02-15 | 中国人民解放军南京军区南京总医院 | Mouse cage of parenteral nutrition feeding type |
| CN106420101A (en) * | 2016-09-22 | 2017-02-22 | 西安医学院 | Injecting and fixing device for mouse |
| CN106420101B (en) * | 2016-09-22 | 2018-01-16 | 西安医学院 | A kind of injection and fixing device for mouse |
| CN108836554A (en) * | 2018-05-09 | 2018-11-20 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | Fixed device is injected intraperitoneally in caudal vein joint |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140813 Termination date: 20180124 |