CN203473563U - Freeze-drying excipient packaging and delivering system - Google Patents
Freeze-drying excipient packaging and delivering system Download PDFInfo
- Publication number
- CN203473563U CN203473563U CN201320361683.4U CN201320361683U CN203473563U CN 203473563 U CN203473563 U CN 203473563U CN 201320361683 U CN201320361683 U CN 201320361683U CN 203473563 U CN203473563 U CN 203473563U
- Authority
- CN
- China
- Prior art keywords
- freeze
- chamber
- preparation
- drying excipient
- packing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Landscapes
- Medicinal Preparation (AREA)
Abstract
The utility model provides a freeze-drying excipient packaging and delivering system, which comprises a freeze-drying excipient, a solvent, and a packaging and delivering device for packaging and delivering the freeze-drying excipient and the solvent, and is characterized in that the packaging and delivering device is a double-cavity blender, the solvent and the freeze-drying excipient are respectively stored in different cavities of the double-cavity blender, and the solvent and the freeze-drying excipient can be instantly blended and exported in use by means of interaction among all parts of the double-cavity blender. The freeze-drying excipient packaging and delivering system has the advantages of protecting the stability of active ingredients, improving the using effect, reducing the potential side reaction, prolonging the shelf life, and being packaged in unit dose, convenient to carry and use, pollution-free, reduced in cost and the like.
Description
Technical field
The utility model relates to a kind of packing of freeze-drying excipient preparation and delivery system and preparation method thereof, a kind of freeze-drying excipient preparation that is applied to food, health food, oral drug, topical drug and cosmetics particularly, when itself and solvent are preserved respectively, used in same packing, join the two-chamber blender of use and pack and delivery system, with and corresponding preparation method.
background technology
Freeze-drying excipient preparation is a kind of preparation form of utilizing freeze-drying excipient technology to prepare, and it is by being filled in forming mould and cryodesiccated technological process moulding forms.Because such preparation adopts freeze drying process; can protect thermally sensitive composition not to be destroyed; preparation itself produces a large amount of micropores and duct simultaneously; make disintegration and dissolving that it can be very fast; therefore be subject to being widely used, be applied in medicine, food, health food and the cosmetic fields such as oral disnitegration tablet, fast-release tablet, chewable tablets, special cosmetics.
Because the technological process of freeze-drying excipient preparation produces the characteristic in a large amount of micropores and duct, make freeze-drying excipient preparation all there is not high, the easy friability of preparation intensity and the defect such as moisture absorption very easily.Therefore the selected packing device of preparation that prepared by freeze-drying excipient technology is mostly two aluminium packings, to guarantee its damp proof insulation, oxygen barrier etc.But two aluminium packings often itself do not have good supportive, the auxiliary package that need to have certain degree of hardness by other strengthens the protectiveness to preparation; It is all comparatively loaded down with trivial details when opening with use, for the experience sense that its product is used is brought certain influence.And two aluminium packings need to open its packing in use, after mixing with its solvent, can use, in mixed process, the process more complicated of open packing, mixing and mixed liquor is derived, and easily sneak into bacterium etc. and cause the secondary pollution after packing is opened.
Traditional pre-fill type dual chamber syringe is mainly used in injecting use, for fear of produce and use procedure in germ and other pollution, must complete original position freeze-drying in syringe after, in hundred grades of clean areas, complete packaging process, greatly improved productive costs; Simultaneously; due to traditional lyophilisation, be to be main freeze drying protectant system based on small molecular sugar class, sugar alcohol and amino acid; its freeze-dried powder form is very responsive to physical mechanical power; if do not use original position freeze-drying; be very easy to broken; cause the inaccurate of dosage, freeze-dried powder fragment broken or that come off also can bring very large problem to assembling and the use of pre-fill type dual chamber syringe simultaneously.
Therefore, contriver dedicates itself to innovation, in order to solve packing and the occupation mode of freeze-drying excipient preparation, simultaneously in order to open up packing and the occupation mode of non-injecting type lyophilized formulations, a large amount of deep research and experimental work have been carried out, thereby completed the utility model, provide a kind of non-injection to use, can join and use in use, freeze-drying excipient preparation separates preservation in same packing with its solvent, during use, directly mix the packing of freeze-drying excipient preparation and the preparation of delivery system and corresponding freeze-drying excipient preparation thereof of deriving, assembly method, completed thus the utility model.
summary of the invention
Packing and the delivery system of a kind of freeze-drying excipient preparation provided by the utility model, comprise freeze-drying excipient preparation, solvent and packing and send packing and the delivery apparatus of described freeze-drying excipient preparation and solvent, it is characterized in that described packing and delivery apparatus are two-chamber blender, wherein solvent and freeze-drying excipient preparation are stored in respectively in the different cavitys of two-chamber blender, and the interaction by each parts of two-chamber blender makes solvent and freeze-drying excipient preparation can immediately mix and derive in use.
The freeze-drying excipient preparation using in the packing of freeze-drying excipient preparation provided by the utility model and delivery system, it is mainly comprised of functional component and adhesive agent, and adhesive agent: functional component=1: 10 to 10: 1.
Described adhesive agent is edible, can does used for cosmetic or pharmaceutically useful a kind of water-soluble high-molecular material, can be polysaccharide, polypeptide, protein, also may be artificial polymerization macromolecule, or through natural macromolecular material or its compound of modification.Conventional adhesive agent includes but not limited to, gelatin class (gelatin, gelatin hydrolysate etc.), cellulose ethers (carboxymethyl cellulose, ethylol methyl textile rope etc.), modified starch series (pulullan, hydroxypropul starch etc.), PVP, PVA, hyalomitome acids, albumin, shitosan and different molecular weight product or their combination etc.
Described functional component can be water-soluble can be also water-fast material, can be for chemicals, bio-pharmaceutical, Chinese medical extract, vitamin, mineral matter, cosmetic beneficiating ingredient and other be to one or more in the useful active component of human body; Can be selected from the composite of following one or more compositions:
Chemicals (active constituents of medicine):
Antipyretic-antalgic anti-inflammatory agent, such as aspirin, Diflunisal, salsalate, paracetamol, Indomethacin, brufen, naproxen, Ketoprofen, pirprofen, suprofen, Flurbiprofen, piroxicam, Meloxicam, Ni Guan Shu Li, Benzbromarone etc.;
Central stimulant, such as pemoline, adrafinil, Piracetam etc.;
Treatment migraine agent, for example Sumatriptan succinate;
Antalgesic, such as rotundin, buprenorphine, pentazocine, naloxone etc.;
Anti-parkinson and treatment senile dementia medicine, for example levodopa, compound carbidopa, compound benserazide, amantadine hydrochloride, piribedil, general sieve phenol amine, donepezil, huperzine are first-class;
Psychotolytic, such as chlorpromazine, fenazil, pethidine, thioridazine, Chlorprothixene, Clozapine, Sulpiride, Tai Bili, penfluridol, Risperidone etc.;
Anti-epileptic disease and anticonvulsive drug, such as dilantin sodium, carbamazepine, Primidone, Gabapentin, Lamotrigine, sodium vedproate, Clonazepam etc.Hypnotic sedative agent, such as diazepam, nitrazepam, Oxazepam, Lorazepam, phenobarbital etc.;
Cholinesterase inhibitor, such as hyoscine etc.;
Antiarrhymic, such as the third pyridine, tocainide, mexiletine, aetmozine, dilantin sodium, Propafenone, amiodarone etc.;
Antianginal and antiatherosclerotic, such as Propranolol, nifedipine, Gemfibrozil, Bezafibrate, Lovastatin, Simvastatin, Pravastatin etc.;
Antihypertensive, such as Enalapril, captopril, Hydrochioro, Amlodipine etc.;
Adrenoreceptor blocking agent, such as acebutolol, alprenolol etc.;
Corticosteroid medicine, such as betamethasone, cortisone acetate etc.;
Antidiabetic, such as Repaglinide etc.;
Antithyroid drug, such as propylthiouracil (PTU), Carbimazole, methimazole etc.;
Antithistamine, such as Cetirizine Hydrochloride, Loratadine etc.;
Autologous active substance, such as dinoprostone, Alprostadil, Betahistine etc.;
Digestive system medication, such as fourth bromine that hyoscyamine, Granisetron Hydrochloride etc.;
Hematological system medicine, such as EPO, cobamamide etc.;
Urinary system medicine, such as azosemide, frusemide etc.;
Reproductive system medicine, such as estrogen, Nandrolone Phenylpropionate etc.;
Antiparasitic agent, such as albendazole, cambendazole etc.;
Antineoplastic, such as aminoglutethimide, amsacrine etc.;
Antimicrobial, such as ampicillin, sulbenicillin disodium etc.;
Tri-Biocin, such as Amoxicillin, cefalexin, Cefprozil, CEFUROXIME AXETIL, Roxithromycin, Erythromycin Ethylsuccinate, josamycin etc.;
Traditional Chinese medicine ingredients:
Effective Component of Chinese Medicine monomer, as: Breviscapinun, qinghaosu etc.;
Single medicinal material material extract and compound Chinese medicine extract, as: tanshinone extract, salvianolic acid extract, composite salvia dropping extract of bolus, cow-bezoar bolus compound extract, ginseng stem and leave general saponin, asiatic moonseed extract, general ginsenoside, Breviscapinun, notoginseng triol-saponin, Glabrous Sarcandra Herb medicinal extract, arasaponin, capillary extract, extractum rhei, andrographolide, hawthorne leaf P.E, asiaticoside etc.;
Natural plant extracts: as aloe extract, yam extract, Bilberry fruit P.E, Bitter Melon P.E, green-tea extract, fucoidin, glabridin, Paeoniflorin etc.;
Bioactive ingredients: EGF, bFGF, aFGF, KGF, IGF, PDGF, VEGF, placenta hydrolyzate, milk extract etc.
Cosmetic beneficiating ingredient: collagen, hyaluronic acid, sodium alginate, aloe extract, general ginsenoside, arasaponin, the yellow extract of people, bamboo lotus water Bulbus Lilii extract, peony extract, EGF, bFGF, aFGF, KGF, IGF, PDGF, VEGF, placenta hydrolyzate, milk extract, various surfactants, algae extract, various vitamin, various beneficial mineral matter, SOD, metallothionein, other raw materials see < < international cosmetic raw material standard Chinese catalogue (version in 2010) > >
Described freeze-drying excipient preparation, it is mainly comprised of functional component, adhesive agent, and needs can add or not add skeleton supporting agent and other auxiliary material (as thickening supensoid agent, antioxidant, flavouring and essence, skin penetration enhancer, pH adjusting agent etc.) according to preparation process.
Described skeleton supporting agent comprises and is not limited to the materials such as the amino acid (as amino acetic acid, alanine, glutamic acid etc.) of sugar (as maltose, trehalose etc.), sugar alcohol (as sweet mellow wine, sorbierite), 2-12 carbon atom and inorganic salts (as sodium phosphate, aluminium silicate etc.).
Other described auxiliary material is including but not limited to thickening supensoid agent, antioxidant, flavouring and essence, skin penetration enhancer, pH adjusting agent etc.; Wherein the mixed earnestly agent of thickening can be selected from the combination of any or they in the natural origin glue classes such as dextran, Arabic gum, xanthans, carragheen, pectin, konjac glucomannan, agar, carbomer, carrageenan and synthetic macromolecular compound and other polypeptide or polysaccharide etc.; Described antioxidant includes but not limited to one or several the compound in the polyhydric phenols of vitamin C and derivant thereof, anthocyanidin, resveratrol, plant origin; Described flavouring and essence include but not limited to the compound of the essence such as mint flavored, chocolate flavoured, vanilla flavored, caf, tea flavour, corn taste, lemon, milk taste or above one or more fragrance; Described skin penetration enhancer include but not limited to lecithin, saponin(e, bay alkyd, any or several the compound in azone, tween, sapn; Described pH adjusting agent includes but not limited to any in citric acid, tartaric acid, carbonate, sodium carbonate, phosphate or several compound.
What in the packing of freeze-drying excipient preparation provided by the utility model and delivery system, use is any device that can realize the utility model object for packing and send packing and the delivery apparatus of described freeze-drying excipient preparation and solvent, is preferably a kind of two-chamber blender.
Described two-chamber blender, comprises that two cavitys (3,6), two pistons (5,7), a bypass (4), a push rod are by hand (10), a discharger (2), discharging lid (1) six part.
Described two cavitys are solid pharmaceutical preparation chamber 3 and liquid preparation chamber 6; Solid pharmaceutical preparation chamber 3 is the cavity near discharger part, and liquid preparation chamber 6 is the cavity away from discharger part; Two parts that it can be separated into by piston for single whole cavity, also can link together and form by two individual cavity, its connection mode comprises the modes such as bonding (welding), non-shape sealed (bonding) or shape sealed (inserting sealed), and it connects and depends on global shape, material and function needs by mode.
Freeze-drying excipient preparation 9 in solid pharmaceutical preparation chamber 3 can be the freeze-drying excipient preparation of various formulas, form, for carry out being distributed into the preparation in solid pharmaceutical preparation chamber 3 after freeze-drying in forming mould; Solvent 8 in liquid preparation chamber 6 can be water, the nutrient solution with certain functional component, Essence and the various solvents that can directly be used in conjunction with freeze-drying excipient.
A described bypass 4, is positioned at side, solid pharmaceutical preparation chamber, and its width is slightly larger than the thickness of piston 5, thereby can make solvent in cavity 6 form opening by piston movement during to bypass 4 place, mixes with the freeze-drying excipient preparation 9 in solid pharmaceutical preparation chamber 3.
A described push rod is pressed hand 10, for exerting pressure to cavity so that the device of piston movement.
A described discharger 2 is any form discharging opening of non-injection needle form, as suction pipe shape, dropper shape, ball shape, the first-class form of spraying.
A described discharging lid 1, is the device of salable discharger mouth, makes chamber substance in vivo and external environment isolation.
The utility model also relates to the preparation method of above-mentioned freeze-drying excipient preparation.
The preparation of described freeze-drying excipient preparation be in forming mould after freeze-drying the demoulding being fitted in the solid pharmaceutical preparation cavity in two-chamber blender pack.Preparation method comprises
(a) functional component, adhesive agent and other auxiliary material are mixed with to solution, emulsion or suspending fluid injection molding; Or by solid functional component injection molding, then add adhesive agent and other auxiliary material wiring solution-forming, emulsion or suspending fluid;
(b) solution (a) being obtained or suspending fluid carry out degassed in quantitative forming mould;
(c) (b) obtained degassed after solution, emulsion or suspending fluid or solution emulsion or the suspending fluid, freezing at low temperatures directly (a) being obtained;
(d) preparation (c) being obtained lyophilisation in quantitative forming mould, except desolventizing, obtain freeze-drying excipient preparation;
(e) the freeze-drying excipient preparation (d) being obtained is detached into mould and packs packing device into or its forming mould is exactly one of them cavity, with this, directly assembles.
Wherein the described injection molding volume of step (a) is 0.01-5.0ml; Wherein injection molding can adopt the liquid-transfering devices such as accurate quantification pipet, liquid-transfering gun, electronic liquor-transferring rifle, also can adopt plunger pump, gear type pump, peristaltic pump etc., and the solution configuring or suspending fluid are injected to quantitative forming mould; Wherein degas method can adopt centrifugal degassing method, vacuum degasification method and ultrasonic degas method etc.; The freezing mode that can adopt liquid nitrogen or liquid, solid carbonic oxide spray refrigeration wherein, turbine expander refrigeration mode or cascade refrigeration mode, at-20 ℃--at 196 ℃ of temperature, rapidly by solution or the freezing solid that becomes of suspending fluid; Wherein freeze-drying adopts the degree of vacuum of 0.01-20 millibar, temperature freeze-drying between-70 ℃ of-50 ℃ of scopes.
The beneficial effects of the utility model are:
1. the stability of prolection composition: by this packing and delivery system, realized solid and liquid separately, high activity material stability is often bad, with solid forms, preserves, its stability improves greatly, can improve result of use, reduce potential side reaction, Shelf-life;
2. unit dose package: compare with many measuring productses of routine, this packing and delivery system are unit dose packages,, its amount of liquid meets aircraft and carries requirement, is easy to carry;
3. avoid polluting: compare with the bottled freeze-dried powder form of traditional double with traditional two aluminium packings of freeze-drying figuration, the all assembling process of this packing and delivery system complete in clean producing tract, do not have exposed component only from discharging opening, to extrude, can not cause the microbial contamination in process for preparation;
4. easy to use: compare with traditional two aluminium packings of freeze-drying figuration, this packing and delivery system, without opening packing, put into the palm, then add liquid, to point the complicated occupation mode of the both hands cooperation mixing, only need one to push away, open two actions of discharging opening and can use, very convenient;
5. reduce costs: compare with freeze-dried powder, there is no complicated two Bottle and bottle cap systems; Compare with traditional two aluminium packings of freeze-drying figuration, there is no complicated support and structure design, full automation packing, significantly reduces production costs;
Accompanying drawing explanation
Fig. 1 is packing and each exploded view of delivery apparatus (two-chamber blender) in the packing of freeze-drying excipient preparation and delivery system;
Fig. 2-Fig. 4 is the packing of freeze-drying excipient preparation and the use step diagram of delivery system.
The specific embodiment
Further illustrate by the following examples the utility model, but the utility model is not restricted to this.
The bottom of the cavity of following examples indication, refers to that cavity is away from the far-end of discharging opening; The top of bypass 4 refers to the one end near discharging opening, and the below of bypass 4 refers to the other end away from discharging opening; The top of piston refers to that piston is near one end of discharging opening, and the bottom of piston refers to that piston is away from the other end of discharging opening.
Embodiment 1:
EGF stoste, after thawing, add gelatin, gelatin hydrolysate, be mixed with EGF (weight ratio), the gelatin+gelatin hydrolysate solution containing 5% containing 5/100000ths, fillingly enter 0.1 milliliter of forming mould, the solid pharmaceutical preparation chamber 3 that packs the two-chamber blender of glass material after freeze-drying moulding into, is then fitted into the piston of quality of rubber materials 53 bottoms, solid pharmaceutical preparation chamber, bypass 4 belows; Again 2 milliliters of 3% hyaluronic acid solutions are filled into the liquid preparation chamber 6 that the piston 5 of quality of rubber materials isolates; The piston 7 that adds afterwards quality of rubber materials, makes that liquid is complete to be stored in liquid preparation chamber 6, can between the piston 5 of quality of rubber materials and the piston 7 of quality of rubber materials, not ooze out, and obtains the two-chamber blender packing device that comprises lyophilized excipient and solvent.
During use, pack a push rod 10 into piston 7, promote push rod 10 6 direction motions to liquid preparation chamber, the interior fluid pressure in liquid preparation chamber 6 drives piston 53 direction motions to solid pharmaceutical preparation chamber; When piston 5 bottom motions surpass bypass 4 below, the interior liquid in liquid preparation chamber 6 is under piston 7 pressure, by bypass 4, directly get around piston 5, enter solid pharmaceutical preparation chamber 3, mix with lyophilized excipient wherein, continue to promote forward push rod to piston 7 tops and contact with piston 5 bottoms, whole liquid preparations chamber 6 hyaluronic acid solutions of interior 2 milliliter 3% mix with lyophilized excipient completely, EGF, 0.25% gelatin+gelatin hydrolysate, 3% hyaluronic solution that formation contains 2.5ppm; Open discharging lid 1, continue to promote push rod 10, drive piston 7 to press piston 5, aforesaid mixed solution is extruded from discharger 2, discharger 2 nose shapes are ball form, in extrusion, can be applied to face by Direct Uniform, become modern biological cosmetics.
Embodiment 2:
Vitamin C: Propiram=5: 1, mixed powder 50mg enters 0.4 milliliter of forming mould so that solid form is filling, then after remaining 10mg being dissolved with 0.4 ml water, fillingly enter to contain powder to forming mould, after freeze-drying, the lyophilized excipient of acquisition is packed in the solid pharmaceutical preparation chamber 3 with the two-chamber blender of the plastic material of bypass 4, then silicon is handed over the piston 5 of material to be fitted into 3 bottoms, solid pharmaceutical preparation chamber, bypass 4 belows of plastic material.
2 milliliters of deionized waters are filled into the liquid preparation chamber 6 of the plastic material that the piston 7 of silica gel material isolates; Afterwards the solid pharmaceutical preparation chamber of plastic material 3 is inserted to the liquid preparation chamber 6 of plastic materials, and with super sonic by two cavity weldings together, the two-chamber blender packing device of the plastic material that obtains comprising lyophilized excipient.
During use, pack a push rod 10 into piston 7, promote push rod 10 6 direction motions to liquid preparation chamber, the interior fluid pressure in liquid preparation chamber 6 drives piston 53 direction motions to solid pharmaceutical preparation chamber; When piston 5 bottom motions surpass bypass 4 below, the interior liquid in liquid preparation chamber 6 is under piston 7 pressure, by bypass 4, directly get around piston 5, enter solid pharmaceutical preparation chamber 3, mix with lyophilized excipient wherein, continue to promote forward push rod to piston 7 tops and contact with piston 5 bottoms, all in liquid preparation chamber 6,2 ml deionized water are mixed with lyophilized excipient completely, form and contain 2.5% ascorbic solution; Open discharging lid 1, continue to promote push rod 10, drive piston 7 to press piston 5, aforesaid mixed solution is extruded from discharger 2, be directly applied to face, become modern cosmetics.
Embodiment 3:
Cordyceps: collagen=1 gram: 5 grams, be mixed with suspension solution, perfusion enters 5 milliliters of forming moulds, after freeze-drying, the lyophilized excipient of acquisition is packed in the solid pharmaceutical preparation chamber 3 with the two-chamber blender of the clad aluminum material of bypass 4, then the piston of butyl rubber material 5 is fitted into clad aluminum material 3 bottoms, solid pharmaceutical preparation chamber, bypass 4 belows.
10 milliliters of the deionized waters that contains natural essence are filled into the liquid preparation chamber 6 of the clad aluminum material that the piston 7 of butyl rubber material isolates; Afterwards the solid pharmaceutical preparation chamber of clad aluminum material 3 is inserted to the liquid preparation chamber 6 of clad aluminum materials, and with high temperature by two cavity weldings together, the two-chamber blender packing device of the clad aluminum material that obtains comprising lyophilized excipient.
During use, pack a push rod 10 into piston 7, promote push rod 10 6 direction motions to liquid preparation chamber, the interior fluid pressure in liquid preparation chamber 6 drives piston 53 direction motions to solid pharmaceutical preparation chamber; When piston 5 bottom motions surpass bypass 4 below, the interior liquid in liquid preparation chamber 6 is under piston 7 pressure, by bypass 4, directly get around piston 5, enter solid pharmaceutical preparation chamber 3, mix with lyophilized excipient wherein, continue to promote forward push rod to piston 7 tops and contact with piston 5 bottoms, all in liquid preparation chamber 6,10 ml deionized water are mixed with lyophilized excipient completely, form the solution that contains Cordyceps and collagen; Open discharging lid 1, continue to promote push rod 10, drive piston 7 to press piston 5, aforesaid mixed solution is extruded from discharger 2, directly oral, become health food.
Embodiment 4:
Arasaponin: PVP=30mmg: 15mmg, be mixed with solution, be filled into 0.3ml forming mould, after freeze-drying, pack the solid pharmaceutical preparation chamber 3 of the two-chamber blender of clad aluminum material into, then the piston of silica gel material 5 is fitted into 3 bottoms, solid pharmaceutical preparation chamber, bypass 4 belows; Again 1 milliliter of large so fragrant sticky deionized water is filled into the liquid preparation chamber 6 that the piston 5 of silica gel material isolates; The piston 7 that adds afterwards silica gel material, makes that liquid is complete to be stored in liquid preparation chamber 6, can between the piston 5 of silica gel material and the piston 7 of silica gel material, not ooze out, and obtains the two-chamber blender packing device that comprises lyophilized excipient.
During use, pack a push rod 10 into piston 7, promote push rod 10 6 direction motions to liquid preparation chamber, the interior fluid pressure in liquid preparation chamber 6 drives piston 53 direction motions to solid pharmaceutical preparation chamber; When piston 5 bottom motions surpass bypass 4 below, the interior liquid in liquid preparation chamber 6 is under piston 7 pressure, by bypass 4, directly get around piston 5, enter solid pharmaceutical preparation chamber 3, mix with lyophilized excipient wherein, continue to promote forward push rod to piston 7 tops with piston 5 bottoms by touching, all in liquid preparations chamber 6,1 ml deionized water is mixed with lyophilized excipient completely, the solution that formation contains 3% arasaponin; Open discharging lid 1, continue to promote push rod 10, drive piston 7 to press piston 5, aforesaid mixed solution is oral by discharging gate 2, form health food.
Embodiment 5:
Bilberry fruit P.E: Propiram=100mg: 15mg, be mixed with solution, perfusion enters 0.5 milliliter of forming mould, packs the solid pharmaceutical preparation chamber 3 of the two-chamber blender of plastic material after freeze-drying into, then the piston of silica gel material 5 is fitted into 3 bottoms, solid pharmaceutical preparation chamber, bypass 4 belows; Again 20 ml deionized water that contain natural colouring matter are filled into the liquid preparation chamber 6 that the piston 5 of silica gel material isolates; The piston 7 that adds afterwards the silica gel material that is connected with push rod 10, makes that liquid is complete to be stored in liquid preparation chamber 6, can between the piston 5 of silica gel material and the piston 7 of silica gel material, not ooze out, and obtains the two-chamber blender packing device that comprises lyophilized excipient.
During use, promote push rod 10 6 direction motions to liquid preparation chamber, the interior fluid pressure in liquid preparation chamber 6 drives piston 53 direction motions to solid pharmaceutical preparation chamber; When piston 5 bottom motions surpass bypass 4 below, the interior liquid in liquid preparation chamber 6 is under piston 7 pressure, by bypass 4, directly get around piston 5, enter solid pharmaceutical preparation chamber 3, mix with lyophilized excipient wherein, continue to promote forward push rod to piston 7 tops and contact with piston 5 bottoms, all the interior 20 milliliters of deionized waters that contain large right pigment in liquid preparation chamber 6 are mixed with lyophilized excipient completely, form the solution that contains 0.5% Bilberry fruit P.E; Open discharging lid 1, continue to promote push rod 10, drive piston 7 to press piston 5, aforesaid mixed solution is oral from discharging gate 2, form solid beverage food.
Packaging structure of the present utility model is not limited to form cited in embodiment, and embodiment is only preferred embodiment of the present utility model, can not limit protection domain with this.All with simple or equivalent variation and modification described in claim scope of the present utility model, all belong to protection domain of the present utility model.
Claims (5)
1. packing and the delivery system of a freeze-drying excipient preparation, comprise freeze-drying excipient preparation, solvent and packing and send packing and the delivery apparatus of described freeze-drying excipient preparation and solvent, it is characterized in that described packing and delivery apparatus are two-chamber blender, wherein solvent and freeze-drying excipient preparation are stored in respectively in the different cavitys of two-chamber blender, and the interaction by each parts of two-chamber blender makes solvent and freeze-drying excipient preparation can immediately mix and derive in use.
2. packing and the delivery system of freeze-drying excipient preparation as claimed in claim 1, is characterized in that described two-chamber blender comprises that two cavitys (3,6), two pistons (5,7), a bypass (4), a push rod are by hand (10), a discharger (2), discharging lid (1) 6 part.
3. packing and the delivery system of a kind of freeze-drying excipient preparation as claimed in claim 2, is characterized in that described two cavitys are solid pharmaceutical preparation chamber (3) and liquid preparation chamber (6); Solid pharmaceutical preparation chamber (3) is the cavity near discharger (2) part, and liquid preparation chamber (6) are the cavity away from discharger (2) part; Two parts that solid pharmaceutical preparation chamber (3) and liquid preparation chamber (6) are separated into by piston for single whole cavity, or link together and form by two individual cavity.
4. packing and the delivery system of a kind of freeze-drying excipient preparation as claimed in claim 3, is characterized in that freeze-drying excipient preparation (9) is arranged in solid pharmaceutical preparation chamber (3); Solvent (8) is arranged in liquid preparation chamber (6).
5. packing and the delivery system of a kind of freeze-drying excipient preparation as claimed in claim 2, it is characterized in that described bypass (4) is positioned at side, solid pharmaceutical preparation chamber, thereby can make solvent in cavity form opening by piston movement during to bypass place, mix with freeze-drying excipient preparation; Described push rod by hand (10) for to exert pressure so that the device of piston movement to cavity; Described discharger (2) is the discharging opening of any form of non-injection needle form; Described discharging lid (1) is the device of salable discharger (2) mouth, makes chamber substance in vivo and external environment isolation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320361683.4U CN203473563U (en) | 2013-06-24 | 2013-06-24 | Freeze-drying excipient packaging and delivering system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320361683.4U CN203473563U (en) | 2013-06-24 | 2013-06-24 | Freeze-drying excipient packaging and delivering system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203473563U true CN203473563U (en) | 2014-03-12 |
Family
ID=50221944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320361683.4U Expired - Lifetime CN203473563U (en) | 2013-06-24 | 2013-06-24 | Freeze-drying excipient packaging and delivering system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203473563U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103318551A (en) * | 2013-06-24 | 2013-09-25 | 李和伟 | System for packaging and delivering freeze-dried excipient and preparation method of freeze-dried excipient |
| WO2015032319A1 (en) * | 2013-09-04 | 2015-03-12 | Li Hewei | Lyophilized excipient formulation packaging and delivery system and preparation method |
| CN109328109A (en) * | 2017-01-03 | 2019-02-12 | 伊鲁米那股份有限公司 | Sample tube with integral type mixing stopper head |
-
2013
- 2013-06-24 CN CN201320361683.4U patent/CN203473563U/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103318551A (en) * | 2013-06-24 | 2013-09-25 | 李和伟 | System for packaging and delivering freeze-dried excipient and preparation method of freeze-dried excipient |
| WO2014206137A1 (en) * | 2013-06-24 | 2014-12-31 | Li Hewei | Packing and delivery system for freeze-dried excipient and method of preparing freeze-dried excipient |
| WO2015032319A1 (en) * | 2013-09-04 | 2015-03-12 | Li Hewei | Lyophilized excipient formulation packaging and delivery system and preparation method |
| CN104417918A (en) * | 2013-09-04 | 2015-03-18 | 李和伟 | Freeze-drying excipient packing and transferring system and production method thereof |
| CN109328109A (en) * | 2017-01-03 | 2019-02-12 | 伊鲁米那股份有限公司 | Sample tube with integral type mixing stopper head |
| CN109328109B (en) * | 2017-01-03 | 2021-06-25 | 伊鲁米那股份有限公司 | Sample tube with integrated mixing plunger head |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103318551A (en) | System for packaging and delivering freeze-dried excipient and preparation method of freeze-dried excipient | |
| CN104417918B (en) | A kind of packaging of lyophilized excipient preparation and delivery system and preparation method thereof | |
| CN103893133B (en) | A kind of formula of lyophilized excipient preparation and preparation method thereof | |
| EP2939664A1 (en) | Freeze-dried excipient and preparation method thereof | |
| CN203997495U (en) | A kind of freeze-drying excipient preparation and matching dissolvent packaging Double-cavity bag | |
| CN104644571B (en) | Freeze-drying excipient protection device and preparation method thereof | |
| CN104644568A (en) | Protective apparatus and preparation method of freeze-dried excipient preparation containing active components and binding agent | |
| EP3357478A1 (en) | Method using rolling mold to prepare freeze-dried excipient, and product thereof | |
| WO2018028531A1 (en) | Lyophilized preparation and preparation method therefor | |
| CN107714654A (en) | A kind of lyophilized formulations and preparation method thereof | |
| CN107468528A (en) | A kind of lyophilized formulations and preparation method thereof | |
| CN203473563U (en) | Freeze-drying excipient packaging and delivering system | |
| CN106963737A (en) | A kind of any form of easy disintegrating freezes shaped preparation and preparation method thereof | |
| CN104760767A (en) | Packaging device of freeze-drying excipient preparation with barrier property and manufacturing method of packaging device | |
| CN106466228A (en) | A kind of multi-mould prepares method of lyophilized excipient of arbitrary shape and products thereof | |
| US20180200150A1 (en) | Freeze-drying excipient preparation of arbitrary shape and preparation method therefor | |
| CN205274216U (en) | Solid -liquid separation joins in marriage packing plant of usefulness promptly | |
| CN108066152A (en) | A kind of preparation method of lyophilized excipient | |
| CN104443822A (en) | Freeze-dried excipient and matched solvent packaging double-cavity bag | |
| CN104648834A (en) | Protecting device of freeze-drying excipient containing skeleton support agent and binder and preparation method thereof | |
| CN104417913A (en) | Packaging device for freeze-drying forming preparation containing adhesive and preparation method of packaging device for freeze-drying forming preparation containing adhesive | |
| CN204038196U (en) | A kind of packaging of freeze-drying excipient preparation and delivery system | |
| CN107280979A (en) | It is a kind of to prepare method of lyophilized formulations of arbitrary shape and products thereof | |
| CN204078456U (en) | A kind of packing device of the freeze-drying excipient preparation containing adhesive agent and townhouse packing device thereof | |
| CN107260557A (en) | A kind of rolling modulus method prepares method of lyophilized formulations and products thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP02 | Change in the address of a patent holder | ||
| CP02 | Change in the address of a patent holder |
Address after: 101312, 6, Anqing Avenue, B District, Shunyi District Airport Industrial Zone, Beijing, 1 Patentee after: Li Hewei Address before: 100102, No. 1204, building 131, Wangjing garden, Beijing, Chaoyang District Patentee before: Li Hewei |
|
| ASS | Succession or assignment of patent right |
Owner name: CHANGZHOU WEIBO HAITAI BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: LI HEWEI Effective date: 20140514 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 101312 SHUNYI, BEIJING TO: 213022 CHANGZHOU, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20140514 Address after: 213022 innovation center, building 2, Xinbei Science Park, Jiangsu, Changzhou, A408-1 Patentee after: CHANGZHOU WEIBO HAITAI BIO-TECH CO.,LTD. Address before: 101312, 6, Anqing Avenue, B District, Shunyi District Airport Industrial Zone, Beijing, 1 Patentee before: Li Hewei |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140312 |