CN203059985U - Absorbable cell carrier support for curing tubal infertility - Google Patents
Absorbable cell carrier support for curing tubal infertility Download PDFInfo
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- CN203059985U CN203059985U CN 201220243727 CN201220243727U CN203059985U CN 203059985 U CN203059985 U CN 203059985U CN 201220243727 CN201220243727 CN 201220243727 CN 201220243727 U CN201220243727 U CN 201220243727U CN 203059985 U CN203059985 U CN 203059985U
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- fallopian tube
- cell carrier
- support
- curing
- tubal infertility
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Abstract
The utility model provides an absorbable cell carrier support for curing tubal infertility, and belongs to medical tools. Degradable absorbing materials which are harmless to human bodies are used, the technology of combining a coating and freeze drying is adopted to prepare a porous support with a double-layer pore structure, the inner surface of the porous support is a micropore low-porosity film layer, and the outer surface of the porous support is a macropore porous structural layer. The inner surface with the low-porosity can guarantee the permeability of the tubular support, and cells are prevented from growing into a lumen and blocking the lumen. The porous outer surface works as carriers of cells and drugs, has certain flexibility, and reduces stimulation to the inner wall of a fallopian tube. The absorbable cell carrier support for curing the tubal infertility is embedded into the lumen of the fallopian tube through a microsurgery or after interventional therapy, the lumen can be prevented from restenosis, and the absorbable cell carrier support can be used as a biological barrier to effectively prevent postoperative adhesions. The absorbable cell carrier support for curing the tubal infertility degrades automatically after treatment is completed, meanwhile composites adult stem cells of the mucous epithelium of the fallopian tube, repairs damaged the intima of the fallopian tube, and recovers the function of the fallopian tube. The absorbable cell carrier support for curing the tubal infertility is innovative therapy, and suitable for clinical use.
Description
Technical field
But the utility model proposes a kind of absorptive cell carrier bracket for the treatment of tubal infertility, belong to medical medical instrument, especially relate to a kind of compound medical medical instrument of support and cell therapy medicine that adopts.
Background technology
Tubal infertility accounts for infertile women's 25%～50%, be to cause the woman infertility most important reason, and sickness rate is ascendant trend year by year, the healthy reproduction that become international problem.Cause the factor of tubal infertility a lot, mainly can be divided into two aspects: the one, mechanical obstruction: thus cause the narrow of fallopian tube tube chamber and block owing to reasons such as inflammation form adhesion and cicatrix.The distortion of peritubal adhesions, tube chamber also can cause oviducal block or not smooth, and the transportation that influences gamete and germ cell causes infertile.The 2nd, functional factor: the destruction of Mucous Epithelium of Fallopian Tube cell, the secretory function disappearance causes the change of environment in the fallopian tube, thus it is infertile to have influenced normally causing of capacitation, the combination of smart ovum, early embryonic development and embryo nidation etc.The destruction of Mucous Epithelium of Fallopian Tube causes the impaired fibre swing that influences of ciliated cell, thereby the conveying that influences gamete causes infertile.
Usually adopt methods such as microsurgery, interventional therapy to remove oviducal blocking clinically, thereby wish the treatment tubal infertility.Though postoperative recanalization rate in a short time reaches as high as about 90%, blocking rate is up to 61.25%～71.05% again for 1 year fallopian tube of postoperative, and the incidence rate of ectopic pregnancy also obviously rises simultaneously.This is that the adhesion of postoperative and cicatrix block fallopian tube again or be narrow because operative treatment can cause new wound to fallopian tube when releasing is blocked.The more important thing is, tubal infertility is by the coefficient result of multiple factor, microsurgery and interventional therapy have only been removed obstruction of fallopian tube, the interior environment change that the endosalpinx primary cellular defect is caused and the infringement of other fallopian tube functions have no to help, the wound again that operation causes also can further increase the weight of the infringement of fallopian tube function, therefore another approach that is difficult to effectively to improve the pregnancy rate treatment tubal infertility of postoperative is test-tube baby, system takes out the ovum on the wife's side down via the B ultrasonic guiding, in laboratory, cultivate under the imitation fallopian tube condition, with the sperm in vitro fertilization on the bridegroom's or husband's side, the embryo who will skip after the fallopian tube link will be cultivated directly implants the uterus.But present medical skill also can't be imitated oviducal physiological function fully, test-tube baby also brings a lot of problems simultaneously, as the multiple pregnancy incidence rate is increased, infull obstructor has the danger that ectopic pregnancy takes place to fallopian tube, and the ethics morals problem of the sensitivity that Assisted Reproductive Technology ART is related is also outstanding day by day.Simultaneously test-tube baby is to the requirement height of technology, the medical expense costliness, and vast basic hospital is difficult to extensively carry out in China.Therefore seek a kind of new technology, can remove oviducal blocking and keep it unobstructed, and to help to recover and keep normal oviducal function be to treat the problem that tubal infertility presses for solution clinically.Do not see as yet both at home and abroad that at present degradable absorbs the report of fallopian tube anti support, the treatment that recovers the fallopian tube function also belongs to blank substantially.
Summary of the invention
But the utility model proposes a kind of absorptive cell carrier bracket for the treatment of tubal infertility, belong to medical medical instrument, mainly be configured to the porous support of double-deck pore structure, outer compound Mucous Epithelium of Fallopian Tube adult stem cell is as healing potion, by implanting the fallopian tube inner chamber behind microsurgery or the interventional therapy, prevent the tube chamber restenosis, can be used as the effective prevention of postoperative adhesion of biological barrier again, degraded voluntarily after finishing treatment, compound Mucous Epithelium of Fallopian Tube adult stem cell of while, repair impaired endosalpinx, recovering oviducal function, is an infertile novelty therapy for the treatment of fallopian tube, suitable clinical use, for the treatment of tubal infertility brings breakthrough, bigger social benefit and economic benefit are arranged.
The utility model is achieved like this: adopt that harmless degradable absorbs with cell compatibility and immunogenic material, prepare a kind of porous support with double-deck pore structure by coating in conjunction with cryodesiccated technology, inner surface is micropore low porosity rete, outer surface is macropore vesicular texture layer, the inner surface of low porosity can guarantee the permeability of tubular bracket, prevent the cell occludes lumen of growing into, cavernous outer surface is as the carrier of cell, medicine, have certain pliability, reduced the stimulation to the fallopian tube inwall.
Adopt separation and Culture, evaluation, cultured and amplified in vitro receptor Mucous Epithelium of Fallopian Tube adult stem cell as the seed cell of healing potion, be compounded in and absorb double-decker tubulose porous support skin, after implanting fallopian tube during treatment, be compounded in the Mucous Epithelium of Fallopian Tube adult stem cell on the support, growth promoter maturation voluntarily in the endosalpinx physiological environment, repair impaired endosalpinx, rebuild Mucous Epithelium of Fallopian Tube, thereby recover the function of oviducal interior environment and cilium, recover oviducal function.
But the absorptive cell carrier bracket for the treatment of tubal infertility is degraded voluntarily after finishing the treatment function.
Description of drawings
But the schematic cross-section of the absorptive cell carrier bracket of the treatment tubal infertility that Fig. 1 is this utility model to be proposed.
Among Fig. 1: 1, low porosity internal layer 2, macroporosity skin 3, cell carrier support
The specific embodiment
Now by reference to the accompanying drawings, concrete composition implementation of the present utility model is further described.
The good material of selecting polylactic acid, chitosan and gelatin etc. and cell compatibility and immunogenicity is made and can be absorbed fallopian tube with cell carrier support 3.
Adopt the coating molding technology earlier, with polylactic acid formulations prepared from solutions low porosity internal layer 1, use the cast of chitosan or gelatin solution then, prepare macroporosity skin 2 through lyophilization, adopt the specific complex mould, prepare the porous cell carrier bracket 3 with double-deck pore structure.
Use flow cytometer etc. and from the Mucous Epithelium of Fallopian Tube cell, isolate adult stem cell, by cultured and amplified in vitro as seed cell.
Adopt the compound training method of cell carrier support 3 and Mucous Epithelium of Fallopian Tube stem cell, the cell carrier support 3 of double-deck pore structure is placed in the culture plate, the Mucous Epithelium of Fallopian Tube stem cell concentration that every hole adds amplification is 4x10
6Individual/ml.In 37 ℃, 5%CO
2, in the saturated humidity constant incubator, cultivate with the K-FsM culture fluid.
With compound good cell carrier support 3, adopt Freeze Drying Technique to finalize the design at last, finish preparation and preserve, use in order to when treatment treatment tubal infertility, implant in the fallopian tube inwall.
Claims (3)
1. but absorptive cell carrier bracket for the treatment of tubal infertility, it is characterized in that: have the double layered tubular structure, close in outer the dredging, porous support is carrier, the outside is compounded with the Mucous Epithelium of Fallopian Tube adult stem cell, finishes in fallopian tube after the treatment function and degrades voluntarily.
2. but the absorptive cell carrier bracket for the treatment of tubal infertility according to claim 1 is characterized in that: be compound to the Mucous Epithelium of Fallopian Tube adult stem cell on the support, adopt coating compound in conjunction with Freeze Drying Technique and porous support.
3. but the absorptive cell carrier bracket for the treatment of tubal infertility according to claim 1, it is characterized in that: carrier bracket is for can absorb the double layered tubular loose structure, the inner surface of low porosity rete, cavernous outer surface is suitable as the carrier of cell, medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220243727 CN203059985U (en) | 2012-05-29 | 2012-05-29 | Absorbable cell carrier support for curing tubal infertility |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220243727 CN203059985U (en) | 2012-05-29 | 2012-05-29 | Absorbable cell carrier support for curing tubal infertility |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203059985U true CN203059985U (en) | 2013-07-17 |
Family
ID=48758816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220243727 Expired - Fee Related CN203059985U (en) | 2012-05-29 | 2012-05-29 | Absorbable cell carrier support for curing tubal infertility |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203059985U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108888384A (en) * | 2018-07-18 | 2018-11-27 | 广州迈普再生医学科技股份有限公司 | A kind of tubular bracket and preparation method thereof with double-layer structure |
| CN110279499A (en) * | 2018-03-14 | 2019-09-27 | 深圳市美好创亿医疗科技有限公司 | The hydrophilic silicon stent of antibacterial |
-
2012
- 2012-05-29 CN CN 201220243727 patent/CN203059985U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110279499A (en) * | 2018-03-14 | 2019-09-27 | 深圳市美好创亿医疗科技有限公司 | The hydrophilic silicon stent of antibacterial |
| CN108888384A (en) * | 2018-07-18 | 2018-11-27 | 广州迈普再生医学科技股份有限公司 | A kind of tubular bracket and preparation method thereof with double-layer structure |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130717 Termination date: 20140529 |