Light painless drug administration device
Technical field
The invention belongs to field of medical technology, relate to a kind of light painless drug administration device, can help the patient that need have an injection for a long time to reduce or remit pain.
Background technology
Diabetes are human body physiological function disorder diseases that the present whole world can't cure; It not only has a strong impact on patient's orthobiosis; Also can cause 80 various acute or chronic complicating diseases such as comprising the heart, brain, liver, lung, kidney, eye, limbs, skin, nerve simultaneously; Cause that the patient is blind, loss of memory, cerebral palsy, gingiva and skin of lower extremity festers, lower limb nerve necrosis, paralysis, sexual disorder and forfeiture, glomerular sclerosis, arteriosclerosis heart disease, and even serious consequence such as death.Current research shows, such sick global patient reaches several hundred millionly at present, and only this type of patient of China just surpasses more than 9,200 ten thousand, and patient's quantity also increases sharply in the speed with annual more than 150 ten thousand.Helping this type patient to keep the best approach of orthobiosis at present is exactly usually to control patient's blood glucose with islets of langerhans.Yet; Insulin is a kind of polypeptide drug; Be easy to by human intestines and stomach's digestive enzyme degraded with because of the first pass effect inactivation of liver; Replenishing of this type of patient medicine can only lean on the vein of every day or subcutaneous injection to realize, this not only brings pain of local skin damage, infection and secular skin and flesh that injection causes to the patient, and it is inconvenient also to have increased a lot of lives simultaneously.How helping the patient to alleviate the administration misery is the focus that the medical science and technology worker endeavours to solve.
The quick insulin syringe that various types of single or multiples use is arisen at the historic moment, and the use of this appliances not only brings suffering of flesh to the patient, and expense is high simultaneously, and waste is big.People also once attempted insulin is processed plaster, attempt to realize administration through the mode of Transdermal absorption, yet because insulin molecule is huge, it were also lower to infiltrate intravital efficient through the human epidermal cutin membrane.
The solution of rising in recent years is to adopt the micropin dispenser to overcome pain of skin and flesh that injection brings, and insulin can't be through problems such as epidermis infiltrate in the body.Although the patent application of micropin dispenser aspect is a lot, most processing that all belong to dissimilar micropins are oozed the medicine application with simple transdermal, have only minority that more complete feasible micropin pesticide application technology is provided.Present micropin pesticide application technology can roughly be divided into Wicresoft's transdermal and ooze two types of medicine and imbedding needle dispensers, and the former is through the perforation of micropin transdermal, impel be coated on the micropin surface or the medicinal liquid on the plaster through micropore to subcutaneous infiltration; Because the defence and the self-repair function of human body skin; Make the Wicresoft of cutin membrane heal rapidly; This can effectively stop the intrusion of external microbe on the one hand, but also hinders macromolecular drug to pass through the subcutaneous dispenser of Wicresoft's passage on the other hand, therefore; This type Wicresoft transdermal oozes the medicine method and exists the curative effect weak point, oozes problems such as medicine is incomplete, drug waste is big.For the latter; It mostly is the micropin that includes medicinal liquid or communicate through imbedding with medicine bag; Through the micropin passage; To the subcutaneous medicine that oozes, although do not receive the puzzlement of cutin membrane minimal invasion healing problem, this type system exists subcutaneous tissue to the anaphylaxis of imbedding micropin with ooze problems such as medicine speed is slow, administration is inhomogeneous.
Recently the microelectronics that emerges controls intelligent loading technology; Adopt microelectronics control and the integrated drug-supplying system of micropin loading assembly, have small and exquisite, convenient, administration on time, administration such as gives at advantage as required, solved that curative effect is short, administration is uneven and ooze medicine waits problem slowly; But still exist subcutaneous tissue to imbedding the allergic problem of micropin for a long time; In addition because microelectronics loading control assembly complex design that system adopted, production cost are high, and be to use up and finish mission, not only cause a lot of wastes and pollution problem with the medicine in this plaster; Increase simultaneously the cost of manufacture and the cost of use of plaster again greatly, make vast ordinary consumer forbidding.In addition, this type drug administration device this bring a lot of inconvenience for patient's daily routines undoubtedly.
In addition, it is pointed out that almost the subcutaneous loading method of all insulins on the market; Comprise micropin loading technology; All adopt insulin solutions, because insulin in unstable, the easy degraded of solution state, not only needs strict aseptic anoxybiotic encapsulation; Also necessary simultaneously cryopreservation, this has brought very big restriction for undoubtedly micropin plaster long-time demand of using under the body temperature environment.
Therefore, be badly in need of a kind of inexpensive, painless convenience, long-acting, demand that loading system that efficiently do not have skin allergy again satisfies extensive patients at present.
Summary of the invention
The present invention relates to a kind of light painless drug administration device, this device is made up of one or more independently loadings unit, contains concealed micropin in each loading unit, when needing, through exerting pressure, makes withdrawal automatically behind the instantaneous transdermal administration of micropin, realizes painless administration.This drug administration device has simple in structure, and cost of manufacture is low, and safety and comfort are ventilative moistureproof, can painless efficient administration, do not cause the skin allergy inflammation again, and both can paste usefulness for a long time, advantages such as also can putting at any time and take off, flexible, economical and practical.
The present invention is achieved in that
At least contain an independent loading unit in this drug administration device, the loading list includes concealed micropin and drug storage chamber.In drug storage chamber, solid drugs and loading drive liquid to be separated by stable barrier film, and the design that this solid drugs and loading driving liquid are stored has respectively promoted long-term drug storage property under stability and the room temperature of insulin greatly.In the moment of loading, the barrier film opening allows the rapid mixed dissolution of solid-liquid, and subcutaneous through the micropin injection, and this long-term branch storage, instant promptly defeated new model have solved technical bottlenecks such as being difficult for storing, needing cold preservation under the insulin medicinal liquid room temperature.
Micropin is connected with elastomeric material, makes elastomeric material deformation through pressure, drives microneedle cutaneously, removes withdrawal automatically behind the pressure, isolates with epidermis.Both guaranteed painless, efficient administration, the problems such as skin allergy inflammation that the long-time needle-embedding therapy of having avoided original micropin loading technology to adopt again causes.
This device is through adopting manually or using external repeatedly used microelectronics to exert pressure automatically and control loading unit dispenser; Replace existing disposable integrated micro loading control system, reduce the manufacturing cost of device and the consumption burden of vast general patient greatly.
Functions such as that the design of this drug administration device has simultaneously added is damp proof, have a good sweat, anti-pressure make that the use of this device is more comfortable, safety.
Advantage of the present invention is:
(1) drug administration device can be realized that the long course of treatment is painless, efficient, make things convenient for administration.
(2) economical and practical, the convenient use both can the long periods of wear dosed administration, also can be as required with going along with.
(3) be not only applicable to the insulin administration of diabetics, be applicable to other type medicine simultaneously yet, replenish the long-term timing transdermal administration of contraception, smoking cessation and beauty and skin care etc. as human body is hormonal.
Description of drawings
Fig. 1 is the partial cross section figure of the micropin loading parts (100) of light painless drug administration device.Wherein, 101 signal medicine outputs drive liquid; 102 signal medicines drive the outer enclosure material of liquid; 103 signals drive the isolated thin film of liquid with solid drugs and medicine output; The solid drugs of output is waited in 104 signals; The thin-film material that 105 signals link to each other with micropin; 106 signals are used for the micropin of transdermal infusion; The micropin part that 107 signals will be equipped with solid drugs joins material with the glue that the loading control system that driving liquid is housed is connected; 108 signals are used to carry the thin slice that micropin, medicine and encapsulating material are connected.It is pointed out that in actual design 108 can be similar or the inhomogeneity material with 105 or 107, when 108 and 105 or 107 same time-likes, it can dispense from these parts (100) structure.
Fig. 2: divide upper, middle and lower figure, the micropin that wherein upper and lower figure is light painless drug administration device is hidden the partial cross section figure of seal member (110) diverse location, the parts of fine web frame in these parts of middle illustrated.Wherein: 111 signals are used for the thin film of sealed damp-proof; The hidden micropin of 112 signals, avoid the rigid support grid of micropin and contact skin; 113 signals have certain tensile elasticity, are used for supporting the filamentary webs of micropin.It is pointed out that 113 are not limited to resilient filament guard, it also can be other resilient thin film or thin slice.
Fig. 3: the partial cross section figure of light painless drug administration device, wherein: 120 signals are used to prevent that the loading control system receives unconscious extruding and leaks the pressure support material of medicine; Other digital signal is said with Fig. 1 and Fig. 2.
Fig. 4: the schematic top plan view of the loading safety block (120) of light painless drug administration device, these parts are used to prevent that the loading control system receives unconscious extruding and leaks medicine.
Fig. 5: be used for drug administration device and the fixed optional feature of skin (130) schematic top plan view, be breathe freely by having well, have a good sweat, thin slice such as the natural or TPR of heat radiation, bio-compatibility and fabric or leather, plastics, paper makes; This thin slice can be that single face scribbles adhesive, drug administration device is bonded in skin surface, but also is not coated with any adhesive, can make above-mentioned material system that device and body part closely contact through any external force.
Fig. 6: the schematic top plan view of the micropin loading parts (100) of light painless drug administration device.Wherein 101 and 102 signal is said with Fig. 1.
Fig. 7: the schematic top plan view of light painless drug administration device, wherein all digital signals are the same.
Fig. 8: the micropin of light painless drug administration device is hidden with the end of seal member and is looked sketch map.Wherein each digital signal is said with Fig. 2.
Fig. 9: the bottom view of light painless drug administration device, wherein each digital signal is with the above.
The specific embodiment
The present invention is a kind of light painless drug administration device that can behind instantaneous transdermal administration, withdraw automatically; This device includes an independent loading unit at least, and each at least one length of independent loading unit and diameter be basically all at the micropin of micrometer range, under some special situation that needs usefulness; The yardstick of micropin sometimes can near or greater than one millimeter; This micropin links to each other with the unitary drug storage chamber of this loading, and solid drugs in micropin and/or the drug storage chamber and loading drive liquid to be separated by stable barrier film, when the moment at loading; When the independent control action that manual or external repeatedly used microelectronics is exerted pressure automatically; The barrier film opening allows the solid-liquid mixed dissolution, and injects subcutaneous through micropin.This device both can be used for long-term subcutaneous dosed administration, also can need not take off as required with going along with, have flexibly just use, easily painless, efficient administration, advantage such as economical and practical.Following description and the diagram that provides only are in order to let the reader of common level can understand and put into practice the principles of science of present patent application and the schematic part illustration that characteristics provide; But be not that our invention of limitation is in this; Varied drug administration device design of any the principles of science that provides based on patent specification and products characteristics all belongs in this invention patent protection category like the mode of the layout of the stressed mode of size, thickness, the quantity that includes the unitary quantity of independent loading and shape, micropin and length, the structure of drug storage nest, loading, used material, safety block and shape, enhancement micropin loading unitary elasticity etc.
Shown in sketch map 1-9, this type device mainly is to be made up of following three assemblies: micropin loading parts (100); Micropin is hidden seal member (110); The safety block of loading control system (120).
The parts of micropin loading (100) are the core components of this drug administration device; Undertaking safety and dividing storage medicine to be executed and drive liquid, and the independent loading unit of opening, each loading unit load has the medicine of various dose; During loading, will drive liquid and medicine and mix rapidly and inject functions such as subcutaneous.Micropin loading parts (100) are made up of 8 parts: 1. medicine output drives liquid (101); 2. medicine drives the outer enclosure material (102) of liquid; 3. solid drugs and medicine output are driven the isolated thin film of liquid (103); 4. wait for the solid drugs (104) of output; 5. the thin-film material that links to each other with micropin (105); 6. the micropin (106) that is used for transdermal infusion; The micropin part that 7. solid drugs will be housed joins material (107) with the glue that the loading control system that driving liquid is housed is connected; 8. be used to carry micropin and medicine thereof and the thin slice (108) that is connected with the encapsulating material that the loading control system that drives liquid is housed.Wherein (108) can with (105) or (107) the similar or inhomogeneity material in the same parts (100).When (108) and (105) or (107) same type of material, it can dispense from this (100) modular construction.
Wherein encapsulating material (102) can be metal or high-molecular organic material, comprises artificial or biological or natural material.
The solid-liquid isolating membrane (103) that here uses can be organic molecule, organic polymer or biomaterial.Be characterized in: under normal pressure, have good seal, can intercept loading driving liquid effectively and permeate, but, can allow liquid to pass through barrier film through modes such as film breaks or film micropore increases when receiving under the ambient pressure effect to solid drugs.
The solid drugs (104) of waiting for output here can be an insulin, also can be that other classes are applicable to hypodermic medicine.
The thin-film material that here links to each other with micropin (105) can be prepared by metal level or alloy, also can be by inorganic material, and high-molecular organic material, organic-inorganic hybrid material is mixed with.
The micropin (106) that is used for transdermal infusion here can also can be mixed with by inorganic material, high-molecular organic material, organic-inorganic hybrid material by the thin-film material that is attached thereto (105) identical or different metal level or alloy preparation.
It can be synthetical or natural macromolecular material that glue joins material (107); Like epoxy resin, silica type, animal glue class, polyester, polyamide etc., also can be to receive ambient light, heat, water or chemical reagent to stimulate the chemical monomer that cross-linked polymeric takes place down to prepare.
Being used to carry micropin and medicine thereof with the thin slice (108) that is connected with the encapsulating material that the loading control system that drives liquid is housed can be and similar or inhomogeneous metal of encapsulating material (102) or high-molecular organic material.
Micropin is hidden seal member (110) and is supported hard grid (112) and elastic force guard or thin film or thin slice (113) and forms by sealing film (111), micropin, is to be used to control instantaneous transdermal infusion in this drug administration device and to prevent the important accessory of skin to the infection of this device allergy.It is being undertaken under non-loading situation and to hide micropin, avoids micropin to contact for a long time with skin and causes anaphylactic reaction; Encapsulate each loading unit, guarantee to treat that the loading thing does not receive the influence and the deliquescence of human body sweat gland secretion thing and moisture; For independent loading unit the elasticity support is provided simultaneously; Make it when loading; Micropin head in this separate unit can sting unitary seal film and the administration of skin surface cutin membrane rapidly; And micropin is rebounded automatically after dispenser, hightails skin, avoids micropin to imbed for a long time and causes the skin allergy inflammation in the body.
Wherein sealing film (111) is to place micropin to support hard grid (112) and elastic force guard or thin film or thin slice (113) biofilms single-ended or two ends up and down or thin synthetic film.It can effectively stop human body sweat gland secretion thing, moisture and oxygen to invade in the micropin loading system, guarantees that the long-term stability of treating the dispenser thing stores; Seal film strength and thickness the leaning out of micropin when not influencing administration, and have good bio-compatibility, do not cause allergic reaction when contacting for a long time with skin.
The micropin here support hard grid (112) be one type by organic or inorganic or hybrid material preparation, highly be slightly larger than the rigid support structure of the arbitrary shape of micropin length.It is characterized in that: can with seal film (111) and elastic force guard or thin film or thin slice (113) constitutes the structure of independent closed hollow unit one by one---the hidden nest of micropin.The shape of single hidden nest can be circle, ellipse, N limit shape (N>3) or other Any shape.Here the inorganic material of indication comprises metal and nonmetal, and the hybrid material of indication is organic and inorganic hybrid material.
Elastic force guard here or thin film or thin slice (113) be place micropin support hard grid (112) single-ended or up and down two ends, seal the film inboard silk screen with tensile elasticity, thin film or thin slice; Can the elasticity support be provided for each the independent loading unit in the drug administration device; Its micropin can be shot out when loading, draw back rapidly after the dispenser.This type elastic force silk screen, thin film or thin slice can be by natural silks; Like silkworm silk, spider silk etc., rubber, Plant fiber, synthetic fibers, metal or metal alloy preparation; Its thickness and elastic strength are different because of need; Should guarantee the no medicine leakage before the transdermal cutin membrane of the unitary pastille micropin of this loading, can help micropin behind loading, to draw back from epidermis automatically again simultaneously.
The safety block of loading control system (120) is to place the drug administration device top, surround that independent loading is unitary, the adnexa of netted or array structure with withstand voltage properties.It is equal to or is higher than the unitary top of loading highly at least, is used to protect the loading unit because of receiving unexpected extruding drug leakage to take place.The manufacturing materials of these parts can be a metal or nonmetal, and also organic polymer or inorganic material can also be organic and inorganic hybrid materials.These parts also can add one have an elastic force puller strap bucker, do not intake to guarantee patient's its drug administration device of being worn when the bathing.
This device also can have an adnexa (130) as required, and adnexa (130) can be used for drug administration device is fixed on the skin.
Be used for drug administration device is fixed on the optional feature (130) on the skin.It is characterized in that: these parts be breathe freely by having well, have a good sweat, thin slice such as the natural or TPR of heat radiation, bio-compatibility and fabric or leather, plastics, paper makes.This thin slice can be that single face scribbles adhesive; Can the loading device be bonded in skin surface; But be not coated with any adhesive yet, can be through any external force, like bandage, vac sorb, manually push etc.; Make above-mentioned material system that device and body part closely contact, guarantee the comfort level that the patient uses.
Light painless drug administration device is placed in the position of physical comfort, when needs, through manual or external exerting pressure automatically; As push, control such as extruding, with the unitary medicine of one or more loadings, through the administration of micropin thorn transdermal; When loosing one's grip; Or behind the automatic control order fulfillment, used loading unit micropin rebounds automatically, isolates with skin.Meanwhile, micropin in the untapped loading of other on the plaster unit and loading system thereof still are in solid-liquid and divide storage, the sealing state of hiding, get ready for a journey, and can launch one by one, life-time service.It is pointed out that the external control system of exerting pressure automatically of indication here, can be any feasible devices such as electronics, microelectronics, machinery.
In fact; When light painless drug administration device of the present invention combines with the external repeatedly used control system of exerting pressure automatically; Timing or administration had as required both been realized; The micropin that solves the intelligent loading system of existing microelectronics control is imbedded problems such as subcutaneous initiation allergy for a long time, greatly reduces the patient economy burden of accepting automatic loading treatment simultaneously again.