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CN202184797U - Hypertension blood vessel internal treatment catheter - Google Patents

Hypertension blood vessel internal treatment catheter Download PDF

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Publication number
CN202184797U
CN202184797U CN2011200968527U CN201120096852U CN202184797U CN 202184797 U CN202184797 U CN 202184797U CN 2011200968527 U CN2011200968527 U CN 2011200968527U CN 201120096852 U CN201120096852 U CN 201120096852U CN 202184797 U CN202184797 U CN 202184797U
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CN
China
Prior art keywords
catheter
hypertension
blood vessel
treatment
conduit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2011200968527U
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Chinese (zh)
Inventor
曾延华
彭文涛
方唯一
周怀其
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HUNAN EVD MEDICAL DEVICE CO Ltd
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HUNAN EVD MEDICAL DEVICE CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Priority to CN2011200968527U priority Critical patent/CN202184797U/en
Application granted granted Critical
Publication of CN202184797U publication Critical patent/CN202184797U/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

A hypertension blood vessel internal treatment catheter is a medical catheter for blood vessel interventional treatment of clinical hypertension treatment, has functions of monitoring the temperature of renal artery blood vessel tissues and measuring local impedance of renal artery tissues, is used for feeding back and adjusting high-radio-frequency current, and has effects of blocking bilateral renal sympathetic nerves and stopping the sympathetic nerves from stimulating kidneys of a patients to produce and secreting renin, namely angiotensin, and blood pressure of the patient can be reduced. Temperature plastic polymer and a metal wire screen are compounded to form the catheter with a harder near end and a softer far end, a plurality of channels are arranged in a catheter body of the catheter, a far end electrode made of platinum (or gold) composite materials is arranged at the front end of the catheter, and a plurality of guide wires and traction wires of the electrode are connected with a handle and a joint via the channels in the catheter body of the catheter. High-efficient electric isolation tubes and wiredrawing tubes are mounted in the channels of the catheter body, so that transmission of electric signals is guaranteed and bending and outwards extending operations can be smoothly realized in a traction manner.

Description

Hypertension endovascular treatment conduit
Technical field
This utility model relates to a kind of conduit, particularly a kind of hypertension endovascular treatment conduit.
Background technology
Hypertension is to have a strong impact on people's life quality and life-threatening common disease, also be the whole world cause dead main diseases because of, the annual whole world 7 million peoples are dead because of hypertension.Point out in " the Chinese residents nutrition and the investigation of health conditions report " of issuing in information office of State Council on the 12nd news briefing October in 2004: China adult hypertension prevalence is 18.8%, and crowd's hypertension awareness, treatment rate and control rate are merely 30.2%, 24.7% and 6.1%.Even in the U.S., the control rate of hypertension treatment in recent years is less than 30% also.Yet treatment, domestic in recent years Epidemiological study show that men and women's prevalence all surpasses more than 20%; China is one of the most serious country of hypertension harm in the world at present; Estimate that national hyperpietic surpasses 200,000,000, in the international coverage, the whole world has 1,000,000,000 people to suffer from hypertension at present; Expecting hyperpietic in 2025 will have 30% people to suffer from hypertension, and sum reaches 1,500,000,000.This shows that hypertension has become that global range comprises that the present prevalence of China is the highest, one of the ill the most general disease of crowd, the research of hypertensive research and new treatment becomes human instant problem.
The serious consequence that hyperpietic's blood pressure increases is the infringement to the whole body vitals.Because the arterial pressure persistence raises; Cause the whole body arteriolosclerosis; Thereby the blood supply that influences histoorgan is not enough, and the lumen of vessels internal pressure raises, and the infringement that causes heart and brain, kidney is severe complications the most; And be prone to cause coronary heart disease, brain apoplexy, renal failure, and disability rate that causes and mortality rate obviously increase:
The hypertensive patient has arteriosclerotic pathology to exist, and when cerebral arteriosclerosis arrived to a certain degree, adding external condition stimulated, and like surexcitation, indignation and strenuous exercise etc., blood pressure will hurriedly raise, and very easily brings out the high apoplexy of disability rate that causes death.Annual this type of the hurried generation of kainogenesis of China, the violent ACVD of the state of an illness have 2,000,000 people, and 2/3 generation is heavy residual or dead.Wherein 76% people has hypertension history.Hyperpietic's blood pressure is high more, and occurrence of stroke is high more.
Hypertensive variation can cause the steady imbalance between myocardial oxygen delivery amount and the oxygen demand, the lasting rising of blood pressure, and left chamber afterload strengthens; Cardiac muscle is powerful to be increased; Myocardial oxygen consumption increases thereupon, and when merging coronary atherosclerosis, the CFR function reduces; Myocardial oxygen delivery reduces, and angina pectoris, myocardial infarction, heart failure etc. therefore occur.Have data to show, the existing patients with coronary heart disease of China is about 1,000 ten thousand, annual newly-increased 30-40 ten thousand New Development patients, and wherein 65% has hypertension history.
Renal arteriosclerosis during hypertension causes kidney damage, and the kidney damage of this moment increases the weight of hypertension.Hypertension and kidney damage can influence each other, and form vicious cycle.The hypertension of hurried development can cause kidney small artery diffuse lesion widely, causes pernicious renal arteriolosclerosis, is uremia thereby develop rapidly.
The cardiovascular and cerebrovascular disease that hypertension causes is the serious harm national health, causes the tremendous economic burden for patient, family and country, estimates that the cardiovascular and cerebrovascular disease diagnosis and treatment that China only causes because of hypertension every year expend 3,000 hundred million yuans.Hypertension is the maximum inducement of cardiovascular and cerebrovascular disease, and in this sense, hypertension is harm people's the health even the killer that hides of life.
Hypertension also causes being prone to as taking place aneurysmal danger because of it to hemodynamic influence.
Domestic and international popular hypertension therapeutic remains Drug therapy at present.The purpose of its treatment be through drug effect in each link that causes hypertension, disturb the effect cause hypertension in the body and controlling blood pressure; Mainly be to rely on medicine on the Therapeutic Method; Wherein of greatest concern and what play a major role is calcium channel blocker, angiotensin-convertion enzyme inhibitor and angiotensin ii receptor antagonist; And two types of medicines are main after outstanding, and the effect of these back two types of medicines is all at RAS.The treatment of the Long term combined medication of such medicine, will not only need take for a long time and expensive, side effect outstanding, most importantly therapeutic effect is still undesirable.Data shows that present hypertensive treatment rate of China and control rate are merely 24.7% and 6.1%.Therefore, generally believe that the hypertension drug treatment of global range is still more because of side effect, individual variation, control rate be not still good, because of the mortality rate that hypertension causes can be in any more.
The basic cause of essential hypertension is brought out owing to the sympathetic nerve overacfivity and is kept.Radiolabel shows that the hyperpietic exists the too much noradrenaline secretion of kidney and gets into blood system.Thereby arranging interior all blood vessel, renal tubules and the juxtaglomerular apparatuses of kidney behind the sympathetic ganglion of domination kidney behind the neural entering kidney regulates renin angiotensin aldosterone system; Conversely, vasotonia speed II can increase central mechanism and the adrenal gland's ability neurotransmission that quickens SNE again.So, orthosympathetic effect causes blood pressure to increase.Thereby generally believe that at present the orthosympathetic activity of kidney is the major reason that causes essential hypertension.
External zoopery and clinical experiment confirm: blocking-up kidney sympathetic nerve; Can not cause that not only the kidney normal function lowers; And systolic pressure and diastole are all descended; This explanation, although essential hypertension has multifactor existence, the orthosympathetic activity of domination kidney and tension force are to play an important role in hypertension existence and the progress.The surgery wide excision visceral nerve operation of previously once carrying out can reduce renin secretion, do not reduce the filtration rate of kidney blood flow and glomerule, still can keep electrolytical balance.But the operation of visceral nerve blocking-up has so widely caused the complication of very high peri-operation period, and because of the sickness rate of lacking of proper care of other viscera functions after visceral nerve is removed widely also very high.The kidney transfer operation of clinical more enforcement at present then can explain well, remove the kidney nerve after, kidney still can keep power and water to separate the stable of matter.In zoopery, also observe, when hypertension, the sympathetic nervous system of kidney and body is closely related.Therefore; If can then can interrupt the effect of the rising blood pressure of RAS, simultaneously optionally at one organ level blocking-up RAS; Because the reduction of RAS vaso-active substance; It also is able to weaken to the orthosympathetic activation effect of whole body, thereby keeping under the complete prerequisite of renal function systemic blood pressure being descended, reaches the hypertensive purpose of treatment.Be that super-selective blocking-up kidney sympathetic nerve will make blood pressure drops, can avoid other unnecessary influences simultaneously bodily tissue and organ.
The utility model content
The purpose of this utility model is to provide a kind of renal function that can keep complete, and can avoid other the hypertensive hypertension endovascular treatment of effective treatment pipes to the unnecessary influence of bodily tissue and organ.
Be to realize above-mentioned purpose, the technical scheme that this utility model adopts is: a kind of hypertension endovascular treatment conduit, by temperature mould polymer become with the metal gauze produced with combination near-end hardness greatly, far-end softer and body in the conduit of many passages is arranged; Catheter proximal end adopts platinum or metallic composite manufacturing terminal electrode, and many leads of this termination electrode link to each other with joint with handle via the intravital passage of catheter tube with drawing silk.
In the above-mentioned hypertension endovascular treatment conduit, be provided with electric isolated tube I, electric isolated tube II and backguy pipe in the said catheter tube passage.
The technique effect of this utility model is: compared with prior art, the method that this utility model adopts Wicresoft to get involved, percutaneous puncture intravascular intracavity arrives renal artery; The bilateral renal arteries tube wall is imposed the high frequency current in short bursts; Sympathetic nerve on the renal artery wall is destroyed, and sympathetic nerve interrupts for the domination of kidney, and renin angiotensin is reduced for a long time; Thereby blood pressure drops reaches the hypertensive effect of treatment.This utility model is optionally at one organ level blocking-up renin angiotensin; Because the reduction of RAS vaso-active substance; It also is able to weaken to the orthosympathetic activation effect of whole body; Thereby renal function is complete keeping, and has avoided other unnecessary influences to bodily tissue and organ simultaneously.
Description of drawings
Fig. 1 is a hypertension endovascular treatment conduit connection layout.
10, joint connects this conduit to radio-frequency therapeutic equipment
11, lead
12, handle, the control conduit gets into and reverses
1, the tractive button affects may command distal end of catheter section crooked
13, handle and catheter tube junction
21, the catheter tube proximal segment, body hardness is higher, is convenient to push conduit
20, the catheter tube distal ports, body is softer, is convenient to the front end bending
19, termination electrode, electric conductivity good metal head end is built-in with critesistor, can accept temperature, impedance signal, and exportable radio-frequency current
Fig. 2 is joint, handle figure.
10, joint connects radiofrequency generator
11, lead
12, handle,
13, handle and catheter tube junction
1, the tractive button affects may command distal end of catheter section crooked
8, drag wire
3,5, drag wire fast pulley, fixedly drag wire
4, driven pulley
2, fixing button is pulled to its fixedly effect of tractive button when suiting the position
6, electric isolated tube, pipe is interior through temperature sensitive, impedance electrical signal lead
7, the radio frequency spool passes through the radio frequency output lead in the pipe
Fig. 3 is catheter tube overall structure figure.
21, the catheter proximal end section, body hardness is higher, is easy to carry
20, the distal end of catheter section, body is softer, is convenient to bending
22, body and handle junction
6, electric isolated tube is through temperature, impedance electrical signal conduction lead
7, electric isolated tube is through radio-frequency current transmission signal conductor
12, the tractive pipe is through drawing silk
18, critesistor
17, the drawing silk fixing point
23, the radio frequency line fixing point
24, impedance measurement line fixing point
19, termination electrode
Fig. 4 is the catheter tube profile.
6, electric isolated tube I
7, electric isolated tube II
12, the backguy pipe
14, the body internal layer
15, metal gauze
16, body is outer
The specific embodiment
Below in conjunction with accompanying drawing this utility model is done detailed explanation.
As shown in Figure 1, the structure of this utility model is followed successively by connecting pin 10, lead 11, handle 12, control knob 1, handle and body connecting portion 13, body near-end 21, body far-end 20, termination electrode 19 from near-end to far-end.Visible among the figure: connecting pin 10 is connected with handle 12 through lead 11, and handle 12 is connected with body near-end 21 with body connecting portion 13 through handle, and body near-end 21 extends to body far-end 20, and distal-most end is a termination electrode 19.
Control pull-button 1 is housed on the handle 12.
Fig. 2 is the handle arrangement figure of this utility model, and wherein visible connecting pin 10, lead 11 are connected with handle 12.
Fig. 3 is the conduit whole interior structure chart of this utility model.It is thus clear that pass through in the electric isolated tube I 6 from critesistor 18 with from the lead of impedance measuring 24, the high frequency electric lead that passes through in the electric isolated tube II 7.The metal backguy of passing through in the backguy pipe 12.
Fig. 4 is the profile of catheter body, strengthens net 15 it is thus clear that tightly hold the tinsel of conduit internal layer 14, strengthens net 15 fusions and covers its outer catheter outer 16 with tinsel.Electric isolated tube I 6 through temperature-sensitive signal and impedance signal lead is arranged in the conduit internal layer 14, through the electric isolated tube II 7 of radio frequency output lead, through tractive backguy pipe 12 wiry.
Termination electrode 19 can be made by platinum, platinumiridio, silver or other metals with excellent conductive performance, and thermal resistor wire, radio frequency output lead, impedance measuring lead can adopt the wire producing with insulating properties.One end of the lead of impedance measuring is welded on the connecting portion 24 of termination electrode 19; One end of each thermal resistor wire is welded on the corresponding connecting portion of critesistor 18; Then through the electric isolated tube 6 in body and the handle, be welded at last on the respective electrode of joint 10.One end of radio frequency output lead is welded on the termination electrode 23, and lead is welded on the respective electrode of joint 10 through electric isolated tube II 7 at last.
The tractive metal wire can adopt the tinsel with favorable elasticity to make the side 17 that is welded to termination electrode, through tractive spool 12, is fixed at last on the tractive wheel 3 in the handle 12.
Body is divided into proximal segment 21 and distal ports 20 with regard to entire length.Two sections main difference is that proximal segment 21 body hardness are high, and 20 bodys of distal ports are softer.Can be through adopting the polymeric material of different hardness, promptly proximal segment 21 adopts the polymer of high rigidity, and distal ports 20 adopts the low polymeric material of hardness number to accomplish.Making after heat respectively fuses and connects two sections and get final product.With regard to the body internal structure, be divided into internal layer 14, metal gauze strengthening layer 15 and outer 16.The material that adopts respectively is polymer, tinsel and polymer.Internal layer can adopt three lumens that plastic extruder is extruded in the making, in each lumen, inserts electric isolated tube I 6, electric isolated tube II 7 and backguy pipe 12 respectively and accomplishes.Electricity isolated tube I 6, electric isolated tube II 7 are good to adopt the good fluorine material of electric isolation performance, and it is first-selected that backguy Guan Zeke selects the polymeric material that coefficient of friction is little, material is harder.After accomplishing the body internal layer,, coat the outer layer copolymer material with the metal gauze 15 tight union body internal layers of braiding, then cover is installed three layers, promptly body internal layer 14, metal gauze strengthening layer 15, body outer 16 together heat fuse the complete body of formation.
Termination electrode 19 fuses completion with being connected equally also of body far-end 20 through heat.
Making step is following:
Termination electrode is made, and termination electrode connects lead and the drawing silk welding is fixing, and the body internal layer is made; Complete body is made, and penetrates electric isolated tube and backguy pipe and penetrates respective wire and drag wire, and termination electrode heat fuses and is fixed on the body far-end; The body near-end is connected with handle, fixes, and joint is installed.
This utility model integral body is the conduit spline structure, and the body front end is signal of telecommunication output and collecting part, and the body rear portion is the joint and the joystick of signal of telecommunication input and output.Handle is convenient to propelling movement, tractive or rotation, with regulate that conduit moves in blood vessel and towards; But the intravital backguy silk of the part tractive pipe of the adjusting on the handle makes the body leading portion attach the renal artery tube wall or stretch conduit to lateral bending song.
Experiment in the animal body: after femoral arteriography is put the conduit that stops blooding; Send 8F guiding catheter through this hemostasis conduit; X line DSA observes the front end that confirms guiding catheter down and arrives in the renal artery, then, hypertension endovascular treatment conduit is sent into through the 8F guiding catheter; X line DSA observes down, notices that termination electrode arrives the renal artery proper site.Jointing is handled the tractive button to radiofrequency generator, makes the catheter end electrode attach the renal artery inwall, measures the impedance of renal artery inwall, and it is that 100 Europe are female that impedance is set in adjustment, and 80 volts of voltages are 50 seconds between power 30 watt-hours; Measure renal artery place's temperature and impedance.The renal artery clockwise direction is located to implement to melt 12 points, 3 points, 6 points, 9 respectively.After one side finishes, accomplish the same operation in the offside renal artery then.After finished both sides, radiofrequency catheter withdrawed from, and withdrawed from externally via guide wire, and local point of puncture hemostasis wrapping finishes operation.Guiding catheter is withdrawed from the collection of hypertension endovascular treatment conduit, withdraw from the hemostasis conduit, point of puncture compressing blood.

Claims (2)

1. hypertension endovascular treatment conduit is characterized in that: moulded the conduit that many passages are arranged in that polymer becomes with the metal gauze produced with combination that near-end hardness is big, far-end is softer and the body by temperature; Catheter proximal end adopts platinum or metallic composite manufacturing terminal electrode, and many leads of this termination electrode link to each other with joint with handle via the intravital passage of catheter tube with drawing silk.
2. hypertension endovascular treatment conduit according to claim 1 is characterized in that: be provided with electric isolated tube I, electric isolated tube II and backguy pipe in the catheter tube passage.
CN2011200968527U 2011-04-06 2011-04-06 Hypertension blood vessel internal treatment catheter Expired - Fee Related CN202184797U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2011200968527U CN202184797U (en) 2011-04-06 2011-04-06 Hypertension blood vessel internal treatment catheter

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2011200968527U CN202184797U (en) 2011-04-06 2011-04-06 Hypertension blood vessel internal treatment catheter

Publications (1)

Publication Number Publication Date
CN202184797U true CN202184797U (en) 2012-04-11

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9743845B2 (en) 2011-08-26 2017-08-29 Symap Medical (Suzhou), Ltd Mapping sympathetic nerve distribution for renal ablation and catheters for same
US9770291B2 (en) 2011-08-26 2017-09-26 Symap Medical (Suzhou), Ltd Device for mapping and ablating renal nerves distributed on the renal artery
US11832965B2 (en) 2018-10-06 2023-12-05 Symap Medical (Suzhou), Limited System and method for mapping the functional nerves innervating the wall of arteries, 3-D mapping and catheters for same

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9743845B2 (en) 2011-08-26 2017-08-29 Symap Medical (Suzhou), Ltd Mapping sympathetic nerve distribution for renal ablation and catheters for same
US9770291B2 (en) 2011-08-26 2017-09-26 Symap Medical (Suzhou), Ltd Device for mapping and ablating renal nerves distributed on the renal artery
US10842559B2 (en) 2011-08-26 2020-11-24 Symap Medical (Suzhou), Limited System and method for locating and identifying the functional nerves innervating the wall of arteries and catheters for same
US11832965B2 (en) 2018-10-06 2023-12-05 Symap Medical (Suzhou), Limited System and method for mapping the functional nerves innervating the wall of arteries, 3-D mapping and catheters for same

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Legal Events

Date Code Title Description
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120411

Termination date: 20130406