CN201823337U - Concentrating and crystallizing equipment for 5-hydroxyl tryptophan - Google Patents

Abstract

The utility model discloses a concentration and crystallization device for 5-hydroxytryptophan, which comprises a raw material tank, a feeding pump, an ion exchange resin tank, an evaporator and a crystallization tank which are successively connected through pipelines, and is characterized in that the ion exchange resin tank The pipelines in the rear and in front of the evaporator are also successively installed with an intermediate material tank, a security filter, a high-pressure pump, a membrane concentration device and a dialysis tank. The hydroxytryptophan extract is first concentrated by membrane, and the membrane concentration has the advantages of energy saving and high efficiency, which reduces the production cost.

Description

A kind of concentration and crystallization equipment of 5-hydroxytryptophan

technical field

The utility model relates to a concentration and crystallization device, in particular to a concentration and crystallization device for 5-hydroxytryptophan.

Background technique

5-Hydroxytryptophan (also known as five-hydroxytryptophan, 5-HTP) is a natural amino acid, its chemical name is 5-hydroxy-3-indolyl-α-alanine, and its molecular weight is 220.23. Penta-hydroxytryptophan is mainly extracted from Ghana seed, which is the dry seed of Griffonia simplicifolia , a tropical leguminous shrub plant, which grows wild in West African countries such as Ghana, Ivory Coast and Togo. Five-hydroxytryptophan has a variety of biological effects, and is an important raw material for neurological drugs and health care drugs. It is widely used in clinical practice, has important utilization value and broad market prospects.

At present, most of the extraction and preparation methods of 5-hydroxytryptophan are: pressing or petroleum ether deoiling→water/solvent extraction→decolorization→filtration→concentration→crystallization→recrystallization, and the concentration of the extract of 5-hydroxytryptophan is mainly It is realized through the process of evaporative concentration, in which the equipment used for evaporative concentration is mainly an evaporator. Evaporation and concentration has the advantages of high concentration multiples, but the evaporative concentrate has the disadvantages of high energy consumption and high cost. The content of 5-hydroxytryptophan in the solution after decolorization and filtration of the extract of 5-hydroxytryptophan is relatively low. If it is directly evaporated and concentrated, the evaporation cost and evaporation time will be greatly increased.

Membrane separation is a new separation technology that appeared in the early 20th century and rose rapidly after the 1960s. Membrane separation technology has been widely used in food, medicine, biology, Environmental protection, chemical industry, metallurgy, energy, petroleum, water treatment, electronics and other fields have produced huge economic and social benefits, and have become one of the most important means in today's separation science.

Contents of the invention

The utility model aims at the shortcomings of traditional 5-hydroxytryptophan evaporation and concentration equipment such as high energy consumption, and designs an improved 5-hydroxytryptophan evaporation and concentration equipment to achieve the purpose of reducing production costs.

In order to achieve the above object, the technical solution proposed by the utility model is: a kind of concentration and crystallization equipment of 5-hydroxytryptophan, including a raw material tank, a feeding pump, an ion exchange resin tank, an evaporator, and a crystallization tank connected in sequence through pipelines , it is also characterized in that an intermediate material tank, a security filter, a high-pressure pump, a valve, a membrane concentration device and a dialysis tank are successively installed on the pipeline behind the ion exchange resin tank and in front of the evaporator, and the outlet of the concentrated solution of the membrane concentration device passes through the backflow The pipeline is connected with the intermediate material tank, and connected with the evaporator through the concentration pipeline, and the feature is that valves are also installed on the return pipeline and the concentration pipeline.

The high-pressure pump is a diaphragm pump or a horizontal centrifugal pump, the filtration precision of the safety filter is 50-200 μm, and the membrane assembly used in the membrane concentration device is a roll-type nanofiltration membrane or a roll-type reverse osmosis membrane.

A heat exchanger is also installed on the return pipeline.

Through the above technical scheme, the main advantage of the utility model equipment for 5-hydroxytryptophan concentration and crystallization is that, compared with the traditional direct evaporation concentration and crystallization method, the 5-hydroxytryptophan extract is first concentrated through the membrane, and the membrane concentration It has the advantages of energy saving and high efficiency, and can greatly reduce production costs.

Description of drawings

Fig. 1 is the equipment structural diagram of the present utility model;

Among them: 1. Raw material tank, 2. Feed pipeline, 3. Feed pump, 4. Ion exchange resin tank, 5. Intermediate material tank, 6. Security filter, 7. High pressure pump, 8. Membrane concentration device, 9 . Dialysis tank, 10. Return pipeline, 11. Heat exchanger, 12. Valve, 13. Concentrator pipeline, 14. Evaporator, 15. Crystallization tank.

Detailed ways

Below in conjunction with specific embodiment and accompanying drawing, the utility model is further described.

As shown in the equipment structure diagram of the present utility model in accompanying drawing 1, a kind of concentrated crystallization equipment of 5-hydroxytryptophan: raw material tank 1 is successively connected with feeding pump 3, ion exchange resin tank 4, intermediate material through feed pipeline 2 Tank 5, security filter 6, high-pressure pump 7, and valve 12 are connected, and then connected to membrane concentration device 8, the dialysate outlet of membrane concentration device 8 is connected to dialysis tank 9 through pipelines, and the concentrated solution outlet of membrane concentration device 8 is connected to backflow The pipeline 10 is connected with the intermediate material tank 5, and is connected with the evaporator 14 through the concentration pipeline 13, and the evaporator 14 is connected with the crystallization tank 15 again. A valve 12 is also installed on the return pipeline 10 and the concentration pipeline 13, and a heat exchanger 11 is also installed on the return pipeline.

The high-pressure pump 6 used can be a diaphragm pump or a horizontal centrifugal pump. The security filter 7 is a filter bag with a filtration accuracy of 50-200 μm. The membrane module used in the membrane separation device 8 is a roll-type nanofiltration membrane or roll-type reverse filter. permeable membrane.

When the equipment is running, the 5-hydroxytryptophan extract is pumped from the raw material tank 1 into the ion exchange resin tank 4 through the feed pump 3 through the feed pipe 2, and after ion exchange adsorption, it is pumped into the membrane concentration device by the high pressure pump 6 In the process, due to the roll-type nanofiltration membrane or roll-type reverse osmosis membrane, the dialysate without 5-hydroxytryptophan passes through the membrane and enters the dialysis tank, and the 5-hydroxytryptophan concentrate passes through the return pipeline 10 Return to the intermediate tank 5 for further circulation and concentration, or enter the evaporator through the concentration pipeline 13 for further evaporation and concentration, and after evaporation and concentration to a certain concentration multiple, enter the crystallization tank 15 for cooling and crystallization.

In summary, the main advantage of using the device of the present invention for the concentration and crystallization of 5-hydroxytryptophan is that, compared with the traditional method of direct evaporation, concentration and crystallization, the 5-hydroxytryptophan extract is first passed through a nanofiltration membrane or Reverse osmosis membrane concentration, and membrane concentration has the advantages of energy saving and high efficiency, which can greatly reduce production costs.

Claims (4)

1. a kind of concentrated crystallization equipment of 5-hydroxytryptophan, comprise the raw material tank that is connected successively by pipeline, feeding pump, ion exchange resin tank, evaporator, crystallization tank, it is characterized in that after ion exchange resin tank, evaporation The pipeline in front of the device is also successively installed with an intermediate material tank, a safety filter, a high-pressure pump, a valve, a membrane concentration device and a dialysis tank, and the outlet of the concentrated solution of the membrane concentration device is connected to the intermediate material tank through a return pipeline, and is connected to the evaporation tank through a concentration pipeline. The device is connected, and it is also characterized in that valves are also installed on the return pipeline and the concentration pipeline. 2. A kind of 5-hydroxytryptophan concentration and crystallization equipment as claimed in claim 1, characterized in that the filtration precision of the security filter is 50-100 μm. 3. The concentration crystallization equipment of a kind of 5-hydroxytryptophan as claimed in claim 1, it is characterized in that the membrane assembly used in the membrane concentration device is a roll-type nanofiltration membrane or a roll-type reverse osmosis membrane. 4. The concentrated crystallization equipment of a kind of 5-hydroxytryptophan as claimed in claim 1, it is characterized in that a heat exchanger is also installed on the described return pipeline.

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