CN201551639U - A dual-chamber fluid reservoir for a bioartificial liver support system - Google Patents

Abstract

The utility model discloses a double-cavity liquid storage tank for a bioartificial liver support system, which includes an inner cavity and an outer cavity; wherein, the top of the outer cavity is provided with a first liquid inlet and a first air pressure balance hole, and the top of the inner cavity is provided with a second cavity. Two liquid inlets and a second air pressure balance hole, the bottom of the inner cavity is provided with a first liquid outlet, and the side wall of the inner cavity is provided with a second liquid outlet near the bottom. Leading to the outside of the double-chamber liquid storage pool, the tubular channel is provided with several external chamber side holes on the side wall of the outer chamber part; the bioartificial liver support system of the present utility model uses the double-chamber liquid storage pool to realize multiple hepatic plasma It flows through the bioreactor to form a highly efficient circulation path, so that it can exert a better therapeutic effect. The dual-chamber fluid storage tank for the bioartificial liver support system provided by the utility model can also be reset, enlarged or reduced in proportion to the volume of the inner and outer double chambers according to specific clinical practice requirements, so that it can be more reasonably used in clinical practice.

Description

A dual-chamber fluid reservoir for a bioartificial liver support system

technical field

The utility model belongs to the technical field of biomedicine and relates to a medical device, in particular to an important device which is applied to the treatment of a bioartificial liver and can effectively improve the treatment effect of the bioartificial liver: a double-chamber fluid storage pool for a bioartificial liver support system.

Background technique

At present, liver failure is a critical condition with rapid progress and high mortality rate. The treatment of liver failure has always been a worldwide problem. At present, the artificial liver treatment has become an irreplaceable treatment for severe hepatitis liver failure, especially the bioartificial liver can theoretically compensate all the functions of the liver, which represents the development trend of artificial liver in the future and is facing a huge clinical demand. It has broad clinical application prospects. The basic principle of the bioartificial liver is that the patient's blood or plasma flows through the bioreactor loaded with bioactive cells. During this process, the bioactive cells complete the metabolism of toxic substances in the blood (plasma) and simultaneously synthesize the Biologically active substances are released into the blood, correct internal environment disorders, temporarily replace part of the function of the failed liver, and win opportunities for autologous liver recovery or liver transplantation, thereby reducing patient mortality and achieving therapeutic purposes.

It is not difficult to understand that the curative effect of the bioartificial liver depends not only on the number and biological function of the hepatocytes in the reactor, but also on the material exchange efficiency between the patient's blood (plasma) and the cultured cells in vitro. The liquid reservoir plays a key role in this link. The bioartificial liver devices that have undergone phase I-III clinical verification in foreign countries include BLSS, AMC-BAL, ELAD, MELS, HepatAssist, etc., and most of them have not achieved the expected clinical efficacy. An important reason for this is that although they focus on the research on the cell source and the characterization of the reactor, the component of the liquid reservoir has not been fully studied. The artificial liver device lacking a liquid reservoir causes the patient's blood (plasma) to return to the body after one cycle, which makes the patient's blood (plasma) lack sufficient material exchange with the cells, and the treatment efficiency of the bioartificial liver is low. Most artificial liver devices are equipped with liquid reservoirs, but most of them are single-chamber structures. Although multiple cycles can be achieved, the structural defects cannot avoid the situation that the blood (plasma) that has not passed through the reactor is directly returned to the body, that is, the so-called Invalid loop.

Utility model content

The purpose of this utility model is to provide a dual-chamber liquid storage tank for a bioartificial liver support system in view of the deficiencies of the prior art. , form a highly efficient circulation pathway, and play a better therapeutic effect.

The purpose of this utility model is achieved through the following technical solutions: a dual-chamber liquid storage pool for a bioartificial liver support system, including an inner chamber and an outer chamber; wherein, the top of the outer chamber is provided with a first liquid inlet and a first air pressure A balance hole, the top of the inner cavity is provided with a second liquid inlet and a second air pressure balance hole, the bottom of the inner cavity is provided with a first liquid outlet, and the side wall of the inner cavity is provided with a second liquid outlet near the bottom, and the second liquid outlet is provided with a tubular The channel passes through the outer cavity, and the inner cavity directly leads to the outside of the double-chamber liquid storage pool. The tubular channel is provided with several outer cavity side holes on the side wall of the outer cavity.

Further, the inner cavity and the outer cavity are composed of two concentric and equal-height hollow cylinders sealed at the top and bottom, and the material is plastic or plexiglass.

Further, the first air pressure balance hole and the second air pressure balance hole have a radius of 0.3 cm, and filter membranes are provided inside.

Further, the thickness of the filter membrane is 0.22 microns, and its material is mixed cellulose ester.

Further, there are three outer cavity side holes 7 with a diameter of 0.15 cm.

The beneficial effect of the utility model is that the bioartificial liver support system of the utility model uses a double-chamber liquid storage tank to realize the heavy liver plasma flowing through the bioreactor multiple times to form a high-efficiency circulation path, so that a better therapeutic effect can be exerted . The dual-chamber fluid storage tank for the bioartificial liver support system provided by the utility model can also be reset, enlarged or reduced in proportion to the volume of the inner and outer double chambers according to specific clinical practice requirements, so that it can be more reasonably used in clinical practice.

Description of drawings

FIG. 1 is a schematic diagram of a three-dimensional structure of a dual-chamber fluid storage tank for a bioartificial liver support system;

Fig. 2 is a schematic diagram of an external system auxiliary device for a dual-chamber fluid reservoir used in a bioartificial liver support system.

Detailed ways

The utility model is described in detail below according to the accompanying drawings, and the purpose and effect of the utility model will become more obvious.

As shown in Figure 1, the dual-chamber fluid reservoir for the bioartificial liver support system of the present invention includes a concentric and equal-height inner chamber 8 and an outer chamber 9, a first liquid inlet 1, a second liquid inlet 2, a first air pressure Balance hole 4, second air pressure balance hole 3, first liquid outlet 5, second liquid outlet 6, outer chamber side hole 7. The overall appearance of the reservoir is composed of two concentric cylinders of equal height, and the interior of the reservoir is correspondingly divided into closed inner and outer double cavities. Both the first liquid inlet 1 and the first air pressure balance hole 4 on the upper top of the reservoir are connected to the inner chamber 8 , and the second liquid inlet 2 and the second air pressure balance hole 3 are both connected to the outer chamber 9 . The first air pressure balance hole 4 and the second air pressure balance hole 3 respectively connect the inner cavity 8 and the outer cavity 9 with the outside of the pool to maintain the balance of atmospheric pressure inside and outside the pool, and the air pressure balance holes are equipped with 0.22 micron filter membranes in the holes to ensure that the inside and outside of the pool In sterile state, the filter membrane material can be mixed cellulose ester and the like.

There is a first liquid outlet 5 at the lower bottom of the liquid storage tank, which serves as a passage for the purified plasma to return to the human body. The side wall is close to the first liquid outlet 6 at the lower bottom. The outlet passes through the outer chamber 9 by means of a tubular passage, and directly leads to the outside of the liquid storage tank from the inner chamber 8, and the passage is provided with several outer chambers on the side wall of the outer chamber 9. The cavity side holes 7 are about 0.15cm in diameter, and there are three in the figure.

The outer cavity 9 will contain heavy liver plasma from the human body through the first liquid inlet 1 , while the inner cavity 8 will contain the purified plasma after acting with the bioreactor through the second liquid inlet 2 . The first liquid inlet 1 is connected to the pipeline of the plasma separator 10, and is driven by the pump to continuously pump heavy liver plasma into the outer cavity 9 of the reservoir through the first liquid inlet 1; the second liquid inlet 2 is connected to the bioreactor 11 After the pipeline, heavy liver plasma and part of the circulating plasma interact with the liver cells in the bioreactor 11, they are driven by the pump and returned to the inner chamber 8 of the storage pool as purified plasma through the second liquid inlet 2. There are two air pressure balance holes on the top of the liquid storage tank, the hole radius is about 0.3cm, which respectively connect the inner chamber 8 and the outer chamber 9 with the outside of the pool, so as to maintain the balance of atmospheric pressure inside and outside the pool, and the two air pressure balance holes are in the hole A 0.22-micron filter membrane is set to maintain a sterile state in the reservoir. There is a first liquid outlet 5 at the lower bottom of the liquid storage pool, which is connected to the inner chamber 8 and connected outward to the plasma pipeline returning to the human body. The partially purified plasma in the inner cavity 8 of the liquid storage pool can return to the human body through the first liquid outlet 5 . Wherein, the amount of hepatic heavy plasma entering the outer cavity 9 from the first liquid inlet 1 is equal to the amount of purified plasma flowing out from the first liquid outlet 5 through the inner cavity 8 . The side wall of the liquid reservoir has a second liquid outlet 6 near the lower bottom, and the liquid outlet 6 leads directly to the outside of the liquid reservoir from the inner cavity 8 by means of a tubular channel, and the channel is provided on the side wall of the part passing through the outer cavity 9 There are 3 holes in the outer cavity side hole 7, and the diameter of each hole is about 0.15cm. The second liquid outlet 6 will be connected to the pipeline of the bioreactor, driven by the pump, the purified plasma in the inner cavity 8 will enter the pipeline of the bioreactor through the second liquid outlet 6, and the heavy liver plasma in the outer cavity 9 will be discharged from the outer cavity side. The hole 7 is sucked through the liquid outlet 6 and mixed with the purified plasma in the inner cavity 8, and enters the bioreactor 11 together, interacts with the liver cells in the bioreactor 11, and finally returns to the inner cavity through the second liquid inlet 2 Cavity 8 forms a circulation. The pipe diameters of the above liquid inlet and liquid outlet are all about 0.6 cm in diameter. In addition, the length of the outer part of the liquid storage tank is 1.5 cm.

The dual-chamber liquid storage tank for the bioartificial liver support system provided by the utility model is composed of inner and outer double chambers. With the help of the second liquid outlet 6 and the side hole 7 of the outer chamber, driven by the pump, it can simultaneously absorb liquid from the inner and outer double chambers. Plasma can form multiple effective bioartificial liver treatment cycles, avoiding the direct return of heavy liver plasma to the body without reacting with the bioreactor and liver cells, so as to play the role of bioartificial liver treatment more efficiently.

The shell material of the double-chamber reservoir for the bioartificial liver support system of this example can be plastic or plexiglass, and its size is: the radius of the inner chamber 8 of the reservoir is 3 cm, and the radius of the outer chamber 9 is 4 cm. It is 9cm, the volume of inner chamber 8 is about 250ml, and the volume of outer chamber 9 is about 200ml. During actual production, it can be enlarged or reduced according to the needs of clinical practice, and the optimal size can be worked out.

As shown in Figure 2: the hepatic blood is pumped out from the patient's vein and enters the plasma separator 10. The hepatic blood is separated into hepatic plasma and blood cells. Cavity 9. Due to the pumping effect of the pump in the bioreactor passage outside the pool, the heavy liver plasma in the outer cavity 9 will flow out through the second liquid outlet 6 through the outer cavity side hole 7 of the outer cavity 9 part passage, and enter the device through the second liquid outlet 6. In the bioreactor 11 with hepatocytes, interact with the hepatocytes. After the first interaction, the plasma, as purified plasma, will enter the inner chamber 8 of the reservoir 12 through the first liquid inlet 2, and mix with the prefilled plasma generation in the inner chamber 8, and most of the diluted purified plasma It will pass through the second liquid outlet 6 and be driven by the pump again into the bioreactor 11 to interact with the liver cells, forming a cycle in which heavy liver plasma enters the bioreactor 11 repeatedly. The purified plasma that has gone through multiple cycles into the bioreactor 11 will be driven by the pump through the first liquid outlet 5, and enter the pipeline returning to the human body, and finally mix with blood cells and return to the human body.

The utility model is a double-cavity liquid storage pool for a bioartificial liver support system, and has huge advantages compared with common circulation liquid storage pools. Ordinary liquid reservoirs are only a closed three-dimensional bottle with several channels for liquid in and out. After the heavy liver plasma enters the ordinary liquid reservoir, it cannot be isolated from the purified plasma, but directly mixed together, and part of the mixed plasma It will be directly returned to the human body, resulting in part of the hepatic plasma directly returning to the body without the interaction between the bioreactor and the liver cells, which will not achieve the therapeutic effect of the bioartificial liver. However, the dual-chamber fluid storage tank for the bioartificial liver support system provided by the utility model is composed of an inner and outer double chamber, the outer chamber holds heavy liver plasma, and the inner chamber holds purified plasma, which ensures the effective isolation of the two parts of plasma. At the same time, with the help of the specially set liquid outlet and the side hole of the outer chamber, the liquid storage pool can absorb the plasma of the inner and outer double chambers at the same time under the drive of the pump, and due to the outward suction of the pump, the heavy liver in the outer chamber Plasma will be pumped into the bioreactor together with the purified plasma in the inner cavity, and will not directly enter the inner cavity, thus effectively preventing heavy liver plasma from returning directly to the body without reacting with the bioreactor and liver cells. The purified plasma in the inner cavity and part of the liver-heavy plasma in the outer cavity continuously form multiple effective bioartificial liver treatment cycles, and more efficiently exert the therapeutic effect of the bioartificial liver. In addition, compared with the ordinary liquid storage tank, the utility model also effectively solves the problem of air pressure balance inside and outside the tank and maintains the aseptic state in the tank by setting the air pressure balance hole with a 0.22 micron filter membrane, so that the air pressure dynamics And biological security reflects a unique advantage.

The bioartificial liver support system uses a double-chamber fluid storage pool, which can effectively improve the treatment efficiency of the bioartificial liver through a unique structure, and has reasonable design, comprehensive functions, strong applicability, wide application range, and good application prospects.

Claims (5)

1. a dual-cavity liquid storage tank for biological artificial liver support system is characterized in that, comprises inner chamber (8) and exocoel (9); Wherein, exocoel (9) top is provided with first liquid-inlet (1) and first air equalizer opening (4), inner chamber (8) top is provided with second liquid-inlet (2) and second air equalizer opening (3), inner chamber (8) bottom is provided with first liquid outlet (5), inner chamber (8) sidewall is provided with second liquid outlet (6) near the bottom, this second liquid outlet (6) by a tubular conduit by way of exocoel (9), directly led to outside the dual-cavity liquid storage tank by inner chamber (8), the sidewall of this tubular conduit exocoel (9) part is provided with several exocoel side openings (7).

2. according to the described dual-cavity liquid storage tank for biological artificial liver support system of claim 1, it is characterized in that described inner chamber (8) and exocoel (9) are made up of the concentric contour hollow cylinder of two tops and bottom sealing, material is plastics or lucite.

3. according to the described dual-cavity liquid storage tank for biological artificial liver support system of claim 1, it is characterized in that the radius of described first air equalizer opening (4) and second air equalizer opening (3) is 0.3cm, establish filter membrane in all.

4. according to the described dual-cavity liquid storage tank for biological artificial liver support system of claim 3, it is characterized in that described filter membrane is thick to be 0.22 micron, its material is a mixed cellulose ester.

5. according to the described dual-cavity liquid storage tank for biological artificial liver support system of claim 1, it is characterized in that described exocoel side opening (7) has three, diameter is 0.15cm.

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